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Protein

Metabotropic glutamate receptor 1

Gene

GRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.3 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Signaling is inhibited by the antagonist LY341495. The LY341495 binding site partially overlaps with the glutamate binding site. Signaling is also inhibited by synthetic allosteric regulators, such as FITM (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide) that bind in a pocket between the transmembrane helices.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74GlutamateCurated1
Binding sitei165GlutamateCurated1
Binding sitei236GlutamateBy similarity1
Binding sitei318GlutamateBy similarity1
Binding sitei409GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-6794361 Neurexins and neuroligins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13255

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13255

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.14.7.1 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRM1
Synonyms:GPRC1A, MGLUR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152822.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4593 GRM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604473 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13255

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 592Extracellular1 PublicationAdd BLAST574
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei593 – 615Helical; Name=1Add BLAST23
Topological domaini616 – 629Cytoplasmic1 PublicationAdd BLAST14
Transmembranei630 – 650Helical; Name=2Add BLAST21
Topological domaini651 – 658Extracellular1 Publication8
Transmembranei659 – 680Helical; Name=3Add BLAST22
Topological domaini681 – 703Cytoplasmic1 PublicationAdd BLAST23
Transmembranei704 – 727Helical; Name=4Add BLAST24
Topological domaini728 – 750Extracellular1 PublicationAdd BLAST23
Transmembranei751 – 772Helical; Name=5Add BLAST22
Topological domaini773 – 785Cytoplasmic1 PublicationAdd BLAST13
Transmembranei786 – 807Helical; Name=6Add BLAST22
Topological domaini808 – 815Extracellular1 Publication8
Transmembranei816 – 840Helical; Name=7Add BLAST25
Topological domaini841 – 1194Cytoplasmic1 PublicationAdd BLAST354

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
See also OMIM:614831
Spinocerebellar ataxia 44 (SCA44)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA44 is a slowly progressive, autosomal dominant form.
See also OMIM:617691
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080186262Y → C in SCA44; enhances G-protein coupled glutamate receptor signaling pathway. 1 Publication1
Natural variantiVAR_080187792Y → C in SCA44; enhances G-protein coupled glutamate receptor signaling pathway. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...
DisGeNETi
2911

MalaCards human disease database

More...
MalaCardsi
GRM1
MIMi614831 phenotype
617691 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000152822

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
324262 Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency
404507 Chondromyxoid fibroma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28990

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3772

Drug and drug target database

More...
DrugBanki
DB04256 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
DB00142 L-Glutamic Acid

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
289

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033443

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001292219 – 1194Metabotropic glutamate receptor 1Add BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 109
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140Interchain
Glycosylationi223N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi289 ↔ 291By similarity
Disulfide bondi378 ↔ 394
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 439
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi657 ↔ 746
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei853PhosphoserineBy similarity1
Modified residuei871PhosphothreonineBy similarity1
Modified residuei894PhosphoserineBy similarity1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1142PhosphoserineBy similarity1
Modified residuei1146PhosphothreonineBy similarity1
Modified residuei1149PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13255

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13255

PeptideAtlas

More...
PeptideAtlasi
Q13255

PRoteomics IDEntifications database

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PRIDEi
Q13255

ProteomicsDB human proteome resource

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ProteomicsDBi
59254
59255 [Q13255-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13255

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13255

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152822 Expressed in 79 organ(s), highest expression level in cerebellum

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13255 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015701

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA1P522942EBI-8527352,EBI-358383

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109168, 35 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13255

Database of interacting proteins

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DIPi
DIP-57522N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13255

Protein interaction database and analysis system

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IntActi
Q13255, 2 interactors

Molecular INTeraction database

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MINTi
Q13255

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282753

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q13255

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13255

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13255

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13255

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 188Glutamate bindingCurated3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1014 – 1035Gln/Pro-richAdd BLAST22
Compositional biasi1067 – 1081Gln/Pro-richAdd BLAST15
Compositional biasi1095 – 1130Asp/Glu-rich (acidic)Add BLAST36
Compositional biasi1142 – 1194Ser-richAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1056 Eukaryota
ENOG410XR6W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153406

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107965

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13255

KEGG Orthology (KO)

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KOi
K04603

Identification of Orthologs from Complete Genome Data

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OMAi
IRIHSPY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G177R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13255

TreeFam database of animal gene trees

More...
TreeFami
TF313240

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01229 GluR_Homer-bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: Q13255-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGLLLFFFP AIFLEVSLLP RSPGRKVLLA GASSQRSVAR MDGDVIIGAL
60 70 80 90 100
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT
110 120 130 140 150
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGINRC LPDGQSLPPG
160 170 180 190 200
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY
210 220 230 240 250
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ
260 270 280 290 300
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL
310 320 330 340 350
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF
360 370 380 390 400
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KRICTGNESL
410 420 430 440 450
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGHVGLCD AMKPIDGSKL
460 470 480 490 500
LDFLIKSSFI GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW
510 520 530 540 550
HEGVLNIDDY KIQMNKSGVV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC
560 570 580 590 600
KENEYVQDEF TCKACDLGWW PNADLTGCEP IPVRYLEWSN IESIIAIAFS
610 620 630 640 650
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA
660 670 680 690 700
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF
710 720 730 740 750
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN
760 770 780 790 800
LGVVAPLGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA
810 820 830 840 850
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF
860 870 880 890 900
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK AGAGNANSNG KSVSWSEPGG
910 920 930 940 950
GQVPKGQHMW HRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDTS
960 970 980 990 1000
TKTLYNVEEE EDAQPIRFSP PGSPSMVVHR RVPSAATTPP LPSHLTAEET
1010 1020 1030 1040 1050
PLFLAEPALP KGLPPPLQQQ QQPPPQQKSL MDQLQGVVSN FSTAIPDFHA
1060 1070 1080 1090 1100
VLAGPGGPGN GLRSLYPPPP PPQHLQMLPL QLSTFGEELV SPPADDDDDS
1110 1120 1130 1140 1150
ERFKLLQEYV YEHEREGNTE EDELEEEEED LQAASKLTPD DSPALTPPSP
1160 1170 1180 1190
FRDSVASGSS VPSSPVSESV LCTPPNVSYA SVILRDYKQS SSTL
Length:1,194
Mass (Da):132,357
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A633505F6D51909
GO
Isoform Beta (identifier: Q13255-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGGQVPKG → KKRQPEFSPTSQCPSAHVQL
     907-1194: Missing.

Show »
Length:906
Mass (Da):101,323
Checksum:iD63470CF9A15361E
GO
Isoform 3 (identifier: Q13255-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-908: NSNGKSVSWSEPGGGQVPKGQH → KWRTGAQGTAYVAPPLCAREDQ
     909-1194: Missing.

Note: No experimental confirmation available.
Show »
Length:908
Mass (Da):101,473
Checksum:i214EC733A9D585B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform Beta (identifier: Q13255-2)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti896T → S in AAA87844 (PubMed:7476890).Curated1
Sequence conflicti904V → A in AAA87844 (PubMed:7476890).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02818434S → Y. Corresponds to variant dbSNP:rs12190109Ensembl.1
Natural variantiVAR_080186262Y → C in SCA44; enhances G-protein coupled glutamate receptor signaling pathway. 1 Publication1
Natural variantiVAR_028185285R → K. Corresponds to variant dbSNP:rs7760248Ensembl.1
Natural variantiVAR_055875593S → P1 PublicationCorresponds to variant dbSNP:rs1047005Ensembl.1
Natural variantiVAR_036194696R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028186741E → D. Corresponds to variant dbSNP:rs3025919Ensembl.1
Natural variantiVAR_080187792Y → C in SCA44; enhances G-protein coupled glutamate receptor signaling pathway. 1 Publication1
Natural variantiVAR_028187884G → E. Corresponds to variant dbSNP:rs362936Ensembl.1
Natural variantiVAR_024482929V → I. Corresponds to variant dbSNP:rs2941Ensembl.1
Natural variantiVAR_028188993S → P2 PublicationsCorresponds to variant dbSNP:rs6923492EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055127887 – 908NSNGK…PKGQH → KWRTGAQGTAYVAPPLCARE DQ in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_002024887 – 906NSNGK…QVPKG → KKRQPEFSPTSQCPSAHVQL in isoform Beta. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_002025907 – 1194Missing in isoform Beta. 2 PublicationsAdd BLAST288
Alternative sequenceiVSP_055128909 – 1194Missing in isoform 3. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31215 mRNA Translation: AAA87843.1
U31216 mRNA Translation: AAA87844.1
L76627 mRNA Translation: AAB05337.1
L76631 mRNA Translation: AAB05338.1
AL031769 Genomic DNA No translation available.
AL592423 Genomic DNA No translation available.
AL096867 Genomic DNA No translation available.
AL035698 Genomic DNA No translation available.
BC136280 mRNA Translation: AAI36281.1
BC143779 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47497.1 [Q13255-2]
CCDS5209.1 [Q13255-1]
CCDS64548.1 [Q13255-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001264993.1, NM_001278064.1 [Q13255-1]
NP_001264994.1, NM_001278065.1 [Q13255-2]
NP_001264995.1, NM_001278066.1 [Q13255-2]
NP_001264996.1, NM_001278067.1 [Q13255-3]
XP_011534084.1, XM_011535782.1 [Q13255-1]
XP_016866272.1, XM_017010783.1 [Q13255-1]
XP_016866273.1, XM_017010784.1 [Q13255-1]
XP_016866274.1, XM_017010785.1 [Q13255-2]
XP_016866275.1, XM_017010786.1 [Q13255-2]
XP_016866276.1, XM_017010787.1 [Q13255-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.32945

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282753; ENSP00000282753; ENSG00000152822 [Q13255-1]
ENST00000355289; ENSP00000347437; ENSG00000152822 [Q13255-3]
ENST00000361719; ENSP00000354896; ENSG00000152822 [Q13255-1]
ENST00000492807; ENSP00000424095; ENSG00000152822 [Q13255-2]
ENST00000507907; ENSP00000425599; ENSG00000152822 [Q13255-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2911

UCSC genome browser

More...
UCSCi
uc003qll.4 human [Q13255-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31215 mRNA Translation: AAA87843.1
U31216 mRNA Translation: AAA87844.1
L76627 mRNA Translation: AAB05337.1
L76631 mRNA Translation: AAB05338.1
AL031769 Genomic DNA No translation available.
AL592423 Genomic DNA No translation available.
AL096867 Genomic DNA No translation available.
AL035698 Genomic DNA No translation available.
BC136280 mRNA Translation: AAI36281.1
BC143779 mRNA No translation available.
CCDSiCCDS47497.1 [Q13255-2]
CCDS5209.1 [Q13255-1]
CCDS64548.1 [Q13255-3]
RefSeqiNP_001264993.1, NM_001278064.1 [Q13255-1]
NP_001264994.1, NM_001278065.1 [Q13255-2]
NP_001264995.1, NM_001278066.1 [Q13255-2]
NP_001264996.1, NM_001278067.1 [Q13255-3]
XP_011534084.1, XM_011535782.1 [Q13255-1]
XP_016866272.1, XM_017010783.1 [Q13255-1]
XP_016866273.1, XM_017010784.1 [Q13255-1]
XP_016866274.1, XM_017010785.1 [Q13255-2]
XP_016866275.1, XM_017010786.1 [Q13255-2]
XP_016866276.1, XM_017010787.1 [Q13255-2]
UniGeneiHs.32945

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KS9X-ray1.90A/B28-518[»]
4OR2X-ray2.80A/B581-860[»]
ProteinModelPortaliQ13255
SMRiQ13255
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109168, 35 interactors
CORUMiQ13255
DIPiDIP-57522N
ELMiQ13255
IntActiQ13255, 2 interactors
MINTiQ13255
STRINGi9606.ENSP00000282753

Chemistry databases

BindingDBiQ13255
ChEMBLiCHEMBL3772
DrugBankiDB04256 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
DB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi289

Protein family/group databases

TCDBi9.A.14.7.1 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ13255
PhosphoSitePlusiQ13255

Polymorphism and mutation databases

DMDMi311033443

Proteomic databases

MaxQBiQ13255
PaxDbiQ13255
PeptideAtlasiQ13255
PRIDEiQ13255
ProteomicsDBi59254
59255 [Q13255-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282753; ENSP00000282753; ENSG00000152822 [Q13255-1]
ENST00000355289; ENSP00000347437; ENSG00000152822 [Q13255-3]
ENST00000361719; ENSP00000354896; ENSG00000152822 [Q13255-1]
ENST00000492807; ENSP00000424095; ENSG00000152822 [Q13255-2]
ENST00000507907; ENSP00000425599; ENSG00000152822 [Q13255-2]
GeneIDi2911
KEGGihsa:2911
UCSCiuc003qll.4 human [Q13255-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2911
DisGeNETi2911
EuPathDBiHostDB:ENSG00000152822.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRM1
HGNCiHGNC:4593 GRM1
HPAiHPA015701
MalaCardsiGRM1
MIMi604473 gene
614831 phenotype
617691 phenotype
neXtProtiNX_Q13255
OpenTargetsiENSG00000152822
Orphaneti324262 Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency
404507 Chondromyxoid fibroma
PharmGKBiPA28990

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00940000153406
HOVERGENiHBG107965
InParanoidiQ13255
KOiK04603
OMAiIRIHSPY
OrthoDBiEOG091G177R
PhylomeDBiQ13255
TreeFamiTF313240

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-6794361 Neurexins and neuroligins
SignaLinkiQ13255
SIGNORiQ13255

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GRM1 human
EvolutionaryTraceiQ13255

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Metabotropic_glutamate_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2911

Protein Ontology

More...
PROi
PR:Q13255

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152822 Expressed in 79 organ(s), highest expression level in cerebellum
GenevisibleiQ13255 HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR
SMARTiView protein in SMART
SM01229 GluR_Homer-bdg, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13255
Secondary accession number(s): B9EG79
, F8W805, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: December 5, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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