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Protein

N-myc-interactor

Gene

NMI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription coregulator activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ13287

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc-interactor
Short name:
Nmi
Alternative name(s):
N-myc and STAT interactor
Gene namesi
Name:NMI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000123609.10
HGNCiHGNC:7854 NMI
MIMi603525 gene
neXtProtiNX_Q13287

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9111
OpenTargetsiENSG00000123609
PharmGKBiPA31659

Polymorphism and mutation databases

BioMutaiNMI
DMDMi116242679

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597021 – 307N-myc-interactorAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13287
MaxQBiQ13287
PaxDbiQ13287
PeptideAtlasiQ13287
PRIDEiQ13287
ProteomicsDBi59282

PTM databases

iPTMnetiQ13287
PhosphoSitePlusiQ13287

Expressioni

Tissue specificityi

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Inductioni

By IL2/interleukin-2 and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000123609 Expressed in 212 organ(s), highest expression level in bone marrow
CleanExiHS_NMI
ExpressionAtlasiQ13287 baseline and differential
GenevisibleiQ13287 HS

Organism-specific databases

HPAiHPA008588

Interactioni

Subunit structurei

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114561, 69 interactors
CORUMiQ13287
IntActiQ13287, 77 interactors
MINTiQ13287
STRINGi9606.ENSP00000243346

Structurei

3D structure databases

ProteinModelPortaliQ13287
SMRiQ13287
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IFIM Eukaryota
ENOG4111N1Z LUCA
GeneTreeiENSGT00530000063686
HOGENOMiHOG000072676
HOVERGENiHBG019086
InParanoidiQ13287
OMAiEDQMRDK
OrthoDBiEOG091G0CE6
PhylomeDBiQ13287
TreeFamiTF332752

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR033527 NMI
IPR009909 Nmi/IFP35_dom
IPR009938 Nmi/IFP35_N
IPR012677 Nucleotide-bd_a/b_plait_sf
PANTHERiPTHR15225:SF4 PTHR15225:SF4, 1 hit
PfamiView protein in Pfam
PF07334 IFP_35_N, 1 hit
PF07292 NID, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q13287-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL KKEIQKLETE
60 70 80 90 100
LQEATKEFQI KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI
110 120 130 140 150
QKGQALITFE KEEVAQNVVS MSKHHVQIKD VNLEVTAKPV PLNSGVRFQV
160 170 180 190 200
YVEVSKMKIN VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS
210 220 230 240 250
GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE IHLKKYQIFS
260 270 280 290 300
GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP

HIAYFEE
Length:307
Mass (Da):35,057
Last modified:October 17, 2006 - v2
Checksum:iEC228BD0C9E643F1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW17C9JW17_HUMAN
N-myc-interactor
NMI
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41K → R in AAH21987 (PubMed:15489334).Curated1
Sequence conflicti184S → F in AAC12949 (PubMed:8668343).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02819016S → L. Corresponds to variant dbSNP:rs1048135Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32849 mRNA Translation: AAC12949.1
AB451305 mRNA Translation: BAG70119.1
AB451436 mRNA Translation: BAG70250.1
AC009311 Genomic DNA Translation: AAY15066.1
CH471058 Genomic DNA Translation: EAX11513.1
BC001268 mRNA Translation: AAH01268.1
BC021987 mRNA Translation: AAH21987.1
CCDSiCCDS2192.1
RefSeqiNP_004679.2, NM_004688.2
XP_005246998.1, XM_005246941.2
XP_016860736.1, XM_017005247.1
UniGeneiHs.54483

Genome annotation databases

EnsembliENST00000243346; ENSP00000243346; ENSG00000123609
GeneIDi9111
KEGGihsa:9111
UCSCiuc002txi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNMI_HUMAN
AccessioniPrimary (citable) accession number: Q13287
Secondary accession number(s): B5BU69
, Q53TI8, Q8WTW2, Q9BVE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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