UniProtKB - Q13136 (LIPA1_HUMAN)

BLAST

>sp|Q13136|LIPA1_HUMAN Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1
MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET
LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN
TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE
RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD
GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM
NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT
EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME
AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL
REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD
GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV
SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI
ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT
LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP
VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ
DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA
CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG
DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG
IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA
LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW
RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTY
SC

Align

Format
Add to basket Added to basket
History
Entry version 169 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Liprin-alpha-1

Gene

PPFIA1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

GO - Biological processⁱ

cell-matrix adhesion
Source: ProtInc
Traceable author statementⁱ
- 7796809
negative regulation of protein localization to plasma membrane
Source: MGI
Inferred from mutant phenotypeⁱ
- 22266902
negative regulation of stress fiber assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 22266902
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7796809

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429 Serotonin Neurotransmitter Release Cycle R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle R-HSA-388844 Receptor-type tyrosine-protein phosphatases
SignaLinkⁱ	Q13136

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Liprin-alpha-1 Alternative name(s): LAR-interacting protein 1 Short name: LIP-1 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 Short name: PTPRF-interacting protein alpha-1
Gene namesⁱ	Name:PPFIA1 Synonyms:LIP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131626.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9245 PPFIA1
MIMⁱ	611054 gene
neXtProtⁱ	NX_Q13136

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8500
Open Targets More...OpenTargetsⁱ	ENSG00000131626
PharmGKBⁱ	PA33566

Polymorphism and mutation databases

BioMutaⁱ	PPFIA1
DMDMⁱ	42558969

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191026	1 – 1202	Liprin-alpha-1Add BLAST		1202

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	150	PhosphoserineCombined sources	1
Modified residueⁱ	230	PhosphothreonineCombined sources	1
Modified residueⁱ	239	PhosphoserineCombined sources	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	244	PhosphoserineCombined sources	1
Modified residueⁱ	448	PhosphoserineCombined sources	1
Modified residueⁱ	666	PhosphoserineCombined sources	1
Modified residueⁱ	668	PhosphoserineCombined sources	1
Modified residueⁱ	693	PhosphoserineCombined sources	1
Modified residueⁱ	761	PhosphothreonineCombined sources	1
Modified residueⁱ	763	PhosphoserineCombined sources	1
Modified residueⁱ	1133	PhosphoserineCombined sources	1
Modified residueⁱ	1159	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q13136
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13136
PaxDbⁱ	Q13136
PeptideAtlas More...PeptideAtlasⁱ	Q13136
PRIDEⁱ	Q13136
ProteomicsDBⁱ	59184 59185 [Q13136-2]

PTM databases

iPTMnetⁱ	Q13136
PhosphoSitePlusⁱ	Q13136

Miscellaneous databases

PMAP-CutDBⁱ	Q13136

PMAP-CutDBⁱ

Q13136

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000131626 Expressed in 229 organ(s), highest expression level in oocyte
CleanExⁱ	HS_PPFIA1
ExpressionAtlasⁱ	Q13136 baseline and differential
Genevisibleⁱ	Q13136 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017032 HPA008272 HPA042271

HPAⁱ

CAB017032
HPA008272
HPA042271

Interactionⁱ

Subunit structureⁱ

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCNH	P51946	3	EBI-745426,EBI-741406
DTNB	O60941	3	EBI-745426,EBI-740402
FAM161A	Q3B820	3	EBI-745426,EBI-719941
Gria2	P19491	2	EBI-745426,EBI-77718	From Rattus norvegicus.
Grip1	P97879	4	EBI-745426,EBI-936113	From Rattus norvegicus.
MBIP	Q9NS73	3	EBI-745426,EBI-741953
PPP2R5D	Q14738	3	EBI-745426,EBI-396563
TXLNA	P40222	3	EBI-745426,EBI-359793

Protein-protein interaction databases

BioGridⁱ	114072, 68 interactors
ELMⁱ	Q13136
IntActⁱ	Q13136, 35 interactors
Molecular INTeraction database More...MINTⁱ	Q13136
STRINGⁱ	9606.ENSP00000253925

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	1198 – 1201	Combined sources		4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q13136
SMRⁱ	Q13136
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	878 – 944	SAM 1PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	963 – 1027	SAM 2PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	1051 – 1120	SAM 3PROSITE-ProRule annotationAdd BLAST	70

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	34 – 141	Sequence analysisAdd BLAST	108
Coiled coilⁱ	176 – 214	Sequence analysisAdd BLAST	39
Coiled coilⁱ	249 – 521	Sequence analysisAdd BLAST	273
Coiled coilⁱ	623 – 669	Sequence analysisAdd BLAST	47
Coiled coilⁱ	847 – 871	Sequence analysisAdd BLAST	25
Coiled coilⁱ	1021 – 1050	Sequence analysisAdd BLAST	30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	17 – 25	Poly-Gly		9

Domainⁱ

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Sequence similaritiesⁱ

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0249 Eukaryota ENOG410XP8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119138
HOGENOMⁱ	HOG000017513
HOVERGENⁱ	HBG052330
InParanoidⁱ	Q13136
OMAⁱ	LGTTHKE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14UK
PhylomeDBⁱ	Q13136
TreeFamⁱ	TF314207

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProⁱ	View protein in InterPro IPR029515 Liprin IPR037620 Liprin-alpha_SAM_rpt_1 IPR037621 Liprin-alpha_SAM_rpt_2 IPR037622 Liprin-alpha_SAM_rpt_3 IPR030438 PPFIA1 IPR001660 SAM IPR013761 SAM/pointed_sf
PANTHERⁱ	PTHR12587 PTHR12587, 1 hit PTHR12587:SF15 PTHR12587:SF15, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00536 SAM_1, 1 hit PF07647 SAM_2, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 3 hits
SUPFAMⁱ	SSF47769 SSF47769, 3 hits
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13136-1) [UniParc]FASTA Add to basket

Also known as: LAR-interacting protein 1b, LIP.1b, b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL 
        60         70         80         90        100
LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC 
       110        120        130        140        150
REQLLEREEE IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS 
       160        170        180        190        200
PAGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVALERCS LLEEELGATH 
       210        220        230        240        250
KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD GSLSHEEDLA 
       260        270        280        290        300
KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM 
       310        320        330        340        350
NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI 
       360        370        380        390        400
ANKDSMHRQT EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA 
       410        420        430        440        450
ALSKAEERHG NIEERLRQME AQLEEKNQEL QRARQREKMN EEHNKRLSDT 
       460        470        480        490        500
VDKLLSESNE RLQLHLKERM AALEDKNSLL REVESAKKQL EETQHDKDQL 
       510        520        530        540        550
VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD GHTDSYSTSA 
       560        570        580        590        600
VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV 
       610        620        630        640        650
SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK 
       660        670        680        690        700
ENTEQRAEEI ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS 
       710        720        730        740        750
TPRRIPHSPA REVDRLGVMT LLPPSREEVR DDKTTIKCET SPPSSPRALR 
       760        770        780        790        800
LDRLHKGALH TVSHEDIRDI RNSTGSQDGP VSNPSSSNSS QDSLHKAPKK 
       810        820        830        840        850
KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ DALGLSKLGG 
       860        870        880        890        900
QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA 
       910        920        930        940        950
CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP 
       960        970        980        990       1000
PTSRTTLAYG DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK 
      1010       1020       1030       1040       1050
DLRGQLKMVD SFHRNSFQCG IMCLRRLNYD RKELERKREE SQSEIKDVLV 
      1060       1070       1080       1090       1100
WSNDRVIRWI LSIGLKEYAN NLIESGVHGA LLALDETFDF SALALLLQIP 
      1110       1120       1130       1140       1150
TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW RKKFRPKDIR 
      1160       1170       1180       1190       1200
GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGNVSGTQ RLDSATVRTY 

SC

Length:1,202

Mass (Da):135,779

Last modified:November 1, 1996 - v1

Checksum:ⁱC8CF7C20B298BFB1

Isoform 2 (identifier: Q13136-2) [UniParc]FASTA Add to basket

Also known as: LAR-interacting protein 1a, LIP.1a, a

The sequence of this isoform differs from the canonical sequence as follows:
1185-1202: NVSGTQRLDSATVRTYSC → M

« Hide

        10         20         30         40         50
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL 
        60         70         80         90        100
LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC 
       110        120        130        140        150
REQLLEREEE IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS 
       160        170        180        190        200
PAGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVALERCS LLEEELGATH 
       210        220        230        240        250
KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD GSLSHEEDLA 
       260        270        280        290        300
KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM 
       310        320        330        340        350
NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI 
       360        370        380        390        400
ANKDSMHRQT EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA 
       410        420        430        440        450
ALSKAEERHG NIEERLRQME AQLEEKNQEL QRARQREKMN EEHNKRLSDT 
       460        470        480        490        500
VDKLLSESNE RLQLHLKERM AALEDKNSLL REVESAKKQL EETQHDKDQL 
       510        520        530        540        550
VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD GHTDSYSTSA 
       560        570        580        590        600
VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV 
       610        620        630        640        650
SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK 
       660        670        680        690        700
ENTEQRAEEI ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS 
       710        720        730        740        750
TPRRIPHSPA REVDRLGVMT LLPPSREEVR DDKTTIKCET SPPSSPRALR 
       760        770        780        790        800
LDRLHKGALH TVSHEDIRDI RNSTGSQDGP VSNPSSSNSS QDSLHKAPKK 
       810        820        830        840        850
KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ DALGLSKLGG 
       860        870        880        890        900
QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA 
       910        920        930        940        950
CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP 
       960        970        980        990       1000
PTSRTTLAYG DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK 
      1010       1020       1030       1040       1050
DLRGQLKMVD SFHRNSFQCG IMCLRRLNYD RKELERKREE SQSEIKDVLV 
      1060       1070       1080       1090       1100
WSNDRVIRWI LSIGLKEYAN NLIESGVHGA LLALDETFDF SALALLLQIP 
      1110       1120       1130       1140       1150
TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW RKKFRPKDIR 
      1160       1170       1180 
GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGM

Note: Due to intron retention. No experimental confirmation available.

Show »

Length:1,185

Mass (Da):133,970

Checksum:ⁱ00E9FA5C94C8217C

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H0YDZ8	H0YDZ8_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	98	Annotation score:
	H0YDW2	H0YDW2_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	389	Annotation score:
	E9PJZ7	E9PJZ7_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	583	Annotation score:
	E9PPF6	E9PPF6_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	158	Annotation score:
	E9PID5	E9PID5_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	99	Annotation score:
	H0YEF9	H0YEF9_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	387	Annotation score:
	H0YD72	H0YD72_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	237	Annotation score:
	H0YF15	H0YF15_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	97	Annotation score:
	A0A1B0GVT3	A0A1B0GVT3_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	271	Annotation score:
	A0A2R8Y7R9	A0A2R8Y7R9_HUMAN	Liprin-alpha-1 Liprin-alpha-1	PPFIA1	1,224	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence BAA08353 differs from that shown. Reason: Frameshift at positions 1033, 1041, 1045, 1067 and 1113.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	492	E → G in AAH34046 (PubMed:15489334).Curated	1
Sequence conflictⁱ	555	P → T in AAH34046 (PubMed:15489334).Curated	1
Sequence conflictⁱ	672 – 674	LGR → EFG in BAA08353 (Ref. 4) Curated	3
Sequence conflictⁱ	800 – 801	KK → EE in BAA08353 (Ref. 4) Curated	2
Sequence conflictⁱ	866	E → G in AAH34046 (PubMed:15489334).Curated	1
Sequence conflictⁱ	994	L → Q in BAA08353 (Ref. 4) Curated	1
Sequence conflictⁱ	1023	C → S in BAA08353 (Ref. 4) Curated	1
Sequence conflictⁱ	1044	E → EVRV in BAA08353 (Ref. 4) Curated	1
Sequence conflictⁱ	1121 – 1123	GTD → PEF in BAA08353 (Ref. 4) Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017756	71	V → I. Corresponds to variant dbSNP:rs546502Ensembl.		1
Natural variantⁱVAR_049998	1072	L → F. Corresponds to variant dbSNP:rs11236045Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009391	1185 – 1202	NVSGT…RTYSC → M in isoform 2. 1 PublicationAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U22815 mRNA Translation: AAC50172.1 U22816 mRNA Translation: AAC50173.1 AP002336 Genomic DNA No translation available. BC034046 mRNA Translation: AAH34046.1 D49354 mRNA Translation: BAA08353.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31627.1 [Q13136-1] CCDS31628.1 [Q13136-2]
PIRⁱ	S55553
NCBI Reference Sequences More...RefSeqⁱ	NP_003617.1, NM_003626.3 [Q13136-1] NP_803172.1, NM_177423.2 [Q13136-2]
UniGeneⁱ	Hs.530749 Hs.708791

Genome annotation databases

Ensemblⁱ	ENST00000253925; ENSP00000253925; ENSG00000131626 [Q13136-1] ENST00000389547; ENSP00000374198; ENSG00000131626 [Q13136-2]
GeneIDⁱ	8500
KEGGⁱ	hsa:8500
UCSC genome browser More...UCSCⁱ	uc001opn.3 human [Q13136-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13136	PTPRF interacting protein alpha 1		CANLF		1257	UniRef90_Q13136
liprin-alpha-1 isoform X14		MESAU		1220
liprin-alpha-1		PHYCD		1213
Liprin-alpha-1 isoform b		CALJA		1212
Uncharacterized protein		PIG		1212
+188

Protein	Similar proteins		Species	Score	Length	Source
Q13136	PTPRF interacting protein alpha 1		CANLF		1257	UniRef50_Q13136
liprin-alpha-1 isoform X14		MESAU		1220
liprin-alpha-1		PHYCD		1213
Liprin-alpha-1 isoform b		CALJA		1212
Uncharacterized protein		PIG		1212
+1648

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U22815 mRNA Translation: AAC50172.1 U22816 mRNA Translation: AAC50173.1 AP002336 Genomic DNA No translation available. BC034046 mRNA Translation: AAH34046.1 D49354 mRNA Translation: BAA08353.1 Frameshift.
CCDSⁱ	CCDS31627.1 [Q13136-1] CCDS31628.1 [Q13136-2]
PIRⁱ	S55553
RefSeqⁱ	NP_003617.1, NM_003626.3 [Q13136-1] NP_803172.1, NM_177423.2 [Q13136-2]
UniGeneⁱ	Hs.530749 Hs.708791

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N7F	X-ray	1.80	C/D	1195-1202	[»]
ProteinModelPortalⁱ	Q13136
SMRⁱ	Q13136
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114072, 68 interactors
ELMⁱ	Q13136
IntActⁱ	Q13136, 35 interactors
MINTⁱ	Q13136
STRINGⁱ	9606.ENSP00000253925

PTM databases

iPTMnetⁱ	Q13136
PhosphoSitePlusⁱ	Q13136

Polymorphism and mutation databases

BioMutaⁱ	PPFIA1
DMDMⁱ	42558969

Proteomic databases

EPDⁱ	Q13136
MaxQBⁱ	Q13136
PaxDbⁱ	Q13136
PeptideAtlasⁱ	Q13136
PRIDEⁱ	Q13136
ProteomicsDBⁱ	59184 59185 [Q13136-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8500
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000253925; ENSP00000253925; ENSG00000131626 [Q13136-1] ENST00000389547; ENSP00000374198; ENSG00000131626 [Q13136-2]
GeneIDⁱ	8500
KEGGⁱ	hsa:8500
UCSCⁱ	uc001opn.3 human [Q13136-1]

Organism-specific databases

CTDⁱ	8500
DisGeNETⁱ	8500
EuPathDBⁱ	HostDB:ENSG00000131626.15
GeneCardsⁱ	PPFIA1
HGNCⁱ	HGNC:9245 PPFIA1
HPAⁱ	CAB017032 HPA008272 HPA042271
MIMⁱ	611054 gene
neXtProtⁱ	NX_Q13136
OpenTargetsⁱ	ENSG00000131626
PharmGKBⁱ	PA33566
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0249 Eukaryota ENOG410XP8Z LUCA
GeneTreeⁱ	ENSGT00760000119138
HOGENOMⁱ	HOG000017513
HOVERGENⁱ	HBG052330
InParanoidⁱ	Q13136
OMAⁱ	LGTTHKE
OrthoDBⁱ	EOG091G14UK
PhylomeDBⁱ	Q13136
TreeFamⁱ	TF314207

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429 Serotonin Neurotransmitter Release Cycle R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle R-HSA-388844 Receptor-type tyrosine-protein phosphatases
SignaLinkⁱ	Q13136

Miscellaneous databases

ChiTaRSⁱ	PPFIA1 human
GeneWikiⁱ	Liprin-alpha-1
GenomeRNAiⁱ	8500
PMAP-CutDBⁱ	Q13136
Protein Ontology More...PROⁱ	PR:Q13136
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131626 Expressed in 229 organ(s), highest expression level in oocyte
CleanExⁱ	HS_PPFIA1
ExpressionAtlasⁱ	Q13136 baseline and differential
Genevisibleⁱ	Q13136 HS

Family and domain databases

CDDⁱ	cd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProⁱ	View protein in InterPro IPR029515 Liprin IPR037620 Liprin-alpha_SAM_rpt_1 IPR037621 Liprin-alpha_SAM_rpt_2 IPR037622 Liprin-alpha_SAM_rpt_3 IPR030438 PPFIA1 IPR001660 SAM IPR013761 SAM/pointed_sf
PANTHERⁱ	PTHR12587 PTHR12587, 1 hit PTHR12587:SF15 PTHR12587:SF15, 1 hit
Pfamⁱ	View protein in Pfam PF00536 SAM_1, 1 hit PF07647 SAM_2, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 3 hits
SUPFAMⁱ	SSF47769 SSF47769, 3 hits
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIPA1_HUMAN
Accessionⁱ	Q13136Primary (citable) accession number: Q13136 Secondary accession number(s): A6NLE3 , Q13135, Q14567, Q8N4I2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13136 (LIPA1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Liprin-alpha-1

PPFIA1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ