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Protein

Krueppel-like factor 10

Gene

KLF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ13118

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
EGR-alpha
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Gene namesi
Name:KLF10
Synonyms:TIEG, TIEG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155090.14
HGNCiHGNC:11810 KLF10
MIMi601878 gene
neXtProtiNX_Q13118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7071
OpenTargetsiENSG00000155090
PharmGKBiPA36517

Chemistry databases

ChEMBLiCHEMBL3407312

Polymorphism and mutation databases

DMDMi11387050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471771 – 480Krueppel-like factor 10Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13118
PaxDbiQ13118
PeptideAtlasiQ13118
PRIDEiQ13118
ProteomicsDBi59171
59172 [Q13118-2]
TopDownProteomicsiQ13118-1 [Q13118-1]

PTM databases

iPTMnetiQ13118
PhosphoSitePlusiQ13118

Expressioni

Inductioni

By TGFB1 and BMP2.1 Publication

Gene expression databases

BgeeiENSG00000155090 Expressed in 231 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_KLF10
GenevisibleiQ13118 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP1P080472EBI-1389509,EBI-298336

Protein-protein interaction databases

BioGridi112927, 19 interactors
CORUMiQ13118
ELMiQ13118
IntActiQ13118, 17 interactors
MINTiQ13118
STRINGi9606.ENSP00000285407

Chemistry databases

BindingDBiQ13118

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13118
SMRiQ13118
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13118

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiQ13118
KOiK09209
OMAiQMVPLPT
OrthoDBiEOG091G1BN0
PhylomeDBiQ13118
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC
60 70 80 90 100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD
110 120 130 140 150
FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA
160 170 180 190 200
QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI
210 220 230 240 250
PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP
260 270 280 290 300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA
310 320 330 340 350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Length:480
Mass (Da):52,555
Last modified:November 1, 1996 - v1
Checksum:i78B1EBB0DB97579D
GO
Isoform 2 (identifier: Q13118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):51,424
Checksum:iE825F2BA7D5F74BD
GO
Isoform 3 (identifier: Q13118-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-102: CLTPPYSPSDFE → QQKSLLRLIHQG
     103-480: Missing.

Show »
Length:91
Mass (Da):10,600
Checksum:i333972E3AEDCCBCD
GO
Isoform 4 (identifier: Q13118-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-134: CLTPPYSPSD...TAKPHIAAPF → EKSLSAVAGK...LRAPCVTGGS
     135-480: Missing.

Show »
Length:123
Mass (Da):13,702
Checksum:i23B95EC936A769C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052716249S → F. Corresponds to variant dbSNP:rs4734653Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426531 – 12MLNFG…LQQTA → M in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST12
Alternative sequenceiVSP_04748291 – 134CLTPP…IAAPF → EKSLSAVAGKVVKGGLPVLM NCPDTGEPTRVRRNLRAPCV TGGS in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_04748391 – 102CLTPP…PSDFE → QQKSLLRLIHQG in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047484103 – 480Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_047485135 – 480Missing in isoform 4. 1 PublicationAdd BLAST346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81439 mRNA Translation: AAB36088.1
U21847 mRNA Translation: AAC50340.1
AF050110 Genomic DNA Translation: AAC34293.1
AF050110 Genomic DNA Translation: AAC34294.1
HF546210 mRNA Translation: CCO02796.1
HF546211 mRNA Translation: CCO02797.1
BT006634 mRNA Translation: AAP35280.1
AK312894 mRNA Translation: BAG35741.1
AP002851 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91850.1
BC011538 mRNA Translation: AAH11538.1
BC095399 mRNA Translation: AAH95399.1
CCDSiCCDS47905.1 [Q13118-2]
CCDS6294.1 [Q13118-1]
RefSeqiNP_001027453.1, NM_001032282.3 [Q13118-2]
NP_005646.1, NM_005655.3 [Q13118-1]
UniGeneiHs.435001

Genome annotation databases

EnsembliENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2]
GeneIDi7071
KEGGihsa:7071
UCSCiuc011lhj.3 human [Q13118-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81439 mRNA Translation: AAB36088.1
U21847 mRNA Translation: AAC50340.1
AF050110 Genomic DNA Translation: AAC34293.1
AF050110 Genomic DNA Translation: AAC34294.1
HF546210 mRNA Translation: CCO02796.1
HF546211 mRNA Translation: CCO02797.1
BT006634 mRNA Translation: AAP35280.1
AK312894 mRNA Translation: BAG35741.1
AP002851 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91850.1
BC011538 mRNA Translation: AAH11538.1
BC095399 mRNA Translation: AAH95399.1
CCDSiCCDS47905.1 [Q13118-2]
CCDS6294.1 [Q13118-1]
RefSeqiNP_001027453.1, NM_001032282.3 [Q13118-2]
NP_005646.1, NM_005655.3 [Q13118-1]
UniGeneiHs.435001

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EPANMR-A359-423[»]
ProteinModelPortaliQ13118
SMRiQ13118
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112927, 19 interactors
CORUMiQ13118
ELMiQ13118
IntActiQ13118, 17 interactors
MINTiQ13118
STRINGi9606.ENSP00000285407

Chemistry databases

BindingDBiQ13118
ChEMBLiCHEMBL3407312

PTM databases

iPTMnetiQ13118
PhosphoSitePlusiQ13118

Polymorphism and mutation databases

DMDMi11387050

Proteomic databases

MaxQBiQ13118
PaxDbiQ13118
PeptideAtlasiQ13118
PRIDEiQ13118
ProteomicsDBi59171
59172 [Q13118-2]
TopDownProteomicsiQ13118-1 [Q13118-1]

Protocols and materials databases

DNASUi7071
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2]
GeneIDi7071
KEGGihsa:7071
UCSCiuc011lhj.3 human [Q13118-1]

Organism-specific databases

CTDi7071
DisGeNETi7071
EuPathDBiHostDB:ENSG00000155090.14
GeneCardsiKLF10
HGNCiHGNC:11810 KLF10
MIMi601878 gene
neXtProtiNX_Q13118
OpenTargetsiENSG00000155090
PharmGKBiPA36517
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiQ13118
KOiK09209
OMAiQMVPLPT
OrthoDBiEOG091G1BN0
PhylomeDBiQ13118
TreeFamiTF315506

Enzyme and pathway databases

SIGNORiQ13118

Miscellaneous databases

ChiTaRSiKLF10 human
EvolutionaryTraceiQ13118
GeneWikiiKLF10
GenomeRNAii7071
PROiPR:Q13118
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155090 Expressed in 231 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_KLF10
GenevisibleiQ13118 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF10_HUMAN
AccessioniPrimary (citable) accession number: Q13118
Secondary accession number(s): A8MVH0
, B2R794, L0R4P6, L0R679, O75411, Q503B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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