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Protein

Probable ATP-dependent RNA helicase DDX10

Gene

DDX10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative ATP-dependent RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 91ATP3
Nucleotide bindingi113 – 120ATP8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • RNA binding Source: UniProtKB
  • RNA helicase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX10 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 10
Gene namesi
Name:DDX10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000178105.9
HGNCiHGNC:2735 DDX10
MIMi601235 gene
neXtProtiNX_Q13206

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1662
OpenTargetsiENSG00000178105
PharmGKBiPA27200

Polymorphism and mutation databases

BioMutaiDDX10
DMDMi76803554

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550831 – 875Probable ATP-dependent RNA helicase DDX10Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphothreonineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei555N6-acetyllysineBy similarity1
Modified residuei577PhosphothreonineCombined sources1
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei780PhosphoserineCombined sources1
Modified residuei831PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13206
MaxQBiQ13206
PaxDbiQ13206
PeptideAtlasiQ13206
PRIDEiQ13206
ProteomicsDBi59224

2D gel databases

SWISS-2DPAGEiQ13206

PTM databases

iPTMnetiQ13206
PhosphoSitePlusiQ13206

Expressioni

Tissue specificityi

High in testis but widely expressed.

Gene expression databases

BgeeiENSG00000178105
CleanExiHS_DDX10
ExpressionAtlasiQ13206 baseline and differential
GenevisibleiQ13206 HS

Organism-specific databases

HPAiHPA004691

Interactioni

Protein-protein interaction databases

BioGridi108027, 36 interactors
IntActiQ13206, 13 interactors
STRINGi9606.ENSP00000314348

Structurei

Secondary structure

1875
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 58Combined sources12
Turni59 – 62Combined sources4
Helixi65 – 67Combined sources3
Helixi71 – 73Combined sources3
Helixi78 – 86Combined sources9
Helixi94 – 104Combined sources11
Beta strandi109 – 112Combined sources4
Helixi119 – 133Combined sources15
Helixi138 – 140Combined sources3
Beta strandi144 – 147Combined sources4
Helixi151 – 164Combined sources14
Turni165 – 167Combined sources3
Beta strandi172 – 175Combined sources4
Helixi182 – 188Combined sources7
Beta strandi192 – 196Combined sources5
Helixi198 – 207Combined sources10
Beta strandi218 – 221Combined sources4
Helixi224 – 229Combined sources6
Turni230 – 232Combined sources3
Helixi233 – 241Combined sources9
Beta strandi247 – 255Combined sources9
Helixi258 – 266Combined sources9
Beta strandi272 – 275Combined sources4

3D structure databases

ProteinModelPortaliQ13206
SMRiQ13206
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13206

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 274Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini287 – 448Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 97Q motifAdd BLAST29
Motifi222 – 225DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0342 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00550000074980
HOGENOMiHOG000268801
HOVERGENiHBG102756
InParanoidiQ13206
KOiK14776
OMAiYGTLHQD
OrthoDBiEOG091G06N7
PhylomeDBiQ13206
TreeFamiTF315215

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR025313 DUF4217
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF13959 DUF4217, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM01178 DUF4217, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q13206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTANSPGS GARPDPVRSF NRWKKKHSHR QNKKKQLRKQ LKKPEWQVER
60 70 80 90 100
ESISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI
110 120 130 140 150
GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT
160 170 180 190 200
RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR
210 220 230 240 250
LLQHMDETVS FHATDLQMLV LDEADRILDM GFADTMNAVI ENLPKKRQTL
260 270 280 290 300
LFSATQTKSV KDLARLSLKN PEYVWVHEKA KYSTPATLEQ NYIVCELQQK
310 320 330 340 350
ISVLYSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGV SILALHGRQQ
360 370 380 390 400
QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI
410 420 430 440 450
HRAGRTARYK EDGEALLILL PSEKAMVQQL LQKKVPVKEI KINPEKLIDV
460 470 480 490 500
QKKLESILAQ DQDLKERAQR CFVSYVRSVY LMKDKEVFDV SKLPIPEYAL
510 520 530 540 550
SLGLAVAPRV RFLQKMQKQP TKELVRSQAD KVIEPRAPSL TNDEVEEFRA
560 570 580 590 600
YFNEKMSILQ KGGKRLEGTE HRQDNDTGNE EQEEEEDDEE EMEEKLAKAK
610 620 630 640 650
GSQAPSLPNT SEAQKIKEVP TQFLDRDEEE EDADFLKVKR HNVFGLDLKD
660 670 680 690 700
EKTLQKKEPS KSSIKKKMTK VAEAKKVMKR NFKVNKKITF TDEGELVQQW
710 720 730 740 750
PQMQKSAIKD AEEDDDTGGI NLHKAKERLQ EEDKFDKEEY RKKIKAKHRE
760 770 780 790 800
KRLKEREARR EANKRQAKAK DEEEAFLDWS DDDDDDDDGF DPSTLPDPDK
810 820 830 840 850
YRSSEDSDSE DMENKISDTK KKQGMKKRSN SEVEDVGPTS HNRKKARWDT
860 870
LEPLDTGLSL AEDEELVLHL LRSQS
Length:875
Mass (Da):100,888
Last modified:September 27, 2005 - v2
Checksum:iB61BF325921C62FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti647D → A in AAC50823 (PubMed:8660968).Curated1
Sequence conflicti658E → D in AAC50823 (PubMed:8660968).Curated1
Sequence conflicti661K → N in AAC50823 (PubMed:8660968).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035840566L → V in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28042 mRNA Translation: AAC50823.1
AB040537 mRNA Translation: BAB18536.1
AK315216 mRNA Translation: BAG37650.1
CH471065 Genomic DNA Translation: EAW67122.1
BC091521 mRNA Translation: AAH91521.1
BC093654 mRNA Translation: AAH93654.1
BC093656 mRNA Translation: AAH93656.1
CCDSiCCDS8342.1
RefSeqiNP_004389.2, NM_004398.3
UniGeneiHs.591931

Genome annotation databases

EnsembliENST00000322536; ENSP00000314348; ENSG00000178105
GeneIDi1662
KEGGihsa:1662
UCSCiuc001pkm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDDX10_HUMAN
AccessioniPrimary (citable) accession number: Q13206
Secondary accession number(s): B2RCQ3, Q5BJD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 27, 2005
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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