UniProtKB - Q13200 (PSMD2_HUMAN)
26S proteasome non-ATPase regulatory subunit 2
PSMD2
Functioni
GO - Molecular functioni
- enzyme regulator activity Source: InterPro
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of protein catabolic process Source: InterPro
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q13200 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q13200 |
Protein family/group databases
MoonDBi | Q13200, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome non-ATPase regulatory subunit 2Alternative name(s): 26S proteasome regulatory subunit RPN1 26S proteasome regulatory subunit S2 26S proteasome subunit p97 Protein 55.11 Tumor necrosis factor type 1 receptor-associated protein 2 |
Gene namesi | Name:PSMD2 Synonyms:TRAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9559, PSMD2 |
MIMi | 606223, gene |
neXtProti | NX_Q13200 |
VEuPathDBi | HostDB:ENSG00000175166.16 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- proteasome storage granule Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle Source: ProtInc
- proteasome regulatory particle, base subcomplex Source: GO_Central
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5708 |
OpenTargetsi | ENSG00000175166 |
PharmGKBi | PA33905 |
Miscellaneous databases
Pharosi | Q13200, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Genetic variation databases
BioMutai | PSMD2 |
DMDMi | 6174930 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173810 | 1 – 908 | 26S proteasome non-ATPase regulatory subunit 2Add BLAST | 908 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 | |
Modified residuei | 194 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 361 | PhosphoserineCombined sources | 1 | |
Modified residuei | 363 | PhosphoserineCombined sources | 1 | |
Modified residuei | 551 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-261 |
EPDi | Q13200 |
jPOSTi | Q13200 |
MassIVEi | Q13200 |
MaxQBi | Q13200 |
PaxDbi | Q13200 |
PeptideAtlasi | Q13200 |
PRIDEi | Q13200 |
ProteomicsDBi | 18762 19502 59219 [Q13200-1] |
PTM databases
iPTMneti | Q13200 |
MetOSitei | Q13200 |
PhosphoSitePlusi | Q13200 |
SwissPalmi | Q13200 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175166, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q13200, baseline and differential |
Genevisiblei | Q13200, HS |
Organism-specific databases
HPAi | ENSG00000175166, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2 (PubMed:27428775, PubMed:27342858).
Interacts with RPGRIP1L (By similarity).
Interacts with CRY1 in a KDM8-dependent manner (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ13200
Protein-protein interaction databases
BioGRIDi | 111681, 266 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | Q13200 |
DIPi | DIP-38204N |
IntActi | Q13200, 193 interactors |
MINTi | Q13200 |
STRINGi | 9606.ENSP00000310129 |
Miscellaneous databases
RNActi | Q13200, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 409 – 442 | PC 1Add BLAST | 34 | |
Repeati | 443 – 479 | PC 2Add BLAST | 37 | |
Repeati | 480 – 514 | PC 3Add BLAST | 35 | |
Repeati | 517 – 551 | PC 4Add BLAST | 35 | |
Repeati | 560 – 589 | PC 5Add BLAST | 30 | |
Repeati | 692 – 723 | PC 6Add BLAST | 32 | |
Repeati | 742 – 757 | PC 7Add BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 623 – 641 | Glu/Lys-richAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2005, Eukaryota |
GeneTreei | ENSGT00940000153386 |
HOGENOMi | CLU_008705_1_0_1 |
InParanoidi | Q13200 |
OMAi | MVDICAY |
OrthoDBi | 229956at2759 |
PhylomeDBi | Q13200 |
TreeFami | TF105739 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR016643, 26S_Psome_Rpn1 IPR011989, ARM-like IPR016024, ARM-type_fold IPR002015, Proteasome/cyclosome_rpt IPR041433, RPN1_C IPR040892, RPN1_N |
PANTHERi | PTHR10943:SF11, PTHR10943:SF11, 1 hit |
Pfami | View protein in Pfam PF01851, PC_rep, 2 hits PF18051, RPN1_C, 1 hit PF17781, RPN1_RPN2_N, 1 hit |
PIRSFi | PIRSF015965, 26S_Psome_Rpn1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEGGRDKAP VQPQQSPAAA PGGTDEKPSG KERRDAGDKD KEQELSEEDK
60 70 80 90 100
QLQDELEMLV ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR
110 120 130 140 150
PHYGKLKEIY ENMAPGENKR FAADIISVLA MTMSGERECL KYRLVGSQEE
160 170 180 190 200
LASWGHEYVR HLAGEVAKEW QELDDAEKVQ REPLLTLVKE IVPYNMAHNA
210 220 230 240 250
EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV PEPENSALLR
260 270 280 290 300
CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
310 320 330 340 350
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK
360 370 380 390 400
THLENNRFGG SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY
410 420 430 440 450
KNKDHGMLSA AASLGMILLW DVDGGLTQID KYLYSSEDYI KSGALLACGI
460 470 480 490 500
VNSGVRNECD PALALLSDYV LHNSNTMRLG SIFGLGLAYA GSNREDVLTL
510 520 530 540 550
LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ TIMEKSETEL
560 570 580 590 600
KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
610 620 630 640 650
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ
660 670 680 690 700
GVAVLGIALI AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS
710 720 730 740 750
NPRLNILDTL SKFSHDADPE VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ
760 770 780 790 800
YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP YHSDRQLMSQ VAVAGLLTVL
810 820 830 840 850
VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL PVSVRVGQAV
860 870 880 890 900
DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL
RKNPNYDL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C1H2 | H7C1H2_HUMAN | 26S proteasome non-ATPase regulator... | PSMD2 | 203 | Annotation score: | ||
C9JPC0 | C9JPC0_HUMAN | 26S proteasome non-ATPase regulator... | PSMD2 | 217 | Annotation score: | ||
H7C2Q3 | H7C2Q3_HUMAN | 26S proteasome non-ATPase regulator... | PSMD2 | 143 | Annotation score: | ||
F8WBS8 | F8WBS8_HUMAN | 26S proteasome non-ATPase regulator... | PSMD2 | 59 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | P → R in CAA60167 (PubMed:7601280).Curated | 1 | |
Sequence conflicti | 21 | P → S (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 32 | E → G (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 43 | Q → L (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 57 | E → V (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 60 | V → A in BAA11226 (PubMed:8774743).Curated | 1 | |
Sequence conflicti | 226 | Y → S in AAA87705 (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 260 | S → T in CAA60167 (PubMed:7601280).Curated | 1 | |
Sequence conflicti | 281 – 283 | IFT → SS in AAA87705 (PubMed:9126987).Curated | 3 | |
Sequence conflicti | 415 | G → A in BAA11226 (PubMed:8774743).Curated | 1 | |
Sequence conflicti | 731 | M → MGM (PubMed:9126987).Curated | 1 | |
Sequence conflicti | 776 | L → P in BAG63219 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 900 – 908 | LRKNPNYDL → FGRTPIMISK (PubMed:15489334).Curated | 9 | |
Sequence conflicti | 900 – 908 | LRKNPNYDL → FGRTPIMISK (PubMed:7601280).Curated | 9 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051554 | 176 | A → T. Corresponds to variant dbSNP:rs11545172Ensembl. | 1 | |
Natural variantiVAR_051555 | 313 | E → D1 PublicationCorresponds to variant dbSNP:rs11545169Ensembl. | 1 | |
Natural variantiVAR_067451 | 724 | N → Y2 PublicationsCorresponds to variant dbSNP:rs17856236Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055065 | 1 – 163 | MEEGG…VRHLA → MSMS in isoform 2. 1 PublicationAdd BLAST | 163 | |
Alternative sequenceiVSP_055066 | 1 – 130 | Missing in isoform 3. 1 PublicationAdd BLAST | 130 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78151 mRNA Translation: BAA11226.1 BT009736 mRNA Translation: AAP88738.1 AK301759 mRNA Translation: BAG63219.1 AK302177 mRNA Translation: BAG63543.1 AC078797 Genomic DNA No translation available. BC002368 mRNA Translation: AAH02368.1 BC002997 mRNA Translation: AAH02997.1 BC007897 mRNA Translation: AAH07897.1 U12596 mRNA Translation: AAA87705.1 Different initiation. X86446 mRNA Translation: CAA60167.1 |
CCDSi | CCDS3258.1 [Q13200-1] CCDS63853.1 [Q13200-3] CCDS63854.1 [Q13200-2] |
RefSeqi | NP_001265637.1, NM_001278708.1 [Q13200-3] NP_001265638.1, NM_001278709.1 [Q13200-2] NP_002799.3, NM_002808.4 [Q13200-1] |
Genome annotation databases
Ensembli | ENST00000310118; ENSP00000310129; ENSG00000175166 [Q13200-1] ENST00000435761; ENSP00000402618; ENSG00000175166 [Q13200-2] ENST00000439383; ENSP00000416028; ENSG00000175166 [Q13200-3] |
GeneIDi | 5708 |
KEGGi | hsa:5708 |
UCSCi | uc003fnn.3, human [Q13200-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78151 mRNA Translation: BAA11226.1 BT009736 mRNA Translation: AAP88738.1 AK301759 mRNA Translation: BAG63219.1 AK302177 mRNA Translation: BAG63543.1 AC078797 Genomic DNA No translation available. BC002368 mRNA Translation: AAH02368.1 BC002997 mRNA Translation: AAH02997.1 BC007897 mRNA Translation: AAH07897.1 U12596 mRNA Translation: AAA87705.1 Different initiation. X86446 mRNA Translation: CAA60167.1 |
CCDSi | CCDS3258.1 [Q13200-1] CCDS63853.1 [Q13200-3] CCDS63854.1 [Q13200-2] |
RefSeqi | NP_001265637.1, NM_001278708.1 [Q13200-3] NP_001265638.1, NM_001278709.1 [Q13200-2] NP_002799.3, NM_002808.4 [Q13200-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GJQ | electron microscopy | 4.50 | Z | 1-908 | [»] | |
5GJR | electron microscopy | 3.50 | AC/Z | 1-908 | [»] | |
5L4K | electron microscopy | 4.50 | Z | 1-908 | [»] | |
5LN3 | electron microscopy | 6.80 | Z | 1-908 | [»] | |
5T0C | electron microscopy | 3.80 | Af/Bf | 1-908 | [»] | |
5T0G | electron microscopy | 4.40 | f | 164-908 | [»] | |
5T0H | electron microscopy | 6.80 | f | 164-908 | [»] | |
5T0I | electron microscopy | 8.00 | f | 164-908 | [»] | |
5T0J | electron microscopy | 8.00 | f | 164-908 | [»] | |
5VFP | electron microscopy | 4.20 | f | 1-908 | [»] | |
5VFQ | electron microscopy | 4.20 | f | 1-908 | [»] | |
5VFR | electron microscopy | 4.90 | f | 1-908 | [»] | |
5VFS | electron microscopy | 3.60 | f | 6-853 | [»] | |
5VFT | electron microscopy | 7.00 | f | 1-908 | [»] | |
5VFU | electron microscopy | 5.80 | f | 1-908 | [»] | |
5VHF | electron microscopy | 5.70 | f | 6-853 | [»] | |
5VHH | electron microscopy | 6.10 | f | 6-853 | [»] | |
5VHI | electron microscopy | 6.80 | f | 6-853 | [»] | |
5VHJ | electron microscopy | 8.50 | f | 70-853 | [»] | |
5VHM | electron microscopy | 8.30 | f | 6-853 | [»] | |
5VHN | electron microscopy | 7.30 | f | 6-853 | [»] | |
5VHO | electron microscopy | 8.30 | f | 6-853 | [»] | |
5VHP | electron microscopy | 7.90 | f | 70-853 | [»] | |
5VHQ | electron microscopy | 8.90 | f | 6-853 | [»] | |
5VHR | electron microscopy | 7.70 | f | 6-853 | [»] | |
5VHS | electron microscopy | 8.80 | f | 70-853 | [»] | |
6MSB | electron microscopy | 3.00 | f | 1-908 | [»] | |
6MSD | electron microscopy | 3.20 | f | 1-908 | [»] | |
6MSG | electron microscopy | 3.50 | f | 1-892 | [»] | |
6MSH | electron microscopy | 3.60 | f | 1-892 | [»] | |
6MSJ | electron microscopy | 3.30 | f | 1-892 | [»] | |
6MSK | electron microscopy | 3.20 | f | 1-892 | [»] | |
6WJD | electron microscopy | 4.80 | f | 1-908 | [»] | |
6WJN | electron microscopy | 5.70 | f | 1-908 | [»] | |
SMRi | Q13200 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111681, 266 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | Q13200 |
DIPi | DIP-38204N |
IntActi | Q13200, 193 interactors |
MINTi | Q13200 |
STRINGi | 9606.ENSP00000310129 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Protein family/group databases
MoonDBi | Q13200, Predicted |
PTM databases
iPTMneti | Q13200 |
MetOSitei | Q13200 |
PhosphoSitePlusi | Q13200 |
SwissPalmi | Q13200 |
Genetic variation databases
BioMutai | PSMD2 |
DMDMi | 6174930 |
Proteomic databases
CPTACi | CPTAC-261 |
EPDi | Q13200 |
jPOSTi | Q13200 |
MassIVEi | Q13200 |
MaxQBi | Q13200 |
PaxDbi | Q13200 |
PeptideAtlasi | Q13200 |
PRIDEi | Q13200 |
ProteomicsDBi | 18762 19502 59219 [Q13200-1] |
Protocols and materials databases
Antibodypediai | 33807, 537 antibodies |
DNASUi | 5708 |
Genome annotation databases
Ensembli | ENST00000310118; ENSP00000310129; ENSG00000175166 [Q13200-1] ENST00000435761; ENSP00000402618; ENSG00000175166 [Q13200-2] ENST00000439383; ENSP00000416028; ENSG00000175166 [Q13200-3] |
GeneIDi | 5708 |
KEGGi | hsa:5708 |
UCSCi | uc003fnn.3, human [Q13200-1] |
Organism-specific databases
CTDi | 5708 |
DisGeNETi | 5708 |
GeneCardsi | PSMD2 |
HGNCi | HGNC:9559, PSMD2 |
HPAi | ENSG00000175166, Tissue enhanced (skeletal) |
MIMi | 606223, gene |
neXtProti | NX_Q13200 |
OpenTargetsi | ENSG00000175166 |
PharmGKBi | PA33905 |
VEuPathDBi | HostDB:ENSG00000175166.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2005, Eukaryota |
GeneTreei | ENSGT00940000153386 |
HOGENOMi | CLU_008705_1_0_1 |
InParanoidi | Q13200 |
OMAi | MVDICAY |
OrthoDBi | 229956at2759 |
PhylomeDBi | Q13200 |
TreeFami | TF105739 |
Enzyme and pathway databases
PathwayCommonsi | Q13200 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q13200 |
Miscellaneous databases
BioGRID-ORCSi | 5708, 731 hits in 880 CRISPR screens |
ChiTaRSi | PSMD2, human |
GeneWikii | PSMD2 |
GenomeRNAii | 5708 |
Pharosi | Q13200, Tbio |
PROi | PR:Q13200 |
RNActi | Q13200, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175166, Expressed in testis and 243 other tissues |
ExpressionAtlasi | Q13200, baseline and differential |
Genevisiblei | Q13200, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR016643, 26S_Psome_Rpn1 IPR011989, ARM-like IPR016024, ARM-type_fold IPR002015, Proteasome/cyclosome_rpt IPR041433, RPN1_C IPR040892, RPN1_N |
PANTHERi | PTHR10943:SF11, PTHR10943:SF11, 1 hit |
Pfami | View protein in Pfam PF01851, PC_rep, 2 hits PF18051, RPN1_C, 1 hit PF17781, RPN1_RPN2_N, 1 hit |
PIRSFi | PIRSF015965, 26S_Psome_Rpn1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSMD2_HUMAN | |
Accessioni | Q13200Primary (citable) accession number: Q13200 Secondary accession number(s): B4DX07 Q96I12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 10, 2021 | |
This is version 209 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants