AIMP2

Functionⁱ

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.2 Publications

Miscellaneous

Accumulates in brains affected by autosomal-recessive juvenile parkinsonism, idiopathic Parkinson disease and diffuse Lewy body disease.

GO - Molecular functionⁱ

protein-containing complex scaffold activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
negative regulation of cell proliferation Source: Ensembl
positive regulation of aminoacyl-tRNA ligase activity Source: Ensembl
positive regulation of neuron death Source: Ensembl
positive regulation of protein ubiquitination Source: Ensembl
protein-containing complex assembly Source: Ensembl
tRNA aminoacylation for protein translation Source: Reactome
type II pneumocyte differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Apoptosis, Differentiation, Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2408517 SeMet incorporation into proteins R-HSA-379716 Cytosolic tRNA aminoacylation

Reactomeⁱ

R-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Alternative name(s): Multisynthase complex auxiliary component p38 Protein JTV-1
Gene namesⁱ	Name:AIMP2 Synonyms:JTV1 ORF Names:PRO0992
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106305.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20609 AIMP2
MIMⁱ	600859 gene
neXtProtⁱ	NX_Q13155

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	163 – 164	EN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication	2
Mutagenesisⁱ	172 – 173	QN → AA: Reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication	2
Mutagenesisⁱ	215	R → A: Nearly abolishes interaction with EPRS. 1 Publication	1
Mutagenesisⁱ	238	D → R: Nearly abolishes interaction with EPRS. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7965
Open Targets More...OpenTargetsⁱ	ENSG00000106305
PharmGKBⁱ	PA165617609

Polymorphism and mutation databases

BioMutaⁱ	AIMP2

BioMutaⁱ

AIMP2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000221129	1 – 320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2Add BLAST		320

Post-translational modificationⁱ

Phosphorylated on serine residues in response to UV irradiation.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q13155
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13155
PaxDbⁱ	Q13155
PeptideAtlas More...PeptideAtlasⁱ	Q13155
PRIDEⁱ	Q13155
ProteomicsDBⁱ	59195

PTM databases

iPTMnetⁱ	Q13155
PhosphoSitePlusⁱ	Q13155
SwissPalmⁱ	Q13155

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106305 Expressed in 235 organ(s), highest expression level in oocyte
ExpressionAtlasⁱ	Q13155 baseline and differential
Genevisibleⁱ	Q13155 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019098 HPA020057

HPAⁱ

HPA019098
HPA020057

Interactionⁱ

Subunit structureⁱ

Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464). Interacts (via N-terminus) with KARS (PubMed:9878398, PubMed:15220430, PubMed:18029264, PubMed:23159739, PubMed:26074468). Interacts with EPRS (PubMed:26472928). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928). Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with PRKN/parkin (via first RING-type domain) (PubMed:16135753).11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AIMP1	Q12904	3	EBI-745226,EBI-1045802
AIMP1	Q12904-2	4	EBI-745226,EBI-12412735
BCAS2	O75934	7	EBI-745226,EBI-1050106
BYSL	Q13895	5	EBI-745226,EBI-358049
C19orf57	Q0VDD7	8	EBI-745226,EBI-741210
CEP170P1	Q96L14	7	EBI-745226,EBI-743488
DARS	P14868	11	EBI-745226,EBI-358730
FHL3	Q13643	11	EBI-745226,EBI-741101
FUBP1	Q96AE4	4	EBI-745226,EBI-711404
gag	P04591	3	EBI-745226,EBI-6179719	From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).
GYS1	P13807	3	EBI-745226,EBI-740553
KARS	Q15046	14	EBI-745226,EBI-356367
LMO2	P25791	3	EBI-745226,EBI-739696
LMO2	P25791-3	4	EBI-745226,EBI-11959475
LNX1	Q8TBB1	6	EBI-745226,EBI-739832
MIS18A	Q9NYP9	5	EBI-745226,EBI-1104552
NDEL1	Q9GZM8	3	EBI-745226,EBI-928842
NECAB2	Q7Z6G3-2	3	EBI-745226,EBI-10172876
PCMT1	P22061	3	EBI-745226,EBI-353343
PLEKHF2	Q9H8W4	3	EBI-745226,EBI-742388
PRKAA2	P54646	3	EBI-745226,EBI-1383852
SPATA18	Q8TC71	4	EBI-745226,EBI-11334239
TERF2IP	Q9NYB0	2	EBI-745226,EBI-750109
TFIP11	Q9UBB9	5	EBI-745226,EBI-1105213
TP53	P04637	6	EBI-745226,EBI-366083
ZGPAT	A0A0S2Z6H0	3	EBI-745226,EBI-16428984
ZGPAT	Q8N5A5	3	EBI-745226,EBI-3439227
ZGPAT	Q8N5A5-2	8	EBI-745226,EBI-10183064

GO - Molecular functionⁱ

protein-containing complex scaffold activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113684, 134 interactors
CORUMⁱ	Q13155
Database of interacting proteins More...DIPⁱ	DIP-34421N
IntActⁱ	Q13155, 89 interactors
Molecular INTeraction database More...MINTⁱ	Q13155
STRINGⁱ	9606.ENSP00000223029

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	12 – 14	Combined sources	3
Helixⁱ	108 – 112	Combined sources	5
Helixⁱ	113 – 115	Combined sources	3
Helixⁱ	116 – 119	Combined sources	4
Beta strandⁱ	120 – 126	Combined sources	7
Beta strandⁱ	128 – 130	Combined sources	3
Helixⁱ	133 – 143	Combined sources	11
Beta strandⁱ	148 – 154	Combined sources	7
Helixⁱ	163 – 166	Combined sources	4
Turnⁱ	167 – 169	Combined sources	3
Beta strandⁱ	182 – 189	Combined sources	8
Beta strandⁱ	196 – 198	Combined sources	3
Beta strandⁱ	202 – 204	Combined sources	3
Beta strandⁱ	207 – 209	Combined sources	3
Helixⁱ	210 – 219	Combined sources	10
Helixⁱ	227 – 242	Combined sources	16
Turnⁱ	243 – 246	Combined sources	4
Helixⁱ	249 – 262	Combined sources	14
Turnⁱ	263 – 265	Combined sources	3
Beta strandⁱ	266 – 268	Combined sources	3
Beta strandⁱ	271 – 273	Combined sources	3
Helixⁱ	276 – 286	Combined sources	11
Helixⁱ	297 – 307	Combined sources	11
Helixⁱ	310 – 318	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13155
SMRⁱ	Q13155
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	220 – 317	GST C-terminalAdd BLAST		98

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	82 – 162	Interaction with PRKN1 PublicationAdd BLAST		81
Regionⁱ	162 – 225	Interaction with TP531 PublicationAdd BLAST		64

Phylogenomic databases

eggNOGⁱ	ENOG410II5D Eukaryota ENOG4110B04 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015826
HOGENOMⁱ	HOG000233491
InParanoidⁱ	Q13155
KEGG Orthology (KO) More...KOⁱ	K15438
OMAⁱ	RVELPTC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q05
PhylomeDBⁱ	Q13155
TreeFamⁱ	TF326322

Family and domain databases

InterProⁱ	View protein in InterPro IPR031889 AIMP2_LysRS-bd IPR036282 Glutathione-S-Trfase_C_sf IPR004046 GST_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16780 AIMP2_LysRS_bd, 1 hit PF00043 GST_C, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.ⁱShow all

Q13155-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPMYQVKPYH GGGAPLRVEL PTCMYRLPNV HGRSYGPAPG AGHVQEESNL 
        60         70         80         90        100
SLQALESRQD DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTT 
       110        120        130        140        150
LTTNALDLNS VLGKDYGALK DIVINANPAS PPLSLLVLHR LLCEHFRVLS 
       160        170        180        190        200
TVHTHSSVKS VPENLLKCFG EQNKKQPRQD YQLGFTLIWK NVPKTQMKFS 
       210        220        230        240        250
IQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA IFQLKEGSSK 
       260        270        280        290        300
EKAAVFRSMN SALGKSPWLA GNELTVADVV LWSVLQQIGG CSVTVPANVQ 
       310        320
RWMRSCENLA PFNTALKLLK

Length:320

Mass (Da):35,349

Last modified:January 11, 2001 - v2

Checksum:ⁱF253726B63C12BAB

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A8MU58	A8MU58_HUMAN	Aminoacyl tRNA synthase complex-int... Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	AIMP2	242	Annotation score:
F8W950	F8W950_HUMAN	Aminoacyl tRNA synthase complex-int... Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	AIMP2	251	Annotation score:
F8WCL2	F8WCL2_HUMAN	Aminoacyl tRNA synthase complex-int... Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	AIMP2	48	Annotation score:

Sequence cautionⁱ

The sequence AAC50391 differs from that shown. Reason: Frameshift at position 312.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058392	92	I → V in a lung cancer cell line; reduced interaction with TP53, loss of TP53 activation and loss of proapoptotic activity. 1 Publication	1
Natural variantⁱVAR_058393	97 – 99	EPT → DLS in a lung cancer cell line; no effect on proapoptotic activity.	3
Natural variantⁱVAR_025521	129	A → G1 PublicationCorresponds to variant dbSNP:rs17855441Ensembl.	1
Natural variantⁱVAR_050125	166	L → I. Corresponds to variant dbSNP:rs34525431Ensembl.	1
Natural variantⁱVAR_058394	209	G → S in a lung cancer cell line; no effect on proapoptotic activity. 1 PublicationCorresponds to variant dbSNP:rs982080297Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U24169 mRNA Translation: AAC50391.1 Frameshift. AC005995 Genomic DNA Translation: AAS00389.1 CH236963 Genomic DNA Translation: EAL23713.1 CH878731 Genomic DNA Translation: EAW55053.1 BC002853 mRNA Translation: AAH02853.1 BC010156 mRNA Translation: AAH10156.1 BC013630 mRNA Translation: AAH13630.1 AF116615 mRNA Translation: AAF71039.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5344.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006294.2, NM_006303.3
UniGeneⁱ	Hs.301613

Genome annotation databases

Ensemblⁱ	ENST00000223029; ENSP00000223029; ENSG00000106305
GeneIDⁱ	7965
KEGGⁱ	hsa:7965
UCSC genome browser More...UCSCⁱ	uc003spo.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13155	JTV1 gene, isoform CRA_a		HUMAN		320	UniRef100_Q13155
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2		HUMAN		242

Protein	Similar proteins		Species	Score	Length	Source
Q13155	JTV1 gene, isoform CRA_a		HUMAN		320	UniRef90_Q13155
AIMP2 isoform 1		PANTR		397
Aminoacyl tRNA synthetase complex interacting multifunctional protein 2		RHIBE		320
Uncharacterized protein		NOMLE		320
Aminoacyl tRNA synthetase complex interacting multifunctional protein 2		PONAB		320
+25

Protein	Similar proteins		Species	Score	Length	Source
Q13155	JTV1 gene, isoform CRA_a		HUMAN		320	UniRef50_Q13155
AIMP2 isoform 1		PANTR		397
Aminoacyl tRNA synthetase complex interacting multifunctional protein 2		PONAB		320
Aminoacyl tRNA synthetase complex interacting multifunctional protein 2		MACNE		320
Uncharacterized protein		NOMLE		320
+30

Entry informationⁱ

Entry nameⁱ	AIMP2_HUMAN
Accessionⁱ	Q13155Primary (citable) accession number: Q13155 Secondary accession number(s): Q75MR1, Q96CZ5, Q9P1L2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 11, 2001
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13155 (AIMP2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ