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Protein

Protein Red

Gene

IK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353).Curated4 Publications
(Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.1 Publication

Caution

Was originally thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • mitotic cell cycle Source: UniProtKB
  • mitotic spindle assembly checkpoint Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • protein localization to kinetochore Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Red1 Publication
Alternative name(s):
Cytokine IK1 Publication
IK factor1 Publication
Protein RER
Gene namesi
Name:IK
Synonyms:RED1 Publication, RER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113141.15
HGNCiHGNC:5958 IK
MIMi600549 gene
neXtProtiNX_Q13123

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi3550
OpenTargetsiENSG00000113141
PharmGKBiPA29774

Chemistry databases

ChEMBLiCHEMBL2321616

Polymorphism and mutation databases

BioMutaiIK
DMDMi296452987

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000972351 – 557Protein RedAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-acetyllysineCombined sources1
Modified residuei137N6-acetyllysineBy similarity1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei287PhosphoserineCombined sources1
Cross-linki310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki404Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki408Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei485PhosphothreonineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki501Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei536PhosphoserineCombined sources1
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki544Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13123
MaxQBiQ13123
PaxDbiQ13123
PeptideAtlasiQ13123
PRIDEiQ13123
ProteomicsDBi59173

PTM databases

iPTMnetiQ13123
PhosphoSitePlusiQ13123

Miscellaneous databases

PMAP-CutDBiQ13123

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed at similar levels in fetal and adult tissues.1 Publication

Inductioni

Up-regulated during mitosis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000113141 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_IK
ExpressionAtlasiQ13123 baseline and differential
GenevisibleiQ13123 HS

Organism-specific databases

HPAiHPA048798

Interactioni

Subunit structurei

(Microbial infection) Identified in a complex with SMU1 and influenza A virus RNA polymerase subunits PB1 and PB2. Directly interacts with SMU1 and with influenza A virus RNA polymerase subunits PB1 and PB2.1 Publication
Component of the spliceosome B complex (PubMed:22365833, PubMed:28781166). Interacts with SMU1 (PubMed:22365833, PubMed:24945353). Interacts with MAD1L1 (PubMed:22351768). May interact with DHX15 (PubMed:24252166).2 Publications3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109766, 89 interactors
CORUMiQ13123
IntActiQ13123, 47 interactors
MINTiQ13123
STRINGi9606.ENSP00000396301

Chemistry databases

BindingDBiQ13123

Structurei

3D structure databases

ProteinModelPortaliQ13123
SMRiQ13123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati342 – 34312
Repeati344 – 34522
Repeati346 – 34732
Repeati348 – 34942
Repeati350 – 35152
Repeati352 – 35362
Repeati354 – 35572
Repeati356 – 35782
Repeati358 – 35992
Repeati360 – 361102
Repeati362 – 363112
Repeati364 – 365122
Repeati366 – 367132
Repeati368 – 369142
Repeati370 – 371152
Repeati372 – 373162
Repeati374 – 375172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni342 – 37517 X 2 AA tandem repeats of R-[ED]Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 187Poly-GluSequence analysis6
Compositional biasi334 – 374Arg-richPROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Belongs to the RED family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2498 Eukaryota
ENOG410YR3Z LUCA
GeneTreeiENSGT00630000089902
HOGENOMiHOG000007717
HOVERGENiHBG017223
InParanoidiQ13123
KOiK13109
OMAiLEEMNDA
OrthoDBiEOG091G0BYA
PhylomeDBiQ13123
TreeFamiTF321907

Family and domain databases

InterProiView protein in InterPro
IPR039896 Red-like
IPR012492 RED_C
IPR012916 RED_N
PANTHERiPTHR12765 PTHR12765, 1 hit
PfamiView protein in Pfam
PF07807 RED_C, 1 hit
PF07808 RED_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD311621 RED_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q13123-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA
60 70 80 90 100
PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR
110 120 130 140 150
DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES
160 170 180 190 200
KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE
210 220 230 240 250
DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT
260 270 280 290 300
DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK
310 320 330 340 350
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER
360 370 380 390 400
DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP
410 420 430 440 450
GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP
460 470 480 490 500
ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP
510 520 530 540 550
KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV

EVKRPKY
Length:557
Mass (Da):65,602
Last modified:May 18, 2010 - v3
Checksum:iBE7B332985D5F4CA
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCQ4D6RCQ4_HUMAN
Protein Red
IK
107Annotation score:
D6REL4D6REL4_HUMAN
Protein Red
IK
212Annotation score:
E7EQZ7E7EQZ7_HUMAN
Protein Red
IK
267Annotation score:
D6RAY9D6RAY9_HUMAN
Protein Red
IK
140Annotation score:
A0A0C4DGW5A0A0C4DGW5_HUMAN
Protein Red
IK
162Annotation score:
D6RAH1D6RAH1_HUMAN
Protein Red
IK
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176A → L in CAA06607 (PubMed:10216252).Curated1
Sequence conflicti182E → D in CAA06607 (PubMed:10216252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005579 mRNA Translation: CAA06607.1
AC116353 Genomic DNA No translation available.
BC071964 mRNA Translation: AAH71964.1
S74221 mRNA Translation: AAB32531.1
CCDSiCCDS47280.1
PIRiI58408
RefSeqiNP_006074.2, NM_006083.3
UniGeneiHs.421245

Genome annotation databases

EnsembliENST00000417647; ENSP00000396301; ENSG00000113141
GeneIDi3550
KEGGihsa:3550
UCSCiuc003lgq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005579 mRNA Translation: CAA06607.1
AC116353 Genomic DNA No translation available.
BC071964 mRNA Translation: AAH71964.1
S74221 mRNA Translation: AAB32531.1
CCDSiCCDS47280.1
PIRiI58408
RefSeqiNP_006074.2, NM_006083.3
UniGeneiHs.421245

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9Zelectron microscopy4.50R1-557[»]
ProteinModelPortaliQ13123
SMRiQ13123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109766, 89 interactors
CORUMiQ13123
IntActiQ13123, 47 interactors
MINTiQ13123
STRINGi9606.ENSP00000396301

Chemistry databases

BindingDBiQ13123
ChEMBLiCHEMBL2321616

PTM databases

iPTMnetiQ13123
PhosphoSitePlusiQ13123

Polymorphism and mutation databases

BioMutaiIK
DMDMi296452987

Proteomic databases

EPDiQ13123
MaxQBiQ13123
PaxDbiQ13123
PeptideAtlasiQ13123
PRIDEiQ13123
ProteomicsDBi59173

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417647; ENSP00000396301; ENSG00000113141
GeneIDi3550
KEGGihsa:3550
UCSCiuc003lgq.4 human

Organism-specific databases

CTDi3550
DisGeNETi3550
EuPathDBiHostDB:ENSG00000113141.15
GeneCardsiIK
HGNCiHGNC:5958 IK
HPAiHPA048798
MIMi600549 gene
neXtProtiNX_Q13123
OpenTargetsiENSG00000113141
PharmGKBiPA29774
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2498 Eukaryota
ENOG410YR3Z LUCA
GeneTreeiENSGT00630000089902
HOGENOMiHOG000007717
HOVERGENiHBG017223
InParanoidiQ13123
KOiK13109
OMAiLEEMNDA
OrthoDBiEOG091G0BYA
PhylomeDBiQ13123
TreeFamiTF321907

Miscellaneous databases

ChiTaRSiIK human
GeneWikiiIK_(gene)
GenomeRNAii3550
PMAP-CutDBiQ13123
PROiPR:Q13123
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113141 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_IK
ExpressionAtlasiQ13123 baseline and differential
GenevisibleiQ13123 HS

Family and domain databases

InterProiView protein in InterPro
IPR039896 Red-like
IPR012492 RED_C
IPR012916 RED_N
PANTHERiPTHR12765 PTHR12765, 1 hit
PfamiView protein in Pfam
PF07807 RED_C, 1 hit
PF07808 RED_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD311621 RED_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRED_HUMAN
AccessioniPrimary (citable) accession number: Q13123
Secondary accession number(s): Q6IPD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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