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UniProtKB - Q13118 (KLF10_HUMAN)

Entry version 195 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Krueppel-like factor 10

Gene

KLF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity).

May play a role in the cell cycle regulation.

By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13118

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13118

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
EGR-alpha
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLF10
Synonyms:TIEG, TIEG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11810, KLF10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601878, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13118

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000155090

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7071

Open Targets

More...OpenTargetsi		ENSG00000155090

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36517

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13118, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3407312

DrugCentral

More...DrugCentrali		Q13118

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KLF10

Domain mapping of disease mutations (DMDM)

More...DMDMi		11387050

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471771 – 480Krueppel-like factor 10Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13118

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13118

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13118

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13118

PeptideAtlas

More...PeptideAtlasi		Q13118

PRoteomics IDEntifications database

More...PRIDEi		Q13118

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59171 [Q13118-1]
59172 [Q13118-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q13118-1 [Q13118-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13118

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13118

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TGFB1 and BMP2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155090, Expressed in thoracic mammary gland and 243 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13118, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155090, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112927, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13118

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13118

Protein interaction database and analysis system

More...IntActi		Q13118, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000285407

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13118

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13118, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13118

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13118

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159405

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046370_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13118

Identification of Orthologs from Complete Genome Data

More...OMAi		CQPMVFM

Database of Orthologous Groups

More...OrthoDBi		582598at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13118

TreeFam database of animal gene trees

More...TreeFami		TF315506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC 
        60         70         80         90        100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD 
       110        120        130        140        150
FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA 
       160        170        180        190        200
QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI 
       210        220        230        240        250
PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP 
       260        270        280        290        300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA 
       310        320        330        340        350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF 
       360        370        380        390        400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS 
       410        420        430        440        450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR 
       460        470        480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Length:480
Mass (Da):52,555
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78B1EBB0DB97579D
GO
Isoform 2 (identifier: Q13118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M

Show »
Length:469
Mass (Da):51,424
Checksum:iE825F2BA7D5F74BD
GO
Isoform 3 (identifier: Q13118-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-102: CLTPPYSPSDFE → QQKSLLRLIHQG
     103-480: Missing.

Show »
Length:91
Mass (Da):10,600
Checksum:i333972E3AEDCCBCD
GO
Isoform 4 (identifier: Q13118-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-134: CLTPPYSPSD...TAKPHIAAPF → EKSLSAVAGK...LRAPCVTGGS
     135-480: Missing.

Show »
Length:123
Mass (Da):13,702
Checksum:i23B95EC936A769C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052716249S → F. Corresponds to variant dbSNP:rs4734653Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0426531 – 12MLNFG…LQQTA → M in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST12
Alternative sequenceiVSP_04748291 – 134CLTPP…IAAPF → EKSLSAVAGKVVKGGLPVLM NCPDTGEPTRVRRNLRAPCV TGGS in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_04748391 – 102CLTPP…PSDFE → QQKSLLRLIHQG in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047484103 – 480Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_047485135 – 480Missing in isoform 4. 1 PublicationAdd BLAST346

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S81439 mRNA Translation: AAB36088.1
U21847 mRNA Translation: AAC50340.1
AF050110 Genomic DNA Translation: AAC34293.1
AF050110 Genomic DNA Translation: AAC34294.1
HF546210 mRNA Translation: CCO02796.1
HF546211 mRNA Translation: CCO02797.1
BT006634 mRNA Translation: AAP35280.1
AK312894 mRNA Translation: BAG35741.1
AP002851 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91850.1
BC011538 mRNA Translation: AAH11538.1
BC095399 mRNA Translation: AAH95399.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47905.1 [Q13118-2]
CCDS6294.1 [Q13118-1]

NCBI Reference Sequences

More...RefSeqi		NP_001027453.1, NM_001032282.3 [Q13118-2]
NP_005646.1, NM_005655.3 [Q13118-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7071

UCSC genome browser

More...UCSCi		uc011lhj.3, human [Q13118-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81439 mRNA Translation: AAB36088.1
U21847 mRNA Translation: AAC50340.1
AF050110 Genomic DNA Translation: AAC34293.1
AF050110 Genomic DNA Translation: AAC34294.1
HF546210 mRNA Translation: CCO02796.1
HF546211 mRNA Translation: CCO02797.1
BT006634 mRNA Translation: AAP35280.1
AK312894 mRNA Translation: BAG35741.1
AP002851 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91850.1
BC011538 mRNA Translation: AAH11538.1
BC095399 mRNA Translation: AAH95399.1
CCDSiCCDS47905.1 [Q13118-2]
CCDS6294.1 [Q13118-1]
RefSeqiNP_001027453.1, NM_001032282.3 [Q13118-2]
NP_005646.1, NM_005655.3 [Q13118-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPANMR-A359-423[»]
SMRiQ13118
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112927, 21 interactors
CORUMiQ13118
ELMiQ13118
IntActiQ13118, 16 interactors
STRINGi9606.ENSP00000285407

Chemistry databases

BindingDBiQ13118
ChEMBLiCHEMBL3407312
DrugCentraliQ13118

PTM databases

iPTMnetiQ13118
PhosphoSitePlusiQ13118

Genetic variation databases

BioMutaiKLF10
DMDMi11387050

Proteomic databases

jPOSTiQ13118
MassIVEiQ13118
MaxQBiQ13118
PaxDbiQ13118
PeptideAtlasiQ13118
PRIDEiQ13118
ProteomicsDBi59171 [Q13118-1]
59172 [Q13118-2]
TopDownProteomicsiQ13118-1 [Q13118-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26326, 295 antibodies

The DNASU plasmid repository

More...DNASUi		7071

Genome annotation databases

EnsembliENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2]
GeneIDi7071
KEGGihsa:7071
UCSCiuc011lhj.3, human [Q13118-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7071
DisGeNETi7071

GeneCards: human genes, protein and diseases

More...GeneCardsi		KLF10
HGNCiHGNC:11810, KLF10
HPAiENSG00000155090, Low tissue specificity
MIMi601878, gene
neXtProtiNX_Q13118
OpenTargetsiENSG00000155090
PharmGKBiPA36517
VEuPathDBiHostDB:ENSG00000155090

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159405
HOGENOMiCLU_046370_1_0_1
InParanoidiQ13118
OMAiCQPMVFM
OrthoDBi582598at2759
PhylomeDBiQ13118
TreeFamiTF315506

Enzyme and pathway databases

PathwayCommonsiQ13118
SIGNORiQ13118

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7071, 19 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KLF10, human
EvolutionaryTraceiQ13118

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KLF10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7071
PharosiQ13118, Tbio

Protein Ontology

More...PROi		PR:Q13118
RNActiQ13118, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155090, Expressed in thoracic mammary gland and 243 other tissues
GenevisibleiQ13118, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLF10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13118
Secondary accession number(s): A8MVH0
, B2R794, L0R4P6, L0R679, O75411, Q503B2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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