UniProtKB - Q13219 (PAPP1_HUMAN)
Protein
Pappalysin-1
Gene
PAPPA
Organism
Homo sapiens (Human)
Status
Functioni
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.3 Publications
Catalytic activityi
- Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5. EC:3.4.24.79
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Activity regulationi
Inhibited by complexation with the proform of PRG2.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 562 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 563 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 566 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 572 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: UniProtKB
- zinc ion binding Source: ProtInc
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- female pregnancy Source: ProtInc
- response to follicle-stimulating hormone Source: Ensembl
- response to glucocorticoid Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000119398-MONOMER |
BRENDAi | 3.4.24.79, 2681 |
PathwayCommonsi | Q13219 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Protein family/group databases
MEROPSi | M43.004 |
Names & Taxonomyi
Protein namesi | Recommended name: Pappalysin-1 (EC:3.4.24.79)Alternative name(s): Insulin-like growth factor-dependent IGF-binding protein 4 protease Short name: IGF-dependent IGFBP-4 protease Short name: IGFBP-4ase Pregnancy-associated plasma protein A Short name: PAPP-A |
Gene namesi | Name:PAPPA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8602, PAPPA |
MIMi | 176385, gene |
neXtProti | NX_Q13219 |
VEuPathDBi | HostDB:ENSG00000182752.9 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5069 |
OpenTargetsi | ENSG00000182752 |
PharmGKBi | PA32935 |
Miscellaneous databases
Pharosi | Q13219, Tbio |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | PAPPA |
DMDMi | 223590248 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000029245 | 23 – 81 | 2 PublicationsAdd BLAST | 59 | |
ChainiPRO_0000029246 | 82 – 1627 | Pappalysin-1Add BLAST | 1546 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 144 ↔ 235 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 327 ↔ 622 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 332 ↔ 657 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 390 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 414 ↔ 428 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 424 ↔ 440 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 429 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 457 ↔ 473 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 461 | Interchain (with C-51 in PRG2 proform)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 474 ↔ 485 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 480 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 583 ↔ 600 | Or C-583 with C-612PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 587 ↔ 612 | Or C-587 with C-600PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 601 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 619 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 710 ↔ 878 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 713 ↔ 881 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 725 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 732 | Interchain (with C-169 in PRG2 proform)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 753 ↔ 835 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 775 ↔ 781 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 825 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 947 ↔ 975 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 960 ↔ 971 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 983 ↔ 990 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 999 ↔ 1011 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 1026 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 1036 ↔ 1070 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1051 ↔ 1139 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1192 ↔ 1205 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1210 | InterchainPROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1215 ↔ 1269 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 1222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1226 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 1227 ↔ 1238 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1242 ↔ 1280 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1285 ↔ 1329 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1300 ↔ 1310 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1314 ↔ 1342 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 1323 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 1346 ↔ 1399 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1362 ↔ 1373 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1377 ↔ 1410 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1415 ↔ 1458 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1428 ↔ 1438 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1442 ↔ 1471 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 1465 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1478 ↔ 1539 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1492 ↔ 1502 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 1506 ↔ 1554 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 1519 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 1558 ↔ 1576 | PROSITE-ProRule annotation1 Publication |
Post-translational modificationi
There appear to be no free sulfhydryl groups.
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | Q13219 |
jPOSTi | Q13219 |
MassIVEi | Q13219 |
PaxDbi | Q13219 |
PeptideAtlasi | Q13219 |
PRIDEi | Q13219 |
ProteomicsDBi | 59231 |
PTM databases
GlyConnecti | 1594, 1 N-Linked glycan (1 site) |
GlyGeni | Q13219, 14 sites |
iPTMneti | Q13219 |
PhosphoSitePlusi | Q13219 |
Expressioni
Tissue specificityi
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.4 Publications
Developmental stagei
Present in serum and placenta during pregnancy; levels increase throughout pregnancy.2 Publications
Inductioni
By 8-bromoadenosine-3',5'-phosphate.1 Publication
Gene expression databases
Bgeei | ENSG00000182752, Expressed in placenta and 208 other tissues |
Genevisiblei | Q13219, HS |
Organism-specific databases
HPAi | ENSG00000182752, Tissue enriched (placenta) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.
3 PublicationsBinary interactionsi
Q13219
With | #Exp. | IntAct |
---|---|---|
PRG2 [P13727] | 2 | EBI-1221991,EBI-716689 |
Protein-protein interaction databases
BioGRIDi | 111104, 13 interactors |
CORUMi | Q13219 |
IntActi | Q13219, 10 interactors |
MINTi | Q13219 |
STRINGi | 9606.ENSP00000330658 |
Miscellaneous databases
RNActi | Q13219, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1213 – 1282 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 70 | |
Domaini | 1283 – 1344 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 1345 – 1412 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 1413 – 1473 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 1476 – 1556 | Sushi 5PROSITE-ProRule annotationAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 272 – 583 | MetalloproteaseAdd BLAST | 312 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 84 | Arg-richAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the peptidase M43B family.Curated
Keywords - Domaini
Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502QQ7Z, Eukaryota |
GeneTreei | ENSGT00940000156654 |
HOGENOMi | CLU_002636_2_0_1 |
InParanoidi | Q13219 |
OMAi | VYQGWQP |
OrthoDBi | 105200at2759 |
PhylomeDBi | Q13219 |
TreeFami | TF331636 |
Family and domain databases
CDDi | cd00033, CCP, 4 hits cd04275, ZnMc_pappalysin_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR006558, LamG-like IPR024079, MetalloPept_cat_dom_sf IPR011936, Myxo_disulph_rpt IPR000800, Notch_dom IPR030433, PAPPA IPR043543, PAPPA/PAPPA2 IPR008754, Peptidase_M43 IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR46130, PTHR46130, 1 hit PTHR46130:SF2, PTHR46130:SF2, 1 hit |
Pfami | View protein in Pfam PF05572, Peptidase_M43, 1 hit PF00084, Sushi, 3 hits |
SMARTi | View protein in SMART SM00032, CCP, 4 hits SM00560, LamGL, 1 hit SM00004, NL, 3 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF57535, SSF57535, 4 hits |
TIGRFAMsi | TIGR02232, myxo_disulf_rpt, 1 hit |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 5 hits PS00142, ZINC_PROTEASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q13219-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLWSWVLHL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR
60 70 80 90 100
AARGRRASPP PPPPPGGAWE AVRVPRRRQQ REARGATEEP SPPSRALYFS
110 120 130 140 150
GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD
160 170 180 190 200
RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA
210 220 230 240 250
ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR
260 270 280 290 300
GYIEHFSLWK VARTQREILS DMETHGAHTA LPQLLLQENW DNVKHAWSPM
310 320 330 340 350
KDGSSPKVEF SNAHGFLLDT SLEPPLCGQT LCDNTEVIAS YNQLSSFRQP
360 370 380 390 400
KVVRYRVVNL YEDDHKNPTV TREQVDFQHH QLAEAFKQYN ISWELDVLEV
410 420 430 440 450
SNSSLRRRLI LANCDISKIG DENCDPECNH TLTGHDGGDC RHLRHPAFVK
460 470 480 490 500
KQHNGVCDMD CNYERFNFDG GECCDPEITN VTQTCFDPDS PHRAYLDVNE
510 520 530 540 550
LKNILKLDGS THLNIFFAKS SEEELAGVAT WPWDKEALMH LGGIVLNPSF
560 570 580 590 600
YGMPGHTHTM IHEIGHSLGL YHVFRGISEI QSCSDPCMET EPSFETGDLC
610 620 630 640 650
NDTNPAPKHK SCGDPGPGND TCGFHSFFNT PYNNFMSYAD DDCTDSFTPN
660 670 680 690 700
QVARMHCYLD LVYQGWQPSR KPAPVALAPQ VLGHTTDSVT LEWFPPIDGH
710 720 730 740 750
FFERELGSAC HLCLEGRILV QYASNASSPM PCSPSGHWSP REAEGHPDVE
760 770 780 790 800
QPCKSSVRTW SPNSAVNPHT VPPACPEPQG CYLELEFLYP LVPESLTIWV
810 820 830 840 850
TFVSTDWDSS GAVNDIKLLA VSGKNISLGP QNVFCDVPLT IRLWDVGEEV
860 870 880 890 900
YGIQIYTLDE HLEIDAAMLT STADTPLCLQ CKPLKYKVVR DPPLQMDVAS
910 920 930 940 950
ILHLNRKFVD MDLNLGSVYQ YWVITISGTE ESEPSPAVTY IHGSGYCGDG
960 970 980 990 1000
IIQKDQGEQC DDMNKINGDG CSLFCRQEVS FNCIDEPSRC YFHDGDGVCE
1010 1020 1030 1040 1050
EFEQKTSIKD CGVYTPQGFL DQWASNASVS HQDQQCPGWV IIGQPAASQV
1060 1070 1080 1090 1100
CRTKVIDLSE GISQHAWYPC TISYPYSQLA QTTFWLRAYF SQPMVAAAVI
1110 1120 1130 1140 1150
VHLVTDGTYY GDQKQETISV QLLDTKDQSH DLGLHVLSCR NNPLIIPVVH
1160 1170 1180 1190 1200
DLSQPFYHSQ AVRVSFSSPL VAISGVALRS FDNFDPVTLS SCQRGETYSP
1210 1220 1230 1240 1250
AEQSCVHFAC EKTDCPELAV ENASLNCSSS DRYHGAQCTV SCRTGYVLQI
1260 1270 1280 1290 1300
RRDDELIKSQ TGPSVTVTCT EGKWNKQVAC EPVDCSIPDH HQVYAASFSC
1310 1320 1330 1340 1350
PEGTTFGSQC SFQCRHPAQL KGNNSLLTCM EDGLWSFPEA LCELMCLAPP
1360 1370 1380 1390 1400
PVPNADLQTA RCRENKHKVG SFCKYKCKPG YHVPGSSRKS KKRAFKTQCT
1410 1420 1430 1440 1450
QDGSWQEGAC VPVTCDPPPP KFHGLYQCTN GFQFNSECRI KCEDSDASQG
1460 1470 1480 1490 1500
LGSNVIHCRK DGTWNGSFHV CQEMQGQCSV PNELNSNLKL QCPDGYAIGS
1510 1520 1530 1540 1550
ECATSCLDHN SESIILPMNV TVRDIPHWLN PTRVERVVCT AGLKWYPHPA
1560 1570 1580 1590 1600
LIHCVKGCEP FMGDNYCDAI NNRAFCNYDG GDCCTSTVKT KKVTPFPMSC
1610 1620
DLQGDCACRD PQAQEHSRKD LRGYSHG
Sequence cautioni
The sequence AAC50543 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 107 | R → RV in AAC50543 (PubMed:8620868).Curated | 1 | |
Sequence conflicti | 107 | R → RV in CAA48341 (PubMed:7508748).Curated | 1 | |
Sequence conflicti | 511 – 512 | TH → RD AA sequence (PubMed:7508748).Curated | 2 | |
Sequence conflicti | 1622 | R → Q in AAH78657 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057091 | 5 | S → I. Corresponds to variant dbSNP:rs417012Ensembl. | 1 | |
Natural variantiVAR_057092 | 325 | P → L. Corresponds to variant dbSNP:rs445159Ensembl. | 1 | |
Natural variantiVAR_011419 | 944 | S → R2 PublicationsCorresponds to variant dbSNP:rs117124330Ensembl. | 1 | |
Natural variantiVAR_018726 | 1224 | S → Y2 PublicationsCorresponds to variant dbSNP:rs7020782Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28727 mRNA Translation: AAC50543.1 Frameshift. AL137024 Genomic DNA No translation available. AL353141 Genomic DNA No translation available. AL691426 Genomic DNA No translation available. BC078657 mRNA Translation: AAH78657.1 X68280 mRNA Translation: CAA48341.1 |
CCDSi | CCDS6813.1 |
PIRi | S65464 |
RefSeqi | NP_002572.2, NM_002581.4 |
Genome annotation databases
Ensembli | ENST00000328252; ENSP00000330658; ENSG00000182752 |
GeneIDi | 5069 |
KEGGi | hsa:5069 |
UCSCi | uc004bjn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28727 mRNA Translation: AAC50543.1 Frameshift. AL137024 Genomic DNA No translation available. AL353141 Genomic DNA No translation available. AL691426 Genomic DNA No translation available. BC078657 mRNA Translation: AAH78657.1 X68280 mRNA Translation: CAA48341.1 |
CCDSi | CCDS6813.1 |
PIRi | S65464 |
RefSeqi | NP_002572.2, NM_002581.4 |
3D structure databases
SMRi | Q13219 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111104, 13 interactors |
CORUMi | Q13219 |
IntActi | Q13219, 10 interactors |
MINTi | Q13219 |
STRINGi | 9606.ENSP00000330658 |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Protein family/group databases
MEROPSi | M43.004 |
PTM databases
GlyConnecti | 1594, 1 N-Linked glycan (1 site) |
GlyGeni | Q13219, 14 sites |
iPTMneti | Q13219 |
PhosphoSitePlusi | Q13219 |
Genetic variation databases
BioMutai | PAPPA |
DMDMi | 223590248 |
Proteomic databases
EPDi | Q13219 |
jPOSTi | Q13219 |
MassIVEi | Q13219 |
PaxDbi | Q13219 |
PeptideAtlasi | Q13219 |
PRIDEi | Q13219 |
ProteomicsDBi | 59231 |
Protocols and materials databases
Antibodypediai | 3385, 869 antibodies |
Genome annotation databases
Ensembli | ENST00000328252; ENSP00000330658; ENSG00000182752 |
GeneIDi | 5069 |
KEGGi | hsa:5069 |
UCSCi | uc004bjn.4, human |
Organism-specific databases
CTDi | 5069 |
DisGeNETi | 5069 |
GeneCardsi | PAPPA |
HGNCi | HGNC:8602, PAPPA |
HPAi | ENSG00000182752, Tissue enriched (placenta) |
MIMi | 176385, gene |
neXtProti | NX_Q13219 |
OpenTargetsi | ENSG00000182752 |
PharmGKBi | PA32935 |
VEuPathDBi | HostDB:ENSG00000182752.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ7Z, Eukaryota |
GeneTreei | ENSGT00940000156654 |
HOGENOMi | CLU_002636_2_0_1 |
InParanoidi | Q13219 |
OMAi | VYQGWQP |
OrthoDBi | 105200at2759 |
PhylomeDBi | Q13219 |
TreeFami | TF331636 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000119398-MONOMER |
BRENDAi | 3.4.24.79, 2681 |
PathwayCommonsi | Q13219 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Miscellaneous databases
BioGRID-ORCSi | 5069, 25 hits in 988 CRISPR screens |
ChiTaRSi | PAPPA, human |
GeneWikii | Pregnancy-associated_plasma_protein_A |
GenomeRNAii | 5069 |
Pharosi | Q13219, Tbio |
PROi | PR:Q13219 |
RNActi | Q13219, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182752, Expressed in placenta and 208 other tissues |
Genevisiblei | Q13219, HS |
Family and domain databases
CDDi | cd00033, CCP, 4 hits cd04275, ZnMc_pappalysin_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR006558, LamG-like IPR024079, MetalloPept_cat_dom_sf IPR011936, Myxo_disulph_rpt IPR000800, Notch_dom IPR030433, PAPPA IPR043543, PAPPA/PAPPA2 IPR008754, Peptidase_M43 IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR46130, PTHR46130, 1 hit PTHR46130:SF2, PTHR46130:SF2, 1 hit |
Pfami | View protein in Pfam PF05572, Peptidase_M43, 1 hit PF00084, Sushi, 3 hits |
SMARTi | View protein in SMART SM00032, CCP, 4 hits SM00560, LamGL, 1 hit SM00004, NL, 3 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF57535, SSF57535, 4 hits |
TIGRFAMsi | TIGR02232, myxo_disulf_rpt, 1 hit |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 5 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAPP1_HUMAN | |
Accessioni | Q13219Primary (citable) accession number: Q13219 Secondary accession number(s): B1AMF9 Q9UDK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | February 10, 2009 | |
Last modified: | April 7, 2021 | |
This is version 212 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families