UniProtKB - Q13291 (SLAF1_HUMAN)
Signaling lymphocytic activation molecule
SLAMF1
Functioni
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999).
However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214).
Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity).
Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity).
Promotes T-cell receptor-induced IL-4 secretion by CD4+ cells (By similarity).
Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells (By similarity).
Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity).
May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102).
May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity).
In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity).
In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity).
In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity).
In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852).
In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity).
Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns3P and NOX2 activity in the phagosomes (PubMed:20818396).
By similarity2 Publications3 Publications(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.
2 PublicationsGO - Molecular functioni
- antigen binding Source: ProtInc
- identical protein binding Source: IntAct
- SH2 domain binding Source: UniProtKB
- signaling receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: ProtInc
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell adhesion Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- leukocyte chemotaxis involved in inflammatory response Source: Ensembl
- myeloid dendritic cell activation involved in immune response Source: UniProtKB
- natural killer cell differentiation Source: Ensembl
- natural killer cell proliferation Source: Ensembl
- negative regulation of CD40 signaling pathway Source: UniProtKB
- negative regulation of interferon-gamma production Source: Ensembl
- negative regulation of interleukin-12 production Source: UniProtKB
- negative regulation of interleukin-6 production Source: UniProtKB
- negative regulation of T cell cytokine production Source: Ensembl
- negative regulation of tumor necrosis factor production Source: UniProtKB
- phagocytosis Source: UniProtKB-KW
- positive regulation of activated T cell proliferation Source: Ensembl
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of dendritic cell chemotaxis Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of interferon-gamma production Source: GO_Central
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of macrophage chemotaxis Source: Ensembl
- positive regulation of T-helper 1 cell cytokine production Source: Ensembl
- regulation of catalytic activity Source: Ensembl
- regulation of vesicle fusion Source: Ensembl
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Adaptive immunity, Cell adhesion, Host-virus interaction, Immunity, Innate immunity, Phagocytosis |
Enzyme and pathway databases
PathwayCommonsi | Q13291 |
SignaLinki | Q13291 |
SIGNORi | Q13291 |
Names & Taxonomyi
Protein namesi | Recommended name: Signaling lymphocytic activation moleculeAlternative name(s): CDw150 IPO-3 SLAM family member 1 CD_antigen: CD150 |
Gene namesi | Name:SLAMF1 Synonyms:SLAM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10903, SLAMF1 |
MIMi | 603492, gene |
neXtProti | NX_Q13291 |
VEuPathDBi | HostDB:ENSG00000117090 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein
Note: Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999).1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- phagocytic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 237 | ExtracellularSequence analysisAdd BLAST | 217 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 335 | CytoplasmicSequence analysisAdd BLAST | 77 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 269 | Y → F: No effect on interaction with INPP5D/SHIP-1, PTPN11/SHP-2 and SH2D1A. 1 Publication | 1 | |
Mutagenesisi | 279 | T → A: Disrupts interaction with SH2D1A; when associated with A-325. 1 Publication | 1 | |
Mutagenesisi | 281 | Y → F: Disrupts interaction with INPP5D/SHIP-1 and PTPN11/SHP-2, no effect on interaction with SH2D1A. 2 Publications | 1 | |
Mutagenesisi | 281 | Y → F: Disrupts interaction with SH2D1A; when associated with F-327. 1 Publication | 1 | |
Mutagenesisi | 307 | Y → F: No effect on interaction with PTPN11/SHP-2 and SH2D1A. 1 Publication | 1 | |
Mutagenesisi | 325 | T → A: Disrupts interaction with SH2D1A; when associated with A-279. 1 Publication | 1 | |
Mutagenesisi | 327 | Y → F: Disrupts interaction with INPP5D/SHIP-1 and PTPN11/SHP-2, no effect on interaction with SH2D1A. 2 Publications | 1 | |
Mutagenesisi | 327 | Y → F: Disrupts interaction with SH2D1A; when associated with F-281. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6504 |
OpenTargetsi | ENSG00000117090 |
PharmGKBi | PA35803 |
Miscellaneous databases
Pharosi | Q13291, Tbio |
Genetic variation databases
BioMutai | SLAMF1 |
DMDMi | 9297047 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014959 | 21 – 335 | Signaling lymphocytic activation moleculeAdd BLAST | 315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 158 ↔ 228 | PROSITE-ProRule annotation | ||
Disulfide bondi | 164 ↔ 209 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 217 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 281 | Phosphotyrosine; by FYN2 Publications | 1 | |
Modified residuei | 307 | Phosphotyrosine; by FYN1 Publication | 1 | |
Modified residuei | 327 | Phosphotyrosine; by FYN1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q13291 |
PaxDbi | Q13291 |
PeptideAtlasi | Q13291 |
PRIDEi | Q13291 |
ProteomicsDBi | 59283 [Q13291-1] 59284 [Q13291-2] 59285 [Q13291-3] |
PTM databases
GlyGeni | Q13291, 8 sites |
iPTMneti | Q13291 |
PhosphoSitePlusi | Q13291 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000117090, Expressed in thymus and 113 other tissues |
ExpressionAtlasi | Q13291, baseline and differential |
Genevisiblei | Q13291, HS |
Organism-specific databases
HPAi | ENSG00000117090, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214).
Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214).
Interacts with MAP4K1 (PubMed:20231852).
Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396).
9 Publications(Microbial infection) Interacts with measles hemagglutinin protein.
1 PublicationBinary interactionsi
Q13291
GO - Molecular functioni
- identical protein binding Source: IntAct
- SH2 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112395, 126 interactors |
DIPi | DIP-40767N |
ELMi | Q13291 |
IntActi | Q13291, 63 interactors |
MINTi | Q13291 |
STRINGi | 9606.ENSP00000306190 |
Miscellaneous databases
RNActi | Q13291, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13291 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13291 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 138 | Ig-like V-typeAdd BLAST | 110 | |
Domaini | 144 – 223 | Ig-like C2-typeAdd BLAST | 80 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 279 – 284 | ITSM 11 Publication | 6 | |
Motifi | 307 – 312 | SH2-bindingSequence analysis | 6 | |
Motifi | 325 – 330 | ITSM 22 Publications | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SVMG, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_066453_0_0_1 |
InParanoidi | Q13291 |
OMAi | DHVAYNW |
OrthoDBi | 1532935at2759 |
PhylomeDBi | Q13291 |
TreeFami | TF334964 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR010407, Sig_lymph_act_molc_N |
Pfami | View protein in Pfam PF06214, SLAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE
60 70 80 90 100
RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL
110 120 130 140 150
ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN
160 170 180 190 200
KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP
210 220 230 240 250
QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM
260 270 280 290 300
ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ
310 320 330
DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ96QJ2 | Q96QJ2_HUMAN | SLAMF1 protein | SLAMF1 | 144 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021924 | 11 | F → L. Corresponds to variant dbSNP:rs2295612Ensembl. | 1 | |
Natural variantiVAR_035524 | 81 | L → F in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1373814964Ensembl. | 1 | |
Natural variantiVAR_021925 | 333 | P → T. Corresponds to variant dbSNP:rs3796504Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002567 | 234 – 263 | Missing in isoform 3. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_058033 | 264 – 335 | GKTNH…TLPES → ATLTTTNQYWSQNVLTQDQE RCPGCLPMVKRTITRQQWKK KALRSMPKSRNQVLFRRNLT PSQLRTLAPPYMLLPQSLSQ SLSRKQIPSQSMLV in isoform 4. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_002568 | 289 – 298 | PLQKKLDSFP → DTHHQTSDLF in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_002569 | 299 – 335 | Missing in isoform 2. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33017 mRNA Translation: AAA75380.1 KF471075 mRNA Translation: AHF72732.1 AL121985 Genomic DNA No translation available. AL138930 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52706.1 BC132792 mRNA Translation: AAI32793.1 AF252305 Genomic DNA Translation: AAG10434.1 |
CCDSi | CCDS1207.1 [Q13291-1] CCDS81389.1 [Q13291-4] |
PIRi | S58892 |
RefSeqi | NP_001317683.1, NM_001330754.1 [Q13291-4] NP_003028.1, NM_003037.4 [Q13291-1] XP_005245513.1, XM_005245456.3 [Q13291-3] |
Genome annotation databases
Ensembli | ENST00000302035; ENSP00000306190; ENSG00000117090 ENST00000538290; ENSP00000438406; ENSG00000117090 [Q13291-4] |
GeneIDi | 6504 |
KEGGi | hsa:6504 |
MANE-Selecti | ENST00000302035.11; ENSP00000306190.6; NM_003037.5; NP_003028.1 |
UCSCi | uc001fwl.6, human [Q13291-1] uc031vca.2, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33017 mRNA Translation: AAA75380.1 KF471075 mRNA Translation: AHF72732.1 AL121985 Genomic DNA No translation available. AL138930 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52706.1 BC132792 mRNA Translation: AAI32793.1 AF252305 Genomic DNA Translation: AAG10434.1 |
CCDSi | CCDS1207.1 [Q13291-1] CCDS81389.1 [Q13291-4] |
PIRi | S58892 |
RefSeqi | NP_001317683.1, NM_001330754.1 [Q13291-4] NP_003028.1, NM_003037.4 [Q13291-1] XP_005245513.1, XM_005245456.3 [Q13291-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D4T | X-ray | 1.10 | B | 276-286 | [»] | |
1D4W | X-ray | 1.80 | C/D | 276-286 | [»] | |
1I3Z | X-ray | 2.15 | B | 273-286 | [»] | |
1KA6 | NMR | - | B | 275-282 | [»] | |
1KA7 | NMR | - | B | 275-286 | [»] | |
1M27 | X-ray | 2.50 | B | 276-286 | [»] | |
SMRi | Q13291 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112395, 126 interactors |
DIPi | DIP-40767N |
ELMi | Q13291 |
IntActi | Q13291, 63 interactors |
MINTi | Q13291 |
STRINGi | 9606.ENSP00000306190 |
PTM databases
GlyGeni | Q13291, 8 sites |
iPTMneti | Q13291 |
PhosphoSitePlusi | Q13291 |
Genetic variation databases
BioMutai | SLAMF1 |
DMDMi | 9297047 |
Proteomic databases
MassIVEi | Q13291 |
PaxDbi | Q13291 |
PeptideAtlasi | Q13291 |
PRIDEi | Q13291 |
ProteomicsDBi | 59283 [Q13291-1] 59284 [Q13291-2] 59285 [Q13291-3] |
Protocols and materials databases
Antibodypediai | 3725, 998 antibodies from 45 providers |
DNASUi | 6504 |
Genome annotation databases
Ensembli | ENST00000302035; ENSP00000306190; ENSG00000117090 ENST00000538290; ENSP00000438406; ENSG00000117090 [Q13291-4] |
GeneIDi | 6504 |
KEGGi | hsa:6504 |
MANE-Selecti | ENST00000302035.11; ENSP00000306190.6; NM_003037.5; NP_003028.1 |
UCSCi | uc001fwl.6, human [Q13291-1] uc031vca.2, human |
Organism-specific databases
CTDi | 6504 |
DisGeNETi | 6504 |
GeneCardsi | SLAMF1 |
HGNCi | HGNC:10903, SLAMF1 |
HPAi | ENSG00000117090, Tissue enriched (lymphoid) |
MIMi | 603492, gene |
neXtProti | NX_Q13291 |
OpenTargetsi | ENSG00000117090 |
PharmGKBi | PA35803 |
VEuPathDBi | HostDB:ENSG00000117090 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SVMG, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_066453_0_0_1 |
InParanoidi | Q13291 |
OMAi | DHVAYNW |
OrthoDBi | 1532935at2759 |
PhylomeDBi | Q13291 |
TreeFami | TF334964 |
Enzyme and pathway databases
PathwayCommonsi | Q13291 |
SignaLinki | Q13291 |
SIGNORi | Q13291 |
Miscellaneous databases
BioGRID-ORCSi | 6504, 11 hits in 1038 CRISPR screens |
ChiTaRSi | SLAMF1, human |
EvolutionaryTracei | Q13291 |
GeneWikii | SLAMF1 |
GenomeRNAii | 6504 |
Pharosi | Q13291, Tbio |
PROi | PR:Q13291 |
RNActi | Q13291, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117090, Expressed in thymus and 113 other tissues |
ExpressionAtlasi | Q13291, baseline and differential |
Genevisiblei | Q13291, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR010407, Sig_lymph_act_molc_N |
Pfami | View protein in Pfam PF06214, SLAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SLAF1_HUMAN | |
Accessioni | Q13291Primary (citable) accession number: Q13291 Secondary accession number(s): Q5W172, Q9HBE8, W0HKK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references