SLA

Functionⁱ

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.2 Publications

GO - Molecular functionⁱ

non-membrane spanning protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 7543898

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-tyrosine autophosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q13239

SignaLinkⁱ

Q13239

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Src-like-adapter Alternative name(s): Src-like-adapter protein 1 Short name: SLAP-1 Short name: hSLAP
Gene namesⁱ	Name:SLA Synonyms:SLAP, SLAP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155926.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10902 SLA
MIMⁱ	601099 gene
neXtProtⁱ	NX_Q13239

Keywords - Cellular componentⁱ

Cytoplasm, Endosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	111	R → K: Strongly reduces interaction with ZAP70, CD3Z, SYK and LAT. 1 Publication	1
Mutagenesisⁱ	218	L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-224 and S-229. 1 Publication	1
Mutagenesisⁱ	224	L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-229. 1 Publication	1
Mutagenesisⁱ	229	L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-224. 1 Publication	1
Mutagenesisⁱ	237 – 239	LSL → QSQ: Abolishes interaction with CBL. Slightly affects dimerization. 1 Publication	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6503
Open Targets More...OpenTargetsⁱ	ENSG00000155926
PharmGKBⁱ	PA35802

Polymorphism and mutation databases

BioMutaⁱ	SLA
DMDMⁱ	30173237

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000071946	2 – 276	Src-like-adapterAdd BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineBy similarity	1
Modified residueⁱ	253	PhosphoserineBy similarity	1
Modified residueⁱ	273	PhosphotyrosineBy similarity	1

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q13239
PeptideAtlas More...PeptideAtlasⁱ	Q13239
PRIDEⁱ	Q13239
ProteomicsDBⁱ	59242

PTM databases

iPTMnetⁱ	Q13239
PhosphoSitePlusⁱ	Q13239

Expressionⁱ

Tissue specificityⁱ

Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.1 Publication

Inductionⁱ

By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000155926 Expressed in 210 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SLA
ExpressionAtlasⁱ	Q13239 baseline and differential
Genevisibleⁱ	Q13239 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012296 HPA074192

HPAⁱ

HPA012296
HPA074192

Interactionⁱ

Subunit structureⁱ

Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EGFR	P00533	2	EBI-726214,EBI-297353
PDGFRB	P09619	4	EBI-726214,EBI-641237

GO - Molecular functionⁱ

SH3/SH2 adaptor activity
Source: ProtInc
Traceable author statementⁱ
- 7543898

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112394, 17 interactors
IntActⁱ	Q13239, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q13239
STRINGⁱ	9606.ENSP00000394049

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	20 – 22	Combined sources	3
Beta strandⁱ	26 – 31	Combined sources	6
Turnⁱ	36 – 38	Combined sources	3
Beta strandⁱ	48 – 55	Combined sources	8
Beta strandⁱ	58 – 63	Combined sources	6
Turnⁱ	64 – 66	Combined sources	3
Beta strandⁱ	69 – 73	Combined sources	5
Helixⁱ	74 – 76	Combined sources	3
Beta strandⁱ	77 – 80	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13239
SMRⁱ	Q13239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q13239

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 82	SH3PROSITE-ProRule annotationAdd BLAST		61
Domainⁱ	84 – 175	SH2PROSITE-ProRule annotationAdd BLAST		92

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	212 – 276	SLA C-terminalAdd BLAST		65

Domainⁱ

The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.

Keywords - Domainⁱ

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGⁱ	ENOG410IFZ7 Eukaryota ENOG4111KT3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001681
HOGENOMⁱ	HOG000234240
HOVERGENⁱ	HBG054908
InParanoidⁱ	Q13239
OMAⁱ	RQTFQCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DST
PhylomeDBⁱ	Q13239

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10344 SH2_SLAP, 1 hit cd12010 SH3_SLAP, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR035055 SLAP IPR035052 SLAP_SH2 IPR035596 SLAP_SH3
PANTHERⁱ	PTHR24418:SF293 PTHR24418:SF293, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50002 SH3, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13239-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNSMKSTPA PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR 
        60         70         80         90        100
VISDEGGWWK AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL 
       110        120        130        140        150
PDTKVGSFMI RESETKKGFY SLSVRHRQVK HYRIFRLPNN WYYISPRLTF 
       160        170        180        190        200
QCLEDLVNHY SEVADGLCCV LTTPCLTQST AAPAVRASSS PVTLRQKTVD 
       210        220        230        240        250
WRRVSRLQED PEGTENPLGV DESLFSYGLR ESIASYLSLT SEDNTSFDRK 
       260        270 
KKSISLMYGG SKRKSSFFSS PPYFED

Length:276

Mass (Da):31,156

Last modified:January 23, 2007 - v3

Checksum:ⁱB0FCC7D7B2ECA378

GO

Isoform 2 (identifier: Q13239-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-108: Missing.

« Hide

        10         20         30         40         50
MIRESETKKG FYSLSVRHRQ VKHYRIFRLP NNWYYISPRL TFQCLEDLVN 
        60         70         80         90        100
HYSEVADGLC CVLTTPCLTQ STAAPAVRAS SSPVTLRQKT VDWRRVSRLQ 
       110        120        130        140        150
EDPEGTENPL GVDESLFSYG LRESIASYLS LTSEDNTSFD RKKKSISLMY 
       160 
GGSKRKSSFF SSPPYFED

Note: No experimental confirmation available.

Show »

Length:168

Mass (Da):19,285

Checksum:ⁱ0BC12A843F32869D

GO

Isoform 3 (identifier: Q13239-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLHRLWASPAAPGKKKEM

« Hide

        10         20         30         40         50
MLHRLWASPA APGKKKEMGN SMKSTPAPAE RPLPNPEGLD SDFLAVLSDY 
        60         70         80         90        100
PSPDISPPIF RRGEKLRVIS DEGGWWKAIS LSTGRESYIP GICVARVYHG 
       110        120        130        140        150
WLFEGLGRDK AEELLQLPDT KVGSFMIRES ETKKGFYSLS VRHRQVKHYR 
       160        170        180        190        200
IFRLPNNWYY ISPRLTFQCL EDLVNHYSEV ADGLCCVLTT PCLTQSTAAP 
       210        220        230        240        250
AVRASSSPVT LRQKTVDWRR VSRLQEDPEG TENPLGVDES LFSYGLRESI 
       260        270        280        290 
ASYLSLTSED NTSFDRKKKS ISLMYGGSKR KSSFFSSPPY FED

Note: No experimental confirmation available.

Show »

Length:293

Mass (Da):33,059

Checksum:ⁱ6721FE5A9562C6DC

GO

Isoform 4 (identifier: Q13239-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLHRLWASPAAPGKKKEM
118-161: Missing.

« Hide

        10         20         30         40         50
MLHRLWASPA APGKKKEMGN SMKSTPAPAE RPLPNPEGLD SDFLAVLSDY 
        60         70         80         90        100
PSPDISPPIF RRGEKLRVIS DEGGWWKAIS LSTGRESYIP GICVARVYHG 
       110        120        130        140        150
WLFEGLGRDK AEELLQLPDT KVGSFMIRES ETKKEVADGL CCVLTTPCLT 
       160        170        180        190        200
QSTAAPAVRA SSSPVTLRQK TVDWRRVSRL QEDPEGTENP LGVDESLFSY 
       210        220        230        240 
GLRESIASYL SLTSEDNTSF DRKKKSISLM YGGSKRKSSF FSSPPYFED

Note: No experimental confirmation available.

Show »

Length:249

Mass (Da):27,558

Checksum:ⁱD072FF483DAA2778

GO

Isoform 5 (identifier: Q13239-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLSKLGHSPLGGLRARLTFPVCLLYHRLWASPAAPGKKKEM

« Hide

        10         20         30         40         50
MLSKLGHSPL GGLRARLTFP VCLLYHRLWA SPAAPGKKKE MGNSMKSTPA 
        60         70         80         90        100
PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR VISDEGGWWK 
       110        120        130        140        150
AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL PDTKVGSFMI 
       160        170        180        190        200
RESETKKGFY SLSVRHRQVK HYRIFRLPNN WYYISPRLTF QCLEDLVNHY 
       210        220        230        240        250
SEVADGLCCV LTTPCLTQST AAPAVRASSS PVTLRQKTVD WRRVSRLQED 
       260        270        280        290        300
PEGTENPLGV DESLFSYGLR ESIASYLSLT SEDNTSFDRK KKSISLMYGG 
       310 
SKRKSSFFSS PPYFED

Note: No experimental confirmation available.

Show »

Length:316

Mass (Da):35,540

Checksum:ⁱ93C3155474168A96

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RJ69	E5RJ69_HUMAN	Src-like-adapter Src-like-adapter	SLA	158	Annotation score:
E5RHT2	E5RHT2_HUMAN	Src-like-adapter Src-like-adapter	SLA	91	Annotation score:
E5RGG0	E5RGG0_HUMAN	Src-like-adapter Src-like-adapter	SLA	48	Annotation score:
E5RK29	E5RK29_HUMAN	Src-like-adapter Src-like-adapter	SLA	28	Annotation score:
E5RK95	E5RK95_HUMAN	Src-like-adapter Src-like-adapter	SLA	40	Annotation score:
E5RH80	E5RH80_HUMAN	Src-like-adapter Src-like-adapter	SLA	55	Annotation score:
E5RJB0	E5RJB0_HUMAN	Src-like-adapter Src-like-adapter	SLA	14	Annotation score:

Sequence cautionⁱ

The sequence AAH07042 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAG35478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	71	Y → D in CAB53536 (PubMed:11179692).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061706	15	P → T. Corresponds to variant dbSNP:rs4486183Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055122	1 – 108	Missing in isoform 2. 1 PublicationAdd BLAST	108
Alternative sequenceⁱVSP_055123	1	M → MLHRLWASPAAPGKKKEM in isoform 3 and isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_055124	1	M → MLSKLGHSPLGGLRARLTFP VCLLYHRLWASPAAPGKKKE M in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_055125	118 – 161	Missing in isoform 4. 1 PublicationAdd BLAST	44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30473 mRNA Translation: AAC50357.1 D89077 mRNA Translation: BAA13758.1 U44403 mRNA Translation: AAC27662.1 CR536537 mRNA Translation: CAG38774.1 AK297423 mRNA Translation: BAH12578.1 AK297519 mRNA Translation: BAH12602.1 AK312584 mRNA Translation: BAG35478.1 Different initiation. AF235100 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92159.1 BC007042 mRNA Translation: AAH07042.1 Different initiation. AJ238591 mRNA Translation: CAB53536.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47922.1 [Q13239-3] CCDS47923.1 [Q13239-5] CCDS6370.1 [Q13239-1] CCDS64977.1 [Q13239-2] CCDS64978.1 [Q13239-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001039021.1, NM_001045556.2 [Q13239-1] NP_001039022.2, NM_001045557.2 [Q13239-3] NP_001269893.1, NM_001282964.1 [Q13239-4] NP_001269894.1, NM_001282965.1 [Q13239-2] NP_006739.2, NM_006748.3 [Q13239-5] XP_016869228.1, XM_017013739.1 [Q13239-2]
UniGeneⁱ	Hs.75367

Genome annotation databases

Ensemblⁱ	ENST00000338087; ENSP00000337548; ENSG00000155926 [Q13239-1] ENST00000395352; ENSP00000378759; ENSG00000155926 [Q13239-3] ENST00000427060; ENSP00000394049; ENSG00000155926 [Q13239-5] ENST00000517648; ENSP00000428559; ENSG00000155926 [Q13239-4] ENST00000524345; ENSP00000427928; ENSG00000155926 [Q13239-2]
GeneIDⁱ	6503
KEGGⁱ	hsa:6503
UCSC genome browser More...UCSCⁱ	uc003ytz.4 human [Q13239-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13239	SLA isoform 20		PANTR		316	UniRef100_Q13239
Src-like-adapter (Fragment)		HUMAN		40
Uncharacterized protein		PANPA		276
Src like adaptor		GORGO		276
Src-like-adapter (Fragment)		HUMAN		158
+9
Q13239-3	Src like adaptor		GORGO		293	UniRef100_A0A2I2Y4P6
Q13239-4	Src like adaptor		GORGO		249	UniRef100_A0A2I2Z1G6

Protein	Similar proteins		Species	Score	Length	Source
Q13239	SLA isoform 20		PANTR		316	UniRef90_Q13239
Src-like-adapter (Fragment)		HUMAN		40
Uncharacterized protein		PANPA		276
Src like adaptor		GORGO		276
Uncharacterized protein		MACFA		317
+103
Q13239-4	Uncharacterized protein		NOMLE		271	UniRef90_A0A2I3HGR0
Uncharacterized protein		AOTNA		251
Uncharacterized protein		CALJA		249
Uncharacterized protein		Cebus capucinus imitator		249
Uncharacterized protein		CERAT		249
+18

Protein	Similar proteins		Species	Score	Length	Source
Q13239	Src-like-adapter		RAT		312	UniRef50_Q13239
Src-like-adapter		MOUSE		281
SLA isoform 20		PANTR		316
Src-like-adapter (Fragment)		HUMAN		40
Uncharacterized protein		PANPA		276
+353
Q13239-4	Uncharacterized protein		NOMLE		271	UniRef50_A0A2I3HGR0
Uncharacterized protein		AOTNA		251
SLA isoform 8		PONAB		249
Uncharacterized protein		CALJA		249
Uncharacterized protein		Cebus capucinus imitator		249
+44

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30473 mRNA Translation: AAC50357.1 D89077 mRNA Translation: BAA13758.1 U44403 mRNA Translation: AAC27662.1 CR536537 mRNA Translation: CAG38774.1 AK297423 mRNA Translation: BAH12578.1 AK297519 mRNA Translation: BAH12602.1 AK312584 mRNA Translation: BAG35478.1 Different initiation. AF235100 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92159.1 BC007042 mRNA Translation: AAH07042.1 Different initiation. AJ238591 mRNA Translation: CAB53536.1
CCDSⁱ	CCDS47922.1 [Q13239-3] CCDS47923.1 [Q13239-5] CCDS6370.1 [Q13239-1] CCDS64977.1 [Q13239-2] CCDS64978.1 [Q13239-4]
RefSeqⁱ	NP_001039021.1, NM_001045556.2 [Q13239-1] NP_001039022.2, NM_001045557.2 [Q13239-3] NP_001269893.1, NM_001282964.1 [Q13239-4] NP_001269894.1, NM_001282965.1 [Q13239-2] NP_006739.2, NM_006748.3 [Q13239-5] XP_016869228.1, XM_017013739.1 [Q13239-2]
UniGeneⁱ	Hs.75367

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CUD	NMR	-	A	15-80	[»]
ProteinModelPortalⁱ	Q13239
SMRⁱ	Q13239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112394, 17 interactors
IntActⁱ	Q13239, 11 interactors
MINTⁱ	Q13239
STRINGⁱ	9606.ENSP00000394049

PTM databases

iPTMnetⁱ	Q13239
PhosphoSitePlusⁱ	Q13239

Polymorphism and mutation databases

BioMutaⁱ	SLA
DMDMⁱ	30173237

Proteomic databases

PaxDbⁱ	Q13239
PeptideAtlasⁱ	Q13239
PRIDEⁱ	Q13239
ProteomicsDBⁱ	59242

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6503
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000338087; ENSP00000337548; ENSG00000155926 [Q13239-1] ENST00000395352; ENSP00000378759; ENSG00000155926 [Q13239-3] ENST00000427060; ENSP00000394049; ENSG00000155926 [Q13239-5] ENST00000517648; ENSP00000428559; ENSG00000155926 [Q13239-4] ENST00000524345; ENSP00000427928; ENSG00000155926 [Q13239-2]
GeneIDⁱ	6503
KEGGⁱ	hsa:6503
UCSCⁱ	uc003ytz.4 human [Q13239-1]

Organism-specific databases

CTDⁱ	6503
DisGeNETⁱ	6503
EuPathDBⁱ	HostDB:ENSG00000155926.13
GeneCardsⁱ	SLA
HGNCⁱ	HGNC:10902 SLA
HPAⁱ	HPA012296 HPA074192
MIMⁱ	601099 gene
neXtProtⁱ	NX_Q13239
OpenTargetsⁱ	ENSG00000155926
PharmGKBⁱ	PA35802
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFZ7 Eukaryota ENOG4111KT3 LUCA
GeneTreeⁱ	ENSGT00390000001681
HOGENOMⁱ	HOG000234240
HOVERGENⁱ	HBG054908
InParanoidⁱ	Q13239
OMAⁱ	RQTFQCL
OrthoDBⁱ	EOG091G0DST
PhylomeDBⁱ	Q13239

Enzyme and pathway databases

SignaLinkⁱ	Q13239

SignaLinkⁱ

Q13239

Miscellaneous databases

EvolutionaryTraceⁱ	Q13239
GenomeRNAiⁱ	6503
Protein Ontology More...PROⁱ	PR:Q13239
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155926 Expressed in 210 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SLA
ExpressionAtlasⁱ	Q13239 baseline and differential
Genevisibleⁱ	Q13239 HS

Family and domain databases

CDDⁱ	cd10344 SH2_SLAP, 1 hit cd12010 SH3_SLAP, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR035055 SLAP IPR035052 SLAP_SH2 IPR035596 SLAP_SH3
PANTHERⁱ	PTHR24418:SF293 PTHR24418:SF293, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SLAP1_HUMAN
Accessionⁱ	Q13239Primary (citable) accession number: Q13239 Secondary accession number(s): B7Z4J2 , B7Z4L6, Q6FI01, Q9UMQ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniRef

Proteomes

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Supporting data

UniProtKB - Q13239 (SLAP1_HUMAN)

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Src-like-adapter

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ