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UniProtKB - Q13155 (AIMP2_HUMAN)

Entry version 185 (02 Jun 2021)
Sequence version 2 (11 Jan 2001)
Previous versions | rss
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Protein

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Gene

AIMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329).

Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

2 Publications

Miscellaneous

Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation, Protein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13155

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Alternative name(s):
Multisynthase complex auxiliary component p38
Protein JTV-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIMP2
Synonyms:JTV1
ORF Names:PRO0992
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20609, AIMP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600859, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13155

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106305.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 17 (HLD17)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by atrophy of cerebral cortex, spinal cord and cerebellum, thin corpus callosum, abnormal signals in the basal ganglia, and features suggesting hypo- or demyelination observed on brain imaging. Clinical manifestations include lack of development, absent speech, microcephaly, spasticity, seizures, and contractures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08110835 – 320Missing in HLD17. 1 PublicationAdd BLAST286

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163 – 164EN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication2
Mutagenesisi172 – 173QN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication2
Mutagenesisi215R → A: Nearly abolishes interaction with EPRS1. 1 Publication1
Mutagenesisi238D → R: Nearly abolishes interaction with EPRS1. 1 Publication1

Keywords - Diseasei

Disease variant, Leukodystrophy

Organism-specific databases

DisGeNET

More...DisGeNETi		7965

MalaCards human disease database

More...MalaCardsi		AIMP2
MIMi618006, phenotype

Open Targets

More...OpenTargetsi		ENSG00000106305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165617609

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13155, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523285

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AIMP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211291 – 320Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Add BLAST320

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues in response to UV irradiation.By similarity
Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13155

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13155

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13155

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13155

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13155

PeptideAtlas

More...PeptideAtlasi		Q13155

PRoteomics IDEntifications database

More...PRIDEi		Q13155

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30261
59195

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13155

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q13155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106305, Expressed in oocyte and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13155, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13155, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106305, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:24312579, PubMed:19131329, PubMed:19289464).

Interacts (via N-terminus) with KARS1 (PubMed:9878398, PubMed:15220430, PubMed:18029264, PubMed:23159739, PubMed:26074468).

Interacts with EPRS1 (PubMed:26472928).

Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Binds FUBP1 (via C-terminus).

Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation.

Interacts (via N-terminus) with PRKN/parkin (via first RING-type domain) (PubMed:16135753).

Interacts with TARS3 (PubMed:24312579).

12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q13155
With#Exp.IntAct
AIMP1 [Q12904]4EBI-745226,EBI-1045802
AIMP1 - isoform 2 [Q12904-2]5EBI-745226,EBI-12412735
APP [P05067]3EBI-745226,EBI-77613
BCAS2 [O75934]12EBI-745226,EBI-1050106
BRME1 [Q0VDD7]8EBI-745226,EBI-741210
BYSL [Q13895]5EBI-745226,EBI-358049
C1orf216 [Q8TAB5]3EBI-745226,EBI-747505
CBY2 - isoform 2 [Q8NA61-2]5EBI-745226,EBI-11524851
CCDC153 - isoform 2 [Q494R4-2]3EBI-745226,EBI-11974185
CEP170P1 [Q96L14]5EBI-745226,EBI-743488
DARS1 [P14868]10EBI-745226,EBI-358730
DISC1 - isoform 2 [Q9NRI5-2]3EBI-745226,EBI-11988027
EXOC8 [Q8IYI6]5EBI-745226,EBI-742102
FHL3 [Q13643]13EBI-745226,EBI-741101
FUBP1 [Q96AE4]4EBI-745226,EBI-711404
GYS1 [P13807]3EBI-745226,EBI-740553
KARS1 [Q15046]21EBI-745226,EBI-356367
KARS1 - isoform Cytoplasmic [Q15046-1]2EBI-745226,EBI-21457670
KRT31 [Q15323]3EBI-745226,EBI-948001
KRT33B [Q14525]3EBI-745226,EBI-1049638
KRT34 [O76011]3EBI-745226,EBI-1047093
KRT36 - isoform 2 [O76013-2]3EBI-745226,EBI-11958506
LMO2 [P25791]3EBI-745226,EBI-739696
LMO2 - isoform 3 [P25791-3]6EBI-745226,EBI-11959475
LNX1 [Q8TBB1]8EBI-745226,EBI-739832
MIS18A [Q9NYP9]6EBI-745226,EBI-1104552
NDEL1 [Q9GZM8]3EBI-745226,EBI-928842
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-745226,EBI-10172876
NTAQ1 [Q96HA8]3EBI-745226,EBI-741158
PCMT1 [P22061]3EBI-745226,EBI-353343
PFDN6 [O15212]3EBI-745226,EBI-356973
PLEKHF2 [Q9H8W4]3EBI-745226,EBI-742388
PRKAA2 [P54646]3EBI-745226,EBI-1383852
RABEP1 [Q15276]3EBI-745226,EBI-447043
SBK3 [P0C264]3EBI-745226,EBI-17181801
SLU7 [O95391]3EBI-745226,EBI-750559
SPATA18 [Q8TC71]3EBI-745226,EBI-11334239
TCP11 - isoform 7 [Q8WWU5-7]3EBI-745226,EBI-17721485
TERF2IP [Q9NYB0]2EBI-745226,EBI-750109
TEX12 [Q9BXU0]3EBI-745226,EBI-12090309
TFIP11 [Q9UBB9]6EBI-745226,EBI-1105213
TP53 [P04637]6EBI-745226,EBI-366083
ZGPAT [A0A0S2Z6H0]3EBI-745226,EBI-16428984
ZGPAT [Q8N5A5]3EBI-745226,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]12EBI-745226,EBI-10183064
Matrix protein p17 (PRO_0000038593) from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).3EBI-745226,EBI-6179719

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113684, 225 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13155

Database of interacting proteins

More...DIPi		DIP-34421N

Protein interaction database and analysis system

More...IntActi		Q13155, 99 interactors

Molecular INTeraction database

More...MINTi		Q13155

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000223029

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13155

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13155, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13155

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 317GST C-terminalAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 162Interaction with PRKN1 PublicationAdd BLAST81
Regioni162 – 225Interaction with TP531 PublicationAdd BLAST64

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUNJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_076114_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13155

Identification of Orthologs from Complete Genome Data

More...OMAi		TCMYKLP

Database of Orthologous Groups

More...OrthoDBi		1382507at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13155

TreeFam database of animal gene trees

More...TreeFami		TF326322

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042360, AIMP2
IPR031889, AIMP2_LysRS-bd
IPR041503, AIMP2_thioredoxin
IPR036282, Glutathione-S-Trfase_C_sf
IPR004046, GST_C

The PANTHER Classification System

More...PANTHERi		PTHR13438, PTHR13438, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16780, AIMP2_LysRS_bd, 1 hit
PF00043, GST_C, 1 hit
PF18569, Thioredoxin_16, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47616, SSF47616, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL 
        60         70         80         90        100
SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT 
       110        120        130        140        150
LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS 
       160        170        180        190        200
TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS 
       210        220        230        240        250
IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK 
       260        270        280        290        300
EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ 
       310        320
RWMRSCENLA PFNTALKLLK
Length:320
Mass (Da):35,349
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF253726B63C12BAB
GO
Isoform 2 (identifier: Q13155-2) [UniParc]FASTAAdd to basket
Also known as: DX21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     46-114: Missing.

Show »
Length:251
Mass (Da):27,809
Checksum:i3A3EFC5D28474899
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MU58A8MU58_HUMAN
Aminoacyl tRNA synthase complex-int...
AIMP2
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCL2F8WCL2_HUMAN
Aminoacyl tRNA synthase complex-int...
AIMP2
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50391 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08110835 – 320Missing in HLD17. 1 PublicationAdd BLAST286
Natural variantiVAR_05839292I → V in a lung cancer cell line; reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication1
Natural variantiVAR_05839397 – 99EPT → DLS in a lung cancer cell line; no effect on proapoptotic activity. 3
Natural variantiVAR_025521129A → G1 PublicationCorresponds to variant dbSNP:rs17855441Ensembl.1
Natural variantiVAR_050125166L → I. Corresponds to variant dbSNP:rs34525431EnsemblClinVar.1
Natural variantiVAR_058394209G → S in a lung cancer cell line; no effect on proapoptotic activity. 1 PublicationCorresponds to variant dbSNP:rs982080297Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05991446 – 114Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U24169 mRNA Translation: AAC50391.1 Frameshift.
AC005995 Genomic DNA Translation: AAS00389.1
CH236963 Genomic DNA Translation: EAL23713.1
CH878731 Genomic DNA Translation: EAW55053.1
BC002853 mRNA Translation: AAH02853.1
BC010156 mRNA Translation: AAH10156.1
BC013630 mRNA Translation: AAH13630.1
AF116615 mRNA Translation: AAF71039.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5344.1 [Q13155-1]
CCDS87475.1 [Q13155-2]

NCBI Reference Sequences

More...RefSeqi		NP_001313536.1, NM_001326607.1 [Q13155-2]
NP_006294.2, NM_006303.3 [Q13155-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000223029; ENSP00000223029; ENSG00000106305 [Q13155-1]
ENST00000395236; ENSP00000378658; ENSG00000106305 [Q13155-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7965

UCSC genome browser

More...UCSCi		uc003spo.4, human [Q13155-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24169 mRNA Translation: AAC50391.1 Frameshift.
AC005995 Genomic DNA Translation: AAS00389.1
CH236963 Genomic DNA Translation: EAL23713.1
CH878731 Genomic DNA Translation: EAW55053.1
BC002853 mRNA Translation: AAH02853.1
BC010156 mRNA Translation: AAH10156.1
BC013630 mRNA Translation: AAH13630.1
AF116615 mRNA Translation: AAF71039.1
CCDSiCCDS5344.1 [Q13155-1]
CCDS87475.1 [Q13155-2]
RefSeqiNP_001313536.1, NM_001326607.1 [Q13155-2]
NP_006294.2, NM_006303.3 [Q13155-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DPGX-ray2.84I/J/K/L1-48[»]
4YCUX-ray2.10C1-36[»]
4YCWX-ray2.90C/D/G/H1-36[»]
5A1NX-ray2.10B90-320[»]
5A34X-ray2.60B/D/F/H90-320[»]
5A5HX-ray2.32B/D/F/H90-320[»]
5Y6LX-ray2.90D89-320[»]
6ILDX-ray1.88C1-36[»]
6IY6X-ray3.60C/D/I/J115-320[»]
6JPVX-ray2.15A/B24-32[»]
6K39X-ray1.40A/B25-32[»]
SMRiQ13155
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113684, 225 interactors
CORUMiQ13155
DIPiDIP-34421N
IntActiQ13155, 99 interactors
MINTiQ13155
STRINGi9606.ENSP00000223029

Chemistry databases

BindingDBiQ13155
ChEMBLiCHEMBL4523285

PTM databases

iPTMnetiQ13155
PhosphoSitePlusiQ13155
SwissPalmiQ13155

Genetic variation databases

BioMutaiAIMP2

Proteomic databases

EPDiQ13155
jPOSTiQ13155
MassIVEiQ13155
MaxQBiQ13155
PaxDbiQ13155
PeptideAtlasiQ13155
PRIDEiQ13155
ProteomicsDBi30261
59195

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q13155, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11563, 204 antibodies

The DNASU plasmid repository

More...DNASUi		7965

Genome annotation databases

EnsembliENST00000223029; ENSP00000223029; ENSG00000106305 [Q13155-1]
ENST00000395236; ENSP00000378658; ENSG00000106305 [Q13155-2]
GeneIDi7965
KEGGihsa:7965
UCSCiuc003spo.4, human [Q13155-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7965
DisGeNETi7965

GeneCards: human genes, protein and diseases

More...GeneCardsi		AIMP2
HGNCiHGNC:20609, AIMP2
HPAiENSG00000106305, Tissue enhanced (skeletal)
MalaCardsiAIMP2
MIMi600859, gene
618006, phenotype
neXtProtiNX_Q13155
OpenTargetsiENSG00000106305
PharmGKBiPA165617609
VEuPathDBiHostDB:ENSG00000106305.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUNJ, Eukaryota
GeneTreeiENSGT00390000015826
HOGENOMiCLU_076114_0_0_1
InParanoidiQ13155
OMAiTCMYKLP
OrthoDBi1382507at2759
PhylomeDBiQ13155
TreeFamiTF326322

Enzyme and pathway databases

PathwayCommonsiQ13155
ReactomeiR-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7965, 10 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AIMP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Multisynthetase_complex_auxiliary_component_p38

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7965
PharosiQ13155, Tbio

Protein Ontology

More...PROi		PR:Q13155
RNActiQ13155, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106305, Expressed in oocyte and 249 other tissues
ExpressionAtlasiQ13155, baseline and differential
GenevisibleiQ13155, HS

Family and domain databases

InterProiView protein in InterPro
IPR042360, AIMP2
IPR031889, AIMP2_LysRS-bd
IPR041503, AIMP2_thioredoxin
IPR036282, Glutathione-S-Trfase_C_sf
IPR004046, GST_C
PANTHERiPTHR13438, PTHR13438, 1 hit
PfamiView protein in Pfam
PF16780, AIMP2_LysRS_bd, 1 hit
PF00043, GST_C, 1 hit
PF18569, Thioredoxin_16, 1 hit
SUPFAMiSSF47616, SSF47616, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIMP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13155
Secondary accession number(s): F8W950
, Q75MR1, Q96CZ5, Q9P1L2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: June 2, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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