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Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

  • prostaglandin D receptor activity Source: GO_Central
  • prostaglandin J receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-418555 G alpha (s) signalling events

Chemistry databases

SwissLipidsiSLP:000001561

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000168229.3
HGNCiHGNC:9591 PTGDR
MIMi604687 gene
neXtProtiNX_Q13258

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 59CytoplasmicSequence analysisAdd BLAST17
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 107ExtracellularSequence analysisAdd BLAST27
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 150CytoplasmicSequence analysisAdd BLAST22
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 195ExtracellularSequence analysisAdd BLAST24
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 262CytoplasmicSequence analysisAdd BLAST46
Transmembranei263 – 283Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini284 – 310ExtracellularSequence analysisAdd BLAST27
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 359CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma-related traits 1 (ASRT1)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
See also OMIM:607277

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNETi5729
MalaCardsiPTGDR
MIMi607277 phenotype
OpenTargetsiENSG00000168229
PharmGKBiPA285

Chemistry databases

ChEMBLiCHEMBL4427
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi338

Polymorphism and mutation databases

BioMutaiPTGDR
DMDMi2495009

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700471 – 359Prostaglandin D2 receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13258
PaxDbiQ13258
PeptideAtlasiQ13258
PRIDEiQ13258
ProteomicsDBi59257

PTM databases

iPTMnetiQ13258
PhosphoSitePlusiQ13258

Expressioni

Tissue specificityi

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.2 Publications

Gene expression databases

BgeeiENSG00000168229 Expressed in 116 organ(s), highest expression level in blood
CleanExiHS_PTGDR
GenevisibleiQ13258 HS

Interactioni

Protein-protein interaction databases

BioGridi111701, 7 interactors
STRINGi9606.ENSP00000303424

Chemistry databases

BindingDBiQ13258

Structurei

3D structure databases

ProteinModelPortaliQ13258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiQ13258
KOiK04332
OMAiWCFIQMV
OrthoDBiEOG091G0F07
PhylomeDBiQ13258
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000376 Pglndn_D_rcpt
IPR008365 Prostanoid_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF14 PTHR11866:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00854 PRSTNOIDDPR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS
60 70 80 90 100
RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL
110 120 130 140 150
DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA
160 170 180 190 200
LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS
210 220 230 240 250
VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG
260 270 280 290 300
REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS
310 320 330 340 350
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS

NSTNMESSL
Length:359
Mass (Da):40,271
Last modified:November 1, 1997 - v2
Checksum:i098F89F08D0BE12A
GO
Isoform 2 (identifier: Q13258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-296: YRAYYGAFKDVKEK → AFVPGVPAKTPGSR
     297-359: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:296
Mass (Da):32,354
Checksum:i08BEEFB74CD0FBF0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0334827R → C1 PublicationCorresponds to variant dbSNP:rs41311442Ensembl.1
Natural variantiVAR_054975198G → E1 PublicationCorresponds to variant dbSNP:rs41312444Ensembl.1
Natural variantiVAR_033483301E → A1 PublicationCorresponds to variant dbSNP:rs41312504Ensembl.1
Natural variantiVAR_054976332R → Q1 PublicationCorresponds to variant dbSNP:rs41312506Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055141283 – 296YRAYY…DVKEK → AFVPGVPAKTPGSR in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_055142297 – 359Missing in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA Translation: AAC50176.1
U31099 mRNA Translation: AAC50177.1
U31332 Genomic DNA Translation: AAC50178.1
EF577397 mRNA Translation: ABQ52417.1
DQ418808 Genomic DNA Translation: ABD72608.1
AL365475 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65657.1
BC040968 mRNA Translation: AAH40968.1
CCDSiCCDS61454.1 [Q13258-2]
CCDS9707.1 [Q13258-1]
PIRiI39153
RefSeqiNP_000944.1, NM_000953.2 [Q13258-1]
NP_001268398.1, NM_001281469.1 [Q13258-2]
XP_005267948.1, XM_005267891.3 [Q13258-1]
UniGeneiHs.306831

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229 [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229 [Q13258-2]
GeneIDi5729
KEGGihsa:5729
UCSCiuc001wzq.3 human [Q13258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31098 Genomic DNA Translation: AAC50176.1
U31099 mRNA Translation: AAC50177.1
U31332 Genomic DNA Translation: AAC50178.1
EF577397 mRNA Translation: ABQ52417.1
DQ418808 Genomic DNA Translation: ABD72608.1
AL365475 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65657.1
BC040968 mRNA Translation: AAH40968.1
CCDSiCCDS61454.1 [Q13258-2]
CCDS9707.1 [Q13258-1]
PIRiI39153
RefSeqiNP_000944.1, NM_000953.2 [Q13258-1]
NP_001268398.1, NM_001281469.1 [Q13258-2]
XP_005267948.1, XM_005267891.3 [Q13258-1]
UniGeneiHs.306831

3D structure databases

ProteinModelPortaliQ13258
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111701, 7 interactors
STRINGi9606.ENSP00000303424

Chemistry databases

BindingDBiQ13258
ChEMBLiCHEMBL4427
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi338
SwissLipidsiSLP:000001561

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13258
PhosphoSitePlusiQ13258

Polymorphism and mutation databases

BioMutaiPTGDR
DMDMi2495009

Proteomic databases

EPDiQ13258
PaxDbiQ13258
PeptideAtlasiQ13258
PRIDEiQ13258
ProteomicsDBi59257

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306051; ENSP00000303424; ENSG00000168229 [Q13258-1]
ENST00000553372; ENSP00000452408; ENSG00000168229 [Q13258-2]
GeneIDi5729
KEGGihsa:5729
UCSCiuc001wzq.3 human [Q13258-1]

Organism-specific databases

CTDi5729
DisGeNETi5729
EuPathDBiHostDB:ENSG00000168229.3
GeneCardsiPTGDR
HGNCiHGNC:9591 PTGDR
MalaCardsiPTGDR
MIMi604687 gene
607277 phenotype
neXtProtiNX_Q13258
OpenTargetsiENSG00000168229
PharmGKBiPA285
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiQ13258
KOiK04332
OMAiWCFIQMV
OrthoDBiEOG091G0F07
PhylomeDBiQ13258
TreeFamiTF324982

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiProstaglandin_D2_receptor
GenomeRNAii5729
PROiPR:Q13258
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168229 Expressed in 116 organ(s), highest expression level in blood
CleanExiHS_PTGDR
GenevisibleiQ13258 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000376 Pglndn_D_rcpt
IPR008365 Prostanoid_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF14 PTHR11866:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00854 PRSTNOIDDPR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPD2R_HUMAN
AccessioniPrimary (citable) accession number: Q13258
Secondary accession number(s): G3V5L3
, Q13250, Q13251, Q1ZZ52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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