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Entry version 212 (07 Apr 2021)
Sequence version 3 (10 Feb 2009)
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Protein

Pappalysin-1

Gene

PAPPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5. EC:3.4.24.79

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by complexation with the proform of PRG2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi562Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei563PROSITE-ProRule annotation1
Metal bindingi566Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi572Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000119398-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.24.79, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13219

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M43.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pappalysin-1 (EC:3.4.24.79)
Alternative name(s):
Insulin-like growth factor-dependent IGF-binding protein 4 protease
Short name:
IGF-dependent IGFBP-4 protease
Short name:
IGFBP-4ase
Pregnancy-associated plasma protein A
Short name:
PAPP-A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAPPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8602, PAPPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176385, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13219

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000182752.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5069

Open Targets

More...
OpenTargetsi
ENSG00000182752

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13219, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB12695, Phenethyl Isothiocyanate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAPPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223590248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002924523 – 812 PublicationsAdd BLAST59
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002924682 – 1627Pappalysin-1Add BLAST1546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi144 ↔ 235PROSITE-ProRule annotation1 Publication
Disulfide bondi327 ↔ 622PROSITE-ProRule annotation1 Publication
Disulfide bondi332 ↔ 657PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi414 ↔ 428PROSITE-ProRule annotation1 Publication
Disulfide bondi424 ↔ 440PROSITE-ProRule annotation1 Publication
Glycosylationi429N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi457 ↔ 473PROSITE-ProRule annotation1 Publication
Disulfide bondi461Interchain (with C-51 in PRG2 proform)PROSITE-ProRule annotation1 Publication
Disulfide bondi474 ↔ 485PROSITE-ProRule annotation1 Publication
Glycosylationi480N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi583 ↔ 600Or C-583 with C-612PROSITE-ProRule annotation1 Publication
Disulfide bondi587 ↔ 612Or C-587 with C-600PROSITE-ProRule annotation1 Publication
Glycosylationi601N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi619N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi710 ↔ 878PROSITE-ProRule annotation1 Publication
Disulfide bondi713 ↔ 881PROSITE-ProRule annotation1 Publication
Glycosylationi725N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi732Interchain (with C-169 in PRG2 proform)PROSITE-ProRule annotation1 Publication
Disulfide bondi753 ↔ 835PROSITE-ProRule annotation1 Publication
Disulfide bondi775 ↔ 781PROSITE-ProRule annotation1 Publication
Glycosylationi825N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi947 ↔ 975PROSITE-ProRule annotation1 Publication
Disulfide bondi960 ↔ 971PROSITE-ProRule annotation1 Publication
Disulfide bondi983 ↔ 990PROSITE-ProRule annotation1 Publication
Disulfide bondi999 ↔ 1011PROSITE-ProRule annotation1 Publication
Glycosylationi1026N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1036 ↔ 1070PROSITE-ProRule annotation1 Publication
Disulfide bondi1051 ↔ 1139PROSITE-ProRule annotation1 Publication
Disulfide bondi1192 ↔ 1205PROSITE-ProRule annotation1 Publication
Disulfide bondi1210InterchainPROSITE-ProRule annotation1 Publication
Disulfide bondi1215 ↔ 1269PROSITE-ProRule annotation1 Publication
Glycosylationi1222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1226N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1227 ↔ 1238PROSITE-ProRule annotation1 Publication
Disulfide bondi1242 ↔ 1280PROSITE-ProRule annotation1 Publication
Disulfide bondi1285 ↔ 1329PROSITE-ProRule annotation1 Publication
Disulfide bondi1300 ↔ 1310PROSITE-ProRule annotation1 Publication
Disulfide bondi1314 ↔ 1342PROSITE-ProRule annotation1 Publication
Glycosylationi1323N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1346 ↔ 1399PROSITE-ProRule annotation1 Publication
Disulfide bondi1362 ↔ 1373PROSITE-ProRule annotation1 Publication
Disulfide bondi1377 ↔ 1410PROSITE-ProRule annotation1 Publication
Disulfide bondi1415 ↔ 1458PROSITE-ProRule annotation1 Publication
Disulfide bondi1428 ↔ 1438PROSITE-ProRule annotation1 Publication
Disulfide bondi1442 ↔ 1471PROSITE-ProRule annotation1 Publication
Glycosylationi1465N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1478 ↔ 1539PROSITE-ProRule annotation1 Publication
Disulfide bondi1492 ↔ 1502PROSITE-ProRule annotation1 Publication
Disulfide bondi1506 ↔ 1554PROSITE-ProRule annotation1 Publication
Glycosylationi1519N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1558 ↔ 1576PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

There appear to be no free sulfhydryl groups.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13219

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13219

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13219

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13219

PeptideAtlas

More...
PeptideAtlasi
Q13219

PRoteomics IDEntifications database

More...
PRIDEi
Q13219

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59231

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1594, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q13219, 14 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present in serum and placenta during pregnancy; levels increase throughout pregnancy.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 8-bromoadenosine-3',5'-phosphate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182752, Expressed in placenta and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13219, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182752, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111104, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13219

Protein interaction database and analysis system

More...
IntActi
Q13219, 10 interactors

Molecular INTeraction database

More...
MINTi
Q13219

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13219, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13219

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1213 – 1282Sushi 1PROSITE-ProRule annotationAdd BLAST70
Domaini1283 – 1344Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini1345 – 1412Sushi 3PROSITE-ProRule annotationAdd BLAST68
Domaini1413 – 1473Sushi 4PROSITE-ProRule annotationAdd BLAST61
Domaini1476 – 1556Sushi 5PROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni272 – 583MetalloproteaseAdd BLAST312

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 84Arg-richAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M43B family.Curated

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ7Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002636_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13219

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYQGWQP

Database of Orthologous Groups

More...
OrthoDBi
105200at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13219

TreeFam database of animal gene trees

More...
TreeFami
TF331636

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 4 hits
cd04275, ZnMc_pappalysin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR006558, LamG-like
IPR024079, MetalloPept_cat_dom_sf
IPR011936, Myxo_disulph_rpt
IPR000800, Notch_dom
IPR030433, PAPPA
IPR043543, PAPPA/PAPPA2
IPR008754, Peptidase_M43
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR46130, PTHR46130, 1 hit
PTHR46130:SF2, PTHR46130:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05572, Peptidase_M43, 1 hit
PF00084, Sushi, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 4 hits
SM00560, LamGL, 1 hit
SM00004, NL, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF57535, SSF57535, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02232, myxo_disulf_rpt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923, SUSHI, 5 hits
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13219-1 [UniParc]FASTAAdd to basket
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MRLWSWVLHL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR
60 70 80 90 100
AARGRRASPP PPPPPGGAWE AVRVPRRRQQ REARGATEEP SPPSRALYFS
110 120 130 140 150
GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD
160 170 180 190 200
RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA
210 220 230 240 250
ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR
260 270 280 290 300
GYIEHFSLWK VARTQREILS DMETHGAHTA LPQLLLQENW DNVKHAWSPM
310 320 330 340 350
KDGSSPKVEF SNAHGFLLDT SLEPPLCGQT LCDNTEVIAS YNQLSSFRQP
360 370 380 390 400
KVVRYRVVNL YEDDHKNPTV TREQVDFQHH QLAEAFKQYN ISWELDVLEV
410 420 430 440 450
SNSSLRRRLI LANCDISKIG DENCDPECNH TLTGHDGGDC RHLRHPAFVK
460 470 480 490 500
KQHNGVCDMD CNYERFNFDG GECCDPEITN VTQTCFDPDS PHRAYLDVNE
510 520 530 540 550
LKNILKLDGS THLNIFFAKS SEEELAGVAT WPWDKEALMH LGGIVLNPSF
560 570 580 590 600
YGMPGHTHTM IHEIGHSLGL YHVFRGISEI QSCSDPCMET EPSFETGDLC
610 620 630 640 650
NDTNPAPKHK SCGDPGPGND TCGFHSFFNT PYNNFMSYAD DDCTDSFTPN
660 670 680 690 700
QVARMHCYLD LVYQGWQPSR KPAPVALAPQ VLGHTTDSVT LEWFPPIDGH
710 720 730 740 750
FFERELGSAC HLCLEGRILV QYASNASSPM PCSPSGHWSP REAEGHPDVE
760 770 780 790 800
QPCKSSVRTW SPNSAVNPHT VPPACPEPQG CYLELEFLYP LVPESLTIWV
810 820 830 840 850
TFVSTDWDSS GAVNDIKLLA VSGKNISLGP QNVFCDVPLT IRLWDVGEEV
860 870 880 890 900
YGIQIYTLDE HLEIDAAMLT STADTPLCLQ CKPLKYKVVR DPPLQMDVAS
910 920 930 940 950
ILHLNRKFVD MDLNLGSVYQ YWVITISGTE ESEPSPAVTY IHGSGYCGDG
960 970 980 990 1000
IIQKDQGEQC DDMNKINGDG CSLFCRQEVS FNCIDEPSRC YFHDGDGVCE
1010 1020 1030 1040 1050
EFEQKTSIKD CGVYTPQGFL DQWASNASVS HQDQQCPGWV IIGQPAASQV
1060 1070 1080 1090 1100
CRTKVIDLSE GISQHAWYPC TISYPYSQLA QTTFWLRAYF SQPMVAAAVI
1110 1120 1130 1140 1150
VHLVTDGTYY GDQKQETISV QLLDTKDQSH DLGLHVLSCR NNPLIIPVVH
1160 1170 1180 1190 1200
DLSQPFYHSQ AVRVSFSSPL VAISGVALRS FDNFDPVTLS SCQRGETYSP
1210 1220 1230 1240 1250
AEQSCVHFAC EKTDCPELAV ENASLNCSSS DRYHGAQCTV SCRTGYVLQI
1260 1270 1280 1290 1300
RRDDELIKSQ TGPSVTVTCT EGKWNKQVAC EPVDCSIPDH HQVYAASFSC
1310 1320 1330 1340 1350
PEGTTFGSQC SFQCRHPAQL KGNNSLLTCM EDGLWSFPEA LCELMCLAPP
1360 1370 1380 1390 1400
PVPNADLQTA RCRENKHKVG SFCKYKCKPG YHVPGSSRKS KKRAFKTQCT
1410 1420 1430 1440 1450
QDGSWQEGAC VPVTCDPPPP KFHGLYQCTN GFQFNSECRI KCEDSDASQG
1460 1470 1480 1490 1500
LGSNVIHCRK DGTWNGSFHV CQEMQGQCSV PNELNSNLKL QCPDGYAIGS
1510 1520 1530 1540 1550
ECATSCLDHN SESIILPMNV TVRDIPHWLN PTRVERVVCT AGLKWYPHPA
1560 1570 1580 1590 1600
LIHCVKGCEP FMGDNYCDAI NNRAFCNYDG GDCCTSTVKT KKVTPFPMSC
1610 1620
DLQGDCACRD PQAQEHSRKD LRGYSHG
Length:1,627
Mass (Da):180,973
Last modified:February 10, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i202ECA62C1107207
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50543 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107R → RV in AAC50543 (PubMed:8620868).Curated1
Sequence conflicti107R → RV in CAA48341 (PubMed:7508748).Curated1
Sequence conflicti511 – 512TH → RD AA sequence (PubMed:7508748).Curated2
Sequence conflicti1622R → Q in AAH78657 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0570915S → I. Corresponds to variant dbSNP:rs417012Ensembl.1
Natural variantiVAR_057092325P → L. Corresponds to variant dbSNP:rs445159Ensembl.1
Natural variantiVAR_011419944S → R2 PublicationsCorresponds to variant dbSNP:rs117124330Ensembl.1
Natural variantiVAR_0187261224S → Y2 PublicationsCorresponds to variant dbSNP:rs7020782Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28727 mRNA Translation: AAC50543.1 Frameshift.
AL137024 Genomic DNA No translation available.
AL353141 Genomic DNA No translation available.
AL691426 Genomic DNA No translation available.
BC078657 mRNA Translation: AAH78657.1
X68280 mRNA Translation: CAA48341.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6813.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S65464

NCBI Reference Sequences

More...
RefSeqi
NP_002572.2, NM_002581.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328252; ENSP00000330658; ENSG00000182752

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5069

UCSC genome browser

More...
UCSCi
uc004bjn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28727 mRNA Translation: AAC50543.1 Frameshift.
AL137024 Genomic DNA No translation available.
AL353141 Genomic DNA No translation available.
AL691426 Genomic DNA No translation available.
BC078657 mRNA Translation: AAH78657.1
X68280 mRNA Translation: CAA48341.1
CCDSiCCDS6813.1
PIRiS65464
RefSeqiNP_002572.2, NM_002581.4

3D structure databases

SMRiQ13219
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111104, 13 interactors
CORUMiQ13219
IntActiQ13219, 10 interactors
MINTiQ13219
STRINGi9606.ENSP00000330658

Chemistry databases

DrugBankiDB12695, Phenethyl Isothiocyanate

Protein family/group databases

MEROPSiM43.004

PTM databases

GlyConnecti1594, 1 N-Linked glycan (1 site)
GlyGeniQ13219, 14 sites
iPTMnetiQ13219
PhosphoSitePlusiQ13219

Genetic variation databases

BioMutaiPAPPA
DMDMi223590248

Proteomic databases

EPDiQ13219
jPOSTiQ13219
MassIVEiQ13219
PaxDbiQ13219
PeptideAtlasiQ13219
PRIDEiQ13219
ProteomicsDBi59231

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3385, 869 antibodies

Genome annotation databases

EnsembliENST00000328252; ENSP00000330658; ENSG00000182752
GeneIDi5069
KEGGihsa:5069
UCSCiuc004bjn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5069
DisGeNETi5069

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PAPPA
HGNCiHGNC:8602, PAPPA
HPAiENSG00000182752, Tissue enriched (placenta)
MIMi176385, gene
neXtProtiNX_Q13219
OpenTargetsiENSG00000182752
PharmGKBiPA32935
VEuPathDBiHostDB:ENSG00000182752.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQ7Z, Eukaryota
GeneTreeiENSGT00940000156654
HOGENOMiCLU_002636_2_0_1
InParanoidiQ13219
OMAiVYQGWQP
OrthoDBi105200at2759
PhylomeDBiQ13219
TreeFamiTF331636

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000119398-MONOMER
BRENDAi3.4.24.79, 2681
PathwayCommonsiQ13219
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5069, 25 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAPPA, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Pregnancy-associated_plasma_protein_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5069
PharosiQ13219, Tbio

Protein Ontology

More...
PROi
PR:Q13219
RNActiQ13219, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182752, Expressed in placenta and 208 other tissues
GenevisibleiQ13219, HS

Family and domain databases

CDDicd00033, CCP, 4 hits
cd04275, ZnMc_pappalysin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR006558, LamG-like
IPR024079, MetalloPept_cat_dom_sf
IPR011936, Myxo_disulph_rpt
IPR000800, Notch_dom
IPR030433, PAPPA
IPR043543, PAPPA/PAPPA2
IPR008754, Peptidase_M43
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PANTHERiPTHR46130, PTHR46130, 1 hit
PTHR46130:SF2, PTHR46130:SF2, 1 hit
PfamiView protein in Pfam
PF05572, Peptidase_M43, 1 hit
PF00084, Sushi, 3 hits
SMARTiView protein in SMART
SM00032, CCP, 4 hits
SM00560, LamGL, 1 hit
SM00004, NL, 3 hits
SUPFAMiSSF49899, SSF49899, 1 hit
SSF57535, SSF57535, 4 hits
TIGRFAMsiTIGR02232, myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923, SUSHI, 5 hits
PS00142, ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13219
Secondary accession number(s): B1AMF9
, Q08371, Q68G52, Q9UDK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 10, 2009
Last modified: April 7, 2021
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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