UniProtKB - Q13131 (AAPK1_HUMAN)
Protein
5'-AMP-activated protein kinase catalytic subunit alpha-1
Gene
PRKAA1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.By similarity13 Publications
Catalytic activityi
- EC:2.7.11.1By similarity
- EC:2.7.11.1By similarity
- ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H+ + O-phospho-L-seryl-[acetyl-CoA carboxylase]By similarityEC:2.7.11.27By similarity
- ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H+ + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]By similarityEC:2.7.11.31By similarity
- EC:2.7.11.26
- EC:2.7.11.26
Cofactori
Activity regulationi
Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis. However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo (PubMed:11602624). Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol.5 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 150 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 41 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- [acetyl-CoA carboxylase] kinase activity Source: UniProtKB-EC
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Source: UniProtKB-EC
- AMP-activated protein kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- cAMP-dependent protein kinase activity Source: UniProtKB
- chromatin binding Source: UniProtKB
- histone serine kinase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: ARUK-UCL
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- bile acid and bile salt transport Source: Ensembl
- bile acid signaling pathway Source: Ensembl
- CAMKK-AMPK signaling cascade Source: ParkinsonsUK-UCL
- cell cycle arrest Source: Reactome
- cellular response to calcium ion Source: ARUK-UCL
- cellular response to drug Source: Ensembl
- cellular response to ethanol Source: Ensembl
- cellular response to glucose starvation Source: UniProtKB
- cellular response to glucose stimulus Source: ARUK-UCL
- cellular response to hydrogen peroxide Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to nutrient levels Source: UniProtKB
- cellular response to organonitrogen compound Source: Ensembl
- cellular response to oxidative stress Source: ARUK-UCL
- cellular response to prostaglandin E stimulus Source: Ensembl
- cholesterol biosynthetic process Source: UniProtKB-KW
- cold acclimation Source: Ensembl
- energy homeostasis Source: UniProtKB
- fatty acid biosynthetic process Source: UniProtKB-KW
- fatty acid homeostasis Source: UniProtKB
- fatty acid oxidation Source: Ensembl
- glucose homeostasis Source: UniProtKB
- glucose metabolic process Source: Ensembl
- intracellular signal transduction Source: GO_Central
- lipid biosynthetic process Source: UniProtKB
- macroautophagy Source: Reactome
- motor behavior Source: ARUK-UCL
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of glucosylceramide biosynthetic process Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: Ensembl
- negative regulation of lipid catabolic process Source: UniProtKB
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of tubulin deacetylation Source: ARUK-UCL
- neuron cellular homeostasis Source: ARUK-UCL
- positive regulation of autophagy Source: ParkinsonsUK-UCL
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cellular protein localization Source: ARUK-UCL
- positive regulation of cholesterol biosynthetic process Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glycolytic process Source: UniProtKB
- positive regulation of mitochondrial transcription Source: Ensembl
- positive regulation of peptidyl-lysine acetylation Source: ARUK-UCL
- positive regulation of protein targeting to mitochondrion Source: Ensembl
- positive regulation of skeletal muscle tissue development Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of bile acid secretion Source: Ensembl
- regulation of circadian rhythm Source: UniProtKB
- regulation of macroautophagy Source: Reactome
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- regulation of peptidyl-serine phosphorylation Source: Ensembl
- regulation of signal transduction by p53 class mediator Source: Reactome
- regulation of stress granule assembly Source: Ensembl
- regulation of vesicle-mediated transport Source: Ensembl
- response to 17alpha-ethynylestradiol Source: Ensembl
- response to activity Source: Ensembl
- response to caffeine Source: Ensembl
- response to camptothecin Source: Ensembl
- response to gamma radiation Source: UniProtKB
- response to hypoxia Source: UniProtKB
- response to UV Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- signal transduction Source: ProtInc
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13131 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-9619483, Activation of AMPK downstream of NMDARs |
SignaLinki | Q13131 |
SIGNORi | Q13131 |
Names & Taxonomyi
Protein namesi | Recommended name: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC:2.7.11.1By similarity)Short name: AMPK subunit alpha-1 Alternative name(s): |
Gene namesi | Name:PRKAA1 Synonyms:AMPK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9376, PRKAA1 |
MIMi | 602739, gene |
neXtProti | NX_Q13131 |
VEuPathDBi | HostDB:ENSG00000132356.11 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: Ensembl
Other locations
- axon Source: ARUK-UCL
- cytoplasm Source: ARUK-UCL
- dendrite Source: ARUK-UCL
- neuronal cell body Source: ARUK-UCL
- nucleotide-activated protein kinase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 307 | V → G or Q: Activates the kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5562 |
OpenTargetsi | ENSG00000132356 |
PharmGKBi | PA33744 |
Miscellaneous databases
Pharosi | Q13131, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4045 |
DrugBanki | DB00945, Acetylsalicylic acid DB00131, Adenosine phosphate DB00171, ATP DB12010, Fostamatinib DB00914, Phenformin DB00273, Topiramate |
DrugCentrali | Q13131 |
Genetic variation databases
BioMutai | PRKAA1 |
DMDMi | 254763436 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085589 | 1 – 559 | 5'-AMP-activated protein kinase catalytic subunit alpha-1Add BLAST | 559 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 183 | Phosphothreonine; by LKB1 and CaMKK2By similarity | 1 | |
Modified residuei | 269 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 355 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 360 | Phosphoserine; by ULK1By similarity | 1 | |
Modified residuei | 368 | Phosphothreonine; by ULK1By similarity | 1 | |
Modified residuei | 382 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 397 | PhosphoserineBy similarity | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 486 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 490 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 508 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphoserineCombined sources | 1 | |
Modified residuei | 527 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Ubiquitinated.By similarity
Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.4 Publications
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13131 |
jPOSTi | Q13131 |
MassIVEi | Q13131 |
MaxQBi | Q13131 |
PaxDbi | Q13131 |
PeptideAtlasi | Q13131 |
PRIDEi | Q13131 |
ProteomicsDBi | 59180 [Q13131-1] 59181 [Q13131-2] |
PTM databases
iPTMneti | Q13131 |
PhosphoSitePlusi | Q13131 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132356, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q13131, baseline and differential |
Genevisiblei | Q13131, HS |
Organism-specific databases
HPAi | ENSG00000132356, Low tissue specificity |
Interactioni
Subunit structurei
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).
Interacts with FNIP1 and FNIP2.
4 PublicationsBinary interactionsi
Hide detailsQ13131
GO - Molecular functioni
- protein C-terminus binding Source: Ensembl
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 111549, 191 interactors |
ComplexPortali | CPX-5633, AMPK complex, alpha1-beta1-gamma1 variant CPX-5786, AMPK complex, alpha1-beta1-gamma2 variant CPX-5791, AMPK complex, alpha1-beta2-gamma1 variant CPX-5841, AMPK complex, alpha1-beta2-gamma3 variant CPX-5842, AMPK complex, alpha1-beta1-gamma3 variant CPX-5846, AMPK complex, alpha1-beta2-gamma2 variant |
CORUMi | Q13131 |
DIPi | DIP-39973N |
IntActi | Q13131, 116 interactors |
MINTi | Q13131 |
STRINGi | 9606.ENSP00000346148 |
Chemistry databases
BindingDBi | Q13131 |
Miscellaneous databases
RNActi | Q13131, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13131 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 279 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 253 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 302 – 381 | AISAdd BLAST | 80 |
Domaini
The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.2 Publications
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000158865 |
HOGENOMi | CLU_000288_59_3_1 |
OMAi | YRSCQKD |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q13131 |
TreeFami | TF314032 |
Family and domain databases
CDDi | cd12199, AMPKA1_C, 1 hit cd14403, UBA_AID_AAPK1, 1 hit |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039137, AMPKA1_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR028797, PRKAA1_UBA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q13131-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG
60 70 80 90 100
HKVAVKILNR QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI
110 120 130 140 150
FMVMEYVSGG ELFDYICKNG RLDEKESRRL FQQILSGVDY CHRHMVVHRD
160 170 180 190 200
LKPENVLLDA HMNAKIADFG LSNMMSDGEF LRTSCGSPNY AAPEVISGRL
210 220 230 240 250
YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG IFYTPQYLNP
260 270 280 290 300
SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID
310 320 330 340 350
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD
360 370 380 390 400
FYLATSPPDS FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ
410 420 430 440 450
GVRKAKWHLG IRSQSRPNDI MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP
460 470 480 490 500
VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE ITEAKSGTAT PQRSGSVSNY
510 520 530 540 550
RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG SHTIEFFEMC
ANLIKILAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ96E92 | Q96E92_HUMAN | 5'-AMP-activated protein kinase cat... | PRKAA1 hCG_37338 | 207 | Annotation score: |
Sequence cautioni
The sequence AAA64850 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD43027 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH37303 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA36547 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG35788 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | S → C in BAG35788 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 9 | K → S in AAD43027 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 37 | T → A in AAA64850 (Ref. 6) Curated | 1 | |
Sequence conflicti | 202 | A → V in AAA64850 (Ref. 6) Curated | 1 | |
Sequence conflicti | 208 | I → L in AAA64850 (Ref. 6) Curated | 1 | |
Sequence conflicti | 269 | T → S in BAA36547 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058401 | 10 | M → L1 PublicationCorresponds to variant dbSNP:rs17855679Ensembl. | 1 | |
Natural variantiVAR_035622 | 16 | Q → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs928784854Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035431 | 121 | R → RKSDVPGVVKTGSTKE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008810 Genomic DNA No translation available. BC048980 mRNA Translation: AAH48980.1 AB022017 mRNA Translation: BAA36547.1 Different initiation. AK312947 mRNA Translation: BAG35788.1 Different initiation. BC037303 mRNA Translation: AAH37303.1 Different initiation. AF100763 mRNA Translation: AAD43027.1 Different initiation. U22456 mRNA Translation: AAA64850.1 Different initiation. Y12856 mRNA Translation: CAA73361.1 |
CCDSi | CCDS3932.2 [Q13131-1] CCDS3933.2 [Q13131-2] |
PIRi | G01743 |
RefSeqi | NP_006242.5, NM_006251.5 [Q13131-1] NP_996790.3, NM_206907.3 [Q13131-2] |
Genome annotation databases
Ensembli | ENST00000354209; ENSP00000346148; ENSG00000132356 [Q13131-2] ENST00000397128; ENSP00000380317; ENSG00000132356 [Q13131-1] |
GeneIDi | 5562 |
KEGGi | hsa:5562 |
UCSCi | uc003jmb.4, human [Q13131-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008810 Genomic DNA No translation available. BC048980 mRNA Translation: AAH48980.1 AB022017 mRNA Translation: BAA36547.1 Different initiation. AK312947 mRNA Translation: BAG35788.1 Different initiation. BC037303 mRNA Translation: AAH37303.1 Different initiation. AF100763 mRNA Translation: AAD43027.1 Different initiation. U22456 mRNA Translation: AAA64850.1 Different initiation. Y12856 mRNA Translation: CAA73361.1 |
CCDSi | CCDS3932.2 [Q13131-1] CCDS3933.2 [Q13131-2] |
PIRi | G01743 |
RefSeqi | NP_006242.5, NM_006251.5 [Q13131-1] NP_996790.3, NM_206907.3 [Q13131-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4RED | X-ray | 2.95 | A/B | 22-362 | [»] | |
4RER | X-ray | 4.05 | A | 20-559 | [»] | |
4REW | X-ray | 4.58 | A | 20-559 | [»] | |
5EZV | X-ray | 2.99 | A/C | 359-401 | [»] | |
6C9F | X-ray | 2.92 | A | 22-559 | [»] | |
6C9G | X-ray | 2.70 | A | 22-559 | [»] | |
6C9H | X-ray | 2.65 | A | 22-559 | [»] | |
6C9J | X-ray | 3.05 | A | 22-559 | [»] | |
SMRi | Q13131 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111549, 191 interactors |
ComplexPortali | CPX-5633, AMPK complex, alpha1-beta1-gamma1 variant CPX-5786, AMPK complex, alpha1-beta1-gamma2 variant CPX-5791, AMPK complex, alpha1-beta2-gamma1 variant CPX-5841, AMPK complex, alpha1-beta2-gamma3 variant CPX-5842, AMPK complex, alpha1-beta1-gamma3 variant CPX-5846, AMPK complex, alpha1-beta2-gamma2 variant |
CORUMi | Q13131 |
DIPi | DIP-39973N |
IntActi | Q13131, 116 interactors |
MINTi | Q13131 |
STRINGi | 9606.ENSP00000346148 |
Chemistry databases
BindingDBi | Q13131 |
ChEMBLi | CHEMBL4045 |
DrugBanki | DB00945, Acetylsalicylic acid DB00131, Adenosine phosphate DB00171, ATP DB12010, Fostamatinib DB00914, Phenformin DB00273, Topiramate |
DrugCentrali | Q13131 |
PTM databases
iPTMneti | Q13131 |
PhosphoSitePlusi | Q13131 |
Genetic variation databases
BioMutai | PRKAA1 |
DMDMi | 254763436 |
Proteomic databases
EPDi | Q13131 |
jPOSTi | Q13131 |
MassIVEi | Q13131 |
MaxQBi | Q13131 |
PaxDbi | Q13131 |
PeptideAtlasi | Q13131 |
PRIDEi | Q13131 |
ProteomicsDBi | 59180 [Q13131-1] 59181 [Q13131-2] |
Protocols and materials databases
Antibodypediai | 3564, 1400 antibodies |
DNASUi | 5562 |
Genome annotation databases
Ensembli | ENST00000354209; ENSP00000346148; ENSG00000132356 [Q13131-2] ENST00000397128; ENSP00000380317; ENSG00000132356 [Q13131-1] |
GeneIDi | 5562 |
KEGGi | hsa:5562 |
UCSCi | uc003jmb.4, human [Q13131-1] |
Organism-specific databases
CTDi | 5562 |
DisGeNETi | 5562 |
GeneCardsi | PRKAA1 |
HGNCi | HGNC:9376, PRKAA1 |
HPAi | ENSG00000132356, Low tissue specificity |
MIMi | 602739, gene |
neXtProti | NX_Q13131 |
OpenTargetsi | ENSG00000132356 |
PharmGKBi | PA33744 |
VEuPathDBi | HostDB:ENSG00000132356.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000158865 |
HOGENOMi | CLU_000288_59_3_1 |
OMAi | YRSCQKD |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q13131 |
TreeFami | TF314032 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q13131 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-9619483, Activation of AMPK downstream of NMDARs |
SignaLinki | Q13131 |
SIGNORi | Q13131 |
Miscellaneous databases
BioGRID-ORCSi | 5562, 20 hits in 905 CRISPR screens |
ChiTaRSi | PRKAA1, human |
GeneWikii | Protein_kinase,_AMP-activated,_alpha_1 |
GenomeRNAii | 5562 |
Pharosi | Q13131, Tchem |
PROi | PR:Q13131 |
RNActi | Q13131, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132356, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q13131, baseline and differential |
Genevisiblei | Q13131, HS |
Family and domain databases
CDDi | cd12199, AMPKA1_C, 1 hit cd14403, UBA_AID_AAPK1, 1 hit |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039137, AMPKA1_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR028797, PRKAA1_UBA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AAPK1_HUMAN | |
Accessioni | Q13131Primary (citable) accession number: Q13131 Secondary accession number(s): A8MTQ6 Q9UNQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 10, 2021 | |
This is version 223 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human and mouse protein kinases
Human and mouse protein kinases: classification and index