SRSF5

Functionⁱ

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

GO - Molecular functionⁱ

protein kinase B binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to insulin stimulus Source: Ensembl
liver regeneration Source: Ensembl
mRNA 3'-end processing Source: Reactome
mRNA cis splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA export from nucleus Source: Reactome
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 7556075
mRNA splice site selection
Source: ProtInc
Traceable author statementⁱ
- 7556075
mRNA splicing, via spliceosome Source: Reactome
positive regulation of RNA splicing Source: Ensembl
regulation of alternative mRNA splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell cycle Source: Ensembl
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/arginine-rich splicing factor 5 Alternative name(s): Delayed-early protein HRS Pre-mRNA-splicing factor SRP40 Splicing factor, arginine/serine-rich 5
Gene namesⁱ	Name:SRSF5 Synonyms:HRS, SFRS5, SRP40
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100650.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10787 SRSF5
MIMⁱ	600914 gene
neXtProtⁱ	NX_Q13243

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6430
Open Targets More...OpenTargetsⁱ	ENSG00000100650
PharmGKBⁱ	PA35703

Polymorphism and mutation databases

BioMutaⁱ	SRSF5
DMDMⁱ	3929378

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081927	1 – 272	Serine/arginine-rich splicing factor 5Add BLAST		272

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	86	PhosphoserineCombined sources	1
Modified residueⁱ	167	N6-acetyllysineCombined sources	1
Modified residueⁱ	227	PhosphoserineCombined sources	1
Modified residueⁱ	229	PhosphoserineCombined sources	1
Modified residueⁱ	233	PhosphoserineCombined sources	1
Modified residueⁱ	250	PhosphoserineCombined sources	1
Modified residueⁱ	253	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q13243
PaxDbⁱ	Q13243
PeptideAtlas More...PeptideAtlasⁱ	Q13243
PRIDEⁱ	Q13243
ProteomicsDBⁱ	59247 59248 [Q13243-2] 59249 [Q13243-3]

PTM databases

iPTMnetⁱ	Q13243
PhosphoSitePlusⁱ	Q13243
SwissPalmⁱ	Q13243

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100650 Expressed in 238 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SFRS5
ExpressionAtlasⁱ	Q13243 baseline and differential
Genevisibleⁱ	Q13243 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043484 HPA056523

HPAⁱ

HPA043484
HPA056523

Interactionⁱ

Subunit structureⁱ

Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.By similarity1 Publication

GO - Molecular functionⁱ

protein kinase B binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112328, 118 interactors
CORUMⁱ	Q13243
Database of interacting proteins More...DIPⁱ	DIP-46894N
IntActⁱ	Q13243, 38 interactors
Molecular INTeraction database More...MINTⁱ	Q13243
STRINGⁱ	9606.ENSP00000377892

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13243
SMRⁱ	Q13243
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 74	RRM 1PROSITE-ProRule annotationAdd BLAST		71
Domainⁱ	108 – 181	RRM 2PROSITE-ProRule annotationAdd BLAST		74

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	78 – 83	Gly-rich (hinge region)		6
Compositional biasⁱ	182 – 267	Arg/Ser-rich (RS domain)Add BLAST		86

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0106 Eukaryota COG0724 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144049
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q13243
KEGG Orthology (KO) More...KOⁱ	K12893
OMAⁱ	RENDDSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R9W
PhylomeDBⁱ	Q13243
TreeFamⁱ	TF351335

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12337 RRM1_SRSF4_like, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR035585 RRM1_SRSF4-like IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform SRP40-1 (identifier: Q13243-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA 
        60         70         80         90        100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN 
       110        120        130        140        150
APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE 
       160        170        180        190        200
FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS 
       210        220        230        240        250
RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS 
       260        270 
PASVDRQRSR SRSRSRSVDS GN

Length:272

Mass (Da):31,264

Last modified:November 1, 1996 - v1

Checksum:ⁱF13AD79845ECBB16

GO

Isoform SRP40-2 (identifier: Q13243-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
100-107: NAPPVRTE → YVKGGWLH
108-272: Missing.

« Hide

        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA 
        60         70         80         90        100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRY 

VKGGWLH

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:107

Mass (Da):12,528

Checksum:ⁱ131B3E530F96F528

GO

Isoform SRP40-3 (identifier: Q13243-4)

Sequence is not available

Length:–

Mass (Da):–

Isoform SRP40-4 (identifier: Q13243-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
43-45: Missing.

« Hide

        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVDPRDADDA 
        60         70         80         90        100
VYELDGKELC SERVTIEHAR ARSRGGRGRG RYSDRFSSRR PRNDRRNAPP 
       110        120        130        140        150
VRTENRLIVE NLSSRVSWQD LKDFMRQAGE VTFADAHRPK LNEGVVEFAS 
       160        170        180        190        200
YGDLKNAIEK LSGKEINGRK IKLIEGSKRH SRSRSRSRSR TRSSSRSRSR 
       210        220        230        240        250
SRSRSRKSYS RSRSRSRSRS RSKSRSVSRS PVPEKSQKRG SSSRSKSPAS 
       260 
VDRQRSRSRS RSRSVDSGN

Note: No experimental confirmation available.

Show »

Length:269

Mass (Da):30,858

Checksum:ⁱEB51CB5B0F51BD78

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DUA4	B4DUA4_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 5 (cDNA FLJ57437, highly similar to Splicing factor, arginine/serine-rich 5)	SRSF5	138	Annotation score:
B4DJK0	B4DJK0_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 5 (cDNA FLJ57379, highly similar to Splicing factor, arginine/serine-rich 5)	SRSF5	124	Annotation score:
G3V5K8	G3V5K8_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 5	SRSF5	99	Annotation score:

Sequence cautionⁱ

The sequence AAC39543 differs from that shown. Reason: Frameshift at positions 113 and 140.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014713	160	A → S. Corresponds to variant dbSNP:rs1057683Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005863	43 – 45	Missing in isoform SRP40-4. Curated	3
Alternative sequenceⁱVSP_005864	100 – 107	NAPPVRTE → YVKGGWLH in isoform SRP40-2. 5 Publications	8
Alternative sequenceⁱVSP_005865	108 – 272	Missing in isoform SRP40-2. 5 PublicationsAdd BLAST	165

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30826 mRNA Translation: AAA93070.1 U30884 mRNA Translation: AAA93074.1 U30827 mRNA Translation: AAB60405.1 BT007089 mRNA Translation: AAP35752.1 AK311805 mRNA Translation: BAG34748.1 CR542167 mRNA Translation: CAG46964.1 CR542182 mRNA Translation: CAG46979.1 BX640605 mRNA Translation: CAE45711.1 AB451250 mRNA Translation: BAG70064.1 BC018823 mRNA Translation: AAH18823.1 BC040209 mRNA Translation: AAH40209.1 AF020307 Genomic DNA Translation: AAC39543.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32109.1 [Q13243-1]
PIRⁱ	S59042
NCBI Reference Sequences More...RefSeqⁱ	NP_001034554.1, NM_001039465.1 [Q13243-1] NP_001307143.1, NM_001320214.1 [Q13243-1] NP_008856.2, NM_006925.4 [Q13243-1]
UniGeneⁱ	Hs.632326

Genome annotation databases

Ensemblⁱ	ENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1] ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1] ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3] ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1]
GeneIDⁱ	6430
KEGGⁱ	hsa:6430
UCSC genome browser More...UCSCⁱ	uc001xll.4 human [Q13243-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13243	Splicing factor, arginine/serine-rich 5, isoform CRA_a		HUMAN		272	UniRef100_Q13243
Serine/arginine-rich splicing factor 5		MACMU		272
Serine and arginine rich splicing factor 5		CALJA		272
SRSF5 isoform 1		PANTR		272
Serine and arginine rich splicing factor 5		MACNE		272
+11
Q13243-3	SRSF5 isoform 7		PONAB		269	UniRef100_Q13243-3
SRSF5 isoform 8		PANTR		269

Protein	Similar proteins		Species	Score	Length	Source
Q13243	Serine/arginine-rich splicing factor 5		MOUSE		269	UniRef90_Q13243
Serine/arginine-rich splicing factor 5		RAT		269
Splicing factor, arginine/serine-rich 5, isoform CRA_a		HUMAN		272
Serine/arginine-rich splicing factor 5		MACMU		272
Serine and arginine rich splicing factor 5		CALJA		272
+209
Q13243-2	Splicing factor arginine/serine-rich 5 (Fragment)		HUMAN		107	UniRef90_Q13243-2
Uncharacterized protein		FELCA		100

Protein	Similar proteins		Species	Score	Length	Source
Q13243	Serine/arginine-rich splicing factor 5		MOUSE		269	UniRef50_Q13243
Serine/arginine-rich splicing factor 5		RAT		269
Splicing factor, arginine/serine-rich 5, isoform CRA_a		HUMAN		272
Serine/arginine-rich splicing factor 5		MACMU		272
Serine and arginine rich splicing factor 5		CALJA		272
+310
Q13243-2	Splicing factor arginine/serine-rich 5 (Fragment)		HUMAN		107	UniRef50_Q13243-2
Uncharacterized protein		FELCA		100
Serine-arginine protein 55		APICE		111
UPI0009E64763		ORBFA		132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30826 mRNA Translation: AAA93070.1 U30884 mRNA Translation: AAA93074.1 U30827 mRNA Translation: AAB60405.1 BT007089 mRNA Translation: AAP35752.1 AK311805 mRNA Translation: BAG34748.1 CR542167 mRNA Translation: CAG46964.1 CR542182 mRNA Translation: CAG46979.1 BX640605 mRNA Translation: CAE45711.1 AB451250 mRNA Translation: BAG70064.1 BC018823 mRNA Translation: AAH18823.1 BC040209 mRNA Translation: AAH40209.1 AF020307 Genomic DNA Translation: AAC39543.1 Frameshift.
CCDSⁱ	CCDS32109.1 [Q13243-1]
PIRⁱ	S59042
RefSeqⁱ	NP_001034554.1, NM_001039465.1 [Q13243-1] NP_001307143.1, NM_001320214.1 [Q13243-1] NP_008856.2, NM_006925.4 [Q13243-1]
UniGeneⁱ	Hs.632326

3D structure databases

ProteinModelPortalⁱ	Q13243
SMRⁱ	Q13243
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112328, 118 interactors
CORUMⁱ	Q13243
DIPⁱ	DIP-46894N
IntActⁱ	Q13243, 38 interactors
MINTⁱ	Q13243
STRINGⁱ	9606.ENSP00000377892

PTM databases

iPTMnetⁱ	Q13243
PhosphoSitePlusⁱ	Q13243
SwissPalmⁱ	Q13243

Polymorphism and mutation databases

BioMutaⁱ	SRSF5
DMDMⁱ	3929378

Proteomic databases

EPDⁱ	Q13243
PaxDbⁱ	Q13243
PeptideAtlasⁱ	Q13243
PRIDEⁱ	Q13243
ProteomicsDBⁱ	59247 59248 [Q13243-2] 59249 [Q13243-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6430
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1] ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1] ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3] ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1]
GeneIDⁱ	6430
KEGGⁱ	hsa:6430
UCSCⁱ	uc001xll.4 human [Q13243-1]

Organism-specific databases

CTDⁱ	6430
DisGeNETⁱ	6430
EuPathDBⁱ	HostDB:ENSG00000100650.15
GeneCardsⁱ	SRSF5
HGNCⁱ	HGNC:10787 SRSF5
HPAⁱ	HPA043484 HPA056523
MIMⁱ	600914 gene
neXtProtⁱ	NX_Q13243
OpenTargetsⁱ	ENSG00000100650
PharmGKBⁱ	PA35703
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0106 Eukaryota COG0724 LUCA
GeneTreeⁱ	ENSGT00910000144049
HOVERGENⁱ	HBG002295
InParanoidⁱ	Q13243
KOⁱ	K12893
OMAⁱ	RENDDSH
OrthoDBⁱ	EOG091G0R9W
PhylomeDBⁱ	Q13243
TreeFamⁱ	TF351335

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSⁱ	SRSF5 human
GeneWikiⁱ	SFRS5
GenomeRNAiⁱ	6430
Protein Ontology More...PROⁱ	PR:Q13243
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100650 Expressed in 238 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SFRS5
ExpressionAtlasⁱ	Q13243 baseline and differential
Genevisibleⁱ	Q13243 HS

Family and domain databases

CDDⁱ	cd12337 RRM1_SRSF4_like, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR035585 RRM1_SRSF4-like IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRSF5_HUMAN
Accessionⁱ	Q13243Primary (citable) accession number: Q13243 Secondary accession number(s): O14797 , Q16662, Q49AD6, Q6FGE0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q13243 (SRSF5_HUMAN)

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Serine/arginine-rich splicing factor 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ