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UniProtKB - Q13118 (KLF10_HUMAN)

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Protein

Krueppel-like factor 10

Gene

KLF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • bone mineralization Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • cellular response to peptide Source: Ensembl
  • cellular response to starvation Source: UniProtKB
  • circadian rhythm Source: Ensembl
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • positive regulation of osteoclast differentiation Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of circadian rhythm Source: UniProtKB
  • skeletal system development Source: ProtInc
  • somatic stem cell population maintenance Source: Ensembl
  • transforming growth factor beta receptor signaling pathway Source: ProtInc
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ13118

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
EGR-alpha
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Gene namesi
Name:KLF10
Synonyms:TIEG, TIEG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155090.14
HGNCiHGNC:11810 KLF10
MIMi601878 gene
neXtProtiNX_Q13118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7071
OpenTargetsiENSG00000155090
PharmGKBiPA36517

Chemistry databases

ChEMBLiCHEMBL3407312

Polymorphism and mutation databases

DMDMi11387050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471771 – 480Krueppel-like factor 10Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13118
PaxDbiQ13118
PeptideAtlasiQ13118
PRIDEiQ13118
ProteomicsDBi59171
59172 [Q13118-2]
TopDownProteomicsiQ13118-1 [Q13118-1]

PTM databases

iPTMnetiQ13118
PhosphoSitePlusiQ13118

Expressioni

Inductioni

By TGFB1 and BMP2.1 Publication

Gene expression databases

BgeeiENSG00000155090
CleanExiHS_KLF10
GenevisibleiQ13118 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP1P080472EBI-1389509,EBI-298336

Protein-protein interaction databases

BioGridi112927, 19 interactors
CORUMiQ13118
ELMiQ13118
IntActiQ13118, 17 interactors
MINTiQ13118
STRINGi9606.ENSP00000285407

Chemistry databases

BindingDBiQ13118

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni374 – 376Combined sources3
Beta strandi379 – 382Combined sources4
Helixi383 – 393Combined sources11
Beta strandi394 – 396Combined sources3
Beta strandi398 – 400Combined sources3
Beta strandi409 – 412Combined sources4
Helixi413 – 419Combined sources7
Turni420 – 422Combined sources3

3D structure databases

ProteinModelPortaliQ13118
SMRiQ13118
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13118

Family & Domainsi

Sequence similaritiesi

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiQ13118
KOiK09209
OMAiKPHIAAP
OrthoDBiEOG091G1BN0
PhylomeDBiQ13118
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNFGASLQQ TAEERMEMIS ERPKESMYSW NKTAEKSDFE AVEALMSMSC 
        60         70         80         90        100
SWKSDFKKYV ENRPVTPVSD LSEEENLLPG TPDFHTIPAF CLTPPYSPSD 
       110        120        130        140        150
FEPSQVSNLM APAPSTVHFK SLSDTAKPHI AAPFKEEEKS PVSAPKLPKA 
       160        170        180        190        200
QATSVIRHTA DAQLCNHQTC PMKAASILNY QNNSFRRRTH LNVEAARKNI 
       210        220        230        240        250
PCAAVSPNRS KCERNTVADV DEKASAALYD FSVPSSETVI CRSQPAPVSP 
       260        270        280        290        300
QQKSVLVSPP AVSAGGVPPM PVICQMVPLP ANNPVVTTVV PSTPPSQPPA 
       310        320        330        340        350
VCPPVVFMGT QVPKGAVMFV VPQPVVQSSK PPVVSPNGTR LSPIAPAPGF 
       360        370        380        390        400
SPSAAKVTPQ IDSSRIRSHI CSHPGCGKTY FKSSHLKAHT RTHTGEKPFS 
       410        420        430        440        450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR 
       460        470        480
HLSAKKLPNW QMEVSKLNDI ALPPTPAPTQ
Length:480
Mass (Da):52,555
Last modified:November 1, 1996 - v1
Checksum:i78B1EBB0DB97579D
GO
Isoform 2 (identifier: Q13118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):51,424
Checksum:iE825F2BA7D5F74BD
GO
Isoform 3 (identifier: Q13118-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-102: CLTPPYSPSDFE → QQKSLLRLIHQG
     103-480: Missing.

Show »
Length:91
Mass (Da):10,600
Checksum:i333972E3AEDCCBCD
GO
Isoform 4 (identifier: Q13118-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLNFGASLQQTA → M
     91-134: CLTPPYSPSD...TAKPHIAAPF → EKSLSAVAGK...LRAPCVTGGS
     135-480: Missing.

Show »
Length:123
Mass (Da):13,702
Checksum:i23B95EC936A769C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052716249S → F. Corresponds to variant dbSNP:rs4734653Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426531 – 12MLNFG…LQQTA → M in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST12
Alternative sequenceiVSP_04748291 – 134CLTPP…IAAPF → EKSLSAVAGKVVKGGLPVLM NCPDTGEPTRVRRNLRAPCV TGGS in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_04748391 – 102CLTPP…PSDFE → QQKSLLRLIHQG in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047484103 – 480Missing in isoform 3. 1 PublicationAdd BLAST378
Alternative sequenceiVSP_047485135 – 480Missing in isoform 4. 1 PublicationAdd BLAST346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81439 mRNA Translation: AAB36088.1
U21847 mRNA Translation: AAC50340.1
AF050110 Genomic DNA Translation: AAC34293.1
AF050110 Genomic DNA Translation: AAC34294.1
HF546210 mRNA Translation: CCO02796.1
HF546211 mRNA Translation: CCO02797.1
BT006634 mRNA Translation: AAP35280.1
AK312894 mRNA Translation: BAG35741.1
AP002851 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91850.1
BC011538 mRNA Translation: AAH11538.1
BC095399 mRNA Translation: AAH95399.1
CCDSiCCDS47905.1 [Q13118-2]
CCDS6294.1 [Q13118-1]
RefSeqiNP_001027453.1, NM_001032282.3 [Q13118-2]
NP_005646.1, NM_005655.3 [Q13118-1]
UniGeneiHs.435001

Genome annotation databases

EnsembliENST00000285407; ENSP00000285407; ENSG00000155090 [Q13118-1]
ENST00000395884; ENSP00000379222; ENSG00000155090 [Q13118-2]
GeneIDi7071
KEGGihsa:7071
UCSCiuc011lhj.3 human [Q13118-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLF10_HUMAN
AccessioniPrimary (citable) accession number: Q13118
Secondary accession number(s): A8MVH0
, B2R794, L0R4P6, L0R679, O75411, Q503B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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