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Protein

Liprin-alpha-1

Gene

PPFIA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

GO - Biological processi

  • cell-matrix adhesion Source: ProtInc
  • negative regulation of protein localization to plasma membrane Source: MGI
  • negative regulation of stress fiber assembly Source: MGI
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
SignaLinkiQ13136

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-alpha-1
Alternative name(s):
LAR-interacting protein 1
Short name:
LIP-1
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
Short name:
PTPRF-interacting protein alpha-1
Gene namesi
Name:PPFIA1
Synonyms:LIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000131626.15
HGNCiHGNC:9245 PPFIA1
MIMi611054 gene
neXtProtiNX_Q13136

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8500
OpenTargetsiENSG00000131626
PharmGKBiPA33566

Polymorphism and mutation databases

BioMutaiPPFIA1
DMDMi42558969

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910261 – 1202Liprin-alpha-1Add BLAST1202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei761PhosphothreonineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1159PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13136
MaxQBiQ13136
PaxDbiQ13136
PeptideAtlasiQ13136
PRIDEiQ13136
ProteomicsDBi59184
59185 [Q13136-2]

PTM databases

iPTMnetiQ13136
PhosphoSitePlusiQ13136

Miscellaneous databases

PMAP-CutDBiQ13136

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSG00000131626 Expressed in 229 organ(s), highest expression level in oocyte
CleanExiHS_PPFIA1
ExpressionAtlasiQ13136 baseline and differential
GenevisibleiQ13136 HS

Organism-specific databases

HPAiCAB017032
HPA008272
HPA042271

Interactioni

Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi114072, 68 interactors
ELMiQ13136
IntActiQ13136, 35 interactors
MINTiQ13136
STRINGi9606.ENSP00000253925

Structurei

Secondary structure

11202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13136
SMRiQ13136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini878 – 944SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini963 – 1027SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1051 – 1120SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 141Sequence analysisAdd BLAST108
Coiled coili176 – 214Sequence analysisAdd BLAST39
Coiled coili249 – 521Sequence analysisAdd BLAST273
Coiled coili623 – 669Sequence analysisAdd BLAST47
Coiled coili847 – 871Sequence analysisAdd BLAST25
Coiled coili1021 – 1050Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 25Poly-Gly9

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000017513
HOVERGENiHBG052330
InParanoidiQ13136
OMAiLGTTHKE
OrthoDBiEOG091G14UK
PhylomeDBiQ13136
TreeFamiTF314207

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030438 PPFIA1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF15 PTHR12587:SF15, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13136-1) [UniParc]FASTAAdd to basket
Also known as: LAR-interacting protein 1b, LIP.1b, b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL
60 70 80 90 100
LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC
110 120 130 140 150
REQLLEREEE IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS
160 170 180 190 200
PAGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVALERCS LLEEELGATH
210 220 230 240 250
KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD GSLSHEEDLA
260 270 280 290 300
KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM
310 320 330 340 350
NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI
360 370 380 390 400
ANKDSMHRQT EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA
410 420 430 440 450
ALSKAEERHG NIEERLRQME AQLEEKNQEL QRARQREKMN EEHNKRLSDT
460 470 480 490 500
VDKLLSESNE RLQLHLKERM AALEDKNSLL REVESAKKQL EETQHDKDQL
510 520 530 540 550
VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD GHTDSYSTSA
560 570 580 590 600
VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV
610 620 630 640 650
SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK
660 670 680 690 700
ENTEQRAEEI ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS
710 720 730 740 750
TPRRIPHSPA REVDRLGVMT LLPPSREEVR DDKTTIKCET SPPSSPRALR
760 770 780 790 800
LDRLHKGALH TVSHEDIRDI RNSTGSQDGP VSNPSSSNSS QDSLHKAPKK
810 820 830 840 850
KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ DALGLSKLGG
860 870 880 890 900
QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA
910 920 930 940 950
CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP
960 970 980 990 1000
PTSRTTLAYG DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK
1010 1020 1030 1040 1050
DLRGQLKMVD SFHRNSFQCG IMCLRRLNYD RKELERKREE SQSEIKDVLV
1060 1070 1080 1090 1100
WSNDRVIRWI LSIGLKEYAN NLIESGVHGA LLALDETFDF SALALLLQIP
1110 1120 1130 1140 1150
TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW RKKFRPKDIR
1160 1170 1180 1190 1200
GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGNVSGTQ RLDSATVRTY

SC
Length:1,202
Mass (Da):135,779
Last modified:November 1, 1996 - v1
Checksum:iC8CF7C20B298BFB1
GO
Isoform 2 (identifier: Q13136-2) [UniParc]FASTAAdd to basket
Also known as: LAR-interacting protein 1a, LIP.1a, a

The sequence of this isoform differs from the canonical sequence as follows:
     1185-1202: NVSGTQRLDSATVRTYSC → M

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:1,185
Mass (Da):133,970
Checksum:i00E9FA5C94C8217C
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDZ8H0YDZ8_HUMAN
Liprin-alpha-1
PPFIA1
98Annotation score:
H0YDW2H0YDW2_HUMAN
Liprin-alpha-1
PPFIA1
389Annotation score:
E9PJZ7E9PJZ7_HUMAN
Liprin-alpha-1
PPFIA1
583Annotation score:
E9PPF6E9PPF6_HUMAN
Liprin-alpha-1
PPFIA1
158Annotation score:
E9PID5E9PID5_HUMAN
Liprin-alpha-1
PPFIA1
99Annotation score:
H0YEF9H0YEF9_HUMAN
Liprin-alpha-1
PPFIA1
387Annotation score:
H0YD72H0YD72_HUMAN
Liprin-alpha-1
PPFIA1
237Annotation score:
H0YF15H0YF15_HUMAN
Liprin-alpha-1
PPFIA1
97Annotation score:
A0A1B0GVT3A0A1B0GVT3_HUMAN
Liprin-alpha-1
PPFIA1
271Annotation score:
A0A2R8Y7R9A0A2R8Y7R9_HUMAN
Liprin-alpha-1
PPFIA1
1,224Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA08353 differs from that shown. Reason: Frameshift at positions 1033, 1041, 1045, 1067 and 1113.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti492E → G in AAH34046 (PubMed:15489334).Curated1
Sequence conflicti555P → T in AAH34046 (PubMed:15489334).Curated1
Sequence conflicti672 – 674LGR → EFG in BAA08353 (Ref. 4) Curated3
Sequence conflicti800 – 801KK → EE in BAA08353 (Ref. 4) Curated2
Sequence conflicti866E → G in AAH34046 (PubMed:15489334).Curated1
Sequence conflicti994L → Q in BAA08353 (Ref. 4) Curated1
Sequence conflicti1023C → S in BAA08353 (Ref. 4) Curated1
Sequence conflicti1044E → EVRV in BAA08353 (Ref. 4) Curated1
Sequence conflicti1121 – 1123GTD → PEF in BAA08353 (Ref. 4) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01775671V → I. Corresponds to variant dbSNP:rs546502Ensembl.1
Natural variantiVAR_0499981072L → F. Corresponds to variant dbSNP:rs11236045Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0093911185 – 1202NVSGT…RTYSC → M in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22815 mRNA Translation: AAC50172.1
U22816 mRNA Translation: AAC50173.1
AP002336 Genomic DNA No translation available.
BC034046 mRNA Translation: AAH34046.1
D49354 mRNA Translation: BAA08353.1 Frameshift.
CCDSiCCDS31627.1 [Q13136-1]
CCDS31628.1 [Q13136-2]
PIRiS55553
RefSeqiNP_003617.1, NM_003626.3 [Q13136-1]
NP_803172.1, NM_177423.2 [Q13136-2]
UniGeneiHs.530749
Hs.708791

Genome annotation databases

EnsembliENST00000253925; ENSP00000253925; ENSG00000131626 [Q13136-1]
ENST00000389547; ENSP00000374198; ENSG00000131626 [Q13136-2]
GeneIDi8500
KEGGihsa:8500
UCSCiuc001opn.3 human [Q13136-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22815 mRNA Translation: AAC50172.1
U22816 mRNA Translation: AAC50173.1
AP002336 Genomic DNA No translation available.
BC034046 mRNA Translation: AAH34046.1
D49354 mRNA Translation: BAA08353.1 Frameshift.
CCDSiCCDS31627.1 [Q13136-1]
CCDS31628.1 [Q13136-2]
PIRiS55553
RefSeqiNP_003617.1, NM_003626.3 [Q13136-1]
NP_803172.1, NM_177423.2 [Q13136-2]
UniGeneiHs.530749
Hs.708791

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N7FX-ray1.80C/D1195-1202[»]
ProteinModelPortaliQ13136
SMRiQ13136
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114072, 68 interactors
ELMiQ13136
IntActiQ13136, 35 interactors
MINTiQ13136
STRINGi9606.ENSP00000253925

PTM databases

iPTMnetiQ13136
PhosphoSitePlusiQ13136

Polymorphism and mutation databases

BioMutaiPPFIA1
DMDMi42558969

Proteomic databases

EPDiQ13136
MaxQBiQ13136
PaxDbiQ13136
PeptideAtlasiQ13136
PRIDEiQ13136
ProteomicsDBi59184
59185 [Q13136-2]

Protocols and materials databases

DNASUi8500
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253925; ENSP00000253925; ENSG00000131626 [Q13136-1]
ENST00000389547; ENSP00000374198; ENSG00000131626 [Q13136-2]
GeneIDi8500
KEGGihsa:8500
UCSCiuc001opn.3 human [Q13136-1]

Organism-specific databases

CTDi8500
DisGeNETi8500
EuPathDBiHostDB:ENSG00000131626.15
GeneCardsiPPFIA1
HGNCiHGNC:9245 PPFIA1
HPAiCAB017032
HPA008272
HPA042271
MIMi611054 gene
neXtProtiNX_Q13136
OpenTargetsiENSG00000131626
PharmGKBiPA33566
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000017513
HOVERGENiHBG052330
InParanoidiQ13136
OMAiLGTTHKE
OrthoDBiEOG091G14UK
PhylomeDBiQ13136
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
SignaLinkiQ13136

Miscellaneous databases

ChiTaRSiPPFIA1 human
GeneWikiiLiprin-alpha-1
GenomeRNAii8500
PMAP-CutDBiQ13136
PROiPR:Q13136
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131626 Expressed in 229 organ(s), highest expression level in oocyte
CleanExiHS_PPFIA1
ExpressionAtlasiQ13136 baseline and differential
GenevisibleiQ13136 HS

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030438 PPFIA1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF15 PTHR12587:SF15, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIPA1_HUMAN
AccessioniPrimary (citable) accession number: Q13136
Secondary accession number(s): A6NLE3
, Q13135, Q14567, Q8N4I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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