UniProtKB - Q13155 (AIMP2_HUMAN)
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
AIMP2
Functioni
Miscellaneous
GO - Molecular functioni
- molecular adaptor activity Source: Ensembl
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of cell population proliferation Source: Ensembl
- positive regulation of aminoacyl-tRNA ligase activity Source: GO_Central
- positive regulation of neuron death Source: Ensembl
- positive regulation of protein ubiquitination Source: Ensembl
- protein-containing complex assembly Source: Ensembl
- tRNA aminoacylation for protein translation Source: Reactome
- type II pneumocyte differentiation Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Apoptosis, Differentiation, Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | Q13155 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
Names & Taxonomyi
Protein namesi | Recommended name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Alternative name(s): Multisynthase complex auxiliary component p38 Protein JTV-1 |
Gene namesi | Name:AIMP2 Synonyms:JTV1 ORF Names:PRO0992 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106305.9 |
HGNCi | HGNC:20609, AIMP2 |
MIMi | 600859, gene |
neXtProti | NX_Q13155 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- aminoacyl-tRNA synthetase multienzyme complex Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Leukodystrophy, hypomyelinating, 17 (HLD17)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081108 | 35 – 320 | Missing in HLD17. 1 PublicationAdd BLAST | 286 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 163 – 164 | EN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication | 2 | |
Mutagenesisi | 172 – 173 | QN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication | 2 | |
Mutagenesisi | 215 | R → A: Nearly abolishes interaction with EPRS1. 1 Publication | 1 | |
Mutagenesisi | 238 | D → R: Nearly abolishes interaction with EPRS1. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, LeukodystrophyOrganism-specific databases
DisGeNETi | 7965 |
MalaCardsi | AIMP2 |
MIMi | 618006, phenotype |
OpenTargetsi | ENSG00000106305 |
PharmGKBi | PA165617609 |
Miscellaneous databases
Pharosi | Q13155, Tbio |
Polymorphism and mutation databases
BioMutai | AIMP2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221129 | 1 – 320 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Add BLAST | 320 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13155 |
jPOSTi | Q13155 |
MassIVEi | Q13155 |
MaxQBi | Q13155 |
PaxDbi | Q13155 |
PeptideAtlasi | Q13155 |
PRIDEi | Q13155 |
ProteomicsDBi | 30261 59195 |
PTM databases
iPTMneti | Q13155 |
PhosphoSitePlusi | Q13155 |
SwissPalmi | Q13155 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106305, Expressed in oocyte and 248 other tissues |
ExpressionAtlasi | Q13155, baseline and differential |
Genevisiblei | Q13155, HS |
Organism-specific databases
HPAi | ENSG00000106305, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:24312579, PubMed:19131329, PubMed:19289464).
Interacts (via N-terminus) with KARS1 (PubMed:9878398, PubMed:15220430, PubMed:18029264, PubMed:23159739, PubMed:26074468).
Interacts with EPRS1 (PubMed:26472928).
Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Binds FUBP1 (via C-terminus).
Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation.
Interacts (via N-terminus) with PRKN/parkin (via first RING-type domain) (PubMed:16135753).
Interacts with TARS3 (PubMed:24312579).
12 PublicationsBinary interactionsi
Hide detailsQ13155
Protein-protein interaction databases
BioGRIDi | 113684, 178 interactors |
CORUMi | Q13155 |
DIPi | DIP-34421N |
IntActi | Q13155, 95 interactors |
MINTi | Q13155 |
STRINGi | 9606.ENSP00000223029 |
Miscellaneous databases
RNActi | Q13155, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13155 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 220 – 317 | GST C-terminalAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 162 | Interaction with PRKN1 PublicationAdd BLAST | 81 | |
Regioni | 162 – 225 | Interaction with TP531 PublicationAdd BLAST | 64 |
Phylogenomic databases
eggNOGi | ENOG502QUNJ, Eukaryota |
GeneTreei | ENSGT00390000015826 |
HOGENOMi | CLU_076114_0_0_1 |
InParanoidi | Q13155 |
OMAi | TCMYKLP |
OrthoDBi | 1382507at2759 |
PhylomeDBi | Q13155 |
TreeFami | TF326322 |
Family and domain databases
InterProi | View protein in InterPro IPR042360, AIMP2 IPR031889, AIMP2_LysRS-bd IPR041503, AIMP2_thioredoxin IPR036282, Glutathione-S-Trfase_C_sf IPR004046, GST_C |
PANTHERi | PTHR13438, PTHR13438, 1 hit |
Pfami | View protein in Pfam PF16780, AIMP2_LysRS_bd, 1 hit PF00043, GST_C, 1 hit PF18569, Thioredoxin_16, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL
60 70 80 90 100
SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT
110 120 130 140 150
LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS
160 170 180 190 200
TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS
210 220 230 240 250
IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK
260 270 280 290 300
EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ
310 320
RWMRSCENLA PFNTALKLLK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MU58 | A8MU58_HUMAN | Aminoacyl tRNA synthase complex-int... | AIMP2 | 242 | Annotation score: | ||
F8WCL2 | F8WCL2_HUMAN | Aminoacyl tRNA synthase complex-int... | AIMP2 | 48 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081108 | 35 – 320 | Missing in HLD17. 1 PublicationAdd BLAST | 286 | |
Natural variantiVAR_058392 | 92 | I → V in a lung cancer cell line; reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication | 1 | |
Natural variantiVAR_058393 | 97 – 99 | EPT → DLS in a lung cancer cell line; no effect on proapoptotic activity. | 3 | |
Natural variantiVAR_025521 | 129 | A → G1 PublicationCorresponds to variant dbSNP:rs17855441Ensembl. | 1 | |
Natural variantiVAR_050125 | 166 | L → I. Corresponds to variant dbSNP:rs34525431EnsemblClinVar. | 1 | |
Natural variantiVAR_058394 | 209 | G → S in a lung cancer cell line; no effect on proapoptotic activity. 1 PublicationCorresponds to variant dbSNP:rs982080297Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059914 | 46 – 114 | Missing in isoform 2. 1 PublicationAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24169 mRNA Translation: AAC50391.1 Frameshift. AC005995 Genomic DNA Translation: AAS00389.1 CH236963 Genomic DNA Translation: EAL23713.1 CH878731 Genomic DNA Translation: EAW55053.1 BC002853 mRNA Translation: AAH02853.1 BC010156 mRNA Translation: AAH10156.1 BC013630 mRNA Translation: AAH13630.1 AF116615 mRNA Translation: AAF71039.1 |
CCDSi | CCDS5344.1 [Q13155-1] CCDS87475.1 [Q13155-2] |
RefSeqi | NP_001313536.1, NM_001326607.1 [Q13155-2] NP_006294.2, NM_006303.3 [Q13155-1] |
Genome annotation databases
Ensembli | ENST00000223029; ENSP00000223029; ENSG00000106305 [Q13155-1] ENST00000395236; ENSP00000378658; ENSG00000106305 [Q13155-2] |
GeneIDi | 7965 |
KEGGi | hsa:7965 |
UCSCi | uc003spo.4, human [Q13155-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24169 mRNA Translation: AAC50391.1 Frameshift. AC005995 Genomic DNA Translation: AAS00389.1 CH236963 Genomic DNA Translation: EAL23713.1 CH878731 Genomic DNA Translation: EAW55053.1 BC002853 mRNA Translation: AAH02853.1 BC010156 mRNA Translation: AAH10156.1 BC013630 mRNA Translation: AAH13630.1 AF116615 mRNA Translation: AAF71039.1 |
CCDSi | CCDS5344.1 [Q13155-1] CCDS87475.1 [Q13155-2] |
RefSeqi | NP_001313536.1, NM_001326607.1 [Q13155-2] NP_006294.2, NM_006303.3 [Q13155-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DPG | X-ray | 2.84 | I/J/K/L | 1-48 | [»] | |
4YCU | X-ray | 2.10 | C | 1-36 | [»] | |
4YCW | X-ray | 2.90 | C/D/G/H | 1-36 | [»] | |
5A1N | X-ray | 2.10 | B | 90-320 | [»] | |
5A34 | X-ray | 2.60 | B/D/F/H | 90-320 | [»] | |
5A5H | X-ray | 2.32 | B/D/F/H | 90-320 | [»] | |
5Y6L | X-ray | 2.90 | D | 89-320 | [»] | |
6ILD | X-ray | 1.88 | C | 1-36 | [»] | |
6IY6 | X-ray | 3.60 | C/D/I/J | 115-320 | [»] | |
6JPV | X-ray | 2.15 | A/B | 24-32 | [»] | |
6K39 | X-ray | 1.40 | A/B | 25-32 | [»] | |
SMRi | Q13155 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113684, 178 interactors |
CORUMi | Q13155 |
DIPi | DIP-34421N |
IntActi | Q13155, 95 interactors |
MINTi | Q13155 |
STRINGi | 9606.ENSP00000223029 |
PTM databases
iPTMneti | Q13155 |
PhosphoSitePlusi | Q13155 |
SwissPalmi | Q13155 |
Polymorphism and mutation databases
BioMutai | AIMP2 |
Proteomic databases
EPDi | Q13155 |
jPOSTi | Q13155 |
MassIVEi | Q13155 |
MaxQBi | Q13155 |
PaxDbi | Q13155 |
PeptideAtlasi | Q13155 |
PRIDEi | Q13155 |
ProteomicsDBi | 30261 59195 |
Protocols and materials databases
ABCDi | Q13155, 1 sequenced antibody |
Antibodypediai | 11563, 198 antibodies |
Genome annotation databases
Ensembli | ENST00000223029; ENSP00000223029; ENSG00000106305 [Q13155-1] ENST00000395236; ENSP00000378658; ENSG00000106305 [Q13155-2] |
GeneIDi | 7965 |
KEGGi | hsa:7965 |
UCSCi | uc003spo.4, human [Q13155-1] |
Organism-specific databases
CTDi | 7965 |
DisGeNETi | 7965 |
EuPathDBi | HostDB:ENSG00000106305.9 |
GeneCardsi | AIMP2 |
HGNCi | HGNC:20609, AIMP2 |
HPAi | ENSG00000106305, Tissue enhanced (skeletal) |
MalaCardsi | AIMP2 |
MIMi | 600859, gene 618006, phenotype |
neXtProti | NX_Q13155 |
OpenTargetsi | ENSG00000106305 |
PharmGKBi | PA165617609 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUNJ, Eukaryota |
GeneTreei | ENSGT00390000015826 |
HOGENOMi | CLU_076114_0_0_1 |
InParanoidi | Q13155 |
OMAi | TCMYKLP |
OrthoDBi | 1382507at2759 |
PhylomeDBi | Q13155 |
TreeFami | TF326322 |
Enzyme and pathway databases
PathwayCommonsi | Q13155 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
Miscellaneous databases
BioGRID-ORCSi | 7965, 8 hits in 851 CRISPR screens |
ChiTaRSi | AIMP2, human |
GeneWikii | Multisynthetase_complex_auxiliary_component_p38 |
GenomeRNAii | 7965 |
Pharosi | Q13155, Tbio |
PROi | PR:Q13155 |
RNActi | Q13155, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106305, Expressed in oocyte and 248 other tissues |
ExpressionAtlasi | Q13155, baseline and differential |
Genevisiblei | Q13155, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042360, AIMP2 IPR031889, AIMP2_LysRS-bd IPR041503, AIMP2_thioredoxin IPR036282, Glutathione-S-Trfase_C_sf IPR004046, GST_C |
PANTHERi | PTHR13438, PTHR13438, 1 hit |
Pfami | View protein in Pfam PF16780, AIMP2_LysRS_bd, 1 hit PF00043, GST_C, 1 hit PF18569, Thioredoxin_16, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AIMP2_HUMAN | |
Accessioni | Q13155Primary (citable) accession number: Q13155 Secondary accession number(s): F8W950 Q9P1L2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 11, 2001 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations