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Protein

Mitogen-activated protein kinase 7

Gene

MAPK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Activity regulationi

Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84ATPPROSITE-ProRule annotation1
Active sitei182Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 69ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: GO_Central
  • mitogen-activated protein kinase binding Source: BHF-UCL
  • protein serine/threonine kinase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Differentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24 2681
ReactomeiR-HSA-198753 ERK/MAPK targets
R-HSA-198765 Signalling to ERK5
R-HSA-202670 ERKs are inactivated
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-8853659 RET signaling
SignaLinkiQ13164
SIGNORiQ13164

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 7 (EC:2.7.11.24)
Short name:
MAP kinase 7
Short name:
MAPK 7
Alternative name(s):
Big MAP kinase 1
Short name:
BMK-1
Extracellular signal-regulated kinase 5
Short name:
ERK-5
Gene namesi
Name:MAPK7
Synonyms:BMK1, ERK5, PRKM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000166484.19
HGNCiHGNC:6880 MAPK7
MIMi602521 gene
neXtProtiNX_Q13164

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi219 – 221TEY → AEF: Loss activation by MAP2K5. 1 Publication3

Organism-specific databases

DisGeNETi5598
MalaCardsiMAPK7
OpenTargetsiENSG00000166484
PharmGKBiPA30625

Chemistry databases

ChEMBLiCHEMBL5332
GuidetoPHARMACOLOGYi2093

Polymorphism and mutation databases

BioMutaiMAPK7
DMDMi205371766

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001862602 – 816Mitogen-activated protein kinase 7Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei720PhosphoserineCombined sources1
Modified residuei733PhosphothreonineCombined sources1

Post-translational modificationi

Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13164
MaxQBiQ13164
PaxDbiQ13164
PeptideAtlasiQ13164
PRIDEiQ13164
ProteomicsDBi59203
59204 [Q13164-2]
59205 [Q13164-3]
59206 [Q13164-4]

PTM databases

iPTMnetiQ13164
PhosphoSitePlusiQ13164

Expressioni

Tissue specificityi

Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.1 Publication

Gene expression databases

BgeeiENSG00000166484 Expressed in 157 organ(s), highest expression level in ectocervix
CleanExiHS_MAPK7
ExpressionAtlasiQ13164 baseline and differential
GenevisibleiQ13164 HS

Organism-specific databases

HPAiCAB018561
HPA031031

Interactioni

Subunit structurei

Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6. Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111584, 70 interactors
IntActiQ13164, 36 interactors
MINTiQ13164
STRINGi9606.ENSP00000311005

Chemistry databases

BindingDBiQ13164

Structurei

Secondary structure

1816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13164
SMRiQ13164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 347Protein kinasePROSITE-ProRule annotationAdd BLAST293

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 77Required for cytoplasmic targetingBy similarityAdd BLAST76
Regioni78 – 139Required for binding to MAP2K5By similarityAdd BLAST62
Regioni140 – 406Necessary for oligomerizationBy similarityAdd BLAST267
Regioni407 – 806May not be required for kinase activity; required to stimulate MEF2C activityBy similarityAdd BLAST400

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 221TXY3
Motifi505 – 539Nuclear localization signalBy similarityAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi338 – 341Poly-Ala4
Compositional biasi403 – 694Pro-richAdd BLAST292
Compositional biasi513 – 543Arg-richAdd BLAST31

Domaini

The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
HOVERGENiHBG108137
InParanoidiQ13164
KOiK04464
OMAiDEYKYFM
OrthoDBiEOG091G08QL
PhylomeDBiQ13164
TreeFamiTF105099

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13164-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD
60 70 80 90 100
VGDEYEIIET IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL
110 120 130 140 150
RELKILKHFK HDNIIAIKDI LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS
160 170 180 190 200
SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV NENCELKIGD
210 220 230 240 250
FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC
260 270 280 290 300
IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS
310 320 330 340 350
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY
360 370 380 390 400
HDPDDEPDCA PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR
410 420 430 440 450
FQPSLQPVAS EPGCPDVEMP SPWAPSGDCA MESPPPAPPP CPGPAPDTID
460 470 480 490 500
LTLQPPPPVS EPAPPKKDGA ISDNTKAALK AALLKSLRSR LRDGPSAPLE
510 520 530 540 550
APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER KERGAGASGG
560 570 580 590 600
PSTDPLAGLV LSDNDRSLLE RWTRMARPAA PALTSVPAPA PAPTPTPTPV
610 620 630 640 650
QPTSPPPGPV AQPTGPQPQS AGSTSGPVPQ PACPPPGPAP HPTGPPGPIP
660 670 680 690 700
VPAPPQIATS TSLLAAQSLV PPPGLPGSST PGVLPYFPPG LPPPDAGGAP
710 720 730 740 750
QSSMSESPDV NLVTQQLSKS QVEDPLPPVF SGTPKGSGAG YGVGFDLEEF
760 770 780 790 800
LNQSFDMGVA DGPQDGQADS ASLSASLLAD WLEGHGMNPA DIESLQREIQ
810
MDSPMLLADL PDLQDP
Length:816
Mass (Da):88,386
Last modified:September 2, 2008 - v2
Checksum:i27729FE31658CE3B
GO
Isoform 2 (identifier: Q13164-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):73,218
Checksum:iEC01D3784EB8AAB0
GO
Isoform 3 (identifier: Q13164-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-816: DGPSAPLEAP...LADLPDLQDP → GALWAGRVGR...KWPQRTPGGS

Show »
Length:533
Mass (Da):59,328
Checksum:i6E654D7CA1287E32
GO
Isoform 4 (identifier: Q13164-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: MAEPLKEEDG...TVPYGEFKSV → MLFFHTMPSA...HASLLPSPSS
     493-816: DGPSAPLEAP...LADLPDLQDP → GALWAGRVGR...KWPQRTPGGS

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):50,152
Checksum:iE0FAC412C3DE60F9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUK9C9JUK9_HUMAN
Mitogen-activated protein kinase
MAPK7
241Annotation score:
I3L0J8I3L0J8_HUMAN
Mitogen-activated protein kinase 7
MAPK7
195Annotation score:
J3KT61J3KT61_HUMAN
Mitogen-activated protein kinase 7
MAPK7
157Annotation score:
S4R3I1S4R3I1_HUMAN
Mitogen-activated protein kinase 7
MAPK7
144Annotation score:
J3KT50J3KT50_HUMAN
Mitogen-activated protein kinase 7
MAPK7
80Annotation score:

Sequence cautioni

The sequence AAA81381 differs from that shown. Reason: Frameshift at positions 19 and 32.Curated
The sequence BAD92848 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti610V → L in AAA81381 (PubMed:7646528).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046225535R → H1 Publication1
Natural variantiVAR_042257550G → A1 PublicationCorresponds to variant dbSNP:rs56388327Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0351981 – 139Missing in isoform 2. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0351991 – 133MAEPL…EFKSV → MLFFHTMPSAPMGSQGKAVT CLESEGCGEDGACPWSVIRP THASLLPSPSS in isoform 4. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_035200493 – 816DGPSA…DLQDP → GALWAGRVGRGETWTWTRLQ AFTFSPAQLPRKWPQRTPGG S in isoform 3 and isoform 4. 2 PublicationsAdd BLAST324

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29725 mRNA Translation: AAA82931.1
U29726 mRNA Translation: AAA82932.1
U29727 Genomic DNA Translation: AAA82933.1
U25278 mRNA Translation: AAA81381.1 Frameshift.
AY534741 mRNA Translation: AAS38577.1
AB209611 mRNA Translation: BAD92848.1 Different initiation.
CH471212 Genomic DNA Translation: EAW50883.1
CH471212 Genomic DNA Translation: EAW50886.1
BC007404 mRNA Translation: AAH07404.1
BC007992 mRNA Translation: AAH07992.1
BC009963 mRNA Translation: AAH09963.1
BC030134 mRNA Translation: AAH30134.1
CCDSiCCDS11206.1 [Q13164-1]
CCDS11207.1 [Q13164-2]
PIRiB56708
RefSeqiNP_002740.2, NM_002749.3 [Q13164-1]
NP_620601.1, NM_139032.2 [Q13164-2]
NP_620602.2, NM_139033.2 [Q13164-1]
NP_620603.2, NM_139034.2 [Q13164-1]
XP_011522259.1, XM_011523957.2 [Q13164-2]
UniGeneiHs.150136

Genome annotation databases

EnsembliENST00000299612; ENSP00000299612; ENSG00000166484 [Q13164-2]
ENST00000308406; ENSP00000311005; ENSG00000166484 [Q13164-1]
ENST00000395602; ENSP00000378966; ENSG00000166484 [Q13164-1]
ENST00000395604; ENSP00000378968; ENSG00000166484 [Q13164-1]
GeneIDi5598
KEGGihsa:5598
UCSCiuc002gvn.4 human [Q13164-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29725 mRNA Translation: AAA82931.1
U29726 mRNA Translation: AAA82932.1
U29727 Genomic DNA Translation: AAA82933.1
U25278 mRNA Translation: AAA81381.1 Frameshift.
AY534741 mRNA Translation: AAS38577.1
AB209611 mRNA Translation: BAD92848.1 Different initiation.
CH471212 Genomic DNA Translation: EAW50883.1
CH471212 Genomic DNA Translation: EAW50886.1
BC007404 mRNA Translation: AAH07404.1
BC007992 mRNA Translation: AAH07992.1
BC009963 mRNA Translation: AAH09963.1
BC030134 mRNA Translation: AAH30134.1
CCDSiCCDS11206.1 [Q13164-1]
CCDS11207.1 [Q13164-2]
PIRiB56708
RefSeqiNP_002740.2, NM_002749.3 [Q13164-1]
NP_620601.1, NM_139032.2 [Q13164-2]
NP_620602.2, NM_139033.2 [Q13164-1]
NP_620603.2, NM_139034.2 [Q13164-1]
XP_011522259.1, XM_011523957.2 [Q13164-2]
UniGeneiHs.150136

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8YX-ray2.00B215-223[»]
4B99X-ray2.80A1-397[»]
4IC7X-ray2.60A/D1-431[»]
4IC8X-ray2.80A/B1-431[»]
4ZSGX-ray1.79A47-393[»]
4ZSJX-ray2.48A50-393[»]
4ZSLX-ray2.25A53-393[»]
5BYYX-ray2.79A49-394[»]
5BYZX-ray1.65A48-395[»]
5O7IX-ray2.38A46-402[»]
ProteinModelPortaliQ13164
SMRiQ13164
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111584, 70 interactors
IntActiQ13164, 36 interactors
MINTiQ13164
STRINGi9606.ENSP00000311005

Chemistry databases

BindingDBiQ13164
ChEMBLiCHEMBL5332
GuidetoPHARMACOLOGYi2093

PTM databases

iPTMnetiQ13164
PhosphoSitePlusiQ13164

Polymorphism and mutation databases

BioMutaiMAPK7
DMDMi205371766

Proteomic databases

EPDiQ13164
MaxQBiQ13164
PaxDbiQ13164
PeptideAtlasiQ13164
PRIDEiQ13164
ProteomicsDBi59203
59204 [Q13164-2]
59205 [Q13164-3]
59206 [Q13164-4]

Protocols and materials databases

DNASUi5598
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299612; ENSP00000299612; ENSG00000166484 [Q13164-2]
ENST00000308406; ENSP00000311005; ENSG00000166484 [Q13164-1]
ENST00000395602; ENSP00000378966; ENSG00000166484 [Q13164-1]
ENST00000395604; ENSP00000378968; ENSG00000166484 [Q13164-1]
GeneIDi5598
KEGGihsa:5598
UCSCiuc002gvn.4 human [Q13164-1]

Organism-specific databases

CTDi5598
DisGeNETi5598
EuPathDBiHostDB:ENSG00000166484.19
GeneCardsiMAPK7
HGNCiHGNC:6880 MAPK7
HPAiCAB018561
HPA031031
MalaCardsiMAPK7
MIMi602521 gene
neXtProtiNX_Q13164
OpenTargetsiENSG00000166484
PharmGKBiPA30625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
HOVERGENiHBG108137
InParanoidiQ13164
KOiK04464
OMAiDEYKYFM
OrthoDBiEOG091G08QL
PhylomeDBiQ13164
TreeFamiTF105099

Enzyme and pathway databases

BRENDAi2.7.11.24 2681
ReactomeiR-HSA-198753 ERK/MAPK targets
R-HSA-198765 Signalling to ERK5
R-HSA-202670 ERKs are inactivated
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-8853659 RET signaling
SignaLinkiQ13164
SIGNORiQ13164

Miscellaneous databases

ChiTaRSiMAPK7 human
GeneWikiiMAPK7
GenomeRNAii5598
PROiPR:Q13164
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166484 Expressed in 157 organ(s), highest expression level in ectocervix
CleanExiHS_MAPK7
ExpressionAtlasiQ13164 baseline and differential
GenevisibleiQ13164 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMK07_HUMAN
AccessioniPrimary (citable) accession number: Q13164
Secondary accession number(s): Q16634
, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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