PRDX4

Functionⁱ

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.1 Publication

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.1 Publication

Catalytic activityⁱ

2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	124	Cysteine sulfenic acid (-SOH) intermediate2 Publications		1

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
thioredoxin peroxidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

4-hydroxyproline metabolic process Source: Ensembl
cell redox homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extracellular matrix organization Source: Ensembl
hydrogen peroxide catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
I-kappaB phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 9388242
male gonad development Source: Ensembl
negative regulation of male germ cell proliferation Source: Ensembl
neutrophil degranulation Source: Reactome
protein maturation by protein folding Source: Ensembl
response to oxidative stress
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antioxidant, Oxidoreductase, Peroxidase

Molecular function

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BRENDAⁱ	1.11.1.15 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

PeroxiBaseⁱ	4530 Hs2CysPrx04

PeroxiBaseⁱ

4530 Hs2CysPrx04

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxiredoxin-4 (EC:1.11.1.152 Publications) Alternative name(s): Antioxidant enzyme AOE372 Short name: AOE37-2 Peroxiredoxin IV Short name: Prx-IV Thioredoxin peroxidase AO372 Thioredoxin-dependent peroxide reductase A0372
Gene namesⁱ	Name:PRDX4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123131.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17169 PRDX4
MIMⁱ	300927 gene
neXtProtⁱ	NX_Q13162

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10549
Open Targets More...OpenTargetsⁱ	ENSG00000123131
PharmGKBⁱ	PA33725

Polymorphism and mutation databases

BioMutaⁱ	PRDX4
DMDMⁱ	3024727

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 37	Combined sources1 PublicationAdd BLAST		37
ChainⁱPRO_0000135098	38 – 271	Peroxiredoxin-4Add BLAST		234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	124	Interchain (with C-245); in linked formCombined sources1 Publication
Disulfide bondⁱ	245	Interchain (with C-124); in linked formCombined sources1 Publication

Post-translational modificationⁱ

The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.2 Publications

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q13162
PaxDbⁱ	Q13162
PeptideAtlas More...PeptideAtlasⁱ	Q13162
PRIDEⁱ	Q13162
ProteomicsDBⁱ	59198
TopDownProteomicsⁱ	Q13162

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q13162
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00011937
UCD-2DPAGEⁱ	Q13162

PTM databases

iPTMnetⁱ	Q13162
PhosphoSitePlusⁱ	Q13162
SwissPalmⁱ	Q13162

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000123131 Expressed in 232 organ(s), highest expression level in duodenum
CleanExⁱ	HS_PRDX4
ExpressionAtlasⁱ	Q13162 baseline and differential
Genevisibleⁱ	Q13162 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB008659 CAB027389 CAB047362

HPAⁱ

CAB008659
CAB027389
CAB047362

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked, upon oxidation (PubMed:9388242). 5 homodimers assemble to form a ring-like decamer (PubMed:21994946). Can form heterodimers with PRDX1 (PubMed:9388242).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
LBP	P18428	4	EBI-2211957,EBI-3927059
P4HB	P07237	2	EBI-2211957,EBI-395883
PDIA3	P30101	2	EBI-2211957,EBI-979862
PDIA6	Q15084	2	EBI-2211957,EBI-1043087
TBXA2R	P21731	3	EBI-2211957,EBI-2625082
TXNDC5	Q8NBS9	2	EBI-2211957,EBI-2510815

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115800, 63 interactors
IntActⁱ	Q13162, 52 interactors
Molecular INTeraction database More...MINTⁱ	Q13162
STRINGⁱ	9606.ENSP00000368646

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	75 – 78	Combined sources	4
Beta strandⁱ	89 – 94	Combined sources	6
Beta strandⁱ	97 – 102	Combined sources	6
Helixⁱ	103 – 106	Combined sources	4
Beta strandⁱ	109 – 115	Combined sources	7
Helixⁱ	123 – 133	Combined sources	11
Helixⁱ	135 – 139	Combined sources	5
Turnⁱ	140 – 142	Combined sources	3
Beta strandⁱ	143 – 151	Combined sources	9
Helixⁱ	153 – 160	Combined sources	8
Helixⁱ	164 – 166	Combined sources	3
Beta strandⁱ	176 – 178	Combined sources	3
Beta strandⁱ	180 – 182	Combined sources	3
Helixⁱ	183 – 187	Combined sources	5
Turnⁱ	193 – 195	Combined sources	3
Beta strandⁱ	196 – 198	Combined sources	3
Beta strandⁱ	200 – 205	Combined sources	6
Beta strandⁱ	209 – 217	Combined sources	9
Helixⁱ	225 – 241	Combined sources	17
Turnⁱ	260 – 262	Combined sources	3
Helixⁱ	263 – 267	Combined sources	5
Turnⁱ	268 – 270	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13162
SMRⁱ	Q13162
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q13162

EvolutionaryTraceⁱ

Q13162

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	79 – 237	ThioredoxinPROSITE-ProRule annotationAdd BLAST		159

Sequence similaritiesⁱ

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.Curated

Keywords - Domainⁱ

Redox-active center, Signal

Phylogenomic databases

eggNOGⁱ	KOG0852 Eukaryota COG0450 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004653
HOGENOMⁱ	HOG000022343
HOVERGENⁱ	HBG000286
InParanoidⁱ	Q13162
KEGG Orthology (KO) More...KOⁱ	K03386
OMAⁱ	GWKPGQD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IE5
PhylomeDBⁱ	Q13162
TreeFamⁱ	TF105181

Family and domain databases

InterProⁱ	View protein in InterPro IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q13162-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEALPLLAAT TPDHGRHRRL LLLPLLLFLL PAGAVQGWET EERPRTREEE 
        60         70         80         90        100
CHFYAGGQVY PGEASRVSVA DHSLHLSKAK ISKPAPYWEG TAVIDGEFKE 
       110        120        130        140        150
LKLTDYRGKY LVFFFYPLDF TFVCPTEIIA FGDRLEEFRS INTEVVACSV 
       160        170        180        190        200
DSQFTHLAWI NTPRRQGGLG PIRIPLLSDL THQISKDYGV YLEDSGHTLR 
       210        220        230        240        250
GLFIIDDKGI LRQITLNDLP VGRSVDETLR LVQAFQYTDK HGEVCPAGWK 
       260        270 
PGSETIIPDP AGKLKYFDKL N

Length:271

Mass (Da):30,540

Last modified:November 1, 1996 - v1

Checksum:ⁱ7E56B580049FC60F

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6NG45	A6NG45_HUMAN	Peroxiredoxin-4 Peroxiredoxin-4	PRDX4	186	Annotation score:
A6NJJ0	A6NJJ0_HUMAN	Peroxiredoxin-4 Peroxiredoxin-4	PRDX4	185	Annotation score:
H7C3T4	H7C3T4_HUMAN	Peroxiredoxin-4 Peroxiredoxin-4	PRDX4	161	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	12	P → S in CAG46469 (PubMed:15489334).Curated		1
Sequence conflictⁱ	51	C → Y in CAG46469 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25182 mRNA Translation: AAB95175.1 CR541668 mRNA Translation: CAG46469.1 CR541705 mRNA Translation: CAG46506.1 BC003609 mRNA Translation: AAH03609.1 BC007107 mRNA Translation: AAH07107.1 BC016770 mRNA Translation: AAH16770.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14206.1
PIRⁱ	G01790
NCBI Reference Sequences More...RefSeqⁱ	NP_006397.1, NM_006406.1
UniGeneⁱ	Hs.83383

Genome annotation databases

Ensemblⁱ	ENST00000379341; ENSP00000368646; ENSG00000123131
GeneIDⁱ	10549
KEGGⁱ	hsa:10549

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13162	Epididymis secretory sperm binding protein Li 97n		HUMAN		271	UniRef100_Q13162
PRDX4 isoform 2		PANTR		271
Uncharacterized protein		PANPA		271

Protein	Similar proteins		Species	Score	Length	Source
Q13162	Epididymis secretory sperm binding protein Li 97n		HUMAN		271	UniRef90_Q13162
PRDX4 isoform 2		PANTR		271
Uncharacterized protein		PANPA		271
peroxiredoxin-4 isoform X1		ODORO		273
Peroxiredoxin-4		MYOBR		272
+47

Protein	Similar proteins		Species	Score	Length	Source
Q13162	Epididymis secretory sperm binding protein Li 97n		HUMAN		271	UniRef50_Q13162
PRDX4 isoform 2		PANTR		271
Uncharacterized protein		PANPA		271
peroxiredoxin-4 isoform X1		ODORO		273
Uncharacterized protein		PIG		272
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25182 mRNA Translation: AAB95175.1 CR541668 mRNA Translation: CAG46469.1 CR541705 mRNA Translation: CAG46506.1 BC003609 mRNA Translation: AAH03609.1 BC007107 mRNA Translation: AAH07107.1 BC016770 mRNA Translation: AAH16770.1
CCDSⁱ	CCDS14206.1
PIRⁱ	G01790
RefSeqⁱ	NP_006397.1, NM_006406.1
UniGeneⁱ	Hs.83383

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2PN8	X-ray	1.80	A/B/C/D/E/F/G/H/I/J	84-271	[»]
	3TJB	X-ray	2.38	A/B/C/D/E	38-271	[»]
	3TJF	X-ray	2.04	A/B/C/D/E	38-271	[»]
	3TJG	X-ray	2.24	A/B/C/D/E	38-271	[»]
	3TJJ	X-ray	1.91	A/B/C/D/E	38-271	[»]
	3TJK	X-ray	2.09	A/B/C/D/E	38-271	[»]
	3TKP	X-ray	2.49	A/B/C/D/E	38-271	[»]
	3TKQ	X-ray	2.22	A/B/C/D/E	38-271	[»]
	3TKR	X-ray	2.10	A/B/C/D/E/F/G/H/I/J	38-271	[»]
	3TKS	X-ray	2.40	A/B/C/D/E	38-271	[»]
	4RQX	X-ray	2.26	A/B/C/D/E	79-271	[»]
	5HQP	X-ray	2.60	A/B	38-271	[»]
ProteinModelPortalⁱ	Q13162
SMRⁱ	Q13162
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115800, 63 interactors
IntActⁱ	Q13162, 52 interactors
MINTⁱ	Q13162
STRINGⁱ	9606.ENSP00000368646

Protein family/group databases

PeroxiBaseⁱ	4530 Hs2CysPrx04

PeroxiBaseⁱ

4530 Hs2CysPrx04

PTM databases

iPTMnetⁱ	Q13162
PhosphoSitePlusⁱ	Q13162
SwissPalmⁱ	Q13162

Polymorphism and mutation databases

BioMutaⁱ	PRDX4
DMDMⁱ	3024727

2D gel databases

OGPⁱ	Q13162
REPRODUCTION-2DPAGEⁱ	IPI00011937
UCD-2DPAGEⁱ	Q13162

Proteomic databases

EPDⁱ	Q13162
PaxDbⁱ	Q13162
PeptideAtlasⁱ	Q13162
PRIDEⁱ	Q13162
ProteomicsDBⁱ	59198
TopDownProteomicsⁱ	Q13162

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10549
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379341; ENSP00000368646; ENSG00000123131
GeneIDⁱ	10549
KEGGⁱ	hsa:10549

Organism-specific databases

CTDⁱ	10549
DisGeNETⁱ	10549
EuPathDBⁱ	HostDB:ENSG00000123131.12
GeneCardsⁱ	PRDX4
HGNCⁱ	HGNC:17169 PRDX4
HPAⁱ	CAB008659 CAB027389 CAB047362
MIMⁱ	300927 gene
neXtProtⁱ	NX_Q13162
OpenTargetsⁱ	ENSG00000123131
PharmGKBⁱ	PA33725
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0852 Eukaryota COG0450 LUCA
GeneTreeⁱ	ENSGT00390000004653
HOGENOMⁱ	HOG000022343
HOVERGENⁱ	HBG000286
InParanoidⁱ	Q13162
KOⁱ	K03386
OMAⁱ	GWKPGQD
OrthoDBⁱ	EOG091G0IE5
PhylomeDBⁱ	Q13162
TreeFamⁱ	TF105181

Enzyme and pathway databases

BRENDAⁱ	1.11.1.15 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	PRDX4 human
EvolutionaryTraceⁱ	Q13162
GeneWikiⁱ	PRDX4
GenomeRNAiⁱ	10549
Protein Ontology More...PROⁱ	PR:Q13162
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123131 Expressed in 232 organ(s), highest expression level in duodenum
CleanExⁱ	HS_PRDX4
ExpressionAtlasⁱ	Q13162 baseline and differential
Genevisibleⁱ	Q13162 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000866 AhpC/TSA IPR024706 Peroxiredoxin_AhpC-typ IPR019479 Peroxiredoxin_C IPR036249 Thioredoxin-like_sf IPR013766 Thioredoxin_domain
Pfamⁱ	View protein in Pfam PF10417 1-cysPrx_C, 1 hit PF00578 AhpC-TSA, 1 hit
PIRSFⁱ	PIRSF000239 AHPC, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51352 THIOREDOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRDX4_HUMAN
Accessionⁱ	Q13162Primary (citable) accession number: Q13162 Secondary accession number(s): Q6FHT3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13162 (PRDX4_HUMAN)

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Peroxiredoxin-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ