Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

EIF2B5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB
  • translation initiation factor activity Source: GO_Central
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-72731 Recycling of eIF2:GDP
SIGNORiQ13144

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene namesi
Name:EIF2B5
Synonyms:EIF2BE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000145191.11
HGNCiHGNC:3261 EIF2B5
MIMi603945 gene
neXtProtiNX_Q13144

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Leukodystrophy with vanishing white matter (VWM)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
See also OMIM:603896
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06845762D → V in VWM. 1 Publication1
Natural variantiVAR_06845868L → S in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994044Ensembl.1
Natural variantiVAR_01232373V → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994045Ensembl.1
Natural variantiVAR_06845974A → T in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994046Ensembl.1
Natural variantiVAR_01229191T → A in VWM. 1 PublicationCorresponds to variant dbSNP:rs28939717EnsemblClinVar.1
Natural variantiVAR_012324106L → F in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994048EnsemblClinVar.1
Natural variantiVAR_068460113R → C in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994050Ensembl.1
Natural variantiVAR_012292113R → H in VWM; with ovarian failure. 3 PublicationsCorresponds to variant dbSNP:rs113994049EnsemblClinVar.1
Natural variantiVAR_016845195R → C in VWM; with ovarian failure. 1 PublicationCorresponds to variant dbSNP:rs113994055EnsemblClinVar.1
Natural variantiVAR_016846195R → H in VWM; Cree leukoencephalopathy type. 1 PublicationCorresponds to variant dbSNP:rs113994054EnsemblClinVar.1
Natural variantiVAR_068461269R → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994058Ensembl.1
Natural variantiVAR_068462269R → Q in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994057Ensembl.1
Natural variantiVAR_068463270D → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs397514646EnsemblClinVar.1
Natural variantiVAR_012325299R → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994060EnsemblClinVar.1
Natural variantiVAR_068464310C → F in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994062Ensembl.1
Natural variantiVAR_068465315R → C in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994063Ensembl.1
Natural variantiVAR_012326315R → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994063Ensembl.1
Natural variantiVAR_012327315R → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994064EnsemblClinVar.1
Natural variantiVAR_068466335C → R in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994067Ensembl.1
Natural variantiVAR_068467335C → S in VWM. 1 Publication1
Natural variantiVAR_012328339R → P in VWM. 2 PublicationsCorresponds to variant dbSNP:rs113994069EnsemblClinVar.1
Natural variantiVAR_012329339R → Q in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994069EnsemblClinVar.1
Natural variantiVAR_012330339R → W in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994068Ensembl.1
Natural variantiVAR_068468376N → D in VWM. 1 Publication1
Natural variantiVAR_012293386G → V in VWM. 2 PublicationsCorresponds to variant dbSNP:rs113994074EnsemblClinVar.1
Natural variantiVAR_012331430V → A in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994079Ensembl.1
Natural variantiVAR_068469447S → L in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994080Ensembl.1
Natural variantiVAR_012294628W → R in VWM. 1 PublicationCorresponds to variant dbSNP:rs28937596EnsemblClinVar.1
Natural variantiVAR_012333650E → K in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994085Ensembl.1

Keywords - Diseasei

Disease mutation, Leukodystrophy

Organism-specific databases

DisGeNETi8893
GeneReviewsiEIF2B5
MalaCardsiEIF2B5
MIMi603896 phenotype
OpenTargetsiENSG00000145191
Orphaneti157713 Congenital or early infantile CACH syndrome
99854 Cree leukoencephalopathy
157719 Juvenile or adult CACH syndrome
157716 Late infantile CACH syndrome
99853 Ovarioleukodystrophy
PharmGKBiPA27692

Polymorphism and mutation databases

BioMutaiEIF2B5
DMDMi160359049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001560732 – 721Translation initiation factor eIF-2B subunit epsilonAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei130PhosphoserineBy similarity1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei322PhosphothreonineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei532PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei544Phosphoserine; by DYRK2Combined sources1
Modified residuei717PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function.By similarity1 Publication
Polyubiquitinated, probably by NEDD4.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13144
MaxQBiQ13144
PaxDbiQ13144
PeptideAtlasiQ13144
PRIDEiQ13144
ProteomicsDBi59187

PTM databases

iPTMnetiQ13144
PhosphoSitePlusiQ13144

Expressioni

Gene expression databases

BgeeiENSG00000145191 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_EIF2B5
ExpressionAtlasiQ13144 baseline and differential
GenevisibleiQ13144 HS

Organism-specific databases

HPAiCAB015412
HPA064370
HPA069303

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498412EBI-4401110,EBI-373586

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114410, 51 interactors
IntActiQ13144, 13 interactors
MINTiQ13144
STRINGi9606.ENSP00000273783

Structurei

Secondary structure

1721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13144
SMRiQ13144
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13144

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini543 – 720W2PROSITE-ProRule annotationAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi505 – 509Poly-Glu5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1461 Eukaryota
COG1208 LUCA
GeneTreeiENSGT00510000047568
HOGENOMiHOG000216610
HOVERGENiHBG051460
InParanoidiQ13144
KOiK03240
OMAiPQMDDIK
OrthoDBiEOG091G065U
PhylomeDBiQ13144
TreeFamiTF101509

Family and domain databases

CDDicd04197 eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD
60 70 80 90 100
SFDRRFFPIS KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA
110 120 130 140 150
QIKEHLLKSK WCRPTSLNVV RIITSELYRS LGDVLRDVDA KALVRSDFLL
160 170 180 190 200
VYGDVISNIN ITRALEEHRL RRKLEKNVSV MTMIFKESSP SHPTRCHEDN
210 220 230 240 250
VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV RYDLLDCHIS
260 270 280 290 300
ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV
310 320 330 340 350
SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL
360 370 380 390 400
GHGSILEENV LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV
410 420 430 440 450
RVAAGAQIHQ SLLCDNAEVK ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS
460 470 480 490 500
LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM KGYNPAEVGA AGKGYLWKAA
510 520 530 540 550
GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS RGGSPQMDDI
560 570 580 590 600
KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV
610 620 630 640 650
LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE
660 670 680 690 700
DFFLEHEALG ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN
710 720
QQLQRFIQWL KEAEEESSED D
Length:721
Mass (Da):80,380
Last modified:October 23, 2007 - v3
Checksum:i08B39D3A5EE7D905
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2X0H7C2X0_HUMAN
Translation initiation factor eIF-2...
EIF2B5
92Annotation score:
C9JRD9C9JRD9_HUMAN
Translation initiation factor eIF-2...
EIF2B5
107Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06845762D → V in VWM. 1 Publication1
Natural variantiVAR_06845868L → S in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994044Ensembl.1
Natural variantiVAR_01232373V → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994045Ensembl.1
Natural variantiVAR_06845974A → T in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994046Ensembl.1
Natural variantiVAR_01229191T → A in VWM. 1 PublicationCorresponds to variant dbSNP:rs28939717EnsemblClinVar.1
Natural variantiVAR_012324106L → F in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994048EnsemblClinVar.1
Natural variantiVAR_068460113R → C in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994050Ensembl.1
Natural variantiVAR_012292113R → H in VWM; with ovarian failure. 3 PublicationsCorresponds to variant dbSNP:rs113994049EnsemblClinVar.1
Natural variantiVAR_016845195R → C in VWM; with ovarian failure. 1 PublicationCorresponds to variant dbSNP:rs113994055EnsemblClinVar.1
Natural variantiVAR_016846195R → H in VWM; Cree leukoencephalopathy type. 1 PublicationCorresponds to variant dbSNP:rs113994054EnsemblClinVar.1
Natural variantiVAR_048919200N → T. Corresponds to variant dbSNP:rs2971409Ensembl.1
Natural variantiVAR_068461269R → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994058Ensembl.1
Natural variantiVAR_068462269R → Q in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994057Ensembl.1
Natural variantiVAR_068463270D → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs397514646EnsemblClinVar.1
Natural variantiVAR_012325299R → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994060EnsemblClinVar.1
Natural variantiVAR_068464310C → F in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994062Ensembl.1
Natural variantiVAR_068465315R → C in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994063Ensembl.1
Natural variantiVAR_012326315R → G in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994063Ensembl.1
Natural variantiVAR_012327315R → H in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994064EnsemblClinVar.1
Natural variantiVAR_068466335C → R in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994067Ensembl.1
Natural variantiVAR_068467335C → S in VWM. 1 Publication1
Natural variantiVAR_012328339R → P in VWM. 2 PublicationsCorresponds to variant dbSNP:rs113994069EnsemblClinVar.1
Natural variantiVAR_012329339R → Q in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994069EnsemblClinVar.1
Natural variantiVAR_012330339R → W in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994068Ensembl.1
Natural variantiVAR_068468376N → D in VWM. 1 Publication1
Natural variantiVAR_012293386G → V in VWM. 2 PublicationsCorresponds to variant dbSNP:rs113994074EnsemblClinVar.1
Natural variantiVAR_012331430V → A in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994079Ensembl.1
Natural variantiVAR_068469447S → L in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994080Ensembl.1
Natural variantiVAR_012332587I → V5 PublicationsCorresponds to variant dbSNP:rs843358EnsemblClinVar.1
Natural variantiVAR_012294628W → R in VWM. 1 PublicationCorresponds to variant dbSNP:rs28937596EnsemblClinVar.1
Natural variantiVAR_012333650E → K in VWM. 1 PublicationCorresponds to variant dbSNP:rs113994085Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091646 mRNA Translation: BAC03712.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78299.1
BC013590 mRNA Translation: AAH13590.1
U23028 mRNA Translation: AAC50646.1
CCDSiCCDS3252.1
RefSeqiNP_003898.2, NM_003907.2
UniGeneiHs.283551

Genome annotation databases

EnsembliENST00000273783; ENSP00000273783; ENSG00000145191
GeneIDi8893
KEGGihsa:8893
UCSCiuc003fmp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Mendelian genes eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091646 mRNA Translation: BAC03712.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78299.1
BC013590 mRNA Translation: AAH13590.1
U23028 mRNA Translation: AAC50646.1
CCDSiCCDS3252.1
RefSeqiNP_003898.2, NM_003907.2
UniGeneiHs.283551

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JUIX-ray2.00A548-721[»]
6CAJelectron microscopy2.80A/B1-721[»]
6EZOelectron microscopy4.10I/J1-721[»]
ProteinModelPortaliQ13144
SMRiQ13144
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114410, 51 interactors
IntActiQ13144, 13 interactors
MINTiQ13144
STRINGi9606.ENSP00000273783

PTM databases

iPTMnetiQ13144
PhosphoSitePlusiQ13144

Polymorphism and mutation databases

BioMutaiEIF2B5
DMDMi160359049

Proteomic databases

EPDiQ13144
MaxQBiQ13144
PaxDbiQ13144
PeptideAtlasiQ13144
PRIDEiQ13144
ProteomicsDBi59187

Protocols and materials databases

DNASUi8893
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273783; ENSP00000273783; ENSG00000145191
GeneIDi8893
KEGGihsa:8893
UCSCiuc003fmp.4 human

Organism-specific databases

CTDi8893
DisGeNETi8893
EuPathDBiHostDB:ENSG00000145191.11
GeneCardsiEIF2B5
GeneReviewsiEIF2B5
H-InvDBiHIX0003921
HGNCiHGNC:3261 EIF2B5
HPAiCAB015412
HPA064370
HPA069303
MalaCardsiEIF2B5
MIMi603896 phenotype
603945 gene
neXtProtiNX_Q13144
OpenTargetsiENSG00000145191
Orphaneti157713 Congenital or early infantile CACH syndrome
99854 Cree leukoencephalopathy
157719 Juvenile or adult CACH syndrome
157716 Late infantile CACH syndrome
99853 Ovarioleukodystrophy
PharmGKBiPA27692
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1461 Eukaryota
COG1208 LUCA
GeneTreeiENSGT00510000047568
HOGENOMiHOG000216610
HOVERGENiHBG051460
InParanoidiQ13144
KOiK03240
OMAiPQMDDIK
OrthoDBiEOG091G065U
PhylomeDBiQ13144
TreeFamiTF101509

Enzyme and pathway databases

ReactomeiR-HSA-72731 Recycling of eIF2:GDP
SIGNORiQ13144

Miscellaneous databases

ChiTaRSiEIF2B5 human
EvolutionaryTraceiQ13144
GeneWikiiEIF2B5
GenomeRNAii8893
PROiPR:Q13144
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145191 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_EIF2B5
ExpressionAtlasiQ13144 baseline and differential
GenevisibleiQ13144 HS

Family and domain databases

CDDicd04197 eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BE_HUMAN
AccessioniPrimary (citable) accession number: Q13144
Secondary accession number(s): Q541Z1, Q96D04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again