UniProtKB - Q13177 (PAK2_HUMAN)
Serine/threonine-protein kinase PAK 2
PAK2
Functioni
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
8 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 278 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 367 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 255 – 263 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein kinase activity Source: ProtInc
- protein kinase binding Source: BHF-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: BHF-UCL
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activator activity Source: BHF-UCL
- small GTPase binding Source: CAFA
GO - Biological processi
- adherens junction assembly Source: ARUK-UCL
- apoptotic process Source: UniProtKB-KW
- bicellular tight junction assembly Source: ARUK-UCL
- cardiac muscle hypertrophy Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- dendritic spine development Source: Ensembl
- intracellular signal transduction Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: UniProtKB
- negative regulation of protein kinase activity Source: ProtInc
- negative regulation of stress fiber assembly Source: ARUK-UCL
- peptidyl-serine phosphorylation Source: BHF-UCL
- phosphorylation Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- protein autophosphorylation Source: MGI
- protein localization to cell-cell junction Source: ARUK-UCL
- protein phosphorylation Source: MGI
- regulation of axonogenesis Source: GO_Central
- regulation of cytoskeleton organization Source: ARUK-UCL
- regulation of growth Source: UniProtKB-KW
- regulation of MAPK cascade Source: GO_Central
- signal transduction Source: ProtInc
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- vascular endothelial growth factor receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Growth regulation, Host-virus interaction |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13177 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-202433, Generation of second messenger molecules R-HSA-211728, Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211736, Stimulation of the cell death response by PAK-2p34 R-HSA-2871796, FCERI mediated MAPK activation R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-3928664, Ephrin signaling R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-428540, Activation of RAC1 R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5627123, RHO GTPases activate PAKs R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013420, RHOU GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9013424, RHOV GTPase cycle |
SignaLinki | Q13177 |
SIGNORi | Q13177 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PAK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8591, PAK2 |
MIMi | 605022, gene |
neXtProti | NX_Q13177 |
VEuPathDBi | HostDB:ENSG00000180370 |
Subcellular locationi
Cytoplasm and Cytosol
Note: MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
Nucleus
Other locations
Note: Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
Cytosol
- cytosol Source: CAFA
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell-cell junction Source: ARUK-UCL
- cytoplasm Source: BHF-UCL
- glutamatergic synapse Source: Ensembl
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- postsynaptic density Source: Ensembl
- secretory granule Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 212 | D → N: Inhibits caspase-mediated cleavage. 1 Publication | 1 | |
Mutagenesisi | 213 | G → A: Abolishes myristoylation of PAK-2p34 and membrane location. | 1 | |
Mutagenesisi | 239 – 243 | IVSIG → REGRS: Abolishes nuclear export. 1 Publication | 5 | |
Mutagenesisi | 246 – 248 | KKK → MHE: Greatly inhibits nuclear localization. 1 Publication | 3 | |
Mutagenesisi | 278 | K → R: Abolishes kinase activity and autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 402 | T → A: Abolishes kinase activity and greatly inhibits autophosphorylation of PAK-2p27 and PAK-2p34. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5062 |
OpenTargetsi | ENSG00000180370 |
PharmGKBi | PA32918 |
Miscellaneous databases
Pharosi | Q13177, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4487 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q13177 |
GuidetoPHARMACOLOGYi | 2134 |
Genetic variation databases
BioMutai | PAK2 |
DMDMi | 143811432 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086465 | 2 – 524 | Serine/threonine-protein kinase PAK 2Add BLAST | 523 | |
ChainiPRO_0000304922 | 2 – 212 | PAK-2p27Add BLAST | 211 | |
ChainiPRO_0000304923 | 213 – 524 | PAK-2p34Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Modified residuei | 55 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 62 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 64 | PhosphoserineCombined sources | 1 | |
Modified residuei | 128 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 134 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 139 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 141 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 152 | PhosphoserineBy similarity | 1 | |
Modified residuei | 154 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 169 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Lipidationi | 213 | N-myristoyl glycine; in form PAK-2p341 Publication | 1 | |
Modified residuei | 402 | Phosphothreonine; by autocatalysisCurated | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 212 – 213 | Cleavage; by caspase-3 or caspase-3-like proteases2 Publications | 2 |
Keywords - PTMi
Acetylation, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1628 CPTAC-1726 |
EPDi | Q13177 |
jPOSTi | Q13177 |
MassIVEi | Q13177 |
MaxQBi | Q13177 |
PaxDbi | Q13177 |
PeptideAtlasi | Q13177 |
PRIDEi | Q13177 |
ProteomicsDBi | 59208 |
2D gel databases
OGPi | Q13177 |
PTM databases
GlyGeni | Q13177, 3 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q13177 |
MetOSitei | Q13177 |
PhosphoSitePlusi | Q13177 |
SwissPalmi | Q13177 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000180370, Expressed in corpus callosum and 255 other tissues |
ExpressionAtlasi | Q13177, baseline and differential |
Genevisiblei | Q13177, HS |
Organism-specific databases
HPAi | ENSG00000180370, Low tissue specificity |
Interactioni
Subunit structurei
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1.
Interacts with SH3MD4.
Interacts with SCRIB.
Interacts with ARHGEF7 and GIT1. PAK-2p34 interacts with ARHGAP10 (PubMed:15471851, PubMed:16374509, PubMed:18716323, PubMed:19273597).
Interacts with RAC1 (PubMed:20696164).
5 Publications(Microbial infection) Interacts with and activated by HIV-1 Nef.
1 PublicationBinary interactionsi
Q13177
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein kinase binding Source: BHF-UCL
- small GTPase binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 111098, 137 interactors |
DIPi | DIP-38249N |
ELMi | Q13177 |
IntActi | Q13177, 70 interactors |
MINTi | Q13177 |
STRINGi | 9606.ENSP00000314067 |
Chemistry databases
BindingDBi | Q13177 |
Miscellaneous databases
RNActi | Q13177, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q13177 |
SMRi | Q13177 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13177 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 87 | CRIBPROSITE-ProRule annotationAdd BLAST | 14 | |
Domaini | 249 – 499 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 81 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 69 – 137 | Autoregulatory regionBy similarityAdd BLAST | 69 | |
Regioni | 69 – 112 | GTPase-bindingBy similarityAdd BLAST | 44 | |
Regioni | 143 – 164 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 169 – 188 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 245 – 251 | Nuclear localization signal | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 78 | Basic and acidic residuesSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0578, Eukaryota |
GeneTreei | ENSGT00950000182988 |
HOGENOMi | CLU_000288_26_6_1 |
InParanoidi | Q13177 |
OMAi | IMMMEMA |
OrthoDBi | 757766at2759 |
PhylomeDBi | Q13177 |
TreeFami | TF105351 |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit cd06655, STKc_PAK2, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
IDEALi | IID00244 |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR035065, PAK2 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR035064, STK_PAK2 |
PANTHERi | PTHR45832:SF1, PTHR45832:SF1, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR
60 70 80 90 100
HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE
110 120 130 140 150
QWARLLQTSN ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF
160 170 180 190 200
PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID
210 220 230 240 250
PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT
260 270 280 290 300
RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE
310 320 330 340 350
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR
360 370 380 390 400
ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR
410 420 430 440 450
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR
460 470 480 490 500
ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL
510 520
KLAKPLSSLT PLIMAAKEAM KSNR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C1X3 | H7C1X3_HUMAN | Serine/threonine-protein kinase PAK... | PAK2 | 221 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | A → T in AAA75468 (PubMed:7744004).Curated | 1 | |
Sequence conflicti | 150 | F → L in AAA65442 (Ref. 1) Curated | 1 | |
Sequence conflicti | 225 | T → P in AAA65442 (Ref. 1) Curated | 1 | |
Sequence conflicti | 258 | G → R in AAH69613 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 329 | G → R in AAA75468 (PubMed:7744004).Curated | 1 | |
Sequence conflicti | 338 | T → TA in AAA65442 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24153 mRNA Translation: AAA65442.1 BC069613 mRNA Translation: AAH69613.1 U25975 mRNA Translation: AAA75468.1 |
CCDSi | CCDS3321.1 |
PIRi | S58682 |
RefSeqi | NP_002568.2, NM_002577.4 XP_011511172.1, XM_011512870.2 XP_016861990.1, XM_017006501.1 |
Genome annotation databases
Ensembli | ENST00000327134.7; ENSP00000314067.3; ENSG00000180370.10 |
GeneIDi | 5062 |
KEGGi | hsa:5062 |
MANE-Selecti | ENST00000327134.7; ENSP00000314067.3; NM_002577.4; NP_002568.2 |
UCSCi | uc003fwy.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24153 mRNA Translation: AAA65442.1 BC069613 mRNA Translation: AAH69613.1 U25975 mRNA Translation: AAA75468.1 |
CCDSi | CCDS3321.1 |
PIRi | S58682 |
RefSeqi | NP_002568.2, NM_002577.4 XP_011511172.1, XM_011512870.2 XP_016861990.1, XM_017006501.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PCS | X-ray | 2.86 | E/F/G/H | 121-136 | [»] | |
AlphaFoldDBi | Q13177 | |||||
SMRi | Q13177 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111098, 137 interactors |
DIPi | DIP-38249N |
ELMi | Q13177 |
IntActi | Q13177, 70 interactors |
MINTi | Q13177 |
STRINGi | 9606.ENSP00000314067 |
Chemistry databases
BindingDBi | Q13177 |
ChEMBLi | CHEMBL4487 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q13177 |
GuidetoPHARMACOLOGYi | 2134 |
PTM databases
GlyGeni | Q13177, 3 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q13177 |
MetOSitei | Q13177 |
PhosphoSitePlusi | Q13177 |
SwissPalmi | Q13177 |
Genetic variation databases
BioMutai | PAK2 |
DMDMi | 143811432 |
2D gel databases
OGPi | Q13177 |
Proteomic databases
CPTACi | CPTAC-1628 CPTAC-1726 |
EPDi | Q13177 |
jPOSTi | Q13177 |
MassIVEi | Q13177 |
MaxQBi | Q13177 |
PaxDbi | Q13177 |
PeptideAtlasi | Q13177 |
PRIDEi | Q13177 |
ProteomicsDBi | 59208 |
Protocols and materials databases
Antibodypediai | 3583, 864 antibodies from 43 providers |
DNASUi | 5062 |
Genome annotation databases
Ensembli | ENST00000327134.7; ENSP00000314067.3; ENSG00000180370.10 |
GeneIDi | 5062 |
KEGGi | hsa:5062 |
MANE-Selecti | ENST00000327134.7; ENSP00000314067.3; NM_002577.4; NP_002568.2 |
UCSCi | uc003fwy.4, human |
Organism-specific databases
CTDi | 5062 |
DisGeNETi | 5062 |
GeneCardsi | PAK2 |
HGNCi | HGNC:8591, PAK2 |
HPAi | ENSG00000180370, Low tissue specificity |
MIMi | 605022, gene |
neXtProti | NX_Q13177 |
OpenTargetsi | ENSG00000180370 |
PharmGKBi | PA32918 |
VEuPathDBi | HostDB:ENSG00000180370 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0578, Eukaryota |
GeneTreei | ENSGT00950000182988 |
HOGENOMi | CLU_000288_26_6_1 |
InParanoidi | Q13177 |
OMAi | IMMMEMA |
OrthoDBi | 757766at2759 |
PhylomeDBi | Q13177 |
TreeFami | TF105351 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13177 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-202433, Generation of second messenger molecules R-HSA-211728, Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211736, Stimulation of the cell death response by PAK-2p34 R-HSA-2871796, FCERI mediated MAPK activation R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-3928664, Ephrin signaling R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-428540, Activation of RAC1 R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445355, Smooth Muscle Contraction R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5627123, RHO GTPases activate PAKs R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9013148, CDC42 GTPase cycle R-HSA-9013149, RAC1 GTPase cycle R-HSA-9013404, RAC2 GTPase cycle R-HSA-9013406, RHOQ GTPase cycle R-HSA-9013407, RHOH GTPase cycle R-HSA-9013408, RHOG GTPase cycle R-HSA-9013409, RHOJ GTPase cycle R-HSA-9013420, RHOU GTPase cycle R-HSA-9013423, RAC3 GTPase cycle R-HSA-9013424, RHOV GTPase cycle |
SignaLinki | Q13177 |
SIGNORi | Q13177 |
Miscellaneous databases
BioGRID-ORCSi | 5062, 106 hits in 1117 CRISPR screens |
ChiTaRSi | PAK2, human |
EvolutionaryTracei | Q13177 |
GeneWikii | PAK2 |
GenomeRNAii | 5062 |
Pharosi | Q13177, Tchem |
PROi | PR:Q13177 |
RNActi | Q13177, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180370, Expressed in corpus callosum and 255 other tissues |
ExpressionAtlasi | Q13177, baseline and differential |
Genevisiblei | Q13177, HS |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit cd06655, STKc_PAK2, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
IDEALi | IID00244 |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR035065, PAK2 IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR035064, STK_PAK2 |
PANTHERi | PTHR45832:SF1, PTHR45832:SF1, 1 hit |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAK2_HUMAN | |
Accessioni | Q13177Primary (citable) accession number: Q13177 Secondary accession number(s): Q13154, Q6ISC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 3, 2007 | |
Last modified: | May 25, 2022 | |
This is version 224 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families