UniProtKB - Q13239 (SLAP1_HUMAN)
Src-like-adapter
SLA
Functioni
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
2 PublicationsGO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: GO_Central
- innate immune response Source: GO_Central
- regulation of signal transduction Source: InterPro
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q13239 |
Reactomei | R-HSA-9706369, Negative regulation of FLT3 |
SignaLinki | Q13239 |
SIGNORi | Q13239 |
Names & Taxonomyi
Protein namesi | Recommended name: Src-like-adapterAlternative name(s): Src-like-adapter protein 1 Short name: SLAP-1 Short name: hSLAP |
Gene namesi | Name:SLA Synonyms:SLAP, SLAP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10902, SLA |
MIMi | 601099, gene |
neXtProti | NX_Q13239 |
VEuPathDBi | HostDB:ENSG00000155926 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- dendritic spine Source: GO_Central
- focal adhesion Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, EndosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 111 | R → K: Strongly reduces interaction with ZAP70, CD3Z, SYK and LAT. 1 Publication | 1 | |
Mutagenesisi | 218 | L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-224 and S-229. 1 Publication | 1 | |
Mutagenesisi | 224 | L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-229. 1 Publication | 1 | |
Mutagenesisi | 229 | L → S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-224. 1 Publication | 1 | |
Mutagenesisi | 237 – 239 | LSL → QSQ: Abolishes interaction with CBL. Slightly affects dimerization. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 6503 |
MalaCardsi | SLA |
OpenTargetsi | ENSG00000155926 |
PharmGKBi | PA35802 |
Miscellaneous databases
Pharosi | Q13239, Tbio |
Genetic variation databases
BioMutai | SLA |
DMDMi | 30173237 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000071946 | 2 – 276 | Src-like-adapterAdd BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | |
Modified residuei | 253 | PhosphoserineBy similarity | 1 | |
Modified residuei | 273 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
MassIVEi | Q13239 |
MaxQBi | Q13239 |
PaxDbi | Q13239 |
PeptideAtlasi | Q13239 |
PRIDEi | Q13239 |
ProteomicsDBi | 59242 [Q13239-1] 6601 6612 |
PTM databases
iPTMneti | Q13239 |
PhosphoSitePlusi | Q13239 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000155926, Expressed in cortical plate and 225 other tissues |
ExpressionAtlasi | Q13239, baseline and differential |
Genevisiblei | Q13239, HS |
Organism-specific databases
HPAi | ENSG00000155926, Group enriched (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain.
Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
By similarity1 PublicationBinary interactionsi
Q13239
With | #Exp. | IntAct |
---|---|---|
EGFR [P00533] | 3 | EBI-726214,EBI-297353 |
PDGFRB [P09619] | 4 | EBI-726214,EBI-641237 |
Isoform 3 [Q13239-3]
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112394, 26 interactors |
IntActi | Q13239, 38 interactors |
MINTi | Q13239 |
STRINGi | 9606.ENSP00000394049 |
Miscellaneous databases
RNActi | Q13239, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q13239 |
BMRBi | Q13239 |
SMRi | Q13239 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13239 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 82 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 84 – 175 | SH2PROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 212 – 276 | SLA C-terminalAdd BLAST | 65 |
Domaini
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | ENOG502QPWY, Eukaryota |
GeneTreei | ENSGT00940000159104 |
HOGENOMi | CLU_084503_1_0_1 |
InParanoidi | Q13239 |
OrthoDBi | 1051480at2759 |
PhylomeDBi | Q13239 |
Family and domain databases
CDDi | cd10344, SH2_SLAP, 1 hit cd12010, SH3_SLAP, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR035055, SLAP IPR035052, SLAP_SH2 IPR035596, SLAP_SH3 |
PANTHERi | PTHR24418:SF293, PTHR24418:SF293, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNSMKSTPA PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR
60 70 80 90 100
VISDEGGWWK AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL
110 120 130 140 150
PDTKVGSFMI RESETKKGFY SLSVRHRQVK HYRIFRLPNN WYYISPRLTF
160 170 180 190 200
QCLEDLVNHY SEVADGLCCV LTTPCLTQST AAPAVRASSS PVTLRQKTVD
210 220 230 240 250
WRRVSRLQED PEGTENPLGV DESLFSYGLR ESIASYLSLT SEDNTSFDRK
260 270
KKSISLMYGG SKRKSSFFSS PPYFED
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHT2 | E5RHT2_HUMAN | Src-like-adapter | SLA | 91 | Annotation score: | ||
E5RH80 | E5RH80_HUMAN | Src-like-adapter | SLA | 55 | Annotation score: | ||
E5RGG0 | E5RGG0_HUMAN | Src-like-adapter | SLA | 48 | Annotation score: | ||
E5RJ69 | E5RJ69_HUMAN | Src-like-adapter | SLA | 158 | Annotation score: | ||
E5RK29 | E5RK29_HUMAN | Src-like-adapter | SLA | 28 | Annotation score: | ||
E5RK95 | E5RK95_HUMAN | Src-like-adapter | SLA | 40 | Annotation score: | ||
E5RJB0 | E5RJB0_HUMAN | Src-like-adapter | SLA | 14 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | Y → D in CAB53536 (PubMed:11179692).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061706 | 15 | P → T. Corresponds to variant dbSNP:rs4486183Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055122 | 1 – 108 | Missing in isoform 2. 1 PublicationAdd BLAST | 108 | |
Alternative sequenceiVSP_055123 | 1 | M → MLHRLWASPAAPGKKKEM in isoform 3 and isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_055124 | 1 | M → MLSKLGHSPLGGLRARLTFP VCLLYHRLWASPAAPGKKKE M in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_055125 | 118 – 161 | Missing in isoform 4. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30473 mRNA Translation: AAC50357.1 D89077 mRNA Translation: BAA13758.1 U44403 mRNA Translation: AAC27662.1 CR536537 mRNA Translation: CAG38774.1 AK297423 mRNA Translation: BAH12578.1 AK297519 mRNA Translation: BAH12602.1 AK312584 mRNA Translation: BAG35478.1 Different initiation. AF235100 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92159.1 BC007042 mRNA Translation: AAH07042.1 Different initiation. AJ238591 mRNA Translation: CAB53536.1 |
CCDSi | CCDS47922.1 [Q13239-3] CCDS47923.1 [Q13239-5] CCDS6370.1 [Q13239-1] CCDS64977.1 [Q13239-2] CCDS64978.1 [Q13239-4] |
RefSeqi | NP_001039021.1, NM_001045556.2 [Q13239-1] NP_001039022.2, NM_001045557.2 [Q13239-3] NP_001269893.1, NM_001282964.1 [Q13239-4] NP_001269894.1, NM_001282965.1 [Q13239-2] NP_006739.2, NM_006748.3 [Q13239-5] XP_016869228.1, XM_017013739.1 [Q13239-2] |
Genome annotation databases
Ensembli | ENST00000338087.10; ENSP00000337548.5; ENSG00000155926.14 ENST00000395352.7; ENSP00000378759.3; ENSG00000155926.14 [Q13239-3] ENST00000427060.6; ENSP00000394049.2; ENSG00000155926.14 [Q13239-5] ENST00000517648.5; ENSP00000428559.1; ENSG00000155926.14 [Q13239-4] ENST00000524345.5; ENSP00000427928.1; ENSG00000155926.14 [Q13239-2] |
GeneIDi | 6503 |
KEGGi | hsa:6503 |
MANE-Selecti | ENST00000338087.10; ENSP00000337548.5; NM_001045556.3; NP_001039021.1 |
UCSCi | uc003ytz.4, human [Q13239-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30473 mRNA Translation: AAC50357.1 D89077 mRNA Translation: BAA13758.1 U44403 mRNA Translation: AAC27662.1 CR536537 mRNA Translation: CAG38774.1 AK297423 mRNA Translation: BAH12578.1 AK297519 mRNA Translation: BAH12602.1 AK312584 mRNA Translation: BAG35478.1 Different initiation. AF235100 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92159.1 BC007042 mRNA Translation: AAH07042.1 Different initiation. AJ238591 mRNA Translation: CAB53536.1 |
CCDSi | CCDS47922.1 [Q13239-3] CCDS47923.1 [Q13239-5] CCDS6370.1 [Q13239-1] CCDS64977.1 [Q13239-2] CCDS64978.1 [Q13239-4] |
RefSeqi | NP_001039021.1, NM_001045556.2 [Q13239-1] NP_001039022.2, NM_001045557.2 [Q13239-3] NP_001269893.1, NM_001282964.1 [Q13239-4] NP_001269894.1, NM_001282965.1 [Q13239-2] NP_006739.2, NM_006748.3 [Q13239-5] XP_016869228.1, XM_017013739.1 [Q13239-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CUD | NMR | - | A | 15-80 | [»] | |
AlphaFoldDBi | Q13239 | |||||
BMRBi | Q13239 | |||||
SMRi | Q13239 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112394, 26 interactors |
IntActi | Q13239, 38 interactors |
MINTi | Q13239 |
STRINGi | 9606.ENSP00000394049 |
PTM databases
iPTMneti | Q13239 |
PhosphoSitePlusi | Q13239 |
Genetic variation databases
BioMutai | SLA |
DMDMi | 30173237 |
Proteomic databases
MassIVEi | Q13239 |
MaxQBi | Q13239 |
PaxDbi | Q13239 |
PeptideAtlasi | Q13239 |
PRIDEi | Q13239 |
ProteomicsDBi | 59242 [Q13239-1] 6601 6612 |
Protocols and materials databases
Antibodypediai | 1995, 132 antibodies from 27 providers |
DNASUi | 6503 |
Genome annotation databases
Ensembli | ENST00000338087.10; ENSP00000337548.5; ENSG00000155926.14 ENST00000395352.7; ENSP00000378759.3; ENSG00000155926.14 [Q13239-3] ENST00000427060.6; ENSP00000394049.2; ENSG00000155926.14 [Q13239-5] ENST00000517648.5; ENSP00000428559.1; ENSG00000155926.14 [Q13239-4] ENST00000524345.5; ENSP00000427928.1; ENSG00000155926.14 [Q13239-2] |
GeneIDi | 6503 |
KEGGi | hsa:6503 |
MANE-Selecti | ENST00000338087.10; ENSP00000337548.5; NM_001045556.3; NP_001039021.1 |
UCSCi | uc003ytz.4, human [Q13239-1] |
Organism-specific databases
CTDi | 6503 |
DisGeNETi | 6503 |
GeneCardsi | SLA |
HGNCi | HGNC:10902, SLA |
HPAi | ENSG00000155926, Group enriched (bone marrow, lymphoid tissue) |
MalaCardsi | SLA |
MIMi | 601099, gene |
neXtProti | NX_Q13239 |
OpenTargetsi | ENSG00000155926 |
PharmGKBi | PA35802 |
VEuPathDBi | HostDB:ENSG00000155926 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPWY, Eukaryota |
GeneTreei | ENSGT00940000159104 |
HOGENOMi | CLU_084503_1_0_1 |
InParanoidi | Q13239 |
OrthoDBi | 1051480at2759 |
PhylomeDBi | Q13239 |
Enzyme and pathway databases
PathwayCommonsi | Q13239 |
Reactomei | R-HSA-9706369, Negative regulation of FLT3 |
SignaLinki | Q13239 |
SIGNORi | Q13239 |
Miscellaneous databases
BioGRID-ORCSi | 6503, 17 hits in 1075 CRISPR screens |
ChiTaRSi | SLA, human |
EvolutionaryTracei | Q13239 |
GenomeRNAii | 6503 |
Pharosi | Q13239, Tbio |
PROi | PR:Q13239 |
RNActi | Q13239, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155926, Expressed in cortical plate and 225 other tissues |
ExpressionAtlasi | Q13239, baseline and differential |
Genevisiblei | Q13239, HS |
Family and domain databases
CDDi | cd10344, SH2_SLAP, 1 hit cd12010, SH3_SLAP, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR035055, SLAP IPR035052, SLAP_SH2 IPR035596, SLAP_SH3 |
PANTHERi | PTHR24418:SF293, PTHR24418:SF293, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SLAP1_HUMAN | |
Accessioni | Q13239Primary (citable) accession number: Q13239 Secondary accession number(s): B7Z4J2 Q9UMQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references