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Entry version 209 (10 Feb 2021)
Sequence version 3 (15 Jul 1999)
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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

PSMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.1 Publication
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q13200

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534, Vpu mediated degradation of CD4
R-HSA-180585, Vif-mediated degradation of APOBEC3G
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-202424, Downstream TCR signaling
R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562, Regulation of ornithine decarboxylase (ODC)
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641257, Degradation of AXIN
R-HSA-4641258, Degradation of DVL
R-HSA-5358346, Hedgehog ligand biogenesis
R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684, Hedgehog 'on' state
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-5678895, Defective CFTR causes cystic fibrosis
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-5689603, UCH proteinases
R-HSA-5689880, Ub-specific processing proteases
R-HSA-6798695, Neutrophil degranulation
R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949, Orc1 removal from chromatin
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481, G2/M Checkpoints
R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-8951664, Neddylation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13200

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q13200, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2
Alternative name(s):
26S proteasome regulatory subunit RPN1
26S proteasome regulatory subunit S2
26S proteasome subunit p97
Protein 55.11
Tumor necrosis factor type 1 receptor-associated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSMD2
Synonyms:TRAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9559, PSMD2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606223, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13200

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000175166.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5708

Open Targets

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OpenTargetsi
ENSG00000175166

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33905

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q13200, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2364701

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PSMD2

Domain mapping of disease mutations (DMDM)

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DMDMi
6174930

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001738101 – 90826S proteasome non-ATPase regulatory subunit 2Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei24PhosphothreonineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei194PhosphotyrosineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei551N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-261

Encyclopedia of Proteome Dynamics

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EPDi
Q13200

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13200

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13200

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13200

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13200

PeptideAtlas

More...
PeptideAtlasi
Q13200

PRoteomics IDEntifications database

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PRIDEi
Q13200

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
18762
19502
59219 [Q13200-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13200

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q13200

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13200

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q13200

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000175166, Expressed in testis and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13200, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13200, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000175166, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (PubMed:27428775, PubMed:27342858).

Interacts with RPGRIP1L (By similarity).

Interacts with CRY1 in a KDM8-dependent manner (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111681, 266 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-5993, 26S Proteasome complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13200

Database of interacting proteins

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DIPi
DIP-38204N

Protein interaction database and analysis system

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IntActi
Q13200, 193 interactors

Molecular INTeraction database

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MINTi
Q13200

STRING: functional protein association networks

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STRINGi
9606.ENSP00000310129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13200, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13200

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati409 – 442PC 1Add BLAST34
Repeati443 – 479PC 2Add BLAST37
Repeati480 – 514PC 3Add BLAST35
Repeati517 – 551PC 4Add BLAST35
Repeati560 – 589PC 5Add BLAST30
Repeati692 – 723PC 6Add BLAST32
Repeati742 – 757PC 7Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi623 – 641Glu/Lys-richAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the proteasome subunit S2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2005, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_008705_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13200

Identification of Orthologs from Complete Genome Data

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OMAi
MVDICAY

Database of Orthologous Groups

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OrthoDBi
229956at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13200

TreeFam database of animal gene trees

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TreeFami
TF105739

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016643, 26S_Psome_Rpn1
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR041433, RPN1_C
IPR040892, RPN1_N

The PANTHER Classification System

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PANTHERi
PTHR10943:SF11, PTHR10943:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01851, PC_rep, 2 hits
PF18051, RPN1_C, 1 hit
PF17781, RPN1_RPN2_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015965, 26S_Psome_Rpn1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13200-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGGRDKAP VQPQQSPAAA PGGTDEKPSG KERRDAGDKD KEQELSEEDK
60 70 80 90 100
QLQDELEMLV ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR
110 120 130 140 150
PHYGKLKEIY ENMAPGENKR FAADIISVLA MTMSGERECL KYRLVGSQEE
160 170 180 190 200
LASWGHEYVR HLAGEVAKEW QELDDAEKVQ REPLLTLVKE IVPYNMAHNA
210 220 230 240 250
EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV PEPENSALLR
260 270 280 290 300
CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
310 320 330 340 350
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK
360 370 380 390 400
THLENNRFGG SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY
410 420 430 440 450
KNKDHGMLSA AASLGMILLW DVDGGLTQID KYLYSSEDYI KSGALLACGI
460 470 480 490 500
VNSGVRNECD PALALLSDYV LHNSNTMRLG SIFGLGLAYA GSNREDVLTL
510 520 530 540 550
LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ TIMEKSETEL
560 570 580 590 600
KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
610 620 630 640 650
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ
660 670 680 690 700
GVAVLGIALI AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS
710 720 730 740 750
NPRLNILDTL SKFSHDADPE VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ
760 770 780 790 800
YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP YHSDRQLMSQ VAVAGLLTVL
810 820 830 840 850
VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL PVSVRVGQAV
860 870 880 890 900
DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYDL
Length:908
Mass (Da):100,200
Last modified:July 15, 1999 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAD71E7B26101BE3
GO
Isoform 2 (identifier: Q13200-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MEEGGRDKAP...WGHEYVRHLA → MSMS

Show »
Length:749
Mass (Da):82,193
Checksum:i4007D2AAADF807A6
GO
Isoform 3 (identifier: Q13200-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Show »
Length:778
Mass (Da):85,606
Checksum:i5564271C57A5959D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1H2H7C1H2_HUMAN
26S proteasome non-ATPase regulator...
PSMD2
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPC0C9JPC0_HUMAN
26S proteasome non-ATPase regulator...
PSMD2
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Q3H7C2Q3_HUMAN
26S proteasome non-ATPase regulator...
PSMD2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBS8F8WBS8_HUMAN
26S proteasome non-ATPase regulator...
PSMD2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA87705 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10P → R in CAA60167 (PubMed:7601280).Curated1
Sequence conflicti21P → S (PubMed:9126987).Curated1
Sequence conflicti32E → G (PubMed:9126987).Curated1
Sequence conflicti43Q → L (PubMed:9126987).Curated1
Sequence conflicti57E → V (PubMed:9126987).Curated1
Sequence conflicti60V → A in BAA11226 (PubMed:8774743).Curated1
Sequence conflicti226Y → S in AAA87705 (PubMed:9126987).Curated1
Sequence conflicti260S → T in CAA60167 (PubMed:7601280).Curated1
Sequence conflicti281 – 283IFT → SS in AAA87705 (PubMed:9126987).Curated3
Sequence conflicti415G → A in BAA11226 (PubMed:8774743).Curated1
Sequence conflicti731M → MGM (PubMed:9126987).Curated1
Sequence conflicti776L → P in BAG63219 (PubMed:14702039).Curated1
Sequence conflicti900 – 908LRKNPNYDL → FGRTPIMISK (PubMed:15489334).Curated9
Sequence conflicti900 – 908LRKNPNYDL → FGRTPIMISK (PubMed:7601280).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051554176A → T. Corresponds to variant dbSNP:rs11545172Ensembl.1
Natural variantiVAR_051555313E → D1 PublicationCorresponds to variant dbSNP:rs11545169Ensembl.1
Natural variantiVAR_067451724N → Y2 PublicationsCorresponds to variant dbSNP:rs17856236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0550651 – 163MEEGG…VRHLA → MSMS in isoform 2. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_0550661 – 130Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78151 mRNA Translation: BAA11226.1
BT009736 mRNA Translation: AAP88738.1
AK301759 mRNA Translation: BAG63219.1
AK302177 mRNA Translation: BAG63543.1
AC078797 Genomic DNA No translation available.
BC002368 mRNA Translation: AAH02368.1
BC002997 mRNA Translation: AAH02997.1
BC007897 mRNA Translation: AAH07897.1
U12596 mRNA Translation: AAA87705.1 Different initiation.
X86446 mRNA Translation: CAA60167.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3258.1 [Q13200-1]
CCDS63853.1 [Q13200-3]
CCDS63854.1 [Q13200-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001265637.1, NM_001278708.1 [Q13200-3]
NP_001265638.1, NM_001278709.1 [Q13200-2]
NP_002799.3, NM_002808.4 [Q13200-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310118; ENSP00000310129; ENSG00000175166 [Q13200-1]
ENST00000435761; ENSP00000402618; ENSG00000175166 [Q13200-2]
ENST00000439383; ENSP00000416028; ENSG00000175166 [Q13200-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5708

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5708

UCSC genome browser

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UCSCi
uc003fnn.3, human [Q13200-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78151 mRNA Translation: BAA11226.1
BT009736 mRNA Translation: AAP88738.1
AK301759 mRNA Translation: BAG63219.1
AK302177 mRNA Translation: BAG63543.1
AC078797 Genomic DNA No translation available.
BC002368 mRNA Translation: AAH02368.1
BC002997 mRNA Translation: AAH02997.1
BC007897 mRNA Translation: AAH07897.1
U12596 mRNA Translation: AAA87705.1 Different initiation.
X86446 mRNA Translation: CAA60167.1
CCDSiCCDS3258.1 [Q13200-1]
CCDS63853.1 [Q13200-3]
CCDS63854.1 [Q13200-2]
RefSeqiNP_001265637.1, NM_001278708.1 [Q13200-3]
NP_001265638.1, NM_001278709.1 [Q13200-2]
NP_002799.3, NM_002808.4 [Q13200-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GJQelectron microscopy4.50Z1-908[»]
5GJRelectron microscopy3.50AC/Z1-908[»]
5L4Kelectron microscopy4.50Z1-908[»]
5LN3electron microscopy6.80Z1-908[»]
5T0Celectron microscopy3.80Af/Bf1-908[»]
5T0Gelectron microscopy4.40f164-908[»]
5T0Helectron microscopy6.80f164-908[»]
5T0Ielectron microscopy8.00f164-908[»]
5T0Jelectron microscopy8.00f164-908[»]
5VFPelectron microscopy4.20f1-908[»]
5VFQelectron microscopy4.20f1-908[»]
5VFRelectron microscopy4.90f1-908[»]
5VFSelectron microscopy3.60f6-853[»]
5VFTelectron microscopy7.00f1-908[»]
5VFUelectron microscopy5.80f1-908[»]
5VHFelectron microscopy5.70f6-853[»]
5VHHelectron microscopy6.10f6-853[»]
5VHIelectron microscopy6.80f6-853[»]
5VHJelectron microscopy8.50f70-853[»]
5VHMelectron microscopy8.30f6-853[»]
5VHNelectron microscopy7.30f6-853[»]
5VHOelectron microscopy8.30f6-853[»]
5VHPelectron microscopy7.90f70-853[»]
5VHQelectron microscopy8.90f6-853[»]
5VHRelectron microscopy7.70f6-853[»]
5VHSelectron microscopy8.80f70-853[»]
6MSBelectron microscopy3.00f1-908[»]
6MSDelectron microscopy3.20f1-908[»]
6MSGelectron microscopy3.50f1-892[»]
6MSHelectron microscopy3.60f1-892[»]
6MSJelectron microscopy3.30f1-892[»]
6MSKelectron microscopy3.20f1-892[»]
6WJDelectron microscopy4.80f1-908[»]
6WJNelectron microscopy5.70f1-908[»]
SMRiQ13200
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111681, 266 interactors
ComplexPortaliCPX-5993, 26S Proteasome complex
CORUMiQ13200
DIPiDIP-38204N
IntActiQ13200, 193 interactors
MINTiQ13200
STRINGi9606.ENSP00000310129

Chemistry databases

ChEMBLiCHEMBL2364701

Protein family/group databases

MoonDBiQ13200, Predicted

PTM databases

iPTMnetiQ13200
MetOSiteiQ13200
PhosphoSitePlusiQ13200
SwissPalmiQ13200

Genetic variation databases

BioMutaiPSMD2
DMDMi6174930

Proteomic databases

CPTACiCPTAC-261
EPDiQ13200
jPOSTiQ13200
MassIVEiQ13200
MaxQBiQ13200
PaxDbiQ13200
PeptideAtlasiQ13200
PRIDEiQ13200
ProteomicsDBi18762
19502
59219 [Q13200-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33807, 537 antibodies

The DNASU plasmid repository

More...
DNASUi
5708

Genome annotation databases

EnsembliENST00000310118; ENSP00000310129; ENSG00000175166 [Q13200-1]
ENST00000435761; ENSP00000402618; ENSG00000175166 [Q13200-2]
ENST00000439383; ENSP00000416028; ENSG00000175166 [Q13200-3]
GeneIDi5708
KEGGihsa:5708
UCSCiuc003fnn.3, human [Q13200-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5708
DisGeNETi5708

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSMD2
HGNCiHGNC:9559, PSMD2
HPAiENSG00000175166, Tissue enhanced (skeletal)
MIMi606223, gene
neXtProtiNX_Q13200
OpenTargetsiENSG00000175166
PharmGKBiPA33905
VEuPathDBiHostDB:ENSG00000175166.16

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2005, Eukaryota
GeneTreeiENSGT00940000153386
HOGENOMiCLU_008705_1_0_1
InParanoidiQ13200
OMAiMVDICAY
OrthoDBi229956at2759
PhylomeDBiQ13200
TreeFamiTF105739

Enzyme and pathway databases

PathwayCommonsiQ13200
ReactomeiR-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534, Vpu mediated degradation of CD4
R-HSA-180585, Vif-mediated degradation of APOBEC3G
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-202424, Downstream TCR signaling
R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562, Regulation of ornithine decarboxylase (ODC)
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641257, Degradation of AXIN
R-HSA-4641258, Degradation of DVL
R-HSA-5358346, Hedgehog ligand biogenesis
R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684, Hedgehog 'on' state
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-5678895, Defective CFTR causes cystic fibrosis
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-5689603, UCH proteinases
R-HSA-5689880, Ub-specific processing proteases
R-HSA-6798695, Neutrophil degranulation
R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949, Orc1 removal from chromatin
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481, G2/M Checkpoints
R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-8951664, Neddylation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ13200

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5708, 731 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PSMD2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PSMD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5708
PharosiQ13200, Tbio

Protein Ontology

More...
PROi
PR:Q13200
RNActiQ13200, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175166, Expressed in testis and 243 other tissues
ExpressionAtlasiQ13200, baseline and differential
GenevisibleiQ13200, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR016643, 26S_Psome_Rpn1
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002015, Proteasome/cyclosome_rpt
IPR041433, RPN1_C
IPR040892, RPN1_N
PANTHERiPTHR10943:SF11, PTHR10943:SF11, 1 hit
PfamiView protein in Pfam
PF01851, PC_rep, 2 hits
PF18051, RPN1_C, 1 hit
PF17781, RPN1_RPN2_N, 1 hit
PIRSFiPIRSF015965, 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSMD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13200
Secondary accession number(s): B4DX07
, B4DXY1, E7EW34, E9PCS3, Q12932, Q15321, Q53XQ4, Q96I12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: February 10, 2021
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
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