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Protein

Syntaxin-3

Gene

STX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: Reactome
  • exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: Ensembl
  • intracellular protein transport Source: GO_Central
  • long-term synaptic potentiation Source: Ensembl
  • neuron projection development Source: HGNC
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of chemotaxis Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB
  • positive regulation of protein localization to plasma membrane Source: UniProtKB
  • synaptic vesicle docking Source: InterPro
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • vesicle docking Source: GO_Central

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:STX3
Synonyms:STX3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166900.14
HGNCiHGNC:11438 STX3
MIMi600876 gene
neXtProtiNX_Q13277

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 284Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini285 – 289ExtracellularSequence analysis5

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6809
MalaCardsiSTX3
OpenTargetsiENSG00000166900
Orphaneti2290 Microvillus inclusion disease
PharmGKBiPA36235

Polymorphism and mutation databases

BioMutaiSTX3
DMDMi116242806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101991 – 289Syntaxin-3Add BLAST289

Proteomic databases

EPDiQ13277
PaxDbiQ13277
PeptideAtlasiQ13277
PRIDEiQ13277
ProteomicsDBi59271
59272 [Q13277-2]
59273 [Q13277-3]

PTM databases

iPTMnetiQ13277
PhosphoSitePlusiQ13277

Expressioni

Gene expression databases

BgeeiENSG00000166900
CleanExiHS_STX3
ExpressionAtlasiQ13277 baseline and differential
GenevisibleiQ13277 HS

Organism-specific databases

HPAiHPA002191
HPA069176

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112678, 79 interactors
CORUMiQ13277
IntActiQ13277, 70 interactors
MINTiQ13277
STRINGi9606.ENSP00000338562

Structurei

3D structure databases

ProteinModelPortaliQ13277
SMRiQ13277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ13277
KOiK08486
OrthoDBiEOG091G0EUK
PhylomeDBiQ13277
TreeFamiTF313763

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q13277-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN
Length:289
Mass (Da):33,155
Last modified:October 17, 2006 - v3
Checksum:i0E12EBC7CBEDB81E
GO
Isoform B (identifier: Q13277-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-262: Missing.

Show »
Length:252
Mass (Da):28,860
Checksum:i3851D8EB8A25D529
GO
Isoform 3 (identifier: Q13277-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-289: IIIVLVVVLLGILALIIGLSVGLN → SLQTGVATLVFR

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):32,018
Checksum:i1881B458BF96C46C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 11Missing (PubMed:9378770).Curated10
Sequence conflicti81T → S in CAA62209 (PubMed:9378770).Curated1
Sequence conflicti152 – 153QL → HV in AAA75303 (Ref. 1) Curated2
Sequence conflicti250T → S (Ref. 1) Curated1
Sequence conflicti250T → S (PubMed:9378770).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02818983E → D. Corresponds to variant dbSNP:rs12282741Ensembl.1
Natural variantiVAR_052246276G → S. Corresponds to variant dbSNP:rs34563654Ensembl.1
Natural variantiVAR_052247285S → P. Corresponds to variant dbSNP:rs34753750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006340226 – 262Missing in isoform B. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_043187266 – 289IIIVL…SVGLN → SLQTGVATLVFR in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32315 mRNA Translation: AAA75303.1
X90581 mRNA Translation: CAA62209.1
AJ002076 mRNA Translation: CAA05175.1
AJ002077 mRNA Translation: CAA05176.1
AK297419 mRNA Translation: BAG59852.1
AP000640 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73854.1
BC007405 mRNA Translation: AAH07405.1
BC007429 mRNA Translation: AAH07429.1
CCDSiCCDS53637.1 [Q13277-3]
CCDS7975.1 [Q13277-1]
PIRiG01969
RefSeqiNP_001171511.1, NM_001178040.1 [Q13277-3]
NP_004168.1, NM_004177.4 [Q13277-1]
XP_005274252.1, XM_005274195.3 [Q13277-1]
XP_005274257.1, XM_005274200.3 [Q13277-2]
UniGeneiHs.180711

Genome annotation databases

EnsembliENST00000337979; ENSP00000338562; ENSG00000166900 [Q13277-1]
ENST00000529177; ENSP00000433248; ENSG00000166900 [Q13277-3]
GeneIDi6809
KEGGihsa:6809
UCSCiuc010rkx.3 human [Q13277-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTX3_HUMAN
AccessioniPrimary (citable) accession number: Q13277
Secondary accession number(s): B4DME0
, O43750, O43751, Q15360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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