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Protein

E3 ubiquitin-protein ligase CBL-B

Gene

CBLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).By similarity6 Publications

Miscellaneous

This protein has one functional calcium-binding site.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei286PhosphotyrosineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi219 – 232PROSITE-ProRule annotationAdd BLAST14
Zinc fingeri373 – 412RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • phosphotyrosine residue binding Source: InterPro
  • receptor tyrosine kinase binding Source: GO_Central
  • SH3 domain binding Source: GO_Central
  • ubiquitin protein ligase activity Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi6.3.2.19 2681
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ13191
SIGNORiQ13191
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBL-B (EC:2.3.2.272 Publications)
Alternative name(s):
Casitas B-lineage lymphoma proto-oncogene b
RING finger protein 56
RING-type E3 ubiquitin transferase CBL-BCurated
SH3-binding protein CBL-B
Signal transduction protein CBL-B
Gene namesi
Name:CBLB
Synonyms:RNF56
ORF Names:Nbla00127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114423.18
HGNCiHGNC:1542 CBLB
MIMi604491 gene
neXtProtiNX_Q13191

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi298G → E: Inhibits interaction with SYK. No effect on E3 activity. 2 Publications1
Mutagenesisi363Y → E: Decreases affinity for E2 ubiquitin-conjugating enzymes. 1 Publication1
Mutagenesisi373C → A: Abolishes E3 activity but does not affect binding to substrates. 2 Publications1
Mutagenesisi665Y → F: Slightly inhibits interaction with CRKL. Abolishes interaction with CRKL; when associated with F-709. 1 Publication1
Mutagenesisi709Y → F: Inhibits interaction with CRKL. Abolishes interaction with CRKL; when associated with F-665. 1 Publication1
Mutagenesisi904R → A: No effect on interaction with CD2AP. Reduced interaction with SH3KBP1. Strongly reduced interaction with SH3KBP1; when associated with A-911. 2 Publications1
Mutagenesisi907K → A: No effect on interaction with SH3KBP1. Reduced interaction with CD2AP. Strongly reduced interaction with CD2AP; when associated with A-911. 1 Publication1
Mutagenesisi911R → A: Reduced interaction with CD2AP and with SH3KBP1. Strongly reduced interaction with CD2AP; when associated with A-907. Strongly reduced interaction with SH3KBP1; when associated with A-904. 2 Publications1
Mutagenesisi937A → E: Loss of ubiquitin binding. Reduced levels of tyrosine phosphorylation. 1 Publication1
Mutagenesisi940M → A: Loss of ubiquitin binding. Reduced levels of tyrosine phosphorylation. 1 Publication1
Mutagenesisi943 – 944GY → AQ: Abolishes interaction with ubiquitinated proteins. 1 Publication2
Mutagenesisi946F → A: Loss of ubiquitin binding. Reduced levels of tyrosine phosphorylation. 1 Publication1
Mutagenesisi966I → E: Interferes with dimerization. Reduced E3 ubiquitin-protein ligase activity. Reduced levels of tyrosine phosphorylation. 1 Publication1
Mutagenesisi967L → A: No effect on interaction with ubiquitinated proteins. 1 Publication1

Organism-specific databases

DisGeNETi868
OpenTargetsiENSG00000114423
PharmGKBiPA26116

Polymorphism and mutation databases

BioMutaiCBLB
DMDMi88911265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558601 – 982E3 ubiquitin-protein ligase CBL-BAdd BLAST982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282Phosphoserine; by PKC/PRKCQ1 Publication1
Modified residuei363Phosphotyrosine1 Publication1
Modified residuei476PhosphoserineBy similarity1
Modified residuei480PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei521PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei634PhosphoserineBy similarity1
Modified residuei665Phosphotyrosine1 Publication1
Modified residuei709Phosphotyrosine1 Publication1
Modified residuei889PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.4 Publications
Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13191
MaxQBiQ13191
PaxDbiQ13191
PeptideAtlasiQ13191
PRIDEiQ13191
ProteomicsDBi59215
59216 [Q13191-2]
59217 [Q13191-3]

PTM databases

iPTMnetiQ13191
PhosphoSitePlusiQ13191

Expressioni

Tissue specificityi

Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).2 Publications

Inductioni

By serum starvation.1 Publication

Gene expression databases

BgeeiENSG00000114423 Expressed in 216 organ(s), highest expression level in pericardium
CleanExiHS_CBLB
ExpressionAtlasiQ13191 baseline and differential
GenevisibleiQ13191 HS

Organism-specific databases

HPAiHPA018327
HPA019880

Interactioni

Subunit structurei

Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. Interacts with CBL (PubMed:29237719). Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Interacts with EGFR (phosphorylated). Interacts with IFT20 (PubMed:29237719).11 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107316, 62 interactors
CORUMiQ13191
DIPiDIP-33091N
IntActiQ13191, 47 interactors
MINTiQ13191
STRINGi9606.ENSP00000264122

Structurei

Secondary structure

1982
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13191
SMRiQ13191
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13191

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 343Cbl-PTBPROSITE-ProRule annotationAdd BLAST309
Domaini931 – 970UBAPROSITE-ProRule annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 1674HAdd BLAST133
Regioni168 – 240EF-hand-likeAdd BLAST73
Regioni241 – 343SH2-likeAdd BLAST103
Regioni344 – 372LinkerAdd BLAST29
Regioni543 – 568Interaction with VAV11 PublicationAdd BLAST26
Regioni891 – 927Interaction with SH3KBP11 PublicationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi477 – 925Pro-richAdd BLAST449

Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
The UBA domain interacts with poly-ubiquitinated proteins.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 412RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
HOVERGENiHBG005255
InParanoidiQ13191
KOiK22517
OMAiAQRRKPH
OrthoDBiEOG091G0GPE
PhylomeDBiQ13191
TreeFamiTF314210

Family and domain databases

CDDicd16709 RING-HC_Cbl-b, 1 hit
cd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR039520 CBL-B_RING-HC
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR015940 UBA
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS50030 UBA, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q13191-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW
60 70 80 90 100
KLMDKVVRLC QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ
110 120 130 140 150
LSENEYFKIY IDSLMKKSKR AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF
160 170 180 190 200
SHMLAEIKAI FPNGQFQGDN FRITKADAAE FWRKFFGDKT IVPWKVFRQC
210 220 230 240 250
LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWGSILRNW
260 270 280 290 300
NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV
310 320 330 340 350
TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH
360 370 380 390 400
DHIKVTQEQY ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW
410 420 430 440 450
QESDGQGCPF CRCEIKGTEP IIVDPFDPRD EGSRCCSIID PFGMPMLDLD
460 470 480 490 500
DDDDREESLM MNRLANVRKC TDRQNSPVTS PGSSPLAQRR KPQPDPLQIP
510 520 530 540 550
HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ DKPLPAPPPP
560 570 580 590 600
LRDPPPPPPE RPPPIPPDNR LSRHIHHVES VPSRDPPMPL EAWCPRDVFG
610 620 630 640 650
TNQLVGCRLL GEGSPKPGIT ASSNVNGRHS RVGSDPVLMR KHRRHDLPLE
660 670 680 690 700
GAKVFSNGHL GSEEYDVPPR LSPPPPVTTL LPSIKCTGPL ANSLSEKTRD
710 720 730 740 750
PVEEDDDEYK IPSSHPVSLN SQPSHCHNVK PPVRSCDNGH CMLNGTHGPS
760 770 780 790 800
SEKKSNIPDL SIYLKGDVFD SASDPVPLPP ARPPTRDNPK HGSSLNRTPS
810 820 830 840 850
DYDLLIPPLG EDAFDALPPS LPPPPPPARH SLIEHSKPPG SSSRPSSGQD
860 870 880 890 900
LFLLPSDPFV DLASGQVPLP PARRLPGENV KTNRTSQDYD QLPSCSDGSQ
910 920 930 940 950
APARPPKPRP RRTAPEIHHR KPHGPEAALE NVDAKIAKLM GEGYAFEEVK
960 970 980
RALEIAQNNV EVARSILREF AFPPPVSPRL NL
Length:982
Mass (Da):109,450
Last modified:February 7, 2006 - v2
Checksum:iB4E307D31B9F0779
GO
Isoform Truncated 1 (identifier: Q13191-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     811-982: Missing.

Show »
Length:810
Mass (Da):90,754
Checksum:iAD22F7C9C677DB9A
GO
Isoform Truncated 2 (identifier: Q13191-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     767-770: DVFD → TYRI
     771-982: Missing.

Show »
Length:770
Mass (Da):86,582
Checksum:iDEE458DFFEE1AF2F
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC15B5MC15_HUMAN
Cas-Br-M (Murine) ecotropic retrovi...
CBLB hCG_1811662
810Annotation score:
H0Y3L9H0Y3L9_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
1,010Annotation score:
C9JU85C9JU85_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
219Annotation score:
A0A2R8YFD4A0A2R8YFD4_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
879Annotation score:
A0A2R8Y5E1A0A2R8Y5E1_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
870Annotation score:
A0A2R8Y8D8A0A2R8Y8D8_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
869Annotation score:
A0A2R8Y7I2A0A2R8Y7I2_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
254Annotation score:
C9JRB3C9JRB3_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
187Annotation score:
C9K048C9K048_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
146Annotation score:
A0A2R8YDW4A0A2R8YDW4_HUMAN
E3 ubiquitin-protein ligase CBL-B
CBLB
131Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAE45748 differs from that shown. Reason: Erroneous termination at position 904. Translated as Arg.Curated
The sequence CAH56175 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210G → S in AAB09291 (PubMed:7784085).Curated1
Sequence conflicti210G → S in AAB09292 (PubMed:7784085).Curated1
Sequence conflicti210G → S in AAB09293 (PubMed:7784085).Curated1
Sequence conflicti911R → C in CAH56175 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025303584R → K1 PublicationCorresponds to variant dbSNP:rs17853100Ensembl.1
Natural variantiVAR_039241883N → D. Corresponds to variant dbSNP:rs35835913EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005730767 – 770DVFD → TYRI in isoform Truncated 2. 1 Publication4
Alternative sequenceiVSP_005731771 – 982Missing in isoform Truncated 2. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_005729811 – 982Missing in isoform Truncated 1. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26710 mRNA Translation: AAB09291.1
U26711 mRNA Translation: AAB09292.1
U26712 mRNA Translation: AAB09293.1
DQ349203 mRNA Translation: ABC86700.1
AK292792 mRNA Translation: BAF85481.1
AC016138 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79752.1
CH471052 Genomic DNA Translation: EAW79753.1
CH471052 Genomic DNA Translation: EAW79754.1
BC032851 mRNA Translation: AAH32851.1
AB075490 mRNA Translation: BAE45748.1 Sequence problems.
BX537484 mRNA Translation: CAH56175.1 Sequence problems.
CCDSiCCDS2948.1 [Q13191-1]
RefSeqiNP_001308717.1, NM_001321788.1 [Q13191-1]
NP_733762.2, NM_170662.4 [Q13191-1]
XP_011511559.1, XM_011513257.1 [Q13191-1]
UniGeneiHs.430589

Genome annotation databases

EnsembliENST00000264122; ENSP00000264122; ENSG00000114423 [Q13191-1]
ENST00000403724; ENSP00000384816; ENSG00000114423 [Q13191-3]
ENST00000405772; ENSP00000384938; ENSG00000114423 [Q13191-2]
GeneIDi868
KEGGihsa:868
UCSCiuc003dwc.4 human [Q13191-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26710 mRNA Translation: AAB09291.1
U26711 mRNA Translation: AAB09292.1
U26712 mRNA Translation: AAB09293.1
DQ349203 mRNA Translation: ABC86700.1
AK292792 mRNA Translation: BAF85481.1
AC016138 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79752.1
CH471052 Genomic DNA Translation: EAW79753.1
CH471052 Genomic DNA Translation: EAW79754.1
BC032851 mRNA Translation: AAH32851.1
AB075490 mRNA Translation: BAE45748.1 Sequence problems.
BX537484 mRNA Translation: CAH56175.1 Sequence problems.
CCDSiCCDS2948.1 [Q13191-1]
RefSeqiNP_001308717.1, NM_001321788.1 [Q13191-1]
NP_733762.2, NM_170662.4 [Q13191-1]
XP_011511559.1, XM_011513257.1 [Q13191-1]
UniGeneiHs.430589

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AK5X-ray1.85D904-911[»]
2BZ8X-ray2.00C902-912[»]
2DO6NMR-A/B931-970[»]
2J6FX-ray1.70C902-912[»]
2JNHNMR-A926-971[»]
2LDRNMR-A351-426[»]
2OOAX-ray1.56A/B924-973[»]
2OOBX-ray1.90A924-973[»]
3PFVX-ray2.27A/B38-344[»]
3VGOX-ray3.10A/B/C39-426[»]
3ZNIX-ray2.21A/E/I/M36-427[»]
ProteinModelPortaliQ13191
SMRiQ13191
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107316, 62 interactors
CORUMiQ13191
DIPiDIP-33091N
IntActiQ13191, 47 interactors
MINTiQ13191
STRINGi9606.ENSP00000264122

PTM databases

iPTMnetiQ13191
PhosphoSitePlusiQ13191

Polymorphism and mutation databases

BioMutaiCBLB
DMDMi88911265

Proteomic databases

EPDiQ13191
MaxQBiQ13191
PaxDbiQ13191
PeptideAtlasiQ13191
PRIDEiQ13191
ProteomicsDBi59215
59216 [Q13191-2]
59217 [Q13191-3]

Protocols and materials databases

DNASUi868
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264122; ENSP00000264122; ENSG00000114423 [Q13191-1]
ENST00000403724; ENSP00000384816; ENSG00000114423 [Q13191-3]
ENST00000405772; ENSP00000384938; ENSG00000114423 [Q13191-2]
GeneIDi868
KEGGihsa:868
UCSCiuc003dwc.4 human [Q13191-1]

Organism-specific databases

CTDi868
DisGeNETi868
EuPathDBiHostDB:ENSG00000114423.18
GeneCardsiCBLB
H-InvDBiHIX0003518
HGNCiHGNC:1542 CBLB
HPAiHPA018327
HPA019880
MIMi604491 gene
neXtProtiNX_Q13191
OpenTargetsiENSG00000114423
PharmGKBiPA26116
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
HOVERGENiHBG005255
InParanoidiQ13191
KOiK22517
OMAiAQRRKPH
OrthoDBiEOG091G0GPE
PhylomeDBiQ13191
TreeFamiTF314210

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi6.3.2.19 2681
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ13191
SIGNORiQ13191

Miscellaneous databases

ChiTaRSiCBLB human
EvolutionaryTraceiQ13191
GeneWikiiCBLB_(gene)
GenomeRNAii868
PROiPR:Q13191
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114423 Expressed in 216 organ(s), highest expression level in pericardium
CleanExiHS_CBLB
ExpressionAtlasiQ13191 baseline and differential
GenevisibleiQ13191 HS

Family and domain databases

CDDicd16709 RING-HC_Cbl-b, 1 hit
cd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.20, 1 hit
3.30.40.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR039520 CBL-B_RING-HC
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR015940 UBA
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS50030 UBA, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBLB_HUMAN
AccessioniPrimary (citable) accession number: Q13191
Secondary accession number(s): A8K9S7
, B7WNM4, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 7, 2006
Last modified: November 7, 2018
This is version 202 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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