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Protein

Nucleoside diphosphate kinase 3

Gene

NME3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29ATPBy similarity1
Binding sitei77ATPBy similarity1
Binding sitei105ATPBy similarity1
Binding sitei111ATPBy similarity1
Binding sitei122ATPBy similarity1
Binding sitei132ATPBy similarity1
Active sitei135Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processApoptosis, Nucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 3 (EC:2.7.4.6)
Short name:
NDK 3
Short name:
NDP kinase 3
Alternative name(s):
DR-nm23
Nucleoside diphosphate kinase C
Short name:
NDPKC
nm23-H3
Gene namesi
Name:NME3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103024.7
HGNCiHGNC:7851 NME3
MIMi601817 gene
neXtProtiNX_Q13232

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4832
OpenTargetsiENSG00000103024
PharmGKBiPA31656

Polymorphism and mutation databases

BioMutaiNME3
DMDMi21264477

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371231 – 169Nucleoside diphosphate kinase 3Add BLAST169

Proteomic databases

EPDiQ13232
MaxQBiQ13232
PaxDbiQ13232
PeptideAtlasiQ13232
PRIDEiQ13232
ProteomicsDBi59239

PTM databases

iPTMnetiQ13232
PhosphoSitePlusiQ13232

Expressioni

Developmental stagei

Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.

Gene expression databases

BgeeiENSG00000103024
CleanExiHS_NME3
ExpressionAtlasiQ13232 baseline and differential
GenevisibleiQ13232 HS

Organism-specific databases

HPAiHPA041113
HPA052733

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110896, 27 interactors
DIPiDIP-49960N
IntActiQ13232, 23 interactors
MINTiQ13232
STRINGi9606.ENSP00000219302

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 21Combined sources3
Beta strandi23 – 28Combined sources6
Helixi30 – 34Combined sources5
Helixi38 – 48Combined sources11
Beta strandi51 – 58Combined sources8
Helixi62 – 68Combined sources7
Helixi70 – 72Combined sources3
Helixi78 – 85Combined sources8
Beta strandi90 – 97Combined sources8
Helixi100 – 108Combined sources9
Helixi113 – 115Combined sources3
Helixi121 – 125Combined sources5
Helixi129 – 131Combined sources3
Beta strandi133 – 136Combined sources4
Helixi140 – 150Combined sources11
Helixi153 – 155Combined sources3
Helixi164 – 167Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZS6X-ray2.30A/B/D1-169[»]
ProteinModelPortaliQ13232
SMRiQ13232
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13232

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224564
HOVERGENiHBG000423
InParanoidiQ13232
KOiK00940
OMAiRLVKYMG
OrthoDBiEOG091G0PLD
PhylomeDBiQ13232
TreeFamiTF106373

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q13232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF
60 70 80 90 100
KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV
110 120 130 140 150
VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW
160
FRADELLCWE DSAGHWLYE
Length:169
Mass (Da):19,015
Last modified:May 27, 2002 - v2
Checksum:iCCA41A122A37202D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60A → S in AAA85097 (PubMed:7638209).Curated1
Sequence conflicti131Missing in AAA85097 (PubMed:7638209).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29656 mRNA Translation: AAA85097.1
AE006639 Genomic DNA Translation: AAK61291.1
BC000250 mRNA Translation: AAH00250.1
CCDSiCCDS10443.1
PIRiI39074
RefSeqiNP_002504.2, NM_002513.2
UniGeneiHs.514065

Genome annotation databases

EnsembliENST00000219302; ENSP00000219302; ENSG00000103024
GeneIDi4832
KEGGihsa:4832
UCSCiuc002cmm.4 human

Similar proteinsi

Entry informationi

Entry nameiNDK3_HUMAN
AccessioniPrimary (citable) accession number: Q13232
Secondary accession number(s): Q9BWH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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