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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

BAMBI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates TGF-beta signaling.

GO - Molecular functioni

  • frizzled binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
SignaLinkiQ13145
SIGNORiQ13145

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Non-metastatic gene A protein
Putative transmembrane protein NMA
Gene namesi
Name:BAMBI
Synonyms:NMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095739.10
HGNCiHGNC:30251 BAMBI
MIMi604444 gene
neXtProtiNX_Q13145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 152ExtracellularSequence analysisAdd BLAST132
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 260CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25805
OpenTargetsiENSG00000095739
PharmGKBiPA134909139

Polymorphism and mutation databases

BioMutaiBAMBI
DMDMi2498645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002077921 – 260BMP and activin membrane-bound inhibitor homologAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13145
PaxDbiQ13145
PeptideAtlasiQ13145
PRIDEiQ13145
ProteomicsDBi59188

PTM databases

iPTMnetiQ13145
PhosphoSitePlusiQ13145

Expressioni

Tissue specificityi

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Developmental stagei

Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

Gene expression databases

BgeeiENSG00000095739 Expressed in 214 organ(s), highest expression level in tibia
CleanExiHS_BAMBI
GenevisibleiQ13145 HS

Organism-specific databases

HPAiHPA010819
HPA010866

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117337, 10 interactors
IntActiQ13145, 5 interactors
MINTiQ13145
STRINGi9606.ENSP00000364683

Structurei

3D structure databases

ProteinModelPortaliQ13145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
HOGENOMiHOG000095174
HOVERGENiHBG050659
InParanoidiQ13145
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
PhylomeDBiQ13145
TreeFamiTF333466

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13145-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,108
Last modified:November 1, 1997 - v1
Checksum:i70C23268838CE8AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23070 mRNA Translation: AAC50435.1
U29189, U29188 Genomic DNA Translation: AAR02414.1
BT006820 mRNA Translation: AAP35466.1
AL161936 Genomic DNA No translation available.
BC019252 mRNA Translation: AAH19252.1
CCDSiCCDS7162.1
RefSeqiNP_036474.1, NM_012342.2
UniGeneiHs.533336

Genome annotation databases

EnsembliENST00000375533; ENSP00000364683; ENSG00000095739
GeneIDi25805
KEGGihsa:25805
UCSCiuc001iuj.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23070 mRNA Translation: AAC50435.1
U29189, U29188 Genomic DNA Translation: AAR02414.1
BT006820 mRNA Translation: AAP35466.1
AL161936 Genomic DNA No translation available.
BC019252 mRNA Translation: AAH19252.1
CCDSiCCDS7162.1
RefSeqiNP_036474.1, NM_012342.2
UniGeneiHs.533336

3D structure databases

ProteinModelPortaliQ13145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117337, 10 interactors
IntActiQ13145, 5 interactors
MINTiQ13145
STRINGi9606.ENSP00000364683

PTM databases

iPTMnetiQ13145
PhosphoSitePlusiQ13145

Polymorphism and mutation databases

BioMutaiBAMBI
DMDMi2498645

Proteomic databases

MaxQBiQ13145
PaxDbiQ13145
PeptideAtlasiQ13145
PRIDEiQ13145
ProteomicsDBi59188

Protocols and materials databases

DNASUi25805
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375533; ENSP00000364683; ENSG00000095739
GeneIDi25805
KEGGihsa:25805
UCSCiuc001iuj.2 human

Organism-specific databases

CTDi25805
DisGeNETi25805
EuPathDBiHostDB:ENSG00000095739.10
GeneCardsiBAMBI
HGNCiHGNC:30251 BAMBI
HPAiHPA010819
HPA010866
MIMi604444 gene
neXtProtiNX_Q13145
OpenTargetsiENSG00000095739
PharmGKBiPA134909139
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
HOGENOMiHOG000095174
HOVERGENiHBG050659
InParanoidiQ13145
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
PhylomeDBiQ13145
TreeFamiTF333466

Enzyme and pathway databases

ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
SignaLinkiQ13145
SIGNORiQ13145

Miscellaneous databases

ChiTaRSiBAMBI human
GeneWikiiBAMBI
GenomeRNAii25805
PROiPR:Q13145
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095739 Expressed in 214 organ(s), highest expression level in tibia
CleanExiHS_BAMBI
GenevisibleiQ13145 HS

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAMBI_HUMAN
AccessioniPrimary (citable) accession number: Q13145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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