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Protein

Ras GTPase-activating protein-binding protein 1

Gene

G3BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Mg2+ is required for helicase activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: ProtInc
  • ATP-dependent RNA helicase activity Source: ProtInc
  • DNA binding Source: UniProtKB-KW
  • endonuclease activity Source: UniProtKB-KW
  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: Ensembl
  • Ras protein signal transduction Source: ProtInc
  • stress granule assembly Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Helicase, Hydrolase, Nuclease, RNA-binding
Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein-binding protein 1 (EC:3.6.4.121 Publication, EC:3.6.4.131 Publication)
Short name:
G3BP-1
Alternative name(s):
ATP-dependent DNA helicase VIII
Short name:
hDH VIII
GAP SH3 domain-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:G3BP1
Synonyms:G3BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145907.14

Human Gene Nomenclature Database

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HGNCi
HGNC:30292 G3BP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608431 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149S → A: Cytoplasmic; no effect on stress granule assembly. 2 Publications1
Mutagenesisi149S → E: Cytoplasmic and nuclear; no assembly of stress granules; no homo-oligomerization. 2 Publications1
Mutagenesisi232S → A: Cytoplasmic. Partially nuclear; when associated with E-149. 1 Publication1
Mutagenesisi232S → E: Cytoplasmic. Partially nuclear; when associated with E-149. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10146

Open Targets

More...
OpenTargetsi
ENSG00000145907

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389105

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
G3BP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14916572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001947982 – 466Ras GTPase-activating protein-binding protein 1Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143PhosphothreonineCombined sources1
Modified residuei149PhosphoserineCombined sources1 Publication1
Modified residuei231Phosphoserine1 Publication1
Modified residuei232PhosphoserineCombined sources2 Publications1
Modified residuei250PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei429Asymmetric dimethylarginineCombined sources1
Modified residuei435Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei435Dimethylated arginine; alternate1 Publication1
Modified residuei435Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei447Omega-N-methylarginineCombined sources1
Modified residuei460Dimethylated arginine; alternate1 Publication1
Modified residuei460Omega-N-methylarginine; alternateCombined sources1
Modified residuei460Omega-N-methylated arginine; alternate1 Publication1
Modified residuei465Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity). RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization.By similarity3 Publications
Arg-435 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13283

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13283

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13283

PeptideAtlas

More...
PeptideAtlasi
Q13283

PRoteomics IDEntifications database

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PRIDEi
Q13283

ProteomicsDB human proteome resource

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ProteomicsDBi
59275

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13283

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145907 Expressed in 248 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
HS_G3BP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13283 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13283 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037068
HPA004052

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and oligomer (PubMed:12642610). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP1 (By similarity). Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells (By similarity). No interaction in quiescent cells (By similarity). Interacts with USP10, and may regulate it (PubMed:11439350). Interacts with RPTOR and SPAG5; this complex is increased by oxidative stress (PubMed:23953116). Interacts with ATXN2L (PubMed:23209657). Interacts with STYXL1 (PubMed:20180778).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115448, 438 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13283

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13283

Protein interaction database and analysis system

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IntActi
Q13283, 87 interactors

Molecular INTeraction database

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MINTi
Q13283

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348578

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1466
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q90X-ray1.70A/B1-139[»]
4FCJX-ray1.62A/B1-139[»]
4FCMX-ray2.69A/B1-139[»]
4IIAX-ray3.30A11-139[»]
5FW5X-ray1.92A/B1-139[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13283

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13283

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 133NTF2PROSITE-ProRule annotationAdd BLAST123
Domaini340 – 415RRMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 225Glu-richAdd BLAST82
Compositional biasi430 – 461Gly-richAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NTF2 domain mediates multimerization.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0116 Eukaryota
ENOG410YV57 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000220838

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055943

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13283

KEGG Orthology (KO)

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KOi
K17265

Identification of Orthologs from Complete Genome Data

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OMAi
ACAFLEF

Database of Orthologous Groups

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OrthoDBi
1526879at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13283

TreeFam database of animal gene trees

More...
TreeFami
TF325464

Family and domain databases

Conserved Domains Database

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CDDi
cd00780 NTF2, 1 hit
cd12463 RRM_G3BP1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034375 G3BP1
IPR034374 G3BP1_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR039539 Ras_GTPase_bind_prot
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR10693 PTHR10693, 1 hit
PTHR10693:SF21 PTHR10693:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNQAPDML HRFYGKNSSY VHGGLDSNGK
60 70 80 90 100
PADAVYGQKE IHRKVMSQNF TNCHTKIRHV DAHATLNDGV VVQVMGLLSN
110 120 130 140 150
NNQALRRFMQ TFVLAPEGSV ANKFYVHNDI FRYQDEVFGG FVTEPQEESE
160 170 180 190 200
EEVEEPEERQ QTPEVVPDDS GTFYDQAVVS NDMEEHLEEP VAEPEPDPEP
210 220 230 240 250
EPEQEPVSEI QEEKPEPVLE ETAPEDAQKS SSPAPADIAQ TVQEDLRTFS
260 270 280 290 300
WASVTSKNLP PSGAVPVTGI PPHVVKVPAS QPRPESKPES QIPPQRPQRD
310 320 330 340 350
QRVREQRINI PPQRGPRPIR EAGEQGDIEP RRMVRHPDSH QLFIGNLPHE
360 370 380 390 400
VDKSELKDFF QSYGNVVELR INSGGKLPNF GFVVFDDSEP VQKVLSNRPI
410 420 430 440 450
MFRGEVRLNV EEKKTRAARE GDRRDNRLRG PGGPRGGLGG GMRGPPRGGM
460
VQKPGFGVGR GLAPRQ
Length:466
Mass (Da):52,164
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9429D78E0C7F59
GO
Isoform 2 (identifier: Q13283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-122: GSVAN → SLKKK
     123-466: Missing.

Show »
Length:122
Mass (Da):13,874
Checksum:iBC791D59A75533DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH42E5RH42_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIF8E5RIF8_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJU8E5RJU8_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIZ6E5RIZ6_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI46E5RI46_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH00E5RH00_HUMAN
Ras GTPase-activating protein-bindi...
G3BP1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056280118 – 122GSVAN → SLKKK in isoform 2. 2 Publications5
Alternative sequenceiVSP_056281123 – 466Missing in isoform 2. 2 PublicationsAdd BLAST344

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32519 mRNA Translation: AAB07787.1
AK300098 mRNA Translation: BAG61899.1
BX647869 mRNA Translation: CAI46065.1
AC091982 Genomic DNA No translation available.
BC006997 mRNA Translation: AAH06997.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4319.1 [Q13283-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005745.1, NM_005754.2 [Q13283-1]
NP_938405.1, NM_198395.1 [Q13283-1]
XP_006714812.1, XM_006714749.3
XP_006714813.1, XM_006714750.3
XP_016864411.1, XM_017008922.1
XP_016864412.1, XM_017008923.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.3353
Hs.587054

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356245; ENSP00000348578; ENSG00000145907 [Q13283-1]
ENST00000394123; ENSP00000377681; ENSG00000145907 [Q13283-1]
ENST00000520177; ENSP00000427810; ENSG00000145907 [Q13283-2]
ENST00000522367; ENSP00000428926; ENSG00000145907 [Q13283-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10146

UCSC genome browser

More...
UCSCi
uc063iwq.1 human [Q13283-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32519 mRNA Translation: AAB07787.1
AK300098 mRNA Translation: BAG61899.1
BX647869 mRNA Translation: CAI46065.1
AC091982 Genomic DNA No translation available.
BC006997 mRNA Translation: AAH06997.1
CCDSiCCDS4319.1 [Q13283-1]
RefSeqiNP_005745.1, NM_005754.2 [Q13283-1]
NP_938405.1, NM_198395.1 [Q13283-1]
XP_006714812.1, XM_006714749.3
XP_006714813.1, XM_006714750.3
XP_016864411.1, XM_017008922.1
XP_016864412.1, XM_017008923.1
UniGeneiHs.3353
Hs.587054

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q90X-ray1.70A/B1-139[»]
4FCJX-ray1.62A/B1-139[»]
4FCMX-ray2.69A/B1-139[»]
4IIAX-ray3.30A11-139[»]
5FW5X-ray1.92A/B1-139[»]
ProteinModelPortaliQ13283
SMRiQ13283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115448, 438 interactors
CORUMiQ13283
ELMiQ13283
IntActiQ13283, 87 interactors
MINTiQ13283
STRINGi9606.ENSP00000348578

PTM databases

iPTMnetiQ13283
PhosphoSitePlusiQ13283
SwissPalmiQ13283

Polymorphism and mutation databases

BioMutaiG3BP1
DMDMi14916572

Proteomic databases

EPDiQ13283
jPOSTiQ13283
PaxDbiQ13283
PeptideAtlasiQ13283
PRIDEiQ13283
ProteomicsDBi59275

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10146
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356245; ENSP00000348578; ENSG00000145907 [Q13283-1]
ENST00000394123; ENSP00000377681; ENSG00000145907 [Q13283-1]
ENST00000520177; ENSP00000427810; ENSG00000145907 [Q13283-2]
ENST00000522367; ENSP00000428926; ENSG00000145907 [Q13283-2]
GeneIDi10146
KEGGihsa:10146
UCSCiuc063iwq.1 human [Q13283-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10146
DisGeNETi10146
EuPathDBiHostDB:ENSG00000145907.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
G3BP1
HGNCiHGNC:30292 G3BP1
HPAiCAB037068
HPA004052
MIMi608431 gene
neXtProtiNX_Q13283
OpenTargetsiENSG00000145907
PharmGKBiPA162389105

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0116 Eukaryota
ENOG410YV57 LUCA
GeneTreeiENSGT00390000011365
HOGENOMiHOG000220838
HOVERGENiHBG055943
InParanoidiQ13283
KOiK17265
OMAiACAFLEF
OrthoDBi1526879at2759
PhylomeDBiQ13283
TreeFamiTF325464

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
G3BP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
G3BP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10146

Protein Ontology

More...
PROi
PR:Q13283

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145907 Expressed in 248 organ(s), highest expression level in female gonad
CleanExiHS_G3BP1
ExpressionAtlasiQ13283 baseline and differential
GenevisibleiQ13283 HS

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd12463 RRM_G3BP1, 1 hit
InterProiView protein in InterPro
IPR034375 G3BP1
IPR034374 G3BP1_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR039539 Ras_GTPase_bind_prot
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10693 PTHR10693, 1 hit
PTHR10693:SF21 PTHR10693:SF21, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3BP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13283
Secondary accession number(s): Q5HYE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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