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Protein

TNF receptor-associated factor 3

Gene

TRAF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.6 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 77RING-typePROSITE-ProRule annotation10
Zinc fingeri135 – 190TRAF-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri191 – 249TRAF-type 2PROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5602571 TRAF3 deficiency - HSE
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
SignaLinkiQ13114
SIGNORiQ13114

Protein family/group databases

MoonDBiQ13114 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 3 (EC:2.3.2.27)
Alternative name(s):
CAP-1
CD40 receptor-associated factor 1
Short name:
CRAF1
CD40-binding protein
Short name:
CD40BP
LMP1-associated protein 1
Short name:
LAP1
RING-type E3 ubiquitin transferase TRAF3Curated
Gene namesi
Name:TRAF3
Synonyms:CAP1, CRAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000131323.14
HGNCiHGNC:12033 TRAF3
MIMi601896 gene
neXtProtiNX_Q13114

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Encephalopathy, acute, infection-induced, Herpes-specific, 5 (IIAE5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
See also OMIM:614849
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069081118R → W in IIAE5. 1 PublicationCorresponds to variant dbSNP:rs143813189EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi441Y → A: Abolishes interaction with RNF216; when associated with A-443. 1 Publication1
Mutagenesisi443Q → A: Abolishes interaction with RNF216; when associated with A-441. 1 Publication1
Mutagenesisi459Y → A: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication1
Mutagenesisi512F → E: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication1
Mutagenesisi521F → A: Abolishes interaction with LTBR, CD40 and TANK. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi7187
MalaCardsiTRAF3
MIMi614849 phenotype
OpenTargetsiENSG00000131323
Orphaneti1930 Herpes simplex virus encephalitis
PharmGKBiPA36710

Polymorphism and mutation databases

BioMutaiTRAF3
DMDMi116242824

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564011 – 568TNF receptor-associated factor 3Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Post-translational modificationi

Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.5 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13114
MaxQBiQ13114
PaxDbiQ13114
PeptideAtlasiQ13114
PRIDEiQ13114
ProteomicsDBi59165
59166 [Q13114-2]

PTM databases

iPTMnetiQ13114
PhosphoSitePlusiQ13114

Miscellaneous databases

PMAP-CutDBiQ13114

Expressioni

Gene expression databases

BgeeiENSG00000131323 Expressed in 200 organ(s), highest expression level in frontal cortex
CleanExiHS_CAP1
HS_TRAF3
ExpressionAtlasiQ13114 baseline and differential
GenevisibleiQ13114 HS

Organism-specific databases

HPAiHPA002933

Interactioni

Subunit structurei

Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14. Interacts (via MATH domain) with PTPN22; the interaction promotes TRAF3 polyubiquitination (PubMed:23871208).By similarity36 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113039, 117 interactors
CORUMiQ13114
DIPiDIP-6222N
IntActiQ13114, 65 interactors
MINTiQ13114
STRINGi9606.ENSP00000376500

Structurei

Secondary structure

1568
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13114
SMRiQ13114
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13114

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini415 – 560MATHPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili267 – 338Sequence analysisAdd BLAST72

Domaini

The MATH/TRAF domain binds to receptor cytoplasmic domains.
The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 77RING-typePROSITE-ProRule annotation10
Zinc fingeri135 – 190TRAF-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri191 – 249TRAF-type 2PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDV Eukaryota
ENOG410YQ97 LUCA
GeneTreeiENSGT00550000074359
HOVERGENiHBG058222
InParanoidiQ13114
KOiK03174
OMAiCETCMAA
OrthoDBiEOG091G0GHD
PhylomeDBiQ13114
TreeFamiTF321154

Family and domain databases

CDDicd03777 MATH_TRAF3, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027128 TRAF3
IPR037304 TRAF3_MATH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PANTHERiPTHR10131:SF76 PTHR10131:SF76, 1 hit
PfamiView protein in Pfam
PF02176 zf-TRAF, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 3 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK
60 70 80 90 100
YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV
110 120 130 140 150
FKDNCCKREI LALQIYCRNE SRGCAEQLML GHLLVHLKND CHFEELPCVR
160 170 180 190 200
PDCKEKVLRK DLRDHVEKAC KYREATCSHC KSQVPMIALQ KHEDTDCPCV
210 220 230 240 250
VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV FQGTNQQIKA
260 270 280 290 300
HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI
310 320 330 340 350
EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM
360 370 380 390 400
KSSVESLQNR VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA
410 420 430 440 450
DMDLRFQVLE TASYNGVLIW KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF
460 470 480 490 500
GYKMCARVYL NGDGMGKGTH LSLFFVIMRG EYDALLPWPF KQKVTLMLMD
510 520 530 540 550
QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ TVLENGTYIK
560
DDTIFIKVIV DTSDLPDP
Length:568
Mass (Da):64,490
Last modified:October 17, 2006 - v2
Checksum:i9456E440C0A90FBF
GO
Isoform 2 (identifier: Q13114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-273: Missing.

Show »
Length:485
Mass (Da):55,306
Checksum:i1280A3E1B054768D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHG8A6NHG8_HUMAN
TNF receptor-associated factor 3
TRAF3
543Annotation score:
H0YL26H0YL26_HUMAN
TNF receptor-associated factor 3
TRAF3
290Annotation score:
H0YL25H0YL25_HUMAN
TNF receptor-associated factor 3
TRAF3
207Annotation score:
H0YMI8H0YMI8_HUMAN
TNF receptor-associated factor 3
TRAF3
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134Missing in AAA56753 (PubMed:7533327).Curated1
Sequence conflicti158L → F in BAH13910 (PubMed:14702039).Curated1
Sequence conflicti218 – 242Missing in AAA68195 (PubMed:7530216).CuratedAdd BLAST25
Sequence conflicti339P → S in AAA68195 (PubMed:7530216).Curated1
Sequence conflicti405R → G in AAA56753 (PubMed:7533327).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069081118R → W in IIAE5. 1 PublicationCorresponds to variant dbSNP:rs143813189EnsemblClinVar.1
Natural variantiVAR_052149129M → T2 PublicationsCorresponds to variant dbSNP:rs1131877Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040040191 – 273Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15637 mRNA Translation: AAA56753.1
U19260 mRNA Translation: AAA65732.1
L38509 mRNA Translation: AAA68195.1
U21092 mRNA Translation: AAC50112.1
BX247977 mRNA Translation: CAD62311.1
AK303172 mRNA Translation: BAH13910.1
AL117209 Genomic DNA No translation available.
BC075087 mRNA Translation: AAH75087.1
BC075086 mRNA Translation: AAH75086.1
AF110908 mRNA Translation: AAD29276.1
CCDSiCCDS55946.1 [Q13114-2]
CCDS9975.1 [Q13114-1]
PIRiA55960
S68467
RefSeqiNP_001186356.1, NM_001199427.1 [Q13114-2]
NP_003291.2, NM_003300.3 [Q13114-1]
NP_663777.1, NM_145725.2 [Q13114-1]
NP_663778.1, NM_145726.2
XP_011535420.1, XM_011537118.2 [Q13114-2]
XP_016877106.1, XM_017021617.1 [Q13114-1]
XP_016877107.1, XM_017021618.1 [Q13114-1]
UniGeneiHs.510528

Genome annotation databases

EnsembliENST00000392745; ENSP00000376500; ENSG00000131323 [Q13114-1]
ENST00000539721; ENSP00000445998; ENSG00000131323 [Q13114-2]
ENST00000560371; ENSP00000454207; ENSG00000131323 [Q13114-1]
GeneIDi7187
KEGGihsa:7187
UCSCiuc001ymc.3 human [Q13114-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15637 mRNA Translation: AAA56753.1
U19260 mRNA Translation: AAA65732.1
L38509 mRNA Translation: AAA68195.1
U21092 mRNA Translation: AAC50112.1
BX247977 mRNA Translation: CAD62311.1
AK303172 mRNA Translation: BAH13910.1
AL117209 Genomic DNA No translation available.
BC075087 mRNA Translation: AAH75087.1
BC075086 mRNA Translation: AAH75086.1
AF110908 mRNA Translation: AAD29276.1
CCDSiCCDS55946.1 [Q13114-2]
CCDS9975.1 [Q13114-1]
PIRiA55960
S68467
RefSeqiNP_001186356.1, NM_001199427.1 [Q13114-2]
NP_003291.2, NM_003300.3 [Q13114-1]
NP_663777.1, NM_145725.2 [Q13114-1]
NP_663778.1, NM_145726.2
XP_011535420.1, XM_011537118.2 [Q13114-2]
XP_016877106.1, XM_017021617.1 [Q13114-1]
XP_016877107.1, XM_017021618.1 [Q13114-1]
UniGeneiHs.510528

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLKX-ray2.80A/B341-568[»]
1FLLX-ray3.50A/B341-568[»]
1KZZX-ray3.50A377-568[»]
1L0AX-ray2.90A377-568[»]
1RF3X-ray3.50A377-568[»]
1ZMSX-ray2.80A377-568[»]
2ECYNMR-A43-101[»]
2GKWX-ray2.70A377-568[»]
ProteinModelPortaliQ13114
SMRiQ13114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113039, 117 interactors
CORUMiQ13114
DIPiDIP-6222N
IntActiQ13114, 65 interactors
MINTiQ13114
STRINGi9606.ENSP00000376500

Protein family/group databases

MoonDBiQ13114 Predicted

PTM databases

iPTMnetiQ13114
PhosphoSitePlusiQ13114

Polymorphism and mutation databases

BioMutaiTRAF3
DMDMi116242824

Proteomic databases

EPDiQ13114
MaxQBiQ13114
PaxDbiQ13114
PeptideAtlasiQ13114
PRIDEiQ13114
ProteomicsDBi59165
59166 [Q13114-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392745; ENSP00000376500; ENSG00000131323 [Q13114-1]
ENST00000539721; ENSP00000445998; ENSG00000131323 [Q13114-2]
ENST00000560371; ENSP00000454207; ENSG00000131323 [Q13114-1]
GeneIDi7187
KEGGihsa:7187
UCSCiuc001ymc.3 human [Q13114-1]

Organism-specific databases

CTDi7187
DisGeNETi7187
EuPathDBiHostDB:ENSG00000131323.14
GeneCardsiTRAF3
HGNCiHGNC:12033 TRAF3
HPAiHPA002933
MalaCardsiTRAF3
MIMi601896 gene
614849 phenotype
neXtProtiNX_Q13114
OpenTargetsiENSG00000131323
Orphaneti1930 Herpes simplex virus encephalitis
PharmGKBiPA36710
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISDV Eukaryota
ENOG410YQ97 LUCA
GeneTreeiENSGT00550000074359
HOVERGENiHBG058222
InParanoidiQ13114
KOiK03174
OMAiCETCMAA
OrthoDBiEOG091G0GHD
PhylomeDBiQ13114
TreeFamiTF321154

Enzyme and pathway databases

ReactomeiR-HSA-5602571 TRAF3 deficiency - HSE
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
SignaLinkiQ13114
SIGNORiQ13114

Miscellaneous databases

ChiTaRSiTRAF3 human
EvolutionaryTraceiQ13114
GeneWikiiTRAF3
GenomeRNAii7187
PMAP-CutDBiQ13114
PROiPR:Q13114
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131323 Expressed in 200 organ(s), highest expression level in frontal cortex
CleanExiHS_CAP1
HS_TRAF3
ExpressionAtlasiQ13114 baseline and differential
GenevisibleiQ13114 HS

Family and domain databases

CDDicd03777 MATH_TRAF3, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027128 TRAF3
IPR037304 TRAF3_MATH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PANTHERiPTHR10131:SF76 PTHR10131:SF76, 1 hit
PfamiView protein in Pfam
PF02176 zf-TRAF, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 3 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTRAF3_HUMAN
AccessioniPrimary (citable) accession number: Q13114
Secondary accession number(s): B7Z8C4
, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 211 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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