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UniProtKB - Q13243 (SRSF5_HUMAN)

Entry version 199 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Serine/arginine-rich splicing factor 5

Gene

SRSF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 5
Alternative name(s):
Delayed-early protein HRS
Pre-mRNA-splicing factor SRP40
Splicing factor, arginine/serine-rich 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRSF5
Synonyms:HRS, SFRS5, SRP40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10787 SRSF5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600914 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13243

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6430

Open Targets

More...OpenTargetsi		ENSG00000100650

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35703

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SRSF5

Domain mapping of disease mutations (DMDM)

More...DMDMi		3929378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819271 – 272Serine/arginine-rich splicing factor 5Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86PhosphoserineCombined sources1
Modified residuei167N6-acetyllysineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13243

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13243

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13243

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13243

PeptideAtlas

More...PeptideAtlasi		Q13243

PRoteomics IDEntifications database

More...PRIDEi		Q13243

ProteomicsDB human proteome resource

More...ProteomicsDBi		59247 [Q13243-1]
59248 [Q13243-2]
59249 [Q13243-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13243

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100650 Expressed in 238 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13243 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13243 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA043484
HPA056523

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity).

Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112328, 131 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13243

Database of interacting proteins

More...DIPi		DIP-46894N

Protein interaction database and analysis system

More...IntActi		Q13243, 45 interactors

Molecular INTeraction database

More...MINTi		Q13243

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000452123

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13243

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 74RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini108 – 181RRM 2PROSITE-ProRule annotationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 83Gly-rich (hinge region)6
Compositional biasi182 – 267Arg/Ser-rich (RS domain)Add BLAST86

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0106 Eukaryota
COG0724 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158275

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13243

KEGG Orthology (KO)

More...KOi		K12893

Identification of Orthologs from Complete Genome Data

More...OMAi		PPQRTDF

Database of Orthologous Groups

More...OrthoDBi		1315388at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13243

TreeFam database of animal gene trees

More...TreeFami		TF351335

Family and domain databases

Conserved Domains Database

More...CDDi		cd12337 RRM1_SRSF4_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform SRP40-1 (identifier: Q13243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA 
        60         70         80         90        100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN 
       110        120        130        140        150
APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE 
       160        170        180        190        200
FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS 
       210        220        230        240        250
RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS 
       260        270 
PASVDRQRSR SRSRSRSVDS GN
Length:272
Mass (Da):31,264
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF13AD79845ECBB16
GO
Isoform SRP40-2 (identifier: Q13243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-107: NAPPVRTE → YVKGGWLH
     108-272: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:107
Mass (Da):12,528
Checksum:i131B3E530F96F528
GO
Isoform SRP40-3 (identifier: Q13243-4)
Sequence is not available
Length:–
Mass (Da):–
Isoform SRP40-4 (identifier: Q13243-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-45: Missing.

Note: No experimental confirmation available.
Show »
Length:269
Mass (Da):30,858
Checksum:iEB51CB5B0F51BD78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DJK0B4DJK0_HUMAN
Serine/arginine-rich-splicing facto...
SRSF5
124Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DUA4B4DUA4_HUMAN
Serine/arginine-rich-splicing facto...
SRSF5
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5K8G3V5K8_HUMAN
Serine/arginine-rich-splicing facto...
SRSF5
99Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC39543 differs from that shown. Reason: Frameshift at positions 113 and 140.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014713160A → S. Corresponds to variant dbSNP:rs1057683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00586343 – 45Missing in isoform SRP40-4. Curated3
Alternative sequenceiVSP_005864100 – 107NAPPVRTE → YVKGGWLH in isoform SRP40-2. 5 Publications8
Alternative sequenceiVSP_005865108 – 272Missing in isoform SRP40-2. 5 PublicationsAdd BLAST165

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U30826 mRNA Translation: AAA93070.1
U30884 mRNA Translation: AAA93074.1
U30827 mRNA Translation: AAB60405.1
BT007089 mRNA Translation: AAP35752.1
AK311805 mRNA Translation: BAG34748.1
CR542167 mRNA Translation: CAG46964.1
CR542182 mRNA Translation: CAG46979.1
BX640605 mRNA Translation: CAE45711.1
AB451250 mRNA Translation: BAG70064.1
BC018823 mRNA Translation: AAH18823.1
BC040209 mRNA Translation: AAH40209.1
AF020307 Genomic DNA Translation: AAC39543.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32109.1 [Q13243-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S59042

NCBI Reference Sequences

More...RefSeqi		NP_001034554.1, NM_001039465.1 [Q13243-1]
NP_001307143.1, NM_001320214.1 [Q13243-1]
NP_008856.2, NM_006925.4 [Q13243-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1]
ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1]
ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3]
ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6430

UCSC genome browser

More...UCSCi		uc001xll.4 human [Q13243-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30826 mRNA Translation: AAA93070.1
U30884 mRNA Translation: AAA93074.1
U30827 mRNA Translation: AAB60405.1
BT007089 mRNA Translation: AAP35752.1
AK311805 mRNA Translation: BAG34748.1
CR542167 mRNA Translation: CAG46964.1
CR542182 mRNA Translation: CAG46979.1
BX640605 mRNA Translation: CAE45711.1
AB451250 mRNA Translation: BAG70064.1
BC018823 mRNA Translation: AAH18823.1
BC040209 mRNA Translation: AAH40209.1
AF020307 Genomic DNA Translation: AAC39543.1 Frameshift.
CCDSiCCDS32109.1 [Q13243-1]
PIRiS59042
RefSeqiNP_001034554.1, NM_001039465.1 [Q13243-1]
NP_001307143.1, NM_001320214.1 [Q13243-1]
NP_008856.2, NM_006925.4 [Q13243-1]

3D structure databases

SMRiQ13243
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112328, 131 interactors
CORUMiQ13243
DIPiDIP-46894N
IntActiQ13243, 45 interactors
MINTiQ13243
STRINGi9606.ENSP00000452123

PTM databases

iPTMnetiQ13243
PhosphoSitePlusiQ13243
SwissPalmiQ13243

Polymorphism and mutation databases

BioMutaiSRSF5
DMDMi3929378

Proteomic databases

EPDiQ13243
jPOSTiQ13243
MassIVEiQ13243
PaxDbiQ13243
PeptideAtlasiQ13243
PRIDEiQ13243
ProteomicsDBi59247 [Q13243-1]
59248 [Q13243-2]
59249 [Q13243-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6430
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1]
ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1]
ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3]
ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1]
GeneIDi6430
KEGGihsa:6430
UCSCiuc001xll.4 human [Q13243-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6430
DisGeNETi6430

GeneCards: human genes, protein and diseases

More...GeneCardsi		SRSF5
HGNCiHGNC:10787 SRSF5
HPAiHPA043484
HPA056523
MIMi600914 gene
neXtProtiNX_Q13243
OpenTargetsiENSG00000100650
PharmGKBiPA35703

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00940000158275
InParanoidiQ13243
KOiK12893
OMAiPPQRTDF
OrthoDBi1315388at2759
PhylomeDBiQ13243
TreeFamiTF351335

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SRSF5 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SFRS5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6430

Pharos

More...Pharosi		Q13243

Protein Ontology

More...PROi		PR:Q13243

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100650 Expressed in 238 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ13243 baseline and differential
GenevisibleiQ13243 HS

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRSF5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13243
Secondary accession number(s): O14797
, Q16662, Q49AD6, Q6FGE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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