UniProtKB - Q13232 (NDK3_HUMAN)
Protein
Nucleoside diphosphate kinase 3
Gene
NME3
Organism
Homo sapiens (Human)
Status
Functioni
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 29 | ATPBy similarity | 1 | |
Binding sitei | 77 | ATPBy similarity | 1 | |
Binding sitei | 105 | ATPBy similarity | 1 | |
Binding sitei | 111 | ATPBy similarity | 1 | |
Binding sitei | 122 | ATPBy similarity | 1 | |
Binding sitei | 132 | ATPBy similarity | 1 | |
Active sitei | 135 | Pros-phosphohistidine intermediateBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- nucleoside diphosphate kinase activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: ProtInc
- CTP biosynthetic process Source: InterPro
- GTP biosynthetic process Source: InterPro
- nucleobase-containing small molecule interconversion Source: Reactome
- UTP biosynthetic process Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Apoptosis, Nucleotide metabolism |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q13232 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoside diphosphate kinase 3 (EC:2.7.4.6)Short name: NDK 3 Short name: NDP kinase 3 Alternative name(s): DR-nm23 Nucleoside diphosphate kinase C Short name: NDPKC nm23-H3 |
Gene namesi | Name:NME3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7851, NME3 |
MIMi | 601817, gene |
neXtProti | NX_Q13232 |
VEuPathDBi | HostDB:ENSG00000103024.7 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4832 |
OpenTargetsi | ENSG00000103024 |
PharmGKBi | PA31656 |
Miscellaneous databases
Pharosi | Q13232, Tbio |
Genetic variation databases
BioMutai | NME3 |
DMDMi | 21264477 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137123 | 1 – 169 | Nucleoside diphosphate kinase 3Add BLAST | 169 |
Proteomic databases
EPDi | Q13232 |
jPOSTi | Q13232 |
MassIVEi | Q13232 |
MaxQBi | Q13232 |
PaxDbi | Q13232 |
PeptideAtlasi | Q13232 |
PRIDEi | Q13232 |
ProteomicsDBi | 59239 |
PTM databases
iPTMneti | Q13232 |
PhosphoSitePlusi | Q13232 |
SwissPalmi | Q13232 |
Expressioni
Developmental stagei
Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.
Gene expression databases
Bgeei | ENSG00000103024, Expressed in pituitary gland and 219 other tissues |
ExpressionAtlasi | Q13232, baseline and differential |
Genevisiblei | Q13232, HS |
Organism-specific databases
HPAi | ENSG00000103024, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ13232
Protein-protein interaction databases
BioGRIDi | 110896, 49 interactors |
DIPi | DIP-49960N |
IntActi | Q13232, 42 interactors |
MINTi | Q13232 |
STRINGi | 9606.ENSP00000219302 |
Miscellaneous databases
RNActi | Q13232, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13232 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13232 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NDK family.Curated
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000161283 |
InParanoidi | Q13232 |
OMAi | WFRAEEL |
OrthoDBi | 1334716at2759 |
PhylomeDBi | Q13232 |
TreeFami | TF106373 |
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
HAMAPi | MF_00451, NDP_kinase, 1 hit |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR001564, Nucleoside_diP_kinase IPR023005, Nucleoside_diP_kinase_AS |
Pfami | View protein in Pfam PF00334, NDK, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
PROSITEi | View protein in PROSITE PS00469, NDP_KINASES, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q13232-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF
60 70 80 90 100
KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV
110 120 130 140 150
VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW
160
FRADELLCWE DSAGHWLYE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BPR2 | H3BPR2_HUMAN | Nucleoside diphosphate kinase | NME3 | 85 | Annotation score: | ||
H3BRA8 | H3BRA8_HUMAN | Nucleoside diphosphate kinase 3 | NME3 | 123 | Annotation score: | ||
H3BMQ7 | H3BMQ7_HUMAN | Nucleoside diphosphate kinase 3 | NME3 | 57 | Annotation score: | ||
H3BPD9 | H3BPD9_HUMAN | Nucleoside diphosphate kinase 3 | NME3 | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | A → S in AAA85097 (PubMed:7638209).Curated | 1 | |
Sequence conflicti | 131 | Missing in AAA85097 (PubMed:7638209).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29656 mRNA Translation: AAA85097.1 AE006639 Genomic DNA Translation: AAK61291.1 BC000250 mRNA Translation: AAH00250.1 |
CCDSi | CCDS10443.1 |
PIRi | I39074 |
RefSeqi | NP_002504.2, NM_002513.2 |
Genome annotation databases
Ensembli | ENST00000219302; ENSP00000219302; ENSG00000103024 |
GeneIDi | 4832 |
KEGGi | hsa:4832 |
UCSCi | uc002cmm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29656 mRNA Translation: AAA85097.1 AE006639 Genomic DNA Translation: AAK61291.1 BC000250 mRNA Translation: AAH00250.1 |
CCDSi | CCDS10443.1 |
PIRi | I39074 |
RefSeqi | NP_002504.2, NM_002513.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZS6 | X-ray | 2.30 | A/B/D | 1-169 | [»] | |
SMRi | Q13232 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110896, 49 interactors |
DIPi | DIP-49960N |
IntActi | Q13232, 42 interactors |
MINTi | Q13232 |
STRINGi | 9606.ENSP00000219302 |
PTM databases
iPTMneti | Q13232 |
PhosphoSitePlusi | Q13232 |
SwissPalmi | Q13232 |
Genetic variation databases
BioMutai | NME3 |
DMDMi | 21264477 |
Proteomic databases
EPDi | Q13232 |
jPOSTi | Q13232 |
MassIVEi | Q13232 |
MaxQBi | Q13232 |
PaxDbi | Q13232 |
PeptideAtlasi | Q13232 |
PRIDEi | Q13232 |
ProteomicsDBi | 59239 |
Protocols and materials databases
Antibodypediai | 23225, 200 antibodies |
DNASUi | 4832 |
Genome annotation databases
Ensembli | ENST00000219302; ENSP00000219302; ENSG00000103024 |
GeneIDi | 4832 |
KEGGi | hsa:4832 |
UCSCi | uc002cmm.4, human |
Organism-specific databases
CTDi | 4832 |
DisGeNETi | 4832 |
GeneCardsi | NME3 |
HGNCi | HGNC:7851, NME3 |
HPAi | ENSG00000103024, Low tissue specificity |
MIMi | 601817, gene |
neXtProti | NX_Q13232 |
OpenTargetsi | ENSG00000103024 |
PharmGKBi | PA31656 |
VEuPathDBi | HostDB:ENSG00000103024.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000161283 |
InParanoidi | Q13232 |
OMAi | WFRAEEL |
OrthoDBi | 1334716at2759 |
PhylomeDBi | Q13232 |
TreeFami | TF106373 |
Enzyme and pathway databases
PathwayCommonsi | Q13232 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates |
Miscellaneous databases
BioGRID-ORCSi | 4832, 7 hits in 992 CRISPR screens |
ChiTaRSi | NME3, human |
EvolutionaryTracei | Q13232 |
GeneWikii | NME3 |
GenomeRNAii | 4832 |
Pharosi | Q13232, Tbio |
PROi | PR:Q13232 |
RNActi | Q13232, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103024, Expressed in pituitary gland and 219 other tissues |
ExpressionAtlasi | Q13232, baseline and differential |
Genevisiblei | Q13232, HS |
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
HAMAPi | MF_00451, NDP_kinase, 1 hit |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR001564, Nucleoside_diP_kinase IPR023005, Nucleoside_diP_kinase_AS |
Pfami | View protein in Pfam PF00334, NDK, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
PROSITEi | View protein in PROSITE PS00469, NDP_KINASES, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDK3_HUMAN | |
Accessioni | Q13232Primary (citable) accession number: Q13232 Secondary accession number(s): Q9BWH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | May 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families