Oxysterols receptor LXR-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cholesterol binding Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Role of LXRs in control of lipogenesis."
    Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., Schwendner S., Wang S., Thoolen M., Mangelsdorf D.J., Lustig K.D., Shan B.
    Genes Dev 14:2831-2838(2000) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "LXR, a nuclear receptor that defines a distinct retinoid response pathway."
    Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., Mangelsdorf D.J.
    Genes Dev. 9:1033-1045(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• nuclear receptor activity Source: GO_Central <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus."
    Jakobsson T., Venteclef N., Toresson G., Damdimopoulos A.E., Ehrlund A., Lou X., Sanyal S., Steffensen K.R., Gustafsson J.A., Treuter E.
    Mol. Cell 34:510-518(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH GPS2 AND NCOA2, MUTAGENESIS OF 268-ILE--LYS-273 AND 438-LEU-LEU-439.
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sterol response element binding Source: UniProtKBInferred from direct assayⁱ
  • "Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages."
    Rebe C., Raveneau M., Chevriaux A., Lakomy D., Sberna A.L., Costa A., Bessede G., Athias A., Steinmetz E., Lobaccaro J.M., Alves G., Menicacci A., Vachenc S., Solary E., Gambert P., Masson D.
    Circ Res 105:393-401(2009) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes."
    Lu R., Ito J., Iwamoto N., Nishimaki-Mogami T., Yokoyama S.
    J Lipid Res 50:1156-1164(2009) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• apoptotic cell clearance Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages."
    Rebe C., Raveneau M., Chevriaux A., Lakomy D., Sberna A.L., Costa A., Bessede G., Athias A., Steinmetz E., Lobaccaro J.M., Alves G., Menicacci A., Vachenc S., Solary E., Gambert P., Masson D.
    Circ Res 105:393-401(2009) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: BHF-UCLInferred from direct assayⁱ
  • "The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages."
    Fontaine C., Rigamonti E., Pourcet B., Duez H., Duhem C., Fruchart J.C., Chinetti-Gbaguidi G., Staels B.
    Mol Endocrinol 22:1797-1811(2008) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: BHF-UCLInferred from direct assayⁱ
  • "The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages."
    Fontaine C., Rigamonti E., Pourcet B., Duez H., Duhem C., Fruchart J.C., Chinetti-Gbaguidi G., Staels B.
    Mol Endocrinol 22:1797-1811(2008) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: BHF-UCL
• lipid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cholesterol storage Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J Lipid Res 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity."
    Korach-Andre M., Archer A., Barros R.P., Parini P., Gustafsson J.A.
    Proc Natl Acad Sci U S A 108:403-408(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: BHF-UCL
• negative regulation of interferon-gamma-mediated signaling pathway Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Molecular mechanisms underlying the inhibition of IFN-gamma-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs."
    Li N., Salter R.C., Ramji D.P.
    J Cell Biochem 112:675-683(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of lipid transport Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J Lipid Res 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage activation Source: BHF-UCL
• negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J Lipid Res 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of pancreatic juice secretion Source: BHF-UCL
• negative regulation of pinocytosis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J Lipid Res 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of response to endoplasmic reticulum stress Source: UniProtKB
• negative regulation of secretion of lysosomal enzymes Source: BHF-UCL
• negative regulation of transcription by RNA polymerase II Source: BHF-UCL
• phosphatidylcholine acyl-chain remodeling Source: UniProtKB
• positive regulation of cellular protein metabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J Biol Chem 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol efflux Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus."
    Jakobsson T., Venteclef N., Toresson G., Damdimopoulos A.E., Ehrlund A., Lou X., Sanyal S., Steffensen K.R., Gustafsson J.A., Treuter E.
    Mol. Cell 34:510-518(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH GPS2 AND NCOA2, MUTAGENESIS OF 268-ILE--LYS-273 AND 438-LEU-LEU-439.
• positive regulation of cholesterol transport Source: BHF-UCLInferred from direct assayⁱ
  • "Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages."
    Rigamonti E., Helin L., Lestavel S., Mutka A.L., Lepore M., Fontaine C., Bouhlel M.A., Bultel S., Fruchart J.C., Ikonen E., Clavey V., Staels B., Chinetti-Gbaguidi G.
    Circ Res 97:682-689(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J Biol Chem 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipoprotein lipase activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J Biol Chem 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of signaling receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages."
    Fontaine C., Rigamonti E., Pourcet B., Duez H., Duhem C., Fruchart J.C., Chinetti-Gbaguidi G., Staels B.
    Mol Endocrinol 22:1797-1811(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of toll-like receptor 4 signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages."
    Fontaine C., Rigamonti E., Pourcet B., Duez H., Duhem C., Fruchart J.C., Chinetti-Gbaguidi G., Staels B.
    Mol Endocrinol 22:1797-1811(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase."
    Sakurabashi A., Wada-Hiraike O., Hirano M., Fu H., Isono W., Fukuda T., Morita Y., Tanikawa M., Miyamoto Y., Oda K., Kawana K., Osuga Y., Fujii T.
    J. Steroid Biochem. Mol. Biol. 149:80-88(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIRT1 AND CCAR2, SUBCELLULAR LOCATION.
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus."
    Jakobsson T., Venteclef N., Toresson G., Damdimopoulos A.E., Ehrlund A., Lou X., Sanyal S., Steffensen K.R., Gustafsson J.A., Treuter E.
    Mol. Cell 34:510-518(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH GPS2 AND NCOA2, MUTAGENESIS OF 268-ILE--LYS-273 AND 438-LEU-LEU-439.
  • "Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells."
    Weedon-Fekjaer M.S., Dalen K.T., Solaas K., Staff A.C., Duttaroy A.K., Nebb H.I.
    J Lipid Res 51:1886-1896(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of triglyceride biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J Lipid Res 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: BHF-UCLTraceable author statementⁱ
  • "The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages."
    Fontaine C., Rigamonti E., Pourcet B., Duez H., Duhem C., Fruchart J.C., Chinetti-Gbaguidi G., Staels B.
    Mol Endocrinol 22:1797-1811(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of nuclear receptor transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus."
    Jakobsson T., Venteclef N., Toresson G., Damdimopoulos A.E., Ehrlund A., Lou X., Sanyal S., Steffensen K.R., Gustafsson J.A., Treuter E.
    Mol. Cell 34:510-518(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH GPS2 AND NCOA2, MUTAGENESIS OF 268-ILE--LYS-273 AND 438-LEU-LEU-439.
• response to progesterone Source: BHF-UCLInferred from direct assayⁱ
  • "Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages."
    Rigamonti E., Helin L., Lestavel S., Mutka A.L., Lepore M., Fontaine C., Bouhlel M.A., Bultel S., Fruchart J.C., Ikonen E., Clavey V., Staels B., Chinetti-Gbaguidi G.
    Circ Res 97:682-689(2005) [PubMed] [Europe PMC] [Abstract]
• sterol homeostasis Source: BHF-UCL
• transcription initiation from RNA polymerase II promoter Source: Reactome
• triglyceride homeostasis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA 
        60         70         80         90        100
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV 
       110        120        130        140        150
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC 
       160        170        180        190        200
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP 
       210        220        230        240        250
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTPWPM APDPHSREAR 
       260        270        280        290        300
QQRFAHFTEL AIVSVQEIVD FAKQLPGFLQ LSREDQIALL KTSAIEVMLL 
       310        320        330        340        350
ETSRRYNPGS ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ 
       360        370        380        390        400
LNDAEFALLI AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD 
       410        420        430        440 
RLMFPRMLMK LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE    

        10         20         30         40         50
MSLWLGAPVP DIPPDSAVEL WKPGAQDASS QAQGGSSCIL REEARMPHSA 
        60         70         80         90        100
GGTAGVGLEA AEPTALLTRA EPPSEPTEIR PQKRKKGPAP KMLGNELCSV 
       110        120        130        140        150
CGDKASGFHY NVLSCEGCKG FFRRSVIKGA HYICHSGGHC PMDTYMRRKC 
       160        170        180        190        200
QECRLRKCRQ AGMREECVLS EEQIRLKKLK RQEEEQAHAT SLPPRASSPP 
       210        220        230        240        250
QILPQLSPEQ LGMIEKLVAA QQQCNRRSFS DRLRVTVMLL ETSRRYNPGS 
       260        270        280        290        300
ESITFLKDFS YNREDFAKAG LQVEFINPIF EFSRAMNELQ LNDAEFALLI 
       310        320        330        340        350
AISIFSADRP NVQDQLQVER LQHTYVEALH AYVSIHHPHD RLMFPRMLMK 
       360        370        380 
LVSLRTLSSV HSEQVFALRL QDKKLPPLLS EIWDVHE               

        10         20         30         40         50
MPHSAGGTAG VGLEAAEPTA LLTRAEPPSE PTEIRPQKRK KGPAPKMLGN 
        60         70         80         90        100
ELCSVCGDKA SGFHYNVLSC EGCKGFFRRS VIKGAHYICH SGGHCPMDTY 
       110        120        130        140        150
MRRKCQECRL RKCRQAGMRE ECVLSEEQIR LKKLKRQEEE QAHATSLPPR 
       160        170        180        190        200
ASSPPQILPQ LSPEQLGMIE KLVAAQQQCN RRSFSDRLRV TPWPMAPDPH 
       210        220        230        240        250
SREARQQRFA HFTELAIVSV QEIVDFAKQL PGFLQLSRED QIALLKTSAI 
       260        270        280        290        300
EVMLLETSRR YNPGSESITF LKDFSYNRED FAKAGLQVEF INPIFEFSRA 
       310        320        330        340        350
MNELQLNDAE FALLIAISIF SADRPNVQDQ LQVERLQHTY VEALHAYVSI 
       360        370        380        390        400
HHPHDRLMFP RMLMKLVSLR TLSSVHSEQV FALRLQDKKL PPLLSEIWDV 

HE                                                     

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families