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Protein

Steroidogenic factor 1

Gene

NR5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei341Lipid headgroup; via amide nitrogen1
Binding sitei436Lipid headgroup1
Binding sitei440Lipid headgroup1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 85Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri13 – 33NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri49 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkiQ13285
SIGNORiQ13285

Names & Taxonomyi

Protein namesi
Recommended name:
Steroidogenic factor 1
Short name:
SF-1
Short name:
STF-1
Short name:
hSF-11 Publication
Alternative name(s):
Adrenal 4-binding protein
Fushi tarazu factor homolog 1
Nuclear receptor subfamily 5 group A member 1
Steroid hormone receptor Ad4BP
Gene namesi
Name:NR5A1
Synonyms:AD4BP, FTZF1, SF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136931.9
HGNCiHGNC:7983 NR5A1
MIMi184757 gene
neXtProtiNX_Q13285

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

46,XY sex reversal 3 (SRXY3)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype.
See also OMIM:612965
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06325515V → M in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894124EnsemblClinVar.1
Natural variantiVAR_07957118 – 22Missing in SRXY3; loss of DNA-binding; significantly decreased transactivator activity. 1 Publication5
Natural variantiVAR_03910633C → S in SRXY3; without adrenal failure; markedly impaired transcriptional activity. 1 Publication1
Natural variantiVAR_00473735G → E in SRXY3; with adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs121918654EnsemblClinVar.1
Natural variantiVAR_07957240T → P in SRXY3; loss of DNA-binding; significantly decreased transactivator activity. 1 Publication1
Natural variantiVAR_07813665C → Y in SRXY3; without adrenal failure. 1 Publication1
Natural variantiVAR_06325678M → I in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894125EnsemblClinVar.1
Natural variantiVAR_03910784R → H in SRXY3; without adrenal failure; markedly impaired transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs375469069Ensembl.1
Natural variantiVAR_06325791G → S in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894126EnsemblClinVar.1
Natural variantiVAR_01698292R → Q in SRXY3, SRXX4 and AINR; decreased transactivator activity; no effect on nuclear location. 4 PublicationsCorresponds to variant dbSNP:rs104894119EnsemblClinVar.1
Natural variantiVAR_063258437L → Q in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894120EnsemblClinVar.1
46,XX sex reversal 4 (SRXX4)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition in which male gonads develop in a genetic female (female to male sex reversal).
See also OMIM:617480
Adrenal insufficiency, NR5A1-related (AINR)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by adrenal insufficiency, muscular hypotonia, decreased sodium and increased potassium levels, elevated ACTH, salt-wasting crisis, prolonged jaundice, hypoglycemia, and vomiting.
See also OMIM:612964
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016983255R → L in AINR. 1 PublicationCorresponds to variant dbSNP:rs104894118EnsemblClinVar.1
Premature ovarian failure 7 (POF7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
See also OMIM:612964
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062969231 – 233Missing in POF7. 1 Publication3
Natural variantiVAR_062970293D → N in POF7; without adrenal failure; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121918655EnsemblClinVar.1
Spermatogenic failure 8 (SPGF8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder characterized by spermatogenesis failure and severe oligozoospermia.
See also OMIM:613957
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065866131P → L in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs387906690EnsemblClinVar.1
Natural variantiVAR_065867191R → C in SPGF8; impairs transactivational activity. 1 Publication1
Natural variantiVAR_065868212G → S in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs201095702EnsemblClinVar.1
Natural variantiVAR_065869238D → N in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs780568525Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119K → R: Loss of sumoylation; when associated with R-194. 1 Publication1
Mutagenesisi194K → R: Loss of sumoylation. 1 Publication1
Mutagenesisi269A → F: Strongly reduced transactivation. 1 Publication1
Mutagenesisi341G → E: Reduced transactivation. Strongly reduced transactivation; when associated with F-344. 1 Publication1
Mutagenesisi344L → F: Reduced transactivation. Strongly reduced transactivation; when associated with E-341. 1 Publication1
Mutagenesisi433A → F: Strongly reduced transactivation. 1 Publication1
Mutagenesisi436Y → F: Loss of transactivation; when associated with A-440. 1 Publication1
Mutagenesisi440K → A: Loss of transactivation; when associated with F-436. 1 Publication1

Keywords - Diseasei

Disease mutation, Premature ovarian failure

Organism-specific databases

DisGeNETi2516
GeneReviewsiNR5A1
MalaCardsiNR5A1
MIMi612964 phenotype
612965 phenotype
613957 phenotype
617480 phenotype
OpenTargetsiENSG00000136931
Orphaneti243 46,XX gonadal dysgenesis
2138 46,XX ovotesticular disorder of sex development
393 46,XX testicular disorder of sex development
242 46,XY complete gonadal dysgenesis
251510 46,XY partial gonadal dysgenesis
399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation
619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA31764

Chemistry databases

ChEMBLiCHEMBL4666
DrugBankiDB04752 Phosphatidyl ethanol

Polymorphism and mutation databases

BioMutaiNR5A1
DMDMi3121738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537291 – 461Steroidogenic factor 1Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysine1 Publication1
Modified residuei38N6-acetyllysine1 Publication1
Modified residuei72N6-acetyllysine1 Publication1
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei203Phosphoserine; by CDK73 Publications1

Post-translational modificationi

Acetylation stimulates the transcriptional activity.1 Publication
Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.2 Publications
Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ13285
PeptideAtlasiQ13285
PRIDEiQ13285
ProteomicsDBi59276

PTM databases

iPTMnetiQ13285
PhosphoSitePlusiQ13285

Expressioni

Tissue specificityi

High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).1 Publication

Gene expression databases

BgeeiENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_NR5A1
HS_SF1
ExpressionAtlasiQ13285 baseline and differential
GenevisibleiQ13285 HS

Interactioni

Subunit structurei

Binds DNA as a monomer. Interacts with NR0B2 and PPARGC1A (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NCOA2. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3.By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108792, 26 interactors
IntActiQ13285, 41 interactors
MINTiQ13285
STRINGi9606.ENSP00000362690

Chemistry databases

BindingDBiQ13285

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13285
SMRiQ13285
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13285

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 459NR LBDPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 461Important for dimerizationAdd BLAST232

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 33NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri49 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000063718
HOVERGENiHBG106677
InParanoidiQ13285
KOiK08560
OMAiLQEPAKG
OrthoDBiEOG091G06RK
PhylomeDBiQ13285
TreeFamiTF350737

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q13285-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT
60 70 80 90 100
ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK
110 120 130 140 150
RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPAPDYVL PPSLHGPEPK
160 170 180 190 200
GLAAGPPAGP LGDFGAPALP MAVPGAHGPL AGYLYPAFPG RAIKSEYPEP
210 220 230 240 250
YASPPQPGLP YGYPEPFSGG PNVPELILQL LQLEPDEDQV RARILGCLQE
260 270 280 290 300
PTKSRPDQPA AFGLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN
310 320 330 340 350
CWSELLVFDH IYRQVQHGKE GSILLVTGQE VELTTVATQA GSLLHSLVLR
360 370 380 390 400
AQELVLQLLA LQLDRQEFVC LKFIILFSLD LKFLNNHILV KDAQEKANAA
410 420 430 440 450
LLDYTLCHYP HCGDKFQQLL LCLVEVRALS MQAKEYLYHK HLGNEMPRNN
460
LLIEMLQAKQ T
Length:461
Mass (Da):51,636
Last modified:January 1, 1998 - v2
Checksum:i622644C62794826C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1DAM0F1DAM0_HUMAN
Steroidogenic factor 1 nuclear rece...
NR5A1
421Annotation score:
Q5T6F7Q5T6F7_HUMAN
Steroidogenic factor 1
NR5A1
245Annotation score:
Q5T6F6Q5T6F6_HUMAN
Steroidogenic factor 1
NR5A1
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63K → N in BAA13546 (PubMed:8806624).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06325515V → M in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894124EnsemblClinVar.1
Natural variantiVAR_07957118 – 22Missing in SRXY3; loss of DNA-binding; significantly decreased transactivator activity. 1 Publication5
Natural variantiVAR_03910633C → S in SRXY3; without adrenal failure; markedly impaired transcriptional activity. 1 Publication1
Natural variantiVAR_00473735G → E in SRXY3; with adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs121918654EnsemblClinVar.1
Natural variantiVAR_07957240T → P in SRXY3; loss of DNA-binding; significantly decreased transactivator activity. 1 Publication1
Natural variantiVAR_07813665C → Y in SRXY3; without adrenal failure. 1 Publication1
Natural variantiVAR_06325678M → I in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894125EnsemblClinVar.1
Natural variantiVAR_03910784R → H in SRXY3; without adrenal failure; markedly impaired transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs375469069Ensembl.1
Natural variantiVAR_06325791G → S in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894126EnsemblClinVar.1
Natural variantiVAR_01698292R → Q in SRXY3, SRXX4 and AINR; decreased transactivator activity; no effect on nuclear location. 4 PublicationsCorresponds to variant dbSNP:rs104894119EnsemblClinVar.1
Natural variantiVAR_07813792R → W in SRXY3 and SRXX4; decreased transactivator activity; loss of DNA binding, at least to some known consensus target sequences; no effect on nuclear location. 3 PublicationsCorresponds to variant dbSNP:rs886039769EnsemblClinVar.1
Natural variantiVAR_062967123G → A in SPGF8 and POF7; activity levels similar to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs200163795EnsemblClinVar.1
Natural variantiVAR_062968129P → L in SPGF8 and POF7; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs200749741EnsemblClinVar.1
Natural variantiVAR_065866131P → L in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs387906690EnsemblClinVar.1
Natural variantiVAR_039108146G → A2 PublicationsCorresponds to variant dbSNP:rs1110061EnsemblClinVar.1
Natural variantiVAR_065867191R → C in SPGF8; impairs transactivational activity. 1 Publication1
Natural variantiVAR_065868212G → S in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs201095702EnsemblClinVar.1
Natural variantiVAR_062969231 – 233Missing in POF7. 1 Publication3
Natural variantiVAR_065869238D → N in SPGF8; impairs transactivational activity. 1 PublicationCorresponds to variant dbSNP:rs780568525Ensembl.1
Natural variantiVAR_016983255R → L in AINR. 1 PublicationCorresponds to variant dbSNP:rs104894118EnsemblClinVar.1
Natural variantiVAR_062970293D → N in POF7; without adrenal failure; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121918655EnsemblClinVar.1
Natural variantiVAR_063258437L → Q in SRXY3; without adrenal failure. 1 PublicationCorresponds to variant dbSNP:rs104894120EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88155 Genomic DNA Translation: BAA13546.1
U76388 mRNA Translation: AAB53105.1
AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87591.1
BC032501 mRNA Translation: AAH32501.1
U32592 Genomic DNA Translation: AAA75332.1
CCDSiCCDS6856.1
PIRiJC4972
RefSeqiNP_004950.2, NM_004959.4
XP_005251928.1, XM_005251871.3
XP_011516757.1, XM_011518455.2
UniGeneiHs.495108

Genome annotation databases

EnsembliENST00000373588; ENSP00000362690; ENSG00000136931
GeneIDi2516
KEGGihsa:2516
UCSCiuc004boo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88155 Genomic DNA Translation: BAA13546.1
U76388 mRNA Translation: AAB53105.1
AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87591.1
BC032501 mRNA Translation: AAH32501.1
U32592 Genomic DNA Translation: AAA75332.1
CCDSiCCDS6856.1
PIRiJC4972
RefSeqiNP_004950.2, NM_004959.4
XP_005251928.1, XM_005251871.3
XP_011516757.1, XM_011518455.2
UniGeneiHs.495108

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YOWX-ray3.00A222-461[»]
1ZDTX-ray2.10A/B221-461[»]
4QJRX-ray2.40A218-461[»]
4QK4X-ray2.81A218-461[»]
ProteinModelPortaliQ13285
SMRiQ13285
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108792, 26 interactors
IntActiQ13285, 41 interactors
MINTiQ13285
STRINGi9606.ENSP00000362690

Chemistry databases

BindingDBiQ13285
ChEMBLiCHEMBL4666
DrugBankiDB04752 Phosphatidyl ethanol

PTM databases

iPTMnetiQ13285
PhosphoSitePlusiQ13285

Polymorphism and mutation databases

BioMutaiNR5A1
DMDMi3121738

Proteomic databases

PaxDbiQ13285
PeptideAtlasiQ13285
PRIDEiQ13285
ProteomicsDBi59276

Protocols and materials databases

DNASUi2516
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373588; ENSP00000362690; ENSG00000136931
GeneIDi2516
KEGGihsa:2516
UCSCiuc004boo.2 human

Organism-specific databases

CTDi2516
DisGeNETi2516
EuPathDBiHostDB:ENSG00000136931.9
GeneCardsiNR5A1
GeneReviewsiNR5A1
HGNCiHGNC:7983 NR5A1
MalaCardsiNR5A1
MIMi184757 gene
612964 phenotype
612965 phenotype
613957 phenotype
617480 phenotype
neXtProtiNX_Q13285
OpenTargetsiENSG00000136931
Orphaneti243 46,XX gonadal dysgenesis
2138 46,XX ovotesticular disorder of sex development
393 46,XX testicular disorder of sex development
242 46,XY complete gonadal dysgenesis
251510 46,XY partial gonadal dysgenesis
399805 Male infertility with azoospermia or oligozoospermia due to single gene mutation
619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA31764
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000063718
HOVERGENiHBG106677
InParanoidiQ13285
KOiK08560
OMAiLQEPAKG
OrthoDBiEOG091G06RK
PhylomeDBiQ13285
TreeFamiTF350737

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
SignaLinkiQ13285
SIGNORiQ13285

Miscellaneous databases

EvolutionaryTraceiQ13285
GeneWikiiSteroidogenic_factor_1
GenomeRNAii2516
PROiPR:Q13285
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_NR5A1
HS_SF1
ExpressionAtlasiQ13285 baseline and differential
GenevisibleiQ13285 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTF1_HUMAN
AccessioniPrimary (citable) accession number: Q13285
Secondary accession number(s): O15196, Q5T6F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 208 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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