SLAMF1

Functionⁱ

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4⁺ cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4^-/CD8^- T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns₃P and NOX2 activity in the phagosomes (PubMed:20818396).By similarity2 Publications3 Publications

(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.2 Publications

GO - Molecular functionⁱ

antigen binding
Source: ProtInc
Traceable author statementⁱ
- 7617038
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21217702
- 21982860
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7617038
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
cell adhesion Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
lymphocyte activation Source: InterPro
myeloid dendritic cell activation involved in immune response
Source: UniProtKB
Inferred from direct assayⁱ
- 16317102
negative regulation of CD40 signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16317102
negative regulation of interleukin-12 production
Source: UniProtKB
Inferred from direct assayⁱ
- 16317102
negative regulation of interleukin-6 production
Source: UniProtKB
Inferred from direct assayⁱ
- 16317102
negative regulation of tumor necrosis factor production
Source: UniProtKB
Inferred from direct assayⁱ
- 16317102
phagocytosis Source: UniProtKB-KW
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 7617038
positive regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 20231852
positive regulation of JNK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 20231852

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Adaptive immunity, Cell adhesion, Host-virus interaction, Immunity, Innate immunity, Phagocytosis

Enzyme and pathway databases

SIGNORⁱ	Q13291

SIGNORⁱ

Q13291

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signaling lymphocytic activation molecule Alternative name(s): CDw150 IPO-3 SLAM family member 1 CD_antigen: CD150
Gene namesⁱ	Name:SLAMF1 Synonyms:SLAM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117090.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10903 SLAMF1
MIMⁱ	603492 gene
neXtProtⁱ	NX_Q13291

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 237	ExtracellularSequence analysisAdd BLAST	217
Transmembraneⁱ	238 – 258	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	259 – 335	CytoplasmicSequence analysisAdd BLAST	77

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	269	Y → F: No effect on interaction with INPP5D/SHIP-1, PTPN11/SHP-2 and SH2D1A. 1 Publication	1
Mutagenesisⁱ	279	T → A: Disrupts interaction with SH2D1A; when associated with A-325. 1 Publication	1
Mutagenesisⁱ	281	Y → F: Disrupts interaction with INPP5D/SHIP-1 and PTPN11/SHP-2, no effect on interaction with SH2D1A. 2 Publications	1
Mutagenesisⁱ	281	Y → F: Disrupts interaction with SH2D1A; when associated with F-327. 1 Publication	1
Mutagenesisⁱ	307	Y → F: No effect on interaction with PTPN11/SHP-2 and SH2D1A. 1 Publication	1
Mutagenesisⁱ	325	T → A: Disrupts interaction with SH2D1A; when associated with A-279. 1 Publication	1
Mutagenesisⁱ	327	Y → F: Disrupts interaction with INPP5D/SHIP-1 and PTPN11/SHP-2, no effect on interaction with SH2D1A. 2 Publications	1
Mutagenesisⁱ	327	Y → F: Disrupts interaction with SH2D1A; when associated with F-281. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6504
Open Targets More...OpenTargetsⁱ	ENSG00000117090
PharmGKBⁱ	PA35803

Polymorphism and mutation databases

BioMutaⁱ	SLAMF1
DMDMⁱ	9297047

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000014959	21 – 335	Signaling lymphocytic activation moleculeAdd BLAST		315

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	150	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	155	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	158 ↔ 228	PROSITE-ProRule annotation
Disulfide bondⁱ	164 ↔ 209	PROSITE-ProRule annotation
Glycosylationⁱ	189	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	217	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	281	Phosphotyrosine; by FYN2 Publications	1
Modified residueⁱ	307	Phosphotyrosine; by FYN1 Publication	1
Modified residueⁱ	327	Phosphotyrosine; by FYN1 Publication	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues by FYN.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q13291
PeptideAtlas More...PeptideAtlasⁱ	Q13291
PRIDEⁱ	Q13291
ProteomicsDBⁱ	59283 59284 [Q13291-2] 59285 [Q13291-3]

PTM databases

iPTMnetⁱ	Q13291
PhosphoSitePlusⁱ	Q13291

Expressionⁱ

Tissue specificityⁱ

Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000117090 Expressed in 94 organ(s), highest expression level in thymus
CleanExⁱ	HS_SLAMF1
ExpressionAtlasⁱ	Q13291 baseline and differential
Genevisibleⁱ	Q13291 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002438 HPA069319

HPAⁱ

CAB002438
HPA069319

Interactionⁱ

Subunit structureⁱ

Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214). Interacts with MAP4K1 (PubMed:20231852). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396).9 Publications

(Microbial infection) Interacts with measles hemagglutinin protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-4315002,EBI-4315002
H	Q786F2	2	EBI-4315002,EBI-5323300	From Measles virus (strain Ichinose-B95a).
MAP4K1	Q92918	3	EBI-4315002,EBI-881
SH2D1A	O60880	12	EBI-4315002,EBI-6983382
SH2D1A	O60880-1	2	EBI-4315002,EBI-15552052

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 21217702
- 21982860

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112395, 120 interactors
Database of interacting proteins More...DIPⁱ	DIP-40767N
ELMⁱ	Q13291
IntActⁱ	Q13291, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q13291
STRINGⁱ	9606.ENSP00000306190

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	278 – 281	Combined sources		4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13291
SMRⁱ	Q13291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13291

EvolutionaryTraceⁱ

Q13291

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	29 – 138	Ig-like V-typeAdd BLAST		110
Domainⁱ	144 – 223	Ig-like C2-typeAdd BLAST		80

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	279 – 284	ITSM 11 Publication	6
Motifⁱ	307 – 312	SH2-bindingSequence analysis	6
Motifⁱ	325 – 330	ITSM 22 Publications	6

Domainⁱ

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). SH2D1A binding is mediated by either three 'prongs' (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-281 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-327 for SH2D1A binding.1 Publication2 Publications

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFKK Eukaryota ENOG4111DAM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048858
HOGENOMⁱ	HOG000125310
HOVERGENⁱ	HBG054224
InParanoidⁱ	Q13291
KEGG Orthology (KO) More...KOⁱ	K06536
OMAⁱ	FPAQDPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EOO
PhylomeDBⁱ	Q13291
TreeFamⁱ	TF334964

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR010407 Sig_lymph_act_molc_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06214 SLAM, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD090491 Sig_lymph_act_molc_N, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q13291-1) [UniParc]FASTA Add to basket

Also known as: Long, mCD150

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE 
        60         70         80         90        100
RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL 
       110        120        130        140        150
ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN 
       160        170        180        190        200
KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP 
       210        220        230        240        250
QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM 
       260        270        280        290        300
ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ 
       310        320        330 
DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

Length:335

Mass (Da):37,231

Last modified:November 1, 1996 - v1

Checksum:ⁱBFB0F27EA31D8C04

GO

Isoform 2 (identifier: Q13291-2) [UniParc]FASTA Add to basket

Also known as: Short, SURslam2, vmSLAM

The sequence of this isoform differs from the canonical sequence as follows:
289-298: PLQKKLDSFP → DTHHQTSDLF
299-335: Missing.

« Hide

        10         20         30         40         50
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE 
        60         70         80         90        100
RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL 
       110        120        130        140        150
ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN 
       160        170        180        190        200
KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP 
       210        220        230        240        250
QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM 
       260        270        280        290 
ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGDT HHQTSDLF

Show »

Length:298

Mass (Da):33,365

Checksum:ⁱDCE97AC03ACDC045

GO

Isoform 3 (identifier: Q13291-3) [UniParc]FASTA Add to basket

Also known as: Secreted, SECslam, sSLAM

The sequence of this isoform differs from the canonical sequence as follows:
234-263: Missing.

« Hide

        10         20         30         40         50
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE 
        60         70         80         90        100
RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL 
       110        120        130        140        150
ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN 
       160        170        180        190        200
KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP 
       210        220        230        240        250
QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSGKTNHYQ TTVEKKSLTI 
       260        270        280        290        300
YAQVQKPGPL QKKLDSFPAQ DPCTTIYVAA TEPVPESVQE TNSITVYASV 

TLPES

Show »

Length:305

Mass (Da):33,839

Checksum:ⁱF5CBDC25B2E19967

GO

Isoform 4 (identifier: Q13291-4) [UniParc]FASTA Add to basket

Also known as: nCD150

The sequence of this isoform differs from the canonical sequence as follows:
264-335: GKTNHYQTTV...VYASVTLPES → ATLTTTNQYW...KQIPSQSMLV

« Hide

        10         20         30         40         50
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE 
        60         70         80         90        100
RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL 
       110        120        130        140        150
ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN 
       160        170        180        190        200
KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP 
       210        220        230        240        250
QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM 
       260        270        280        290        300
ILIMVVILQL RRRATLTTTN QYWSQNVLTQ DQERCPGCLP MVKRTITRQQ 
       310        320        330        340        350
WKKKALRSMP KSRNQVLFRR NLTPSQLRTL APPYMLLPQS LSQSLSRKQI 

PSQSMLV

Show »

Length:357

Mass (Da):40,292

Checksum:ⁱDA43C3AE974A5013

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q96QJ2	Q96QJ2_HUMAN		SLAMF1 protein SLAMF1 protein (Signaling lymphocytic activation molecule)	SLAMF1	144	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021924	11	F → L. Corresponds to variant dbSNP:rs2295612Ensembl.	1
Natural variantⁱVAR_035524	81	L → F in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_021925	333	P → T. Corresponds to variant dbSNP:rs3796504Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002567	234 – 263	Missing in isoform 3. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_058033	264 – 335	GKTNH…TLPES → ATLTTTNQYWSQNVLTQDQE RCPGCLPMVKRTITRQQWKK KALRSMPKSRNQVLFRRNLT PSQLRTLAPPYMLLPQSLSQ SLSRKQIPSQSMLV in isoform 4. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_002568	289 – 298	PLQKKLDSFP → DTHHQTSDLF in isoform 2. 1 Publication	10
Alternative sequenceⁱVSP_002569	299 – 335	Missing in isoform 2. 1 PublicationAdd BLAST	37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33017 mRNA Translation: AAA75380.1 KF471075 mRNA Translation: AHF72732.1 AL121985 Genomic DNA No translation available. AL138930 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52706.1 BC132792 mRNA Translation: AAI32793.1 AF252305 Genomic DNA Translation: AAG10434.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1207.1 [Q13291-1] CCDS81389.1 [Q13291-4]
PIRⁱ	S58892
NCBI Reference Sequences More...RefSeqⁱ	NP_001317683.1, NM_001330754.1 [Q13291-4] NP_003028.1, NM_003037.4 [Q13291-1] XP_005245513.1, XM_005245456.3 [Q13291-3]
UniGeneⁱ	Hs.523660

Genome annotation databases

Ensemblⁱ	ENST00000302035; ENSP00000306190; ENSG00000117090 [Q13291-1] ENST00000538290; ENSP00000438406; ENSG00000117090 [Q13291-4]
GeneIDⁱ	6504
KEGGⁱ	hsa:6504
UCSC genome browser More...UCSCⁱ	uc001fwl.6 human [Q13291-1] uc031vca.2 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13291	cDNA, FLJ94989, highly similar to Homo sapiens signaling lymphocytic activation molecule family member 1 (SLAMF1), mRNA		HUMAN		335	UniRef90_Q13291
SLAMF1 isoform 1		PANTR		335
Signaling lymphocytic activation molecule		MACMU		335
Signaling lymphocytic activation molecule family member 1		MACFA		335
Signaling lymphocytic activation molecule family member 1 (Fragment)		MACNE		335
+16
Q13291-2	Isoform 4 of Signaling lymphocytic activation molecule		HUMAN		357	UniRef90_Q13291-4
SLAMF1 isoform 3		PANTR		357
Signaling lymphocytic activation molecule (Fragment)		PIG		63
Uncharacterized protein		COLAP		357
SLAMF1 isoform 3		PONAB		357
+14
Q13291-3	Uncharacterized protein		MACNE		305	UniRef90_Q13291-3
UPI000B7B2993		PAPAN		314
UPI00045DE267		CHLSB		305
UPI0005F3A0CA		CERAT		305
Q13291-4	SLAMF1 isoform 3		PANTR		357	UniRef90_Q13291-4
Signaling lymphocytic activation molecule (Fragment)		HUMAN		207
Signaling lymphocytic activation molecule (Fragment)		PIG		63
Uncharacterized protein		COLAP		357
SLAMF1 isoform 3		PONAB		357
+14

Protein	Similar proteins		Species	Score	Length	Source
Q13291	Signaling lymphocytic activation molecule		CANLF		342	UniRef50_Q13291
SLAMF1 isoform 1		PANTR		335
Uncharacterized protein		COLAP		335
SLAM		HUMAN		335
Uncharacterized protein		PONAB		335
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33017 mRNA Translation: AAA75380.1 KF471075 mRNA Translation: AHF72732.1 AL121985 Genomic DNA No translation available. AL138930 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52706.1 BC132792 mRNA Translation: AAI32793.1 AF252305 Genomic DNA Translation: AAG10434.1
CCDSⁱ	CCDS1207.1 [Q13291-1] CCDS81389.1 [Q13291-4]
PIRⁱ	S58892
RefSeqⁱ	NP_001317683.1, NM_001330754.1 [Q13291-4] NP_003028.1, NM_003037.4 [Q13291-1] XP_005245513.1, XM_005245456.3 [Q13291-3]
UniGeneⁱ	Hs.523660

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1D4T	X-ray	1.10	B	276-286	[»]
	1D4W	X-ray	1.80	C/D	276-286	[»]
	1I3Z	X-ray	2.15	B	273-286	[»]
	1KA6	NMR	-	B	275-282	[»]
	1KA7	NMR	-	B	275-286	[»]
	1M27	X-ray	2.50	B	276-286	[»]
	2DZF	model	-	@	1-335	[»]
	2IE9	model	-	@	1-335	[»]
	2IFL	model	-	@	3-335	[»]
	2IG5	model	-	@	1-335	[»]
ProteinModelPortalⁱ	Q13291
SMRⁱ	Q13291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112395, 120 interactors
DIPⁱ	DIP-40767N
ELMⁱ	Q13291
IntActⁱ	Q13291, 11 interactors
MINTⁱ	Q13291
STRINGⁱ	9606.ENSP00000306190

PTM databases

iPTMnetⁱ	Q13291
PhosphoSitePlusⁱ	Q13291

Polymorphism and mutation databases

BioMutaⁱ	SLAMF1
DMDMⁱ	9297047

Proteomic databases

PaxDbⁱ	Q13291
PeptideAtlasⁱ	Q13291
PRIDEⁱ	Q13291
ProteomicsDBⁱ	59283 59284 [Q13291-2] 59285 [Q13291-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6504
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302035; ENSP00000306190; ENSG00000117090 [Q13291-1] ENST00000538290; ENSP00000438406; ENSG00000117090 [Q13291-4]
GeneIDⁱ	6504
KEGGⁱ	hsa:6504
UCSCⁱ	uc001fwl.6 human [Q13291-1] uc031vca.2 human

Organism-specific databases

CTDⁱ	6504
DisGeNETⁱ	6504
EuPathDBⁱ	HostDB:ENSG00000117090.14
GeneCardsⁱ	SLAMF1
HGNCⁱ	HGNC:10903 SLAMF1
HPAⁱ	CAB002438 HPA069319
MIMⁱ	603492 gene
neXtProtⁱ	NX_Q13291
OpenTargetsⁱ	ENSG00000117090
PharmGKBⁱ	PA35803
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFKK Eukaryota ENOG4111DAM LUCA
GeneTreeⁱ	ENSGT00510000048858
HOGENOMⁱ	HOG000125310
HOVERGENⁱ	HBG054224
InParanoidⁱ	Q13291
KOⁱ	K06536
OMAⁱ	FPAQDPC
OrthoDBⁱ	EOG091G0EOO
PhylomeDBⁱ	Q13291
TreeFamⁱ	TF334964

Enzyme and pathway databases

SIGNORⁱ	Q13291

SIGNORⁱ

Q13291

Miscellaneous databases

ChiTaRSⁱ	SLAMF1 human
EvolutionaryTraceⁱ	Q13291
GeneWikiⁱ	SLAMF1
GenomeRNAiⁱ	6504
Protein Ontology More...PROⁱ	PR:Q13291
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117090 Expressed in 94 organ(s), highest expression level in thymus
CleanExⁱ	HS_SLAMF1
ExpressionAtlasⁱ	Q13291 baseline and differential
Genevisibleⁱ	Q13291 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR010407 Sig_lymph_act_molc_N
Pfamⁱ	View protein in Pfam PF06214 SLAM, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD090491 Sig_lymph_act_molc_N, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SLAF1_HUMAN
Accessionⁱ	Q13291Primary (citable) accession number: Q13291 Secondary accession number(s): Q5W172, Q9HBE8, W0HKK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - Q13291 (SLAF1_HUMAN)

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Signaling lymphocytic activation molecule

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ