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Protein

Zinc finger protein Rlf

Gene

RLF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Miscellaneous

In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri582 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 696C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri714 – 736C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 766C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri771 – 795C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri801 – 825C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri954 – 979C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1127 – 1152C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1172 – 1195C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1310 – 1335C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1362 – 1387C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1407 – 1432C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1444 – 1469C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1549 – 1574C2H2-type 14PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • chromosome organization Source: UniProtKB
  • DNA integration Source: UniProtKB
  • histone H3-K4 monomethylation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of DNA methylation Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ13129

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Rlf
Alternative name(s):
Rearranged L-myc fusion gene protein
Zn-15-related protein
Gene namesi
Name:RLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117000.8
HGNCiHGNC:10025 RLF
MIMi180610 gene
neXtProtiNX_Q13129

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6018
OpenTargetsiENSG00000117000
PharmGKBiPA34398

Polymorphism and mutation databases

BioMutaiRLF
DMDMi62296764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473251 – 1914Zinc finger protein RlfAdd BLAST1914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei632PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Cross-linki839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1696Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13129
MaxQBiQ13129
PaxDbiQ13129
PeptideAtlasiQ13129
PRIDEiQ13129
ProteomicsDBi59179

PTM databases

iPTMnetiQ13129
PhosphoSitePlusiQ13129

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues.

Gene expression databases

BgeeiENSG00000117000
CleanExiHS_RLF
GenevisibleiQ13129 HS

Organism-specific databases

HPAiHPA054653
HPA057300

Interactioni

Subunit structurei

Interacts with RIT1 and RIT2.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111950, 13 interactors
IntActiQ13129, 11 interactors
MINTiQ13129
STRINGi9606.ENSP00000361857

Structurei

3D structure databases

ProteinModelPortaliQ13129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri582 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 696C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri714 – 736C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 766C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri771 – 795C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri801 – 825C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri954 – 979C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1127 – 1152C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1172 – 1195C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1310 – 1335C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1362 – 1387C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1407 – 1432C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1444 – 1469C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1549 – 1574C2H2-type 14PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139400
HOGENOMiHOG000231080
HOVERGENiHBG057472
InParanoidiQ13129
OMAiGQLYHHE
OrthoDBiEOG091G006P
PhylomeDBiQ13129
TreeFamiTF350813

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q13129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGKGDAAA VAGAGAEAPA VAGAGDGVET ESMVRGHRPV SPAPGASGLR
60 70 80 90 100
PCLWQLETEL REQEVSEVSS LNYCRSFCQT LLQYASNKNA SEHIVYLLEV
110 120 130 140 150
YRLAIQSFAS ARPYLTTECE DVLLVLGRLV LSCFELLLSV SESELPCEVW
160 170 180 190 200
LPFLQSLQES HDALLEFGNN NLQILVHVTK EGVWKNPVLL KILSQQPVET
210 220 230 240 250
EEVNKLIAQE GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE SKEISNVSSF
260 270 280 290 300
QQAYITCLCS MLPNEDAIKE IAKVDCKEVL DIICNLESEG QDNTAFVLCT
310 320 330 340 350
TYLTQQLQTA SVYCSWELTL FWSKLQRRID PSLDTFLERC RQFGVIAKTQ
360 370 380 390 400
QHLFCLIRVI QTEAQDAGLG VSILLCVRAL QLRSSEDEEM KASVCKTIAC
410 420 430 440 450
LLPEDLEVRR ACQLTEFLIE PSLDGFNMLE ELYLQPDQKF DEENAPVPNS
460 470 480 490 500
LRCELLLALK AHWPFDPEFW DWKTLKRHCH QLLGQEASDS DDDLSGYEMS
510 520 530 540 550
INDTDVLESF LSDYDEGKED KQYRRRDLTD QHKEKRDKKP IGSSERYQRW
560 570 580 590 600
LQYKFFCLLC KRECIEARIL HHSKMHMEDG IYTCPVCIKK FKRKEMFVPH
610 620 630 640 650
VMEHVKMPPS RRDRSKKKLL LKGSQKGICP KSPSAIPEQN HSLNDQAKGE
660 670 680 690 700
SHEYVTFSKL EDCHLQDRDL YPCPGTDCSR VFKQFKYLSV HLKAEHQNND
710 720 730 740 750
ENAKHYLDMK NRREKCTYCR RHFMSAFHLR EHEQVHCGPQ PYMCVSIDCY
760 770 780 790 800
ARFGSVNELL NHKQKHDDLR YKCELNGCNI VFSDLGQLYH HEAQHFRDAS
810 820 830 840 850
YTCNFLGCKK FYYSKIEYQN HLSMHNVENS NGDIKKSVKL EESATGEKQD
860 870 880 890 900
CINQPHLLNQ TDKSHLPEDL FCAESANSQI DTETAENLKE NSDSNSSDQL
910 920 930 940 950
SHSSSASMNE ELIDTLDHSE TMQDVLLSNE KVFGPSSLKE KCSSMAVCFD
960 970 980 990 1000
GTKFTCGFDG CGSTYKNARG MQKHLRKVHP YHFKPKKIKT KDLFPSLGNE
1010 1020 1030 1040 1050
HNQTTEKLDA EPKPCSDTNS DSPDEGLDHN IHIKCKREHQ GYSSESSICA
1060 1070 1080 1090 1100
SKRPCTEDTM LELLLRLKHL SLKNSITHGS FSGSLQGYPS SGAKSLQSVS
1110 1120 1130 1140 1150
SISDLNFQNQ DENMPSQYLA QLAAKPFFCE LQGCKYEFVT REALLMHYLK
1160 1170 1180 1190 1200
KHNYSKEKVL QLTMFQHRYS PFQCHICQRS FTRKTHLRIH YKNKHQIGSD
1210 1220 1230 1240 1250
RATHKLLDNE KCDHEGPCSV DRLKGDCSAE LGGDPSSNSE KPHCHPKKDE
1260 1270 1280 1290 1300
CSSETDLESS CEETESKTSD ISSPIGSHRE EQEGREGRGS RRTVAKGNLC
1310 1320 1330 1340 1350
YILNKYHKPF HCIHKTCNSS FTNLKGLIRH YRTVHQYNKE QLCLEKDKAR
1360 1370 1380 1390 1400
TKRELVKCKK IFACKYKECN KRFLCSKALA KHCSDSHNLD HIEEPKVLSE
1410 1420 1430 1440 1450
AGSAARFSCN QPQCPAVFYT FNKLKHHLME QHNIEGEIHS DYEIHCDLNG
1460 1470 1480 1490 1500
CGQIFTHRSN YSQHVYYRHK DYYDDLFRSQ KVANERLLRS EKVCQTADTQ
1510 1520 1530 1540 1550
GHEHQTTRRS FNAKSKKCGL IKEKKAPISF KTRAEALHMC VEHSEHTQYP
1560 1570 1580 1590 1600
CMVQGCLSVV KLESSIVRHY KRTHQMSSAY LEQQMENLVV CVKYGTKIKE
1610 1620 1630 1640 1650
EPPSEADPCI KKEENRSCES ERTEHSHSPG DSSAPIQNTD CCHSSERDGG
1660 1670 1680 1690 1700
QKGCIESSSV FDADTLLYRG TLKCNHSSKT TSLEQCNIVQ PPPPCKIENS
1710 1720 1730 1740 1750
IPNPNGTESG TYFTSFQLPL PRIKESETRQ HSSGQENTVK NPTHVPKENF
1760 1770 1780 1790 1800
RKHSQPRSFD LKTYKPMGFE SSFLKFIQES EEKEDDFDDW EPSEHLTLSN
1810 1820 1830 1840 1850
SSQSSNDLTG NVVANNMVND SEPEVDIPHS SSDSTIHENL TAIPPLIVAE
1860 1870 1880 1890 1900
TTTVPSLENL RVVLDKALTD CGELALKQLH YLRPVVVLER SKFSTPILDL
1910
FPTKKTDELC VGSS
Length:1,914
Mass (Da):217,953
Last modified:March 29, 2005 - v2
Checksum:i105C85C645563999
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1546 – 1548HTQ → LSL in AAC50396 (PubMed:8545128).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052739668R → K. Corresponds to variant dbSNP:rs35189918Ensembl.1
Natural variantiVAR_052740932V → A. Corresponds to variant dbSNP:rs35563960Ensembl.1
Natural variantiVAR_052741957G → D. Corresponds to variant dbSNP:rs35042446Ensembl.1
Natural variantiVAR_0619291629P → L. Corresponds to variant dbSNP:rs34123123Ensembl.1
Natural variantiVAR_0619301685Q → E. Corresponds to variant dbSNP:rs34141181Ensembl.1
Natural variantiVAR_0527421784E → D. Corresponds to variant dbSNP:rs10889205Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22377 mRNA Translation: AAC50396.1
AL050341 Genomic DNA No translation available.
AL929567 Genomic DNA No translation available.
AL512599 Genomic DNA No translation available.
AL356424 Genomic DNA No translation available.
BC113666 mRNA Translation: AAI13667.1
CCDSiCCDS448.1
PIRiS21662
RefSeqiNP_036553.2, NM_012421.3
UniGeneiHs.205627

Genome annotation databases

EnsembliENST00000372771; ENSP00000361857; ENSG00000117000
GeneIDi6018
KEGGihsa:6018
UCSCiuc001cfc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRLF_HUMAN
AccessioniPrimary (citable) accession number: Q13129
Secondary accession number(s): Q14CQ1, Q9NU60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 29, 2005
Last modified: July 18, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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