UniProtKB - Q13118 (KLF10_HUMAN)
Protein
Krueppel-like factor 10
Gene
KLF10
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 369 – 393 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 399 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 429 – 451 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- core promoter sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- bone mineralization Source: Ensembl
- cell-cell signaling Source: ProtInc
- cellular response to peptide Source: Ensembl
- cellular response to starvation Source: UniProtKB
- circadian rhythm Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of circadian rhythm Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatic stem cell population maintenance Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q13118 |
SIGNORi | Q13118 |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 10Alternative name(s): EGR-alpha Transforming growth factor-beta-inducible early growth response protein 1 Short name: TGFB-inducible early growth response protein 1 Short name: TIEG-1 |
Gene namesi | Name:KLF10 Synonyms:TIEG, TIEG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155090.14 |
HGNCi | HGNC:11810, KLF10 |
MIMi | 601878, gene |
neXtProti | NX_Q13118 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7071 |
OpenTargetsi | ENSG00000155090 |
PharmGKBi | PA36517 |
Miscellaneous databases
Pharosi | Q13118, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3407312 |
DrugCentrali | Q13118 |
Polymorphism and mutation databases
BioMutai | KLF10 |
DMDMi | 11387050 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047177 | 1 – 480 | Krueppel-like factor 10Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 249 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q13118 |
MassIVEi | Q13118 |
MaxQBi | Q13118 |
PaxDbi | Q13118 |
PeptideAtlasi | Q13118 |
PRIDEi | Q13118 |
ProteomicsDBi | 59171 [Q13118-1] 59172 [Q13118-2] |
TopDownProteomicsi | Q13118-1 [Q13118-1] |
PTM databases
iPTMneti | Q13118 |
PhosphoSitePlusi | Q13118 |
Expressioni
Inductioni
By TGFB1 and BMP2.1 Publication
Gene expression databases
Bgeei | ENSG00000155090, Expressed in thoracic mammary gland and 242 other tissues |
Genevisiblei | Q13118, HS |
Organism-specific databases
HPAi | ENSG00000155090, Low tissue specificity |
Interactioni
Binary interactionsi
Q13118
With | #Exp. | IntAct |
---|---|---|
SP1 [P08047] | 2 | EBI-1389509,EBI-298336 |
Protein-protein interaction databases
BioGRIDi | 112927, 20 interactors |
CORUMi | Q13118 |
ELMi | Q13118 |
IntActi | Q13118, 16 interactors |
MINTi | Q13118 |
STRINGi | 9606.ENSP00000285407 |
Chemistry databases
BindingDBi | Q13118 |
Miscellaneous databases
RNActi | Q13118, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13118 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13118 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 369 – 393 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 399 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 429 – 451 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | Q13118 |
OMAi | QMVPLPT |
OrthoDBi | 582598at2759 |
PhylomeDBi | Q13118 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q13118-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC
60 70 80 90 100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD
110 120 130 140 150
FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA
160 170 180 190 200
QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI
210 220 230 240 250
PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP
260 270 280 290 300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA
310 320 330 340 350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052716 | 249 | S → F. Corresponds to variant dbSNP:rs4734653Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042653 | 1 – 12 | MLNFG…LQQTA → M in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_047482 | 91 – 134 | CLTPP…IAAPF → EKSLSAVAGKVVKGGLPVLM NCPDTGEPTRVRRNLRAPCV TGGS in isoform 4. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_047483 | 91 – 102 | CLTPP…PSDFE → QQKSLLRLIHQG in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_047484 | 103 – 480 | Missing in isoform 3. 1 PublicationAdd BLAST | 378 | |
Alternative sequenceiVSP_047485 | 135 – 480 | Missing in isoform 4. 1 PublicationAdd BLAST | 346 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S81439 mRNA Translation: AAB36088.1 U21847 mRNA Translation: AAC50340.1 AF050110 Genomic DNA Translation: AAC34293.1 AF050110 Genomic DNA Translation: AAC34294.1 HF546210 mRNA Translation: CCO02796.1 HF546211 mRNA Translation: CCO02797.1 BT006634 mRNA Translation: AAP35280.1 AK312894 mRNA Translation: BAG35741.1 AP002851 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91850.1 BC011538 mRNA Translation: AAH11538.1 BC095399 mRNA Translation: AAH95399.1 |
CCDSi | CCDS47905.1 [Q13118-2] CCDS6294.1 [Q13118-1] |
RefSeqi | NP_001027453.1, NM_001032282.3 [Q13118-2] NP_005646.1, NM_005655.3 [Q13118-1] |
Genome annotation databases
Ensembli | ENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1] ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2] |
GeneIDi | 7071 |
KEGGi | hsa:7071 |
UCSCi | uc011lhj.3, human [Q13118-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S81439 mRNA Translation: AAB36088.1 U21847 mRNA Translation: AAC50340.1 AF050110 Genomic DNA Translation: AAC34293.1 AF050110 Genomic DNA Translation: AAC34294.1 HF546210 mRNA Translation: CCO02796.1 HF546211 mRNA Translation: CCO02797.1 BT006634 mRNA Translation: AAP35280.1 AK312894 mRNA Translation: BAG35741.1 AP002851 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91850.1 BC011538 mRNA Translation: AAH11538.1 BC095399 mRNA Translation: AAH95399.1 |
CCDSi | CCDS47905.1 [Q13118-2] CCDS6294.1 [Q13118-1] |
RefSeqi | NP_001027453.1, NM_001032282.3 [Q13118-2] NP_005646.1, NM_005655.3 [Q13118-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EPA | NMR | - | A | 359-423 | [»] | |
SMRi | Q13118 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112927, 20 interactors |
CORUMi | Q13118 |
ELMi | Q13118 |
IntActi | Q13118, 16 interactors |
MINTi | Q13118 |
STRINGi | 9606.ENSP00000285407 |
Chemistry databases
BindingDBi | Q13118 |
ChEMBLi | CHEMBL3407312 |
DrugCentrali | Q13118 |
PTM databases
iPTMneti | Q13118 |
PhosphoSitePlusi | Q13118 |
Polymorphism and mutation databases
BioMutai | KLF10 |
DMDMi | 11387050 |
Proteomic databases
jPOSTi | Q13118 |
MassIVEi | Q13118 |
MaxQBi | Q13118 |
PaxDbi | Q13118 |
PeptideAtlasi | Q13118 |
PRIDEi | Q13118 |
ProteomicsDBi | 59171 [Q13118-1] 59172 [Q13118-2] |
TopDownProteomicsi | Q13118-1 [Q13118-1] |
Protocols and materials databases
Antibodypediai | 26326, 287 antibodies |
DNASUi | 7071 |
Genome annotation databases
Ensembli | ENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1] ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2] |
GeneIDi | 7071 |
KEGGi | hsa:7071 |
UCSCi | uc011lhj.3, human [Q13118-1] |
Organism-specific databases
CTDi | 7071 |
DisGeNETi | 7071 |
EuPathDBi | HostDB:ENSG00000155090.14 |
GeneCardsi | KLF10 |
HGNCi | HGNC:11810, KLF10 |
HPAi | ENSG00000155090, Low tissue specificity |
MIMi | 601878, gene |
neXtProti | NX_Q13118 |
OpenTargetsi | ENSG00000155090 |
PharmGKBi | PA36517 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | Q13118 |
OMAi | QMVPLPT |
OrthoDBi | 582598at2759 |
PhylomeDBi | Q13118 |
TreeFami | TF315506 |
Enzyme and pathway databases
PathwayCommonsi | Q13118 |
SIGNORi | Q13118 |
Miscellaneous databases
BioGRID-ORCSi | 7071, 15 hits in 863 CRISPR screens |
ChiTaRSi | KLF10, human |
EvolutionaryTracei | Q13118 |
GeneWikii | KLF10 |
GenomeRNAii | 7071 |
Pharosi | Q13118, Tbio |
PROi | PR:Q13118 |
RNActi | Q13118, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155090, Expressed in thoracic mammary gland and 242 other tissues |
Genevisiblei | Q13118, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF10_HUMAN | |
Accessioni | Q13118Primary (citable) accession number: Q13118 Secondary accession number(s): A8MVH0 Q503B2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations