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Entry version 188 (11 Dec 2019)
Sequence version 2 (29 Mar 2005)
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Protein

Zinc finger protein Rlf

Gene

RLF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Miscellaneous

In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri582 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 696C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri714 – 736C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 766C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri771 – 795C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri801 – 825C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri954 – 979C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1127 – 1152C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1172 – 1195C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1310 – 1335C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1362 – 1387C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1407 – 1432C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1444 – 1469C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1549 – 1574C2H2-type 14PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • zinc ion binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13129

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein Rlf
Alternative name(s):
Rearranged L-myc fusion gene protein
Zn-15-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RLF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117000.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10025 RLF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13129

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6018

Open Targets

More...
OpenTargetsi
ENSG00000117000

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34398

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13129 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RLF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62296764

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473251 – 1914Zinc finger protein RlfAdd BLAST1914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei632PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Cross-linki839Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1696Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13129

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13129

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13129

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13129

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13129

PeptideAtlas

More...
PeptideAtlasi
Q13129

PRoteomics IDEntifications database

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PRIDEi
Q13129

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59179

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13129

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13129

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in fetal and adult tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117000 Expressed in 223 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13129 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA054653
HPA057300

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RIT1 and RIT2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111950, 20 interactors

Protein interaction database and analysis system

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IntActi
Q13129, 12 interactors

Molecular INTeraction database

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MINTi
Q13129

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361857

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q13129 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri582 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 696C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri714 – 736C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 766C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri771 – 795C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri801 – 825C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri954 – 979C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1127 – 1152C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1172 – 1195C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1310 – 1335C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1362 – 1387C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1407 – 1432C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1444 – 1469C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1549 – 1574C2H2-type 14PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183034

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231080

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13129

Identification of Orthologs from Complete Genome Data

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OMAi
VLCKREC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13129

TreeFam database of animal gene trees

More...
TreeFami
TF350813

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q13129-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGKGDAAA VAGAGAEAPA VAGAGDGVET ESMVRGHRPV SPAPGASGLR
60 70 80 90 100
PCLWQLETEL REQEVSEVSS LNYCRSFCQT LLQYASNKNA SEHIVYLLEV
110 120 130 140 150
YRLAIQSFAS ARPYLTTECE DVLLVLGRLV LSCFELLLSV SESELPCEVW
160 170 180 190 200
LPFLQSLQES HDALLEFGNN NLQILVHVTK EGVWKNPVLL KILSQQPVET
210 220 230 240 250
EEVNKLIAQE GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE SKEISNVSSF
260 270 280 290 300
QQAYITCLCS MLPNEDAIKE IAKVDCKEVL DIICNLESEG QDNTAFVLCT
310 320 330 340 350
TYLTQQLQTA SVYCSWELTL FWSKLQRRID PSLDTFLERC RQFGVIAKTQ
360 370 380 390 400
QHLFCLIRVI QTEAQDAGLG VSILLCVRAL QLRSSEDEEM KASVCKTIAC
410 420 430 440 450
LLPEDLEVRR ACQLTEFLIE PSLDGFNMLE ELYLQPDQKF DEENAPVPNS
460 470 480 490 500
LRCELLLALK AHWPFDPEFW DWKTLKRHCH QLLGQEASDS DDDLSGYEMS
510 520 530 540 550
INDTDVLESF LSDYDEGKED KQYRRRDLTD QHKEKRDKKP IGSSERYQRW
560 570 580 590 600
LQYKFFCLLC KRECIEARIL HHSKMHMEDG IYTCPVCIKK FKRKEMFVPH
610 620 630 640 650
VMEHVKMPPS RRDRSKKKLL LKGSQKGICP KSPSAIPEQN HSLNDQAKGE
660 670 680 690 700
SHEYVTFSKL EDCHLQDRDL YPCPGTDCSR VFKQFKYLSV HLKAEHQNND
710 720 730 740 750
ENAKHYLDMK NRREKCTYCR RHFMSAFHLR EHEQVHCGPQ PYMCVSIDCY
760 770 780 790 800
ARFGSVNELL NHKQKHDDLR YKCELNGCNI VFSDLGQLYH HEAQHFRDAS
810 820 830 840 850
YTCNFLGCKK FYYSKIEYQN HLSMHNVENS NGDIKKSVKL EESATGEKQD
860 870 880 890 900
CINQPHLLNQ TDKSHLPEDL FCAESANSQI DTETAENLKE NSDSNSSDQL
910 920 930 940 950
SHSSSASMNE ELIDTLDHSE TMQDVLLSNE KVFGPSSLKE KCSSMAVCFD
960 970 980 990 1000
GTKFTCGFDG CGSTYKNARG MQKHLRKVHP YHFKPKKIKT KDLFPSLGNE
1010 1020 1030 1040 1050
HNQTTEKLDA EPKPCSDTNS DSPDEGLDHN IHIKCKREHQ GYSSESSICA
1060 1070 1080 1090 1100
SKRPCTEDTM LELLLRLKHL SLKNSITHGS FSGSLQGYPS SGAKSLQSVS
1110 1120 1130 1140 1150
SISDLNFQNQ DENMPSQYLA QLAAKPFFCE LQGCKYEFVT REALLMHYLK
1160 1170 1180 1190 1200
KHNYSKEKVL QLTMFQHRYS PFQCHICQRS FTRKTHLRIH YKNKHQIGSD
1210 1220 1230 1240 1250
RATHKLLDNE KCDHEGPCSV DRLKGDCSAE LGGDPSSNSE KPHCHPKKDE
1260 1270 1280 1290 1300
CSSETDLESS CEETESKTSD ISSPIGSHRE EQEGREGRGS RRTVAKGNLC
1310 1320 1330 1340 1350
YILNKYHKPF HCIHKTCNSS FTNLKGLIRH YRTVHQYNKE QLCLEKDKAR
1360 1370 1380 1390 1400
TKRELVKCKK IFACKYKECN KRFLCSKALA KHCSDSHNLD HIEEPKVLSE
1410 1420 1430 1440 1450
AGSAARFSCN QPQCPAVFYT FNKLKHHLME QHNIEGEIHS DYEIHCDLNG
1460 1470 1480 1490 1500
CGQIFTHRSN YSQHVYYRHK DYYDDLFRSQ KVANERLLRS EKVCQTADTQ
1510 1520 1530 1540 1550
GHEHQTTRRS FNAKSKKCGL IKEKKAPISF KTRAEALHMC VEHSEHTQYP
1560 1570 1580 1590 1600
CMVQGCLSVV KLESSIVRHY KRTHQMSSAY LEQQMENLVV CVKYGTKIKE
1610 1620 1630 1640 1650
EPPSEADPCI KKEENRSCES ERTEHSHSPG DSSAPIQNTD CCHSSERDGG
1660 1670 1680 1690 1700
QKGCIESSSV FDADTLLYRG TLKCNHSSKT TSLEQCNIVQ PPPPCKIENS
1710 1720 1730 1740 1750
IPNPNGTESG TYFTSFQLPL PRIKESETRQ HSSGQENTVK NPTHVPKENF
1760 1770 1780 1790 1800
RKHSQPRSFD LKTYKPMGFE SSFLKFIQES EEKEDDFDDW EPSEHLTLSN
1810 1820 1830 1840 1850
SSQSSNDLTG NVVANNMVND SEPEVDIPHS SSDSTIHENL TAIPPLIVAE
1860 1870 1880 1890 1900
TTTVPSLENL RVVLDKALTD CGELALKQLH YLRPVVVLER SKFSTPILDL
1910
FPTKKTDELC VGSS
Length:1,914
Mass (Da):217,953
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i105C85C645563999
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1546 – 1548HTQ → LSL in AAC50396 (PubMed:8545128).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052739668R → K. Corresponds to variant dbSNP:rs35189918Ensembl.1
Natural variantiVAR_052740932V → A. Corresponds to variant dbSNP:rs35563960Ensembl.1
Natural variantiVAR_052741957G → D. Corresponds to variant dbSNP:rs35042446Ensembl.1
Natural variantiVAR_0619291629P → L. Corresponds to variant dbSNP:rs34123123Ensembl.1
Natural variantiVAR_0619301685Q → E. Corresponds to variant dbSNP:rs34141181Ensembl.1
Natural variantiVAR_0527421784E → D. Corresponds to variant dbSNP:rs10889205Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U22377 mRNA Translation: AAC50396.1
AL050341 Genomic DNA No translation available.
AL929567 Genomic DNA No translation available.
AL512599 Genomic DNA No translation available.
AL356424 Genomic DNA No translation available.
BC113666 mRNA Translation: AAI13667.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS448.1

Protein sequence database of the Protein Information Resource

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PIRi
S21662

NCBI Reference Sequences

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RefSeqi
NP_036553.2, NM_012421.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000372771; ENSP00000361857; ENSG00000117000

Database of genes from NCBI RefSeq genomes

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GeneIDi
6018

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6018

UCSC genome browser

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UCSCi
uc001cfc.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22377 mRNA Translation: AAC50396.1
AL050341 Genomic DNA No translation available.
AL929567 Genomic DNA No translation available.
AL512599 Genomic DNA No translation available.
AL356424 Genomic DNA No translation available.
BC113666 mRNA Translation: AAI13667.1
CCDSiCCDS448.1
PIRiS21662
RefSeqiNP_036553.2, NM_012421.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi111950, 20 interactors
IntActiQ13129, 12 interactors
MINTiQ13129
STRINGi9606.ENSP00000361857

PTM databases

iPTMnetiQ13129
PhosphoSitePlusiQ13129

Polymorphism and mutation databases

BioMutaiRLF
DMDMi62296764

Proteomic databases

EPDiQ13129
jPOSTiQ13129
MassIVEiQ13129
MaxQBiQ13129
PaxDbiQ13129
PeptideAtlasiQ13129
PRIDEiQ13129
ProteomicsDBi59179

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6018

Genome annotation databases

EnsembliENST00000372771; ENSP00000361857; ENSG00000117000
GeneIDi6018
KEGGihsa:6018
UCSCiuc001cfc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6018
DisGeNETi6018
EuPathDBiHostDB:ENSG00000117000.8

GeneCards: human genes, protein and diseases

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GeneCardsi
RLF
HGNCiHGNC:10025 RLF
HPAiHPA054653
HPA057300
MIMi180610 gene
neXtProtiNX_Q13129
OpenTargetsiENSG00000117000
PharmGKBiPA34398

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000183034
HOGENOMiHOG000231080
InParanoidiQ13129
OMAiVLCKREC
OrthoDBi1318335at2759
PhylomeDBiQ13129
TreeFamiTF350813

Enzyme and pathway databases

SIGNORiQ13129

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RLF human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RLF_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6018
PharosiQ13129 Tbio

Protein Ontology

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PROi
PR:Q13129
RNActiQ13129 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117000 Expressed in 223 organ(s), highest expression level in heart
GenevisibleiQ13129 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRLF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13129
Secondary accession number(s): Q14CQ1, Q9NU60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 29, 2005
Last modified: December 11, 2019
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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