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Entry version 157 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Calcium-binding and coiled-coil domain-containing protein 2

Gene

CALCOCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • positive regulation of autophagosome maturation Source: GO_Central
  • response to interferon-gamma Source: BHF-UCL
  • viral process Source: ProtInc
  • xenophagy Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 2
Alternative name(s):
Antigen nuclear dot 52 kDa protein
Nuclear domain 10 protein NDP52Curated
Short name:
Nuclear domain 10 protein 521 Publication
Nuclear dot protein 521 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALCOCO2
Synonyms:NDP521 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29912 CALCOCO2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604587 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q13137

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi136V → S: Abrogates the interaction with MAP1LC3C. 1 Publication1
Mutagenesisi203 – 206DYWE → AAAA: Abrogates interaction with MAPLC3A, MAPLC3B and GABARAPL2. 1 Publication4
Mutagenesisi374L → A: Severely reduces affinity for LGALS8. 2 Publications1
Mutagenesisi376Y → A: Severely reduces affinity for LGALS8. 1 Publication1
Mutagenesisi378N → A: Prevents interaction with LGALS8. 1 Publication1
Mutagenesisi380Y → A or F: Severely reduced affinity for LGALS8. 2 Publications1
Mutagenesisi400C → A: Does not affect interaction with MYO6. 1 Publication1
Mutagenesisi425C → A: Fails interact with MYO6 and to promote maturation of autophagosomes. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10241

Open Targets

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OpenTargetsi
ENSG00000136436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA143485407

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CALCOCO2

Domain mapping of disease mutations (DMDM)

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DMDMi
74735623

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003123371 – 446Calcium-binding and coiled-coil domain-containing protein 2Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13137

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13137

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13137

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13137

PeptideAtlas

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PeptideAtlasi
Q13137

PRoteomics IDEntifications database

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PRIDEi
Q13137

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59186

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13137

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13137

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm (PubMed:7540613). IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression (PubMed:9230084).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136436 Expressed in 234 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13137 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13137 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022989
HPA023019
HPA023195

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer (PubMed:23511477). Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6 (PubMed:17635994). Interacts with GEMIN4 (PubMed:12869526). Interacts with ATG8 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:25771791). Interacts with ATG8 family member MAP1LC3C (PubMed:23022382). Interacts with LGALS8 (PubMed:22246324, PubMed:25771791, PubMed:23511477, PubMed:23386746).7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9Y13EBI-739580,EBI-10175746
Q8WU023EBI-739580,EBI-747182
Q9WMX23EBI-739580,EBI-6863741From Hepatitis C virus genotype 1b (isolate Con1).
AESQ081173EBI-739580,EBI-717810
AKAP17AQ02040-33EBI-739580,EBI-10222656
AMMECR1Q9Y4X03EBI-739580,EBI-8583355
ARD1AQ6P4J03EBI-739580,EBI-10252815
ARHGEF39Q8N4T43EBI-739580,EBI-745468
ARHGEF5Q127743EBI-739580,EBI-602199
AXIN1A0A0S2Z4M13EBI-739580,EBI-16429430
AXIN1O151693EBI-739580,EBI-710484
BAHD1Q8TBE03EBI-739580,EBI-742750
BCL6BA8KA133EBI-739580,EBI-10174813
BEX2Q9BXY83EBI-739580,EBI-745073
CBX8Q9HC525EBI-739580,EBI-712912
CCNHP519463EBI-739580,EBI-741406
CEP57L1Q8IYX83EBI-739580,EBI-1104570
CHCHD3Q9NX633EBI-739580,EBI-743375
CWF19L2Q2TBE03EBI-739580,EBI-5453285
DAZAP2Q150384EBI-739580,EBI-724310
DCTN4Q9UJW03EBI-739580,EBI-2134033
DCXO436023EBI-739580,EBI-8646694
DDIT4LQ96D033EBI-739580,EBI-742054
DDX6P261965EBI-739580,EBI-351257
DOCK2Q926083EBI-739580,EBI-448771
DUSP12Q9UNI64EBI-739580,EBI-715161
DUSP26Q9BV473EBI-739580,EBI-2924519
EEF1E1O433243EBI-739580,EBI-1048486
ENKD1Q9H0I23EBI-739580,EBI-744099
EXOSC5Q9NQT43EBI-739580,EBI-371876
FAM161AQ3B8205EBI-739580,EBI-719941
FAM168AQ925673EBI-739580,EBI-7957930
FAM90A1Q86YD76EBI-739580,EBI-6658203
FARS2O953635EBI-739580,EBI-2513774
FBF1Q8TES7-63EBI-739580,EBI-10244131
FBXL18Q96D164EBI-739580,EBI-744419
FKBPLQ9UIM33EBI-739580,EBI-719882
FNDC11Q9BVV24EBI-739580,EBI-744935
GABARAPL1Q9H0R86EBI-739580,EBI-746969
GABARAPL2P605206EBI-739580,EBI-720116
GATAD2BQ8WXI93EBI-739580,EBI-923440
GLYCTKQ8IVS83EBI-739580,EBI-748515
HDAC7Q8WUI4-53EBI-739580,EBI-10276431
HOXB9P174823EBI-739580,EBI-745290
KANSL1Q7Z3B34EBI-739580,EBI-740244
KLHL42Q9P2K63EBI-739580,EBI-739890
LENG1Q96BZ83EBI-739580,EBI-726510
LGALS8O002144EBI-739580,EBI-740058
LIMS2Q7Z4I7-53EBI-739580,EBI-10257651
LITAFQ997327EBI-739580,EBI-725647
LMF2Q9BU233EBI-739580,EBI-10298556
LMO2P257913EBI-739580,EBI-739696
LMO4P619683EBI-739580,EBI-2798728
LONRF1Q17RB83EBI-739580,EBI-2341787
LSM4Q9Y4Z06EBI-739580,EBI-372521
MAGOHBQ96A725EBI-739580,EBI-746778
MAVSQ7Z4343EBI-739580,EBI-995373
METTL17Q9H7H06EBI-739580,EBI-749353
METTL17Q9H7H0-23EBI-739580,EBI-11098807
MID2Q9UJV3-23EBI-739580,EBI-10172526
MOSP005405EBI-739580,EBI-1757866
MTPAPQ9NVV42EBI-739580,EBI-2556166
MXI1P505393EBI-739580,EBI-752241
MXI1P50539-35EBI-739580,EBI-10211940
NAA10P412275EBI-739580,EBI-747693
NFU1Q9UMS03EBI-739580,EBI-725252
PEF1Q9UBV84EBI-739580,EBI-724639
PEG10Q86TG73EBI-739580,EBI-2858265
PFDN5Q994714EBI-739580,EBI-357275
PHF1O431893EBI-739580,EBI-530034
PPP1R18Q6NYC83EBI-739580,EBI-2557469
PRPF31Q8WWY36EBI-739580,EBI-1567797
PSMA1P257863EBI-739580,EBI-359352
PSME4Q149973EBI-739580,EBI-1236916
RBM15Q96T373EBI-739580,EBI-2514922
RIN1Q136714EBI-739580,EBI-366017
RPL9P9P329693EBI-739580,EBI-358122
RPS27AP629793EBI-739580,EBI-357375
RTP5Q14D335EBI-739580,EBI-10217913
RXRBP28702-33EBI-739580,EBI-16429492
SDCBPO005603EBI-739580,EBI-727004
SLC15A3Q05CH43EBI-739580,EBI-10223741
SMCPP499013EBI-739580,EBI-750494
SNRPBP14678-23EBI-739580,EBI-372475
SPATA24Q86W543EBI-739580,EBI-3916986
SRIP306265EBI-739580,EBI-750459
STK16O757163EBI-739580,EBI-749295
TBC1D22BQ9NU193EBI-739580,EBI-8787464
TBK1Q9UHD25EBI-739580,EBI-356402
TBRG4Q969Z03EBI-739580,EBI-702328
TCL1AP562797EBI-739580,EBI-749995
TEKT3Q9BXF93EBI-739580,EBI-8644516
TENT2Q6PIY73EBI-739580,EBI-2802204
TP53RKQ96S444EBI-739580,EBI-739588
UBAC2Q8NBM43EBI-739580,EBI-724045
UBBQ5U5U63EBI-739580,EBI-1642104
UBCQ96C323EBI-739580,EBI-745483
VARSP266403EBI-739580,EBI-355765
ZNF337Q9Y3M93EBI-739580,EBI-714987
ZNF408Q9H9D43EBI-739580,EBI-347633
ZNF564Q8TBZ83EBI-739580,EBI-10273713
ZNF581Q9P0T43EBI-739580,EBI-745520
ZNF688A0A0S2Z5X43EBI-739580,EBI-16429014

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115535, 224 interactors

Database of interacting proteins

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DIPi
DIP-57534N

Protein interaction database and analysis system

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IntActi
Q13137, 193 interactors

Molecular INTeraction database

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MINTi
Q13137

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398523

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1446
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MXPNMR-A414-446[»]
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
4XKLX-ray2.10B/D414-446[»]
5AAQNMR-A388-446[»]
5Z7AX-ray2.38A/B1-126[»]
5Z7LX-ray2.02A/B10-126[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13137

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni371 – 381Interaction with LGALS82 PublicationsAdd BLAST11
Regioni395 – 446Interaction with MYO61 PublicationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili137 – 349Sequence analysisAdd BLAST213

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 136CLIR2 Publications4
Motifi203 – 206LIR-like1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MYO6-binding domain is required for autophagy-mediated degradation of infecting bacteria such as Salmonella typhimurium, but not for bacteria targeting to autophagosomes.1 Publication
The CLIR (LC3C-interacting region) motif is required for interaction with MAP1LC3C, but dispensable for CALCOCO2-mediated autophagosome maturation.2 Publications
The LIR-like motif is required for interaction with MAP1LC3A, MAP1LC3B and GABARAPL2, as well as for CALCOCO2-mediated autophagosome maturation.1 Publication
The LGALS8-binding domain is essential for the recruitment to cytosol-exposed infecting bacteria.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CALCOCO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKI3 Eukaryota
ENOG4112B0R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000050230

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13137

KEGG Orthology (KO)

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KOi
K21348

Identification of Orthologs from Complete Genome Data

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OMAi
TCYYTLT

Database of Orthologous Groups

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OrthoDBi
179838at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13137

TreeFam database of animal gene trees

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TreeFami
TF329501

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP
60 70 80 90 100
RRKDWIGIFR VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK
110 120 130 140 150
DDEYYQFCYV DEDGVVRGAS IPFQFRPENE EDILVVTTQG EVEEIEQHNK
160 170 180 190 200
ELCKENQELK DSCISLQKQN SDMQAELQKK QEELETLQSI NKKLELKVKE
210 220 230 240 250
QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ EKEMEKLVQG
260 270 280 290 300
DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
310 320 330 340 350
QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG
360 370 380 390 400
LDFNSLPYQV PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC
410 420 430 440
KADDICDHTL EQQQMQPLCF NCPICDKIFP ATEKQIFEDH VFCHSL
Length:446
Mass (Da):52,254
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i609B121DA1A9DCB8
GO
Isoform 2 (identifier: Q13137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-180: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):47,340
Checksum:i096590EDA273DE3E
GO
Isoform 3 (identifier: Q13137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RCSLNQTIQLLITPDTGSIWHQ

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):54,605
Checksum:iCF0B512C4C91DB91
GO
Isoform 4 (identifier: Q13137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: R → RAFKCFQDKLEQELLKWRSQGQKLQ

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):55,188
Checksum:iDC114D09C4737FEC
GO
Isoform 5 (identifier: Q13137-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):43,669
Checksum:iF20EB9A4621F735A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REB0D6REB0_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF70D6RF70_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJE7D6RJE7_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBP4H0YBP4_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9G3H0Y9G3_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4E1I3L4E1_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L493I3L493_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBI4D6RBI4_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBF9D6RBF9_HUMAN
Calcium-binding and coiled-coil dom...
CALCOCO2
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102D → Y in BAG64382 (PubMed:14702039).Curated1
Sequence conflicti313R → G in BAG56685 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037489140G → E1 PublicationCorresponds to variant dbSNP:rs550510Ensembl.1
Natural variantiVAR_037490227G → R. Corresponds to variant dbSNP:rs2303016Ensembl.1
Natural variantiVAR_037491248V → A2 PublicationsCorresponds to variant dbSNP:rs2303015Ensembl.1
Natural variantiVAR_037492273T → A1 PublicationCorresponds to variant dbSNP:rs17849804Ensembl.1
Natural variantiVAR_037493389P → A3 PublicationsCorresponds to variant dbSNP:rs10278Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474141 – 72Missing in isoform 5. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_04676660R → RCSLNQTIQLLITPDTGSIW HQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_04676760R → RAFKCFQDKLEQELLKWRSQ GQKLQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_044728139 – 180Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U22897 mRNA Translation: AAA75297.1
AK293137 mRNA Translation: BAG56685.1
AK293329 mRNA Translation: BAG56845.1
AK298177 mRNA Translation: BAG60448.1
AK303313 mRNA Translation: BAG64382.1
AK314796 mRNA Translation: BAG37327.1
CR456763 mRNA Translation: CAG33044.1
AK222666 mRNA Translation: BAD96386.1
AK223227 mRNA Translation: BAD96947.1
AC068531 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94707.1
BC004130 mRNA Translation: AAH04130.1
BC015893 mRNA Translation: AAH15893.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11538.1 [Q13137-1]
CCDS58558.1 [Q13137-3]
CCDS58559.1 [Q13137-4]
CCDS58560.1 [Q13137-2]
CCDS58561.1 [Q13137-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56733

NCBI Reference Sequences

More...
RefSeqi
NP_001248319.1, NM_001261390.1 [Q13137-4]
NP_001248320.1, NM_001261391.1 [Q13137-3]
NP_001248322.1, NM_001261393.1 [Q13137-2]
NP_001248324.1, NM_001261395.1 [Q13137-5]
NP_005822.1, NM_005831.4 [Q13137-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258947; ENSP00000258947; ENSG00000136436 [Q13137-1]
ENST00000416445; ENSP00000406974; ENSG00000136436 [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436 [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436 [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436 [Q13137-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10241

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10241

UCSC genome browser

More...
UCSCi
uc002iof.4 human [Q13137-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22897 mRNA Translation: AAA75297.1
AK293137 mRNA Translation: BAG56685.1
AK293329 mRNA Translation: BAG56845.1
AK298177 mRNA Translation: BAG60448.1
AK303313 mRNA Translation: BAG64382.1
AK314796 mRNA Translation: BAG37327.1
CR456763 mRNA Translation: CAG33044.1
AK222666 mRNA Translation: BAD96386.1
AK223227 mRNA Translation: BAD96947.1
AC068531 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94707.1
BC004130 mRNA Translation: AAH04130.1
BC015893 mRNA Translation: AAH15893.1
CCDSiCCDS11538.1 [Q13137-1]
CCDS58558.1 [Q13137-3]
CCDS58559.1 [Q13137-4]
CCDS58560.1 [Q13137-2]
CCDS58561.1 [Q13137-5]
PIRiA56733
RefSeqiNP_001248319.1, NM_001261390.1 [Q13137-4]
NP_001248320.1, NM_001261391.1 [Q13137-3]
NP_001248322.1, NM_001261393.1 [Q13137-2]
NP_001248324.1, NM_001261395.1 [Q13137-5]
NP_005822.1, NM_005831.4 [Q13137-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MXPNMR-A414-446[»]
3VVVX-ray1.35A21-141[»]
3VVWX-ray2.50A21-141[»]
4GXLX-ray2.02B368-381[»]
4HANX-ray2.55C/D372-385[»]
4XKLX-ray2.10B/D414-446[»]
5AAQNMR-A388-446[»]
5Z7AX-ray2.38A/B1-126[»]
5Z7LX-ray2.02A/B10-126[»]
SMRiQ13137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115535, 224 interactors
DIPiDIP-57534N
IntActiQ13137, 193 interactors
MINTiQ13137
STRINGi9606.ENSP00000398523

PTM databases

iPTMnetiQ13137
PhosphoSitePlusiQ13137

Polymorphism and mutation databases

BioMutaiCALCOCO2
DMDMi74735623

Proteomic databases

EPDiQ13137
jPOSTiQ13137
MaxQBiQ13137
PaxDbiQ13137
PeptideAtlasiQ13137
PRIDEiQ13137
ProteomicsDBi59186

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258947; ENSP00000258947; ENSG00000136436 [Q13137-1]
ENST00000416445; ENSP00000406974; ENSG00000136436 [Q13137-2]
ENST00000448105; ENSP00000398523; ENSG00000136436 [Q13137-4]
ENST00000508679; ENSP00000423437; ENSG00000136436 [Q13137-5]
ENST00000509507; ENSP00000424352; ENSG00000136436 [Q13137-3]
GeneIDi10241
KEGGihsa:10241
UCSCiuc002iof.4 human [Q13137-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10241
DisGeNETi10241

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CALCOCO2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0013950
HGNCiHGNC:29912 CALCOCO2
HPAiHPA022989
HPA023019
HPA023195
MIMi604587 gene
neXtProtiNX_Q13137
OpenTargetsiENSG00000136436
PharmGKBiPA143485407

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKI3 Eukaryota
ENOG4112B0R LUCA
GeneTreeiENSGT00950000183025
HOGENOMiHOG000050230
InParanoidiQ13137
KOiK21348
OMAiTCYYTLT
OrthoDBi179838at2759
PhylomeDBiQ13137
TreeFamiTF329501

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CALCOCO2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CALCOCO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10241

Protein Ontology

More...
PROi
PR:Q13137

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136436 Expressed in 234 organ(s), highest expression level in testis
ExpressionAtlasiQ13137 baseline and differential
GenevisibleiQ13137 HS

Family and domain databases

InterProiView protein in InterPro
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH
PfamiView protein in Pfam
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCACO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13137
Secondary accession number(s): B2RBT0
, B4DDC4, B4DDT4, B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, Q53FQ5, Q53HB5, Q6IBN9, Q9BTF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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