MAP2K5

Functionⁱ

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	195	ATP		1
Active siteⁱ	283	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	172 – 180	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 7759517
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to growth factor stimulus
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
cellular response to laminar fluid shear stress
Source: BHF-UCL
Traceable author statementⁱ
- 20551324
ERK5 cascade Source: Ensembl
heart development Source: Ensembl
negative regulation of cell migration involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of chemokine (C-X-C motif) ligand 2 production
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of heterotypic cell-cell adhesion
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of interleukin-8 biosynthetic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of NF-kappaB transcription factor activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of response to cytokine stimulus
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 20551324
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of cell growth Source: Ensembl
positive regulation of epithelial cell proliferation Source: Ensembl
positive regulation of protein metabolic process Source: BHF-UCL
positive regulation of transcription by RNA polymerase II Source: BHF-UCL
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7759517
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-198765 Signalling to ERK5
SignaLinkⁱ	Q13163
SIGNORⁱ	Q13163

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) Short name: MAP kinase kinase 5 Short name: MAPKK 5 Alternative name(s): MAPK/ERK kinase 5 Short name: MEK 5
Gene namesⁱ	Name:MAP2K5 Synonyms:MEK5, MKK5, PRKMK5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137764.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6845 MAP2K5
MIMⁱ	602520 gene
neXtProtⁱ	NX_Q13163

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	195	K → M: Inactivation. 1 Publication	1
Mutagenesisⁱ	311	S → A: Inactivation. 1 Publication	1
Mutagenesisⁱ	315	T → A: Inactivation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5607
Open Targets More...OpenTargetsⁱ	ENSG00000137764
PharmGKBⁱ	PA30590

Chemistry databases

ChEMBLⁱ	CHEMBL4948
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2066

Polymorphism and mutation databases

BioMutaⁱ	MAP2K5
DMDMⁱ	118572669

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086383	1 – 448	Dual specificity mitogen-activated protein kinase kinase 5Add BLAST		448

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	311	PhosphoserineCombined sources1 Publication		1
Modified residueⁱ	315	Phosphothreonine1 Publication		1

Post-translational modificationⁱ

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.By similarity

Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q13163
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13163
PaxDbⁱ	Q13163
PeptideAtlas More...PeptideAtlasⁱ	Q13163
PRIDEⁱ	Q13163
ProteomicsDBⁱ	59199 59200 [Q13163-2] 59201 [Q13163-3] 59202 [Q13163-4]

PTM databases

iPTMnetⁱ	Q13163
PhosphoSitePlusⁱ	Q13163

Expressionⁱ

Tissue specificityⁱ

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000137764 Expressed in 218 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_MAP2K5
ExpressionAtlasⁱ	Q13163 baseline and differential
Genevisibleⁱ	Q13163 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022094 HPA027347 HPA027755

HPAⁱ

CAB022094
HPA027347
HPA027755

Interactionⁱ

Subunit structureⁱ

Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GRB2	P62993	2	EBI-307294,EBI-401755
MAP3K3	Q99759	2	EBI-307294,EBI-307281
MAPK7	Q13164	4	EBI-307294,EBI-1213983

Protein-protein interaction databases

BioGridⁱ	111593, 24 interactors
CORUMⁱ	Q13163
Database of interacting proteins More...DIPⁱ	DIP-27558N
IntActⁱ	Q13163, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q13163
STRINGⁱ	9606.ENSP00000178640

Chemistry databases

BindingDBⁱ

Q13163

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	17 – 23	Combined sources	7
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	27 – 33	Combined sources	7
Helixⁱ	41 – 51	Combined sources	11
Beta strandⁱ	58 – 63	Combined sources	6
Beta strandⁱ	65 – 67	Combined sources	3
Beta strandⁱ	69 – 72	Combined sources	4
Helixⁱ	75 – 93	Combined sources	19
Turnⁱ	94 – 96	Combined sources	3
Beta strandⁱ	102 – 107	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13163
SMRⁱ	Q13163
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13163

EvolutionaryTraceⁱ

Q13163

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 109	PB1PROSITE-ProRule annotationAdd BLAST		92
Domainⁱ	166 – 409	Protein kinasePROSITE-ProRule annotationAdd BLAST		244

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	18 – 25	Interaction with MAPK7By similarity	8
Regionⁱ	64 – 68	Interaction with MAP3K2/MAP3K3By similarity	5
Regionⁱ	117 – 131	Interaction with MAPK7By similarityAdd BLAST	15

Domainⁱ

Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	Q13163
KEGG Orthology (KO) More...KOⁱ	K04463
OMAⁱ	EDLMGHP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06I7
PhylomeDBⁱ	Q13163
TreeFamⁱ	TF106468

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06395 PB1_Map2k5, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000270 PB1_dom IPR034851 PB1_MAP2K5 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00564 PB1, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00666 PB1, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51745 PB1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform B (identifier: Q13163-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ 
        60         70         80         90        100
VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE 
       110        120        130        140        150
PLQIFPRACK PPGERNIHGL KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA 
       160        170        180        190        200
ELKKILANGQ MNEQDIRYRD TLGHGNGGTV YKAYHVPSGK ILAVKVILLD 
       210        220        230        240        250
ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD 
       260        270        280        290        300
VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 
       310        320        330        340        350
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA 
       360        370        380        390        400
LGRFPYPQIQ KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM 
       410        420        430        440 
RKQPKERPAP EELMGHPFIV QFNDGNAAVV SMWVCRALEE RRSQQGPP

Length:448

Mass (Da):50,112

Last modified:November 28, 2006 - v2

Checksum:ⁱF23BB327E2A9C7DC

GO

Isoform A (identifier: Q13163-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
349-358: Missing.

« Hide

        10         20         30         40         50
MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ 
        60         70         80         90        100
VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE 
       110        120        130        140        150
PLQIFPRACK PPGERNIHGL KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA 
       160        170        180        190        200
ELKKILANGQ MNEQDIRYRD TLGHGNGGTV YKAYHVPSGK ILAVKVILLD 
       210        220        230        240        250
ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD 
       260        270        280        290        300
VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 
       310        320        330        340        350
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMEIQ 
       360        370        380        390        400
KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP 
       410        420        430 
EELMGHPFIV QFNDGNAAVV SMWVCRALEE RRSQQGPP

Show »

Length:438

Mass (Da):48,968

Checksum:ⁱ21246312F1640EE2

GO

Isoform C (identifier: Q13163-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
349-358: Missing.
444-448: QQGPP → LASLPSPSPSV

« Hide

        10         20         30         40         50
MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ 
        60         70         80         90        100
VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE 
       110        120        130        140        150
PLQIFPRACK PPGERNIHGL KVNTRAGPSQ HSSPAVSDSL PSNSLKKSSA 
       160        170        180        190        200
ELKKILANGQ MNEQDIRYRD TLGHGNGGTV YKAYHVPSGK ILAVKVILLD 
       210        220        230        240        250
ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC TEFMDGGSLD 
       260        270        280        290        300
VYRKMPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 
       310        320        330        340        350
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMEIQ 
       360        370        380        390        400
KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP 
       410        420        430        440 
EELMGHPFIV QFNDGNAAVV SMWVCRALEE RRSLASLPSP SPSV

Note: Incomplete sequence.

Show »

Length:444

Mass (Da):49,497

Checksum:ⁱ574D15B06FD49134

GO

Isoform 4 (identifier: Q13163-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-45: MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVL → MMEGHFPQS

« Hide

        10         20         30         40         50
MMEGHFPQSD VIGQVLPEAT TTAFEYEDED GDRITVRSDE EMKAMLSYYY 
        60         70         80         90        100
STVMEQQVNG QLIEPLQIFP RACKPPGERN IHGLKVNTRA GPSQHSSPAV 
       110        120        130        140        150
SDSLPSNSLK KSSAELKKIL ANGQMNEQDI RYRDTLGHGN GGTVYKAYHV 
       160        170        180        190        200
PSGKILAVKV ILLDITLELQ KQIMSELEIL YKCDSSYIIG FYGAFFVENR 
       210        220        230        240        250
ISICTEFMDG GSLDVYRKMP EHVLGRIAVA VVKGLTYLWS LKILHRDVKP 
       260        270        280        290        300
SNMLVNTRGQ VKLCDFGVST QLVNSIAKTY VGTNAYMAPE RISGEQYGIH 
       310        320        330        340        350
SDVWSLGISF MELALGRFPY PQIQKNQGSL MPLQLLQCIV DEDSPVLPVG 
       360        370        380        390        400
EFSEPFVHFI TQCMRKQPKE RPAPEELMGH PFIVQFNDGN AAVVSMWVCR 
       410 
ALEERRSQQG PP

Note: No experimental confirmation available.

Show »

Length:412

Mass (Da):46,131

Checksum:ⁱ7B00956329FCAEDB

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6NK28	A6NK28_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 5	MAP2K5	258	Annotation score:
H7BZL1	H7BZL1_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 5	MAP2K5	128	Annotation score:
A0A087WWX7	A0A087WWX7_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 5	MAP2K5	182	Annotation score:
A0A087X0Z8	A0A087X0Z8_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 5	MAP2K5	49	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040823	118	H → R1 PublicationCorresponds to variant dbSNP:rs56241934Ensembl.	1
Natural variantⁱVAR_040824	427	A → V1 PublicationCorresponds to variant dbSNP:rs1226964455Ensembl.	1
Natural variantⁱVAR_046070	428	A → T1 PublicationCorresponds to variant dbSNP:rs55811347Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043333	1 – 45	MLWLA…FRDVL → MMEGHFPQS in isoform 4. 1 PublicationAdd BLAST	45
Alternative sequenceⁱVSP_021825	349 – 358	Missing in isoform A and isoform C. 2 Publications	10
Alternative sequenceⁱVSP_021826	444 – 448	QQGPP → LASLPSPSPSV in isoform C. 1 Publication	5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25265 mRNA Translation: AAA96146.1 U71087 mRNA Translation: AAB16851.1 U71088 mRNA Translation: AAB16852.2 BT006780 mRNA Translation: AAP35426.1 AK293459 mRNA Translation: BAG56954.1 CR542229 mRNA Translation: CAG47025.1 AC009292 Genomic DNA No translation available. AC016355 Genomic DNA No translation available. AC103753 Genomic DNA No translation available. BC008838 mRNA Translation: AAH08838.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10224.1 [Q13163-1] CCDS42051.1 [Q13163-2] CCDS55970.1 [Q13163-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001193733.1, NM_001206804.1 [Q13163-4] NP_002748.1, NM_002757.3 [Q13163-2] NP_660143.1, NM_145160.2 [Q13163-1]
UniGeneⁱ	Hs.114198

Genome annotation databases

Ensemblⁱ	ENST00000178640; ENSP00000178640; ENSG00000137764 [Q13163-1] ENST00000354498; ENSP00000346493; ENSG00000137764 [Q13163-4] ENST00000395476; ENSP00000378859; ENSG00000137764 [Q13163-2]
GeneIDⁱ	5607
KEGGⁱ	hsa:5607
UCSC genome browser More...UCSCⁱ	uc002aqu.4 human [Q13163-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q13163	Mitogen-activated protein kinase kinase 5, isoform CRA_a		HUMAN		448	UniRef100_Q13163
MAP2K5 isoform 1		PANTR		448
Dual specificity mitogen-activated protein kinase kinase 5		MACFA		448
Uncharacterized protein		PONAB		448
Uncharacterized protein		PANPA		448
+6
Q13163-2	Mitogen-activated protein kinase kinase 5, isoform CRA_b		HUMAN		438	UniRef100_A0A024R5X5
MAP2K5 isoform 2		PANTR		438
Uncharacterized protein		PANPA		438
Mitogen-activated protein kinase kinase 5		GORGO		438
Uncharacterized protein		MACFA		438
Q13163-4	MAP2K5 isoform 4		PANTR		412	UniRef100_A0A2J8NR05

Protein	Similar proteins		Species	Score	Length	Source
Q13163	Dual specificity mitogen-activated protein kinase kinase 5		RAT		448	UniRef90_Q62862
Mitogen-activated protein kinase kinase 5, isoform CRA_a		HUMAN		448
MAP2K5 isoform 1		PANTR		448
Dual specificity mitogen-activated protein kinase kinase 5		MACFA		448
Uncharacterized protein		PONAB		448
+176
Q13163-4	Uncharacterized protein		MACMU		405	UniRef90_F7GJI0
MAP2K5 isoform 4		PONAB		460
MAP2K5 isoform 4		PANTR		412
dual specificity mitogen-activated protein kinase kinase 5 isoform X4		TURTR		409
UPI000717C460		HORSE		506
+21

Protein	Similar proteins		Species	Score	Length	Source
Q13163	Dual specificity mitogen-activated protein kinase kinase 5		RAT		448	UniRef50_Q62862
Dual specificity mitogen-activated protein kinase kinase 5	)	MOUSE		448
dual specificity mitogen-activated protein kinase kinase 5 isoform X1		PHYCD		448
Uncharacterized protein		SHEEP		448
Dual specificity mitogen-activated protein kinase kinase 5		wild yak		448
+668

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25265 mRNA Translation: AAA96146.1 U71087 mRNA Translation: AAB16851.1 U71088 mRNA Translation: AAB16852.2 BT006780 mRNA Translation: AAP35426.1 AK293459 mRNA Translation: BAG56954.1 CR542229 mRNA Translation: CAG47025.1 AC009292 Genomic DNA No translation available. AC016355 Genomic DNA No translation available. AC103753 Genomic DNA No translation available. BC008838 mRNA Translation: AAH08838.1
CCDSⁱ	CCDS10224.1 [Q13163-1] CCDS42051.1 [Q13163-2] CCDS55970.1 [Q13163-4]
RefSeqⁱ	NP_001193733.1, NM_001206804.1 [Q13163-4] NP_002748.1, NM_002757.3 [Q13163-2] NP_660143.1, NM_145160.2 [Q13163-1]
UniGeneⁱ	Hs.114198

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2NPT	X-ray	1.75	A/C	5-108	[»]
	2O2V	X-ray	1.83	A	5-108	[»]
	4IC7	X-ray	2.60	B/E	16-130	[»]
ProteinModelPortalⁱ	Q13163
SMRⁱ	Q13163
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111593, 24 interactors
CORUMⁱ	Q13163
DIPⁱ	DIP-27558N
IntActⁱ	Q13163, 21 interactors
MINTⁱ	Q13163
STRINGⁱ	9606.ENSP00000178640

Chemistry databases

BindingDBⁱ	Q13163
ChEMBLⁱ	CHEMBL4948
GuidetoPHARMACOLOGYⁱ	2066

PTM databases

iPTMnetⁱ	Q13163
PhosphoSitePlusⁱ	Q13163

Polymorphism and mutation databases

BioMutaⁱ	MAP2K5
DMDMⁱ	118572669

Proteomic databases

EPDⁱ	Q13163
MaxQBⁱ	Q13163
PaxDbⁱ	Q13163
PeptideAtlasⁱ	Q13163
PRIDEⁱ	Q13163
ProteomicsDBⁱ	59199 59200 [Q13163-2] 59201 [Q13163-3] 59202 [Q13163-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5607
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000178640; ENSP00000178640; ENSG00000137764 [Q13163-1] ENST00000354498; ENSP00000346493; ENSG00000137764 [Q13163-4] ENST00000395476; ENSP00000378859; ENSG00000137764 [Q13163-2]
GeneIDⁱ	5607
KEGGⁱ	hsa:5607
UCSCⁱ	uc002aqu.4 human [Q13163-1]

Organism-specific databases

CTDⁱ	5607
DisGeNETⁱ	5607
EuPathDBⁱ	HostDB:ENSG00000137764.19
GeneCardsⁱ	MAP2K5
HGNCⁱ	HGNC:6845 MAP2K5
HPAⁱ	CAB022094 HPA027347 HPA027755
MIMⁱ	602520 gene
neXtProtⁱ	NX_Q13163
OpenTargetsⁱ	ENSG00000137764
PharmGKBⁱ	PA30590
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	Q13163
KOⁱ	K04463
OMAⁱ	EDLMGHP
OrthoDBⁱ	EOG091G06I7
PhylomeDBⁱ	Q13163
TreeFamⁱ	TF106468

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-198765 Signalling to ERK5
SignaLinkⁱ	Q13163
SIGNORⁱ	Q13163

Miscellaneous databases

ChiTaRSⁱ	MAP2K5 human
EvolutionaryTraceⁱ	Q13163
GeneWikiⁱ	MAP2K5
GenomeRNAiⁱ	5607
Protein Ontology More...PROⁱ	PR:Q13163
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137764 Expressed in 218 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_MAP2K5
ExpressionAtlasⁱ	Q13163 baseline and differential
Genevisibleⁱ	Q13163 HS

Family and domain databases

CDDⁱ	cd06395 PB1_Map2k5, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000270 PB1_dom IPR034851 PB1_MAP2K5 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00564 PB1, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00666 PB1, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51745 PB1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MP2K5_HUMAN
Accessionⁱ	Q13163Primary (citable) accession number: Q13163 Secondary accession number(s): B4DE43, Q92961, Q92962
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 28, 2006
	Last modified:	November 7, 2018
	This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q13163 (MP2K5_HUMAN)

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Dual specificity mitogen-activated protein kinase kinase 5

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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Family & Domainsⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ