UniProtKB - Q13243 (SRSF5_HUMAN)
Serine/arginine-rich splicing factor 5
SRSF5
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
- protein kinase B binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular response to insulin stimulus Source: Ensembl
- liver regeneration Source: Ensembl
- mRNA 3'-end processing Source: Reactome
- mRNA export from nucleus Source: Reactome
- mRNA processing Source: ProtInc
- mRNA splice site selection Source: ProtInc
- mRNA splicing, via spliceosome Source: GO_Central
- positive regulation of RNA splicing Source: Ensembl
- regulation of cell cycle Source: Ensembl
- RNA export from nucleus Source: Reactome
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q13243 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q13243 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/arginine-rich splicing factor 5Alternative name(s): Delayed-early protein HRS Pre-mRNA-splicing factor SRP40 Splicing factor, arginine/serine-rich 5 |
Gene namesi | Name:SRSF5 Synonyms:HRS, SFRS5, SRP40 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10787, SRSF5 |
MIMi | 600914, gene |
neXtProti | NX_Q13243 |
VEuPathDBi | HostDB:ENSG00000100650.15 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: UniProtKB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6430 |
OpenTargetsi | ENSG00000100650 |
PharmGKBi | PA35703 |
Miscellaneous databases
Pharosi | Q13243, Tbio |
Genetic variation databases
BioMutai | SRSF5 |
DMDMi | 3929378 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081927 | 1 – 272 | Serine/arginine-rich splicing factor 5Add BLAST | 272 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Modified residuei | 229 | PhosphoserineCombined sources | 1 | |
Modified residuei | 233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 250 | PhosphoserineCombined sources | 1 | |
Modified residuei | 253 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q13243 |
jPOSTi | Q13243 |
MassIVEi | Q13243 |
PaxDbi | Q13243 |
PeptideAtlasi | Q13243 |
PRIDEi | Q13243 |
ProteomicsDBi | 59247 [Q13243-1] 59248 [Q13243-2] 59249 [Q13243-3] |
PTM databases
iPTMneti | Q13243 |
PhosphoSitePlusi | Q13243 |
SwissPalmi | Q13243 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100650, Expressed in left lobe of thyroid gland and 248 other tissues |
ExpressionAtlasi | Q13243, baseline and differential |
Genevisiblei | Q13243, HS |
Organism-specific databases
HPAi | ENSG00000100650, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity).
Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
By similarity1 PublicationBinary interactionsi
Q13243
With | #Exp. | IntAct |
---|---|---|
ZRSR2 [Q15696] | 3 | EBI-720503,EBI-6657923 |
GO - Molecular functioni
- protein kinase B binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112328, 177 interactors |
CORUMi | Q13243 |
DIPi | DIP-46894N |
IntActi | Q13243, 58 interactors |
MINTi | Q13243 |
STRINGi | 9606.ENSP00000452123 |
Miscellaneous databases
RNActi | Q13243, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 74 | RRM 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 108 – 181 | RRM 2PROSITE-ProRule annotationAdd BLAST | 74 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 78 – 83 | Gly-rich (hinge region) | 6 | |
Compositional biasi | 182 – 267 | Arg/Ser-rich (RS domain)Add BLAST | 86 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0106, Eukaryota |
GeneTreei | ENSGT00940000158275 |
HOGENOMi | CLU_012062_34_2_1 |
InParanoidi | Q13243 |
OMAi | XDLKDFM |
PhylomeDBi | Q13243 |
TreeFami | TF351335 |
Family and domain databases
CDDi | cd12337, RRM1_SRSF4_like, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR035585, RRM1_SRSF4-like IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA
60 70 80 90 100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN
110 120 130 140 150
APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE
160 170 180 190 200
FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHSRSRSRS RSRTRSSSRS
210 220 230 240 250
RSRSRSRSRK SYSRSRSRSR SRSRSKSRSV SRSPVPEKSQ KRGSSSRSKS
260 270
PASVDRQRSR SRSRSRSVDS GN
The sequence of this isoform differs from the canonical sequence as follows:
100-107: NAPPVRTE → YVKGGWLH
108-272: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
43-45: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DJK0 | B4DJK0_HUMAN | Serine/arginine-rich-splicing facto... | SRSF5 | 124 | Annotation score: | ||
B4DUA4 | B4DUA4_HUMAN | Serine/arginine-rich-splicing facto... | SRSF5 | 138 | Annotation score: | ||
G3V5K8 | G3V5K8_HUMAN | Serine/arginine-rich-splicing facto... | SRSF5 | 99 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014713 | 160 | A → S. Corresponds to variant dbSNP:rs1057683Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005863 | 43 – 45 | Missing in isoform SRP40-4. Curated | 3 | |
Alternative sequenceiVSP_005864 | 100 – 107 | NAPPVRTE → YVKGGWLH in isoform SRP40-2. 5 Publications | 8 | |
Alternative sequenceiVSP_005865 | 108 – 272 | Missing in isoform SRP40-2. 5 PublicationsAdd BLAST | 165 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30826 mRNA Translation: AAA93070.1 U30884 mRNA Translation: AAA93074.1 U30827 mRNA Translation: AAB60405.1 BT007089 mRNA Translation: AAP35752.1 AK311805 mRNA Translation: BAG34748.1 CR542167 mRNA Translation: CAG46964.1 CR542182 mRNA Translation: CAG46979.1 BX640605 mRNA Translation: CAE45711.1 AB451250 mRNA Translation: BAG70064.1 BC018823 mRNA Translation: AAH18823.1 BC040209 mRNA Translation: AAH40209.1 AF020307 Genomic DNA Translation: AAC39543.1 Frameshift. |
CCDSi | CCDS32109.1 [Q13243-1] |
PIRi | S59042 |
RefSeqi | NP_001034554.1, NM_001039465.1 [Q13243-1] NP_001307143.1, NM_001320214.1 [Q13243-1] NP_008856.2, NM_006925.4 [Q13243-1] |
Genome annotation databases
Ensembli | ENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1] ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1] ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3] ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1] |
GeneIDi | 6430 |
KEGGi | hsa:6430 |
UCSCi | uc001xll.4, human [Q13243-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30826 mRNA Translation: AAA93070.1 U30884 mRNA Translation: AAA93074.1 U30827 mRNA Translation: AAB60405.1 BT007089 mRNA Translation: AAP35752.1 AK311805 mRNA Translation: BAG34748.1 CR542167 mRNA Translation: CAG46964.1 CR542182 mRNA Translation: CAG46979.1 BX640605 mRNA Translation: CAE45711.1 AB451250 mRNA Translation: BAG70064.1 BC018823 mRNA Translation: AAH18823.1 BC040209 mRNA Translation: AAH40209.1 AF020307 Genomic DNA Translation: AAC39543.1 Frameshift. |
CCDSi | CCDS32109.1 [Q13243-1] |
PIRi | S59042 |
RefSeqi | NP_001034554.1, NM_001039465.1 [Q13243-1] NP_001307143.1, NM_001320214.1 [Q13243-1] NP_008856.2, NM_006925.4 [Q13243-1] |
3D structure databases
SMRi | Q13243 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112328, 177 interactors |
CORUMi | Q13243 |
DIPi | DIP-46894N |
IntActi | Q13243, 58 interactors |
MINTi | Q13243 |
STRINGi | 9606.ENSP00000452123 |
PTM databases
iPTMneti | Q13243 |
PhosphoSitePlusi | Q13243 |
SwissPalmi | Q13243 |
Genetic variation databases
BioMutai | SRSF5 |
DMDMi | 3929378 |
Proteomic databases
EPDi | Q13243 |
jPOSTi | Q13243 |
MassIVEi | Q13243 |
PaxDbi | Q13243 |
PeptideAtlasi | Q13243 |
PRIDEi | Q13243 |
ProteomicsDBi | 59247 [Q13243-1] 59248 [Q13243-2] 59249 [Q13243-3] |
Protocols and materials databases
Antibodypediai | 25065, 109 antibodies |
DNASUi | 6430 |
Genome annotation databases
Ensembli | ENST00000394366; ENSP00000377892; ENSG00000100650 [Q13243-1] ENST00000553521; ENSP00000452123; ENSG00000100650 [Q13243-1] ENST00000553635; ENSP00000451391; ENSG00000100650 [Q13243-3] ENST00000557154; ENSP00000451088; ENSG00000100650 [Q13243-1] |
GeneIDi | 6430 |
KEGGi | hsa:6430 |
UCSCi | uc001xll.4, human [Q13243-1] |
Organism-specific databases
CTDi | 6430 |
DisGeNETi | 6430 |
GeneCardsi | SRSF5 |
HGNCi | HGNC:10787, SRSF5 |
HPAi | ENSG00000100650, Low tissue specificity |
MIMi | 600914, gene |
neXtProti | NX_Q13243 |
OpenTargetsi | ENSG00000100650 |
PharmGKBi | PA35703 |
VEuPathDBi | HostDB:ENSG00000100650.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0106, Eukaryota |
GeneTreei | ENSGT00940000158275 |
HOGENOMi | CLU_012062_34_2_1 |
InParanoidi | Q13243 |
OMAi | XDLKDFM |
PhylomeDBi | Q13243 |
TreeFami | TF351335 |
Enzyme and pathway databases
PathwayCommonsi | Q13243 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q13243 |
Miscellaneous databases
BioGRID-ORCSi | 6430, 32 hits in 999 CRISPR screens |
ChiTaRSi | SRSF5, human |
GeneWikii | SFRS5 |
GenomeRNAii | 6430 |
Pharosi | Q13243, Tbio |
PROi | PR:Q13243 |
RNActi | Q13243, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100650, Expressed in left lobe of thyroid gland and 248 other tissues |
ExpressionAtlasi | Q13243, baseline and differential |
Genevisiblei | Q13243, HS |
Family and domain databases
CDDi | cd12337, RRM1_SRSF4_like, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR035585, RRM1_SRSF4-like IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRSF5_HUMAN | |
Accessioni | Q13243Primary (citable) accession number: Q13243 Secondary accession number(s): O14797 Q6FGE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families