Mitogen-activated protein kinase 7

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• MAP kinase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• mitogen-activated protein kinase binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 23043106
• protein serine/threonine kinase activity Source: Reactome

GO - Biological processⁱ

• axon guidance Source: Reactome
• cAMP-mediated signaling Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 16177794
• cell cycle Source: UniProtKB-KW
• cellular response to growth factor stimulus Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 20551324
• cellular response to hydrogen peroxide Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23043106
• cellular response to laminar fluid shear stress Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 23043106
• cellular response to organic substance Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to transforming growth factor beta stimulus Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18588859
• intracellular signal transduction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
• negative regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCLNon-traceable author statementⁱ
  • 16177794
• negative regulation of endothelial cell apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 23043106
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCLInferred from genetic interactionⁱ
  • 20551324
• negative regulation of heterotypic cell-cell adhesion Source: BHF-UCLInferred from genetic interactionⁱ
  • 20551324
• negative regulation of inflammatory response Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 20551324
• negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 23043106
• negative regulation of response to cytokine stimulus Source: BHF-UCLInferred from genetic interactionⁱ
  • 20551324
• peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of protein metabolic process Source: BHF-UCLInferred from genetic interactionⁱ
  • 20551324
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from genetic interactionⁱ
  • 20551324
• positive regulation of transcription from RNA polymerase II promoter in response to stress Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 23043106
• regulation of angiogenesis Source: Ensembl
• regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• signal transduction Source: ProtIncTraceable author statementⁱ
  • 7646528

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• mitogen-activated protein kinase binding Source: BHF-UCLInferred from physical interactionⁱ
  • 23043106

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD 
        60         70         80         90        100
VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL 
       110        120        130        140        150
RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS 
       160        170        180        190        200
SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD 
       210        220        230        240        250
FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC 
       260        270        280        290        300
IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS 
       310        320        330        340        350
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY 
       360        370        380        390        400
HDPDDEPDCA PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR 
       410        420        430        440        450
FQPSLQPVAS EPGCPDVEMP SPWAPSGDCA MESPPPAPPP CPGPAPDTID 
       460        470        480        490        500
LTLQPPPPVS EPAPPKKDGA ISDNTKAALK AALLKSLRSR LRDGPSAPLE 
       510        520        530        540        550
APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER KERGAGASGG 
       560        570        580        590        600
PSTDPLAGLV LSDNDRSLLE RWTRMARPAA PALTSVPAPA PAPTPTPTPV 
       610        620        630        640        650
QPTSPPPGPV AQPTGPQPQS AGSTSGPVPQ PACPPPGPAP HPTGPPGPIP 
       660        670        680        690        700
VPAPPQIATS TSLLAAQSLV PPPGLPGSST PGVLPYFPPG LPPPDAGGAP 
       710        720        730        740        750
QSSMSESPDV NLVTQQLSKS QVEDPLPPVF SGTPKGSGAG YGVGFDLEEF 
       760        770        780        790        800
LNQSFDMGVA DGPQDGQADS ASLSASLLAD WLEGHGMNPA DIESLQREIQ 
       810 
MDSPMLLADL PDLQDP                                      

        10         20         30         40         50
MESDLHQIIH SSQPLTLEHV RYFLYQLLRG LKYMHSAQVI HRDLKPSNLL 
        60         70         80         90        100
VNENCELKIG DFGMARGLCT SPAEHQYFMT EYVATRWYRA PELMLSLHEY 
       110        120        130        140        150
TQAIDLWSVG CIFGEMLARR QLFPGKNYVH QLQLIMMVLG TPSPAVIQAV 
       160        170        180        190        200
GAERVRAYIQ SLPPRQPVPW ETVYPGADRQ ALSLLGRMLR FEPSARISAA 
       210        220        230        240        250
AALRHPFLAK YHDPDDEPDC APPFDFAFDR EALTRERIKE AIVAEIEDFH 
       260        270        280        290        300
ARREGIRQQI RFQPSLQPVA SEPGCPDVEM PSPWAPSGDC AMESPPPAPP 
       310        320        330        340        350
PCPGPAPDTI DLTLQPPPPV SEPAPPKKDG AISDNTKAAL KAALLKSLRS 
       360        370        380        390        400
RLRDGPSAPL EAPEPRKPVT AQERQREREE KRRRRQERAK EREKRRQERE 
       410        420        430        440        450
RKERGAGASG GPSTDPLAGL VLSDNDRSLL ERWTRMARPA APALTSVPAP 
       460        470        480        490        500
APAPTPTPTP VQPTSPPPGP VAQPTGPQPQ SAGSTSGPVP QPACPPPGPA 
       510        520        530        540        550
PHPTGPPGPI PVPAPPQIAT STSLLAAQSL VPPPGLPGSS TPGVLPYFPP 
       560        570        580        590        600
GLPPPDAGGA PQSSMSESPD VNLVTQQLSK SQVEDPLPPV FSGTPKGSGA 
       610        620        630        640        650
GYGVGFDLEE FLNQSFDMGV ADGPQDGQAD SASLSASLLA DWLEGHGMNP 
       660        670 
ADIESLQREI QMDSPMLLAD LPDLQDP                          

        10         20         30         40         50
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD 
        60         70         80         90        100
VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL 
       110        120        130        140        150
RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS 
       160        170        180        190        200
SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD 
       210        220        230        240        250
FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC 
       260        270        280        290        300
IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS 
       310        320        330        340        350
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY 
       360        370        380        390        400
HDPDDEPDCA PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR 
       410        420        430        440        450
FQPSLQPVAS EPGCPDVEMP SPWAPSGDCA MESPPPAPPP CPGPAPDTID 
       460        470        480        490        500
LTLQPPPPVS EPAPPKKDGA ISDNTKAALK AALLKSLRSR LRGALWAGRV 
       510        520        530 
GRGETWTWTR LQAFTFSPAQ LPRKWPQRTP GGS                   

        10         20         30         40         50
MLFFHTMPSA PMGSQGKAVT CLESEGCGED GACPWSVIRP THASLLPSPS 
        60         70         80         90        100
SYVVLDLMES DLHQIIHSSQ PLTLEHVRYF LYQLLRGLKY MHSAQVIHRD 
       110        120        130        140        150
LKPSNLLVNE NCELKIGDFG MARGLCTSPA EHQYFMTEYV ATRWYRAPEL 
       160        170        180        190        200
MLSLHEYTQA IDLWSVGCIF GEMLARRQLF PGKNYVHQLQ LIMMVLGTPS 
       210        220        230        240        250
PAVIQAVGAE RVRAYIQSLP PRQPVPWETV YPGADRQALS LLGRMLRFEP 
       260        270        280        290        300
SARISAAAAL RHPFLAKYHD PDDEPDCAPP FDFAFDREAL TRERIKEAIV 
       310        320        330        340        350
AEIEDFHARR EGIRQQIRFQ PSLQPVASEP GCPDVEMPSP WAPSGDCAME 
       360        370        380        390        400
SPPPAPPPCP GPAPDTIDLT LQPPPPVSEP APPKKDGAIS DNTKAALKAA 
       410        420        430        440        450
LLKSLRSRLR GALWAGRVGR GETWTWTRLQ AFTFSPAQLP RKWPQRTPGG 

S                                                      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
6. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
7. Human and mouse protein kinases
   Human and mouse protein kinases: classification and index