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Protein

Myosin-binding protein H

Gene

MYBPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
H-protein
Gene namesi
Name:MYBPH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000133055.8
HGNCiHGNC:7552 MYBPH
MIMi160795 gene
neXtProtiNX_Q13203

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi4608
OpenTargetsiENSG00000133055
PharmGKBiPA31352

Polymorphism and mutation databases

BioMutaiMYBPH
DMDMi116242667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726981 – 477Myosin-binding protein HAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphothreonineBy similarity1
Modified residuei26PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ13203
PeptideAtlasiQ13203
PRIDEiQ13203
ProteomicsDBi59223

PTM databases

iPTMnetiQ13203
PhosphoSitePlusiQ13203

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSG00000133055 Expressed in 74 organ(s), highest expression level in gastrocnemius
CleanExiHS_MYBPH
ExpressionAtlasiQ13203 baseline and differential
GenevisibleiQ13203 HS

Organism-specific databases

HPAiHPA061383

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110693, 5 interactors
IntActiQ13203, 9 interactors
MINTiQ13203
STRINGi9606.ENSP00000255416

Structurei

3D structure databases

ProteinModelPortaliQ13203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 168Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini172 – 260Ig-like C2-type 1Add BLAST89
Domaini269 – 364Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini382 – 466Ig-like C2-type 2Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF9Q Eukaryota
ENOG410YAE6 LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000290713
HOVERGENiHBG056788
InParanoidiQ13203
OMAiRYVANVG
OrthoDBiEOG091G07IP
PhylomeDBiQ13203
TreeFamiTF334735

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13203-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEKNTSEGP ACSPEETASE SAKVPTAEPP GEVAVSESTR EEQVPKPQAP
60 70 80 90 100
APQAPTASTA TKPAPPSEDV PSAPLLLTLD DVSSSSVTVS WEPPERLGRL
110 120 130 140 150
GLQGYVLELC REGASEWVPV SARPMMVTQQ TVRNLALGDK FLLRVSAVSS
160 170 180 190 200
AGAGPPAMLD QPIHIRENIE APKIRVPRHL RQTYIRQVGE TVNLQIPFQG
210 220 230 240 250
KPKPQATWTH NGHALDSQRV SMRTGDQDSI LFIRSAQRSD SGRYELTVRV
260 270 280 290 300
EDLEAKAVID ILVIEKPGPP SSIRLLDVWG CNAALQWTPP QDTGNTELLG
310 320 330 340 350
YMVQKADKKT GQWFTVLERY HPTTCTISDL IIGNSYSFRV FSENLCGLST
360 370 380 390 400
SATVTKELAH IQKADIAAKP KGFIERDFSE APSFTQPLAD HTSTPGYSTQ
410 420 430 440 450
LFCSVRASPK PKIIWMKNKM EIQGNPKYRA LSEQGVCTLE IRKPSPFDSG
460 470
VYTCKAINVL GEASVDCRLE VKASAAH
Length:477
Mass (Da):52,050
Last modified:October 17, 2006 - v4
Checksum:i2246862478EAF033
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X023A0A087X023_HUMAN
Myosin-binding protein H
MYBPH
476Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 150SS → RP in AAB86737 (Ref. 2) Curated2
Sequence conflicti271 – 272SS → CC in AAB86737 (Ref. 2) Curated2
Sequence conflicti406 – 411RASPKP → ELHQA in AAA36339 (PubMed:8486381).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02818148Q → H2 PublicationsCorresponds to variant dbSNP:rs2788532Ensembl.1
Natural variantiVAR_02818249A → G2 PublicationsCorresponds to variant dbSNP:rs2791721Ensembl.1
Natural variantiVAR_028183114A → G. Corresponds to variant dbSNP:rs2642531Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05606 mRNA Translation: AAA36339.1
L05607 Genomic DNA Translation: AAA02904.2
U27266 Genomic DNA Translation: AAB86737.1
BC044226 mRNA Translation: AAH44226.1
CCDSiCCDS30975.1
PIRiA46118
RefSeqiNP_004988.2, NM_004997.2
UniGeneiHs.927

Genome annotation databases

EnsembliENST00000255416; ENSP00000255416; ENSG00000133055
GeneIDi4608
KEGGihsa:4608
UCSCiuc001gzh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05606 mRNA Translation: AAA36339.1
L05607 Genomic DNA Translation: AAA02904.2
U27266 Genomic DNA Translation: AAB86737.1
BC044226 mRNA Translation: AAH44226.1
CCDSiCCDS30975.1
PIRiA46118
RefSeqiNP_004988.2, NM_004997.2
UniGeneiHs.927

3D structure databases

ProteinModelPortaliQ13203
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110693, 5 interactors
IntActiQ13203, 9 interactors
MINTiQ13203
STRINGi9606.ENSP00000255416

PTM databases

iPTMnetiQ13203
PhosphoSitePlusiQ13203

Polymorphism and mutation databases

BioMutaiMYBPH
DMDMi116242667

Proteomic databases

PaxDbiQ13203
PeptideAtlasiQ13203
PRIDEiQ13203
ProteomicsDBi59223

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255416; ENSP00000255416; ENSG00000133055
GeneIDi4608
KEGGihsa:4608
UCSCiuc001gzh.2 human

Organism-specific databases

CTDi4608
DisGeNETi4608
EuPathDBiHostDB:ENSG00000133055.8
GeneCardsiMYBPH
HGNCiHGNC:7552 MYBPH
HPAiHPA061383
MIMi160795 gene
neXtProtiNX_Q13203
OpenTargetsiENSG00000133055
PharmGKBiPA31352
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9Q Eukaryota
ENOG410YAE6 LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000290713
HOVERGENiHBG056788
InParanoidiQ13203
OMAiRYVANVG
OrthoDBiEOG091G07IP
PhylomeDBiQ13203
TreeFamiTF334735

Miscellaneous databases

GenomeRNAii4608
PROiPR:Q13203
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133055 Expressed in 74 organ(s), highest expression level in gastrocnemius
CleanExiHS_MYBPH
ExpressionAtlasiQ13203 baseline and differential
GenevisibleiQ13203 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYBPH_HUMAN
AccessioniPrimary (citable) accession number: Q13203
Secondary accession number(s): Q16886, Q86YC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 154 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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