UniProtKB - Q13164 (MK07_HUMAN)
Mitogen-activated protein kinase 7
MAPK7
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 84 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 182 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 61 – 69 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase activity Source: GO_Central
- mitogen-activated protein kinase binding Source: BHF-UCL
GO - Biological processi
- axon guidance Source: Reactome
- cAMP-mediated signaling Source: BHF-UCL
- cell cycle Source: UniProtKB-KW
- cellular response to growth factor stimulus Source: BHF-UCL
- cellular response to hydrogen peroxide Source: BHF-UCL
- cellular response to laminar fluid shear stress Source: BHF-UCL
- cellular response to transforming growth factor beta stimulus Source: UniProtKB
- intracellular signal transduction Source: GO_Central
- negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- negative regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
- negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- negative regulation of inflammatory response Source: BHF-UCL
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of response to cytokine stimulus Source: BHF-UCL
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of protein metabolic process Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter in response to stress Source: BHF-UCL
- regulation of angiogenesis Source: Ensembl
- regulation of gene expression Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Differentiation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | Q13164 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-198765, Signalling to ERK5 R-HSA-202670, ERKs are inactivated R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-8853659, RET signaling |
SignaLinki | Q13164 |
SIGNORi | Q13164 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase 7 (EC:2.7.11.24)Short name: MAP kinase 7 Short name: MAPK 7 Alternative name(s): Big MAP kinase 1 Short name: BMK-1 Extracellular signal-regulated kinase 5 Short name: ERK-5 |
Gene namesi | Name:MAPK7 Synonyms:BMK1, ERK5, PRKM7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166484.19 |
HGNCi | HGNC:6880, MAPK7 |
MIMi | 602521, gene |
neXtProti | NX_Q13164 |
Subcellular locationi
Cytosol
- cytosol Source: BHF-UCL
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- PML body Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 219 – 221 | TEY → AEF: Loss activation by MAP2K5. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 5598 |
MalaCardsi | MAPK7 |
OpenTargetsi | ENSG00000166484 |
PharmGKBi | PA30625 |
Miscellaneous databases
Pharosi | Q13164, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5332 |
DrugBanki | DB00945, Acetylsalicylic acid DB12010, Fostamatinib DB01017, Minocycline |
DrugCentrali | Q13164 |
GuidetoPHARMACOLOGYi | 2093 |
Polymorphism and mutation databases
BioMutai | MAPK7 |
DMDMi | 205371766 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000186260 | 2 – 816 | Mitogen-activated protein kinase 7Add BLAST | 815 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 720 | PhosphoserineCombined sources | 1 | |
Modified residuei | 733 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-887 CPTAC-888 |
EPDi | Q13164 |
jPOSTi | Q13164 |
MassIVEi | Q13164 |
MaxQBi | Q13164 |
PaxDbi | Q13164 |
PeptideAtlasi | Q13164 |
PRIDEi | Q13164 |
ProteomicsDBi | 59203 [Q13164-1] 59204 [Q13164-2] 59205 [Q13164-3] 59206 [Q13164-4] |
PTM databases
iPTMneti | Q13164 |
PhosphoSitePlusi | Q13164 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166484, Expressed in subventricular zone (inner) (primate) and 174 other tissues |
ExpressionAtlasi | Q13164, baseline and differential |
Genevisiblei | Q13164, HS |
Organism-specific databases
HPAi | ENSG00000166484, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAP2K5. Forms oligomers (By similarity).
Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity).
Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6.
Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ13164
GO - Molecular functioni
- mitogen-activated protein kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111584, 74 interactors |
IntActi | Q13164, 95 interactors |
MINTi | Q13164 |
STRINGi | 9606.ENSP00000311005 |
Chemistry databases
BindingDBi | Q13164 |
Miscellaneous databases
RNActi | Q13164, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13164 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 347 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 293 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 77 | Required for cytoplasmic targetingBy similarityAdd BLAST | 76 | |
Regioni | 78 – 139 | Required for binding to MAP2K5By similarityAdd BLAST | 62 | |
Regioni | 140 – 406 | Necessary for oligomerizationBy similarityAdd BLAST | 267 | |
Regioni | 407 – 806 | May not be required for kinase activity; required to stimulate MEF2C activityBy similarityAdd BLAST | 400 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 219 – 221 | TXY | 3 | |
Motifi | 505 – 539 | Nuclear localization signalBy similarityAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 338 – 341 | Poly-Ala | 4 | |
Compositional biasi | 403 – 694 | Pro-richAdd BLAST | 292 | |
Compositional biasi | 513 – 543 | Arg-richAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0660, Eukaryota |
GeneTreei | ENSGT00940000160215 |
HOGENOMi | CLU_008789_1_0_1 |
InParanoidi | Q13164 |
OMAi | PSETMRD |
OrthoDBi | 741207at2759 |
PhylomeDBi | Q13164 |
TreeFami | TF105099 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD
60 70 80 90 100
VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL
110 120 130 140 150
RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS
160 170 180 190 200
SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD
210 220 230 240 250
FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC
260 270 280 290 300
IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS
310 320 330 340 350
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY
360 370 380 390 400
HDPDDEPDCA PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR
410 420 430 440 450
FQPSLQPVAS EPGCPDVEMP SPWAPSGDCA MESPPPAPPP CPGPAPDTID
460 470 480 490 500
LTLQPPPPVS EPAPPKKDGA ISDNTKAALK AALLKSLRSR LRDGPSAPLE
510 520 530 540 550
APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER KERGAGASGG
560 570 580 590 600
PSTDPLAGLV LSDNDRSLLE RWTRMARPAA PALTSVPAPA PAPTPTPTPV
610 620 630 640 650
QPTSPPPGPV AQPTGPQPQS AGSTSGPVPQ PACPPPGPAP HPTGPPGPIP
660 670 680 690 700
VPAPPQIATS TSLLAAQSLV PPPGLPGSST PGVLPYFPPG LPPPDAGGAP
710 720 730 740 750
QSSMSESPDV NLVTQQLSKS QVEDPLPPVF SGTPKGSGAG YGVGFDLEEF
760 770 780 790 800
LNQSFDMGVA DGPQDGQADS ASLSASLLAD WLEGHGMNPA DIESLQREIQ
810
MDSPMLLADL PDLQDP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JUK9 | C9JUK9_HUMAN | Mitogen-activated protein kinase | MAPK7 | 241 | Annotation score: | ||
J3KT61 | J3KT61_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 157 | Annotation score: | ||
S4R3I1 | S4R3I1_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 144 | Annotation score: | ||
J3KT50 | J3KT50_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 80 | Annotation score: | ||
I3L0J8 | I3L0J8_HUMAN | Mitogen-activated protein kinase 7 | MAPK7 | 195 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 610 | V → L in AAA81381 (PubMed:7646528).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046225 | 535 | R → H1 Publication | 1 | |
Natural variantiVAR_042257 | 550 | G → A1 PublicationCorresponds to variant dbSNP:rs56388327Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035198 | 1 – 139 | Missing in isoform 2. 1 PublicationAdd BLAST | 139 | |
Alternative sequenceiVSP_035199 | 1 – 133 | MAEPL…EFKSV → MLFFHTMPSAPMGSQGKAVT CLESEGCGEDGACPWSVIRP THASLLPSPSS in isoform 4. 1 PublicationAdd BLAST | 133 | |
Alternative sequenceiVSP_035200 | 493 – 816 | DGPSA…DLQDP → GALWAGRVGRGETWTWTRLQ AFTFSPAQLPRKWPQRTPGG S in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 324 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29725 mRNA Translation: AAA82931.1 U29726 mRNA Translation: AAA82932.1 U29727 Genomic DNA Translation: AAA82933.1 U25278 mRNA Translation: AAA81381.1 Frameshift. AY534741 mRNA Translation: AAS38577.1 AB209611 mRNA Translation: BAD92848.1 Different initiation. CH471212 Genomic DNA Translation: EAW50883.1 CH471212 Genomic DNA Translation: EAW50886.1 BC007404 mRNA Translation: AAH07404.1 BC007992 mRNA Translation: AAH07992.1 BC009963 mRNA Translation: AAH09963.1 BC030134 mRNA Translation: AAH30134.1 |
CCDSi | CCDS11206.1 [Q13164-1] CCDS11207.1 [Q13164-2] |
PIRi | B56708 |
RefSeqi | NP_002740.2, NM_002749.3 [Q13164-1] NP_620601.1, NM_139032.2 [Q13164-2] NP_620602.2, NM_139033.2 [Q13164-1] NP_620603.2, NM_139034.2 [Q13164-1] XP_011522259.1, XM_011523957.2 [Q13164-2] |
Genome annotation databases
Ensembli | ENST00000299612; ENSP00000299612; ENSG00000166484 [Q13164-2] ENST00000308406; ENSP00000311005; ENSG00000166484 [Q13164-1] ENST00000395602; ENSP00000378966; ENSG00000166484 [Q13164-1] ENST00000395604; ENSP00000378968; ENSG00000166484 [Q13164-1] |
GeneIDi | 5598 |
KEGGi | hsa:5598 |
UCSCi | uc002gvn.4, human [Q13164-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29725 mRNA Translation: AAA82931.1 U29726 mRNA Translation: AAA82932.1 U29727 Genomic DNA Translation: AAA82933.1 U25278 mRNA Translation: AAA81381.1 Frameshift. AY534741 mRNA Translation: AAS38577.1 AB209611 mRNA Translation: BAD92848.1 Different initiation. CH471212 Genomic DNA Translation: EAW50883.1 CH471212 Genomic DNA Translation: EAW50886.1 BC007404 mRNA Translation: AAH07404.1 BC007992 mRNA Translation: AAH07992.1 BC009963 mRNA Translation: AAH09963.1 BC030134 mRNA Translation: AAH30134.1 |
CCDSi | CCDS11206.1 [Q13164-1] CCDS11207.1 [Q13164-2] |
PIRi | B56708 |
RefSeqi | NP_002740.2, NM_002749.3 [Q13164-1] NP_620601.1, NM_139032.2 [Q13164-2] NP_620602.2, NM_139033.2 [Q13164-1] NP_620603.2, NM_139034.2 [Q13164-1] XP_011522259.1, XM_011523957.2 [Q13164-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Q8Y | X-ray | 2.00 | B | 215-223 | [»] | |
4B99 | X-ray | 2.80 | A | 1-397 | [»] | |
4IC7 | X-ray | 2.60 | A/D | 1-431 | [»] | |
4IC8 | X-ray | 2.80 | A/B | 1-431 | [»] | |
4ZSG | X-ray | 1.79 | A | 47-393 | [»] | |
4ZSJ | X-ray | 2.48 | A | 50-393 | [»] | |
4ZSL | X-ray | 2.25 | A | 53-393 | [»] | |
5BYY | X-ray | 2.79 | A | 49-394 | [»] | |
5BYZ | X-ray | 1.65 | A | 48-395 | [»] | |
5O7I | X-ray | 2.38 | A | 46-402 | [»] | |
6HKM | X-ray | 2.47 | A | 49-395 | [»] | |
6HKN | X-ray | 2.33 | A | 54-393 | [»] | |
SMRi | Q13164 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111584, 74 interactors |
IntActi | Q13164, 95 interactors |
MINTi | Q13164 |
STRINGi | 9606.ENSP00000311005 |
Chemistry databases
BindingDBi | Q13164 |
ChEMBLi | CHEMBL5332 |
DrugBanki | DB00945, Acetylsalicylic acid DB12010, Fostamatinib DB01017, Minocycline |
DrugCentrali | Q13164 |
GuidetoPHARMACOLOGYi | 2093 |
PTM databases
iPTMneti | Q13164 |
PhosphoSitePlusi | Q13164 |
Polymorphism and mutation databases
BioMutai | MAPK7 |
DMDMi | 205371766 |
Proteomic databases
CPTACi | CPTAC-887 CPTAC-888 |
EPDi | Q13164 |
jPOSTi | Q13164 |
MassIVEi | Q13164 |
MaxQBi | Q13164 |
PaxDbi | Q13164 |
PeptideAtlasi | Q13164 |
PRIDEi | Q13164 |
ProteomicsDBi | 59203 [Q13164-1] 59204 [Q13164-2] 59205 [Q13164-3] 59206 [Q13164-4] |
Protocols and materials databases
Antibodypediai | 4345, 618 antibodies |
DNASUi | 5598 |
Genome annotation databases
Ensembli | ENST00000299612; ENSP00000299612; ENSG00000166484 [Q13164-2] ENST00000308406; ENSP00000311005; ENSG00000166484 [Q13164-1] ENST00000395602; ENSP00000378966; ENSG00000166484 [Q13164-1] ENST00000395604; ENSP00000378968; ENSG00000166484 [Q13164-1] |
GeneIDi | 5598 |
KEGGi | hsa:5598 |
UCSCi | uc002gvn.4, human [Q13164-1] |
Organism-specific databases
CTDi | 5598 |
DisGeNETi | 5598 |
EuPathDBi | HostDB:ENSG00000166484.19 |
GeneCardsi | MAPK7 |
HGNCi | HGNC:6880, MAPK7 |
HPAi | ENSG00000166484, Low tissue specificity |
MalaCardsi | MAPK7 |
MIMi | 602521, gene |
neXtProti | NX_Q13164 |
OpenTargetsi | ENSG00000166484 |
PharmGKBi | PA30625 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0660, Eukaryota |
GeneTreei | ENSGT00940000160215 |
HOGENOMi | CLU_008789_1_0_1 |
InParanoidi | Q13164 |
OMAi | PSETMRD |
OrthoDBi | 741207at2759 |
PhylomeDBi | Q13164 |
TreeFami | TF105099 |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | Q13164 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-198765, Signalling to ERK5 R-HSA-202670, ERKs are inactivated R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-8853659, RET signaling |
SignaLinki | Q13164 |
SIGNORi | Q13164 |
Miscellaneous databases
BioGRID-ORCSi | 5598, 6 hits in 873 CRISPR screens |
ChiTaRSi | MAPK7, human |
GeneWikii | MAPK7 |
GenomeRNAii | 5598 |
Pharosi | Q13164, Tchem |
PROi | PR:Q13164 |
RNActi | Q13164, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166484, Expressed in subventricular zone (inner) (primate) and 174 other tissues |
ExpressionAtlasi | Q13164, baseline and differential |
Genevisiblei | Q13164, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MK07_HUMAN | |
Accessioni | Q13164Primary (citable) accession number: Q13164 Secondary accession number(s): Q16634 Q96G51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 200 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index