UniProtKB - Q13188 (STK3_HUMAN)
Serine/threonine-protein kinase 3
STK3
Functioni
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity).
Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
By similarity11 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | ATP | 1 | |
Active sitei | 146 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 41 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- identical protein binding Source: IntAct
- magnesium ion binding Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activator activity Source: BHF-UCL
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- apoptotic process Source: UniProtKB
- cell differentiation involved in embryonic placenta development Source: Ensembl
- central nervous system development Source: Ensembl
- endocardium development Source: Ensembl
- hepatocyte apoptotic process Source: Ensembl
- hippo signaling Source: BHF-UCL
- intracellular signal transduction Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of organ growth Source: Ensembl
- neural tube formation Source: Ensembl
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: MGI
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of protein binding Source: MGI
- positive regulation of protein kinase B signaling Source: Ensembl
- primitive hemopoiesis Source: Ensembl
- protein import into nucleus Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- protein stabilization Source: MGI
- protein tetramerization Source: InterPro
- regulation of cell differentiation involved in embryonic placenta development Source: Ensembl
- regulation of MAPK cascade Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13188 |
Reactomei | R-HSA-2028269, Signaling by Hippo |
SignaLinki | Q13188 |
SIGNORi | Q13188 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 3 (EC:2.7.11.1)Alternative name(s): Mammalian STE20-like protein kinase 2 Short name: MST-2 STE20-like kinase MST2 Serine/threonine-protein kinase Krs-1 Cleaved into the following 2 chains: |
Gene namesi | Name:STK3 Synonyms:KRS1, MST2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11406, STK3 |
MIMi | 605030, gene |
neXtProti | NX_Q13188 |
VEuPathDBi | HostDB:ENSG00000104375 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 56 | K → R: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 322 | D → N: Resistant to proteolytic cleavage. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6788 |
OpenTargetsi | ENSG00000104375 |
PharmGKBi | PA36213 |
Miscellaneous databases
Pharosi | Q13188, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4708 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q13188 |
GuidetoPHARMACOLOGYi | 2219 |
Genetic variation databases
BioMutai | STK3 |
DMDMi | 46577700 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086689 | 1 – 491 | Serine/threonine-protein kinase 3Add BLAST | 491 | |
ChainiPRO_0000413713 | 1 – 322 | Serine/threonine-protein kinase 3 36kDa subunitAdd BLAST | 322 | |
ChainiPRO_0000413714 | 323 – 491 | Serine/threonine-protein kinase 3 20kDa subunitAdd BLAST | 169 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 117 | Phosphothreonine; by PKB/AKT12 Publications | 1 | |
Modified residuei | 180 | Phosphothreonine; by autocatalysisBy similarityCurated | 1 | |
Modified residuei | 316 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 384 | Phosphothreonine; by PKB/AKT11 Publication | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources | 1 | |
Modified residuei | 444 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 322 – 323 | Cleavage; by caspase-3 | 2 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q13188 |
jPOSTi | Q13188 |
MassIVEi | Q13188 |
MaxQBi | Q13188 |
PaxDbi | Q13188 |
PeptideAtlasi | Q13188 |
PRIDEi | Q13188 |
ProteomicsDBi | 3835 59211 [Q13188-1] |
2D gel databases
OGPi | Q13188 |
PTM databases
GlyGeni | Q13188, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13188 |
MetOSitei | Q13188 |
PhosphoSitePlusi | Q13188 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000104375, Expressed in chorionic villus and 234 other tissues |
ExpressionAtlasi | Q13188, baseline and differential |
Genevisiblei | Q13188, HS |
Organism-specific databases
HPAi | ENSG00000104375, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; mediated via the coiled-coil region.
Interacts with NORE1, which inhibits autoactivation (By similarity).
Interacts with and stabilizes SAV1 (PubMed:15688006, PubMed:16930133, PubMed:28087714).
Interacts with RAF1, which prevents dimerization and phosphorylation.
Interacts with RASSF1.
Interacts (via SARAH domain) with isoform 1 of NEK2.
Interacts with ESR1 only in the presence of SAV1.
Interacts with PKB/AKT1.
Forms a tripartite complex with MOBKL1B and STK38.
Interacts with RASSF2 (via SARAH domain).
Interacts with DLG5 (via PDZ domain 3) (PubMed:28087714).
Interacts with LATS1; this interaction is inhibited in the presence of DLG5 (PubMed:28087714).
Interacts with MARK3 in the presence of DLG5 (PubMed:28087714).
By similarity12 PublicationsBinary interactionsi
Q13188
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 112664, 131 interactors |
CORUMi | Q13188 |
DIPi | DIP-36128N |
ELMi | Q13188 |
IntActi | Q13188, 98 interactors |
MINTi | Q13188 |
STRINGi | 9606.ENSP00000429744 |
Chemistry databases
BindingDBi | Q13188 |
Miscellaneous databases
RNActi | Q13188, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13188 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 278 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 437 – 484 | SARAHPROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 327 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 370 – 392 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 287 – 328 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 442 – 475 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0574, Eukaryota |
GeneTreei | ENSGT00940000154984 |
HOGENOMi | CLU_000288_63_23_1 |
InParanoidi | Q13188 |
OMAi | QRMANLD |
OrthoDBi | 967913at2759 |
PhylomeDBi | Q13188 |
TreeFami | TF354217 |
Family and domain databases
DisProti | DP01461 |
Gene3Di | 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024205, Mst1_SARAH_domain IPR036674, p53_tetramer_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR011524, SARAH_dom |
Pfami | View protein in Pfam PF11629, Mst1_SARAH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50951, SARAH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG
60 70 80 90 100
QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME
110 120 130 140 150
YCGAGSVSDI IRLRNKTLIE DEIATILKST LKGLEYLHFM RKIHRDIKAG
160 170 180 190 200
NILLNTEGHA KLADFGVAGQ LTDTMAKRNT VIGTPFWMAP EVIQEIGYNC
210 220 230 240 250
VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT FRKPELWSDD
260 270 280 290 300
FTDFVKKCLV KNPEQRATAT QLLQHPFIKN AKPVSILRDL ITEAMEIKAK
310 320 330 340 350
RHEEQQRELE EEEENSDEDE LDSHTMVKTS VESVGTMRAT STMSEGAQTM
360 370 380 390 400
IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ
410 420 430 440 450
DFKNKSHENC NQNMHEPFPM SKNVFPDNWK VPQDGDFDFL KNLSLEELQM
460 470 480 490
RLKALDPMME REIEELRQRY TAKRQPILDA MDAKKRRQQN F
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ06 | A0A087WZ06_HUMAN | Non-specific serine/threonine prote... | STK3 | 380 | Annotation score: | ||
E5RFQ9 | E5RFQ9_HUMAN | Serine/threonine-protein kinase 3 | STK3 | 228 | Annotation score: | ||
E5RIM6 | E5RIM6_HUMAN | Serine/threonine-protein kinase 3 | STK3 | 82 | Annotation score: | ||
Q8NBU1 | Q8NBU1_HUMAN | Serine/threonine-protein kinase 3 | STK3 | 168 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 – 98 | WIV → YLY in CAA80909 (PubMed:8274451).Curated | 3 | |
Sequence conflicti | 121 | D → Y in CAA80909 (PubMed:8274451).Curated | 1 | |
Sequence conflicti | 203 | D → G in CAA80909 (PubMed:8274451).Curated | 1 | |
Sequence conflicti | 303 | E → D in AAC50386 (PubMed:8566796).Curated | 1 | |
Sequence conflicti | 332 – 334 | ESV → GEC in AAC50386 (PubMed:8566796).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041122 | 60 | V → L in an ovarian clear cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_051670 | 418 | F → C. Corresponds to variant dbSNP:rs36047674Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054167 | 1 – 8 | MEQPPAPK → MLQLMDSGITICLRNGAASV FKKKEWSTQGEENKQD in isoform 2. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26424 mRNA Translation: AAC50386.1 U60206 mRNA Translation: AAB17261.1 AK131363 mRNA Translation: BAG54769.1 AK291837 mRNA Translation: BAF84526.1 AC016877 Genomic DNA No translation available. AP002087 Genomic DNA No translation available. AP003355 Genomic DNA No translation available. AP003467 Genomic DNA No translation available. AP003551 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91781.1 BC010640 mRNA Translation: AAH10640.1 Z25422 mRNA Translation: CAA80909.1 |
CCDSi | CCDS47900.1 [Q13188-1] CCDS59108.1 [Q13188-2] |
PIRi | I38212 |
RefSeqi | NP_001243241.1, NM_001256312.1 [Q13188-2] NP_006272.2, NM_006281.3 [Q13188-1] |
Genome annotation databases
Ensembli | ENST00000419617; ENSP00000390500; ENSG00000104375 ENST00000523601; ENSP00000429744; ENSG00000104375 [Q13188-2] |
GeneIDi | 6788 |
KEGGi | hsa:6788 |
MANE-Selecti | ENST00000419617.7; ENSP00000390500.2; NM_006281.4; NP_006272.2 |
UCSCi | uc003yio.5, human [Q13188-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26424 mRNA Translation: AAC50386.1 U60206 mRNA Translation: AAB17261.1 AK131363 mRNA Translation: BAG54769.1 AK291837 mRNA Translation: BAF84526.1 AC016877 Genomic DNA No translation available. AP002087 Genomic DNA No translation available. AP003355 Genomic DNA No translation available. AP003467 Genomic DNA No translation available. AP003551 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91781.1 BC010640 mRNA Translation: AAH10640.1 Z25422 mRNA Translation: CAA80909.1 |
CCDSi | CCDS47900.1 [Q13188-1] CCDS59108.1 [Q13188-2] |
PIRi | I38212 |
RefSeqi | NP_001243241.1, NM_001256312.1 [Q13188-2] NP_006272.2, NM_006281.3 [Q13188-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3WWS | X-ray | 2.01 | A/B/C/D | 436-484 | [»] | |
4HKD | X-ray | 1.50 | A/B/C/D | 436-484 | [»] | |
4L0N | X-ray | 1.40 | A/B/C/D/E/F/G/H/I/J | 436-484 | [»] | |
4LG4 | X-ray | 2.42 | A/B/C/D/E/F | 16-313 | [»] | |
4LGD | X-ray | 3.05 | A/B/C/D | 9-491 | [»] | |
4OH9 | X-ray | 1.70 | A/B | 436-484 | [»] | |
5BRM | X-ray | 2.65 | G/H/I/J/K/L/M/N/O | 371-401 | [»] | |
5DH3 | X-ray | 2.47 | A/B | 15-313 | [»] | |
6AO5 | X-ray | 2.96 | A | 16-491 | [»] | |
6AR2 | X-ray | 1.55 | C/D | 373-382 | [»] | |
SMRi | Q13188 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112664, 131 interactors |
CORUMi | Q13188 |
DIPi | DIP-36128N |
ELMi | Q13188 |
IntActi | Q13188, 98 interactors |
MINTi | Q13188 |
STRINGi | 9606.ENSP00000429744 |
Chemistry databases
BindingDBi | Q13188 |
ChEMBLi | CHEMBL4708 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q13188 |
GuidetoPHARMACOLOGYi | 2219 |
PTM databases
GlyGeni | Q13188, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q13188 |
MetOSitei | Q13188 |
PhosphoSitePlusi | Q13188 |
Genetic variation databases
BioMutai | STK3 |
DMDMi | 46577700 |
2D gel databases
OGPi | Q13188 |
Proteomic databases
EPDi | Q13188 |
jPOSTi | Q13188 |
MassIVEi | Q13188 |
MaxQBi | Q13188 |
PaxDbi | Q13188 |
PeptideAtlasi | Q13188 |
PRIDEi | Q13188 |
ProteomicsDBi | 3835 59211 [Q13188-1] |
Protocols and materials databases
Antibodypediai | 26075, 476 antibodies from 42 providers |
DNASUi | 6788 |
Genome annotation databases
Ensembli | ENST00000419617; ENSP00000390500; ENSG00000104375 ENST00000523601; ENSP00000429744; ENSG00000104375 [Q13188-2] |
GeneIDi | 6788 |
KEGGi | hsa:6788 |
MANE-Selecti | ENST00000419617.7; ENSP00000390500.2; NM_006281.4; NP_006272.2 |
UCSCi | uc003yio.5, human [Q13188-1] |
Organism-specific databases
CTDi | 6788 |
DisGeNETi | 6788 |
GeneCardsi | STK3 |
HGNCi | HGNC:11406, STK3 |
HPAi | ENSG00000104375, Low tissue specificity |
MIMi | 605030, gene |
neXtProti | NX_Q13188 |
OpenTargetsi | ENSG00000104375 |
PharmGKBi | PA36213 |
VEuPathDBi | HostDB:ENSG00000104375 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0574, Eukaryota |
GeneTreei | ENSGT00940000154984 |
HOGENOMi | CLU_000288_63_23_1 |
InParanoidi | Q13188 |
OMAi | QRMANLD |
OrthoDBi | 967913at2759 |
PhylomeDBi | Q13188 |
TreeFami | TF354217 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13188 |
Reactomei | R-HSA-2028269, Signaling by Hippo |
SignaLinki | Q13188 |
SIGNORi | Q13188 |
Miscellaneous databases
BioGRID-ORCSi | 6788, 42 hits in 1077 CRISPR screens |
ChiTaRSi | STK3, human |
GeneWikii | STK3 |
GenomeRNAii | 6788 |
Pharosi | Q13188, Tchem |
PROi | PR:Q13188 |
RNActi | Q13188, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104375, Expressed in chorionic villus and 234 other tissues |
ExpressionAtlasi | Q13188, baseline and differential |
Genevisiblei | Q13188, HS |
Family and domain databases
DisProti | DP01461 |
Gene3Di | 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024205, Mst1_SARAH_domain IPR036674, p53_tetramer_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR011524, SARAH_dom |
Pfami | View protein in Pfam PF11629, Mst1_SARAH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50951, SARAH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STK3_HUMAN | |
Accessioni | Q13188Primary (citable) accession number: Q13188 Secondary accession number(s): A8K722 Q96FM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 23, 2022 | |
This is version 215 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families