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UniProtKB - Q13113 (PDZ1I_HUMAN)
Protein
PDZK1-interacting protein 1
Gene
PDZK1IP1
Organism
Homo sapiens (Human)
Status
Functioni
May play an important role in tumor biology.
Enzyme and pathway databases
PathwayCommonsi | Q13113 |
SignaLinki | Q13113 |
Names & Taxonomyi
Protein namesi | Recommended name: PDZK1-interacting protein 1Alternative name(s): 17 kDa membrane-associated protein Protein DD96 |
Gene namesi | Name:PDZK1IP1 Synonyms:MAP17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16887, PDZK1IP1 |
MIMi | 607178, gene |
neXtProti | NX_Q13113 |
VEuPathDBi | HostDB:ENSG00000162366 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10158 |
OpenTargetsi | ENSG00000162366 |
PharmGKBi | PA142671188 |
Miscellaneous databases
Pharosi | Q13113, Tbio |
Genetic variation databases
BioMutai | PDZK1IP1 |
DMDMi | 6225642 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058282 | 1 – 114 | PDZK1-interacting protein 1Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 85 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13113 |
jPOSTi | Q13113 |
MassIVEi | Q13113 |
PaxDbi | Q13113 |
PeptideAtlasi | Q13113 |
PRIDEi | Q13113 |
ProteomicsDBi | 59164 |
PTM databases
iPTMneti | Q13113 |
PhosphoSitePlusi | Q13113 |
SwissPalmi | Q13113 |
Expressioni
Tissue specificityi
Expressed at significant levels only in a single epithelial cell population, the proximal tubular epithelial cells of the kidney. Diffusely expressed in various carcinomas originating from kidney, colon, lung and breast.
Gene expression databases
Bgeei | ENSG00000162366, Expressed in adult mammalian kidney and 164 other tissues |
Genevisiblei | Q13113, HS |
Organism-specific databases
HPAi | ENSG00000162366, Tissue enriched (kidney) |
Interactioni
Subunit structurei
Interacts with PDZK1.
1 PublicationBinary interactionsi
Q13113
Protein-protein interaction databases
BioGRIDi | 115460, 77 interactors |
IntActi | Q13113, 86 interactors |
STRINGi | 9606.ENSP00000294338 |
Miscellaneous databases
RNActi | Q13113, protein |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 114 | DisorderedSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SAPW, Eukaryota |
GeneTreei | ENSGT00940000154660 |
HOGENOMi | CLU_168651_0_0_1 |
InParanoidi | Q13113 |
OMAi | NFRSSEH |
OrthoDBi | 1588365at2759 |
PhylomeDBi | Q13113 |
TreeFami | TF328829 |
Family and domain databases
InterProi | View protein in InterPro IPR026628, PDZK-int_prot1 IPR031627, PDZK1IP1/SMIM24 |
PANTHERi | PTHR15296, PTHR15296, 1 hit PTHR15296:SF0, PTHR15296:SF0, 1 hit |
Pfami | View protein in Pfam PF15807, MAP17, 1 hit |
i Sequence
Sequence statusi: Complete.
Q13113-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSALSLLILG LLTAVPPASC QQGLGNLQPW MQGLIAVAVF LVLVAIAFAV
60 70 80 90 100
NHFWCQEEPE PAHMILTVGN KADGVLVGTD GRYSSMAASF RSSEHENAYE
110
NVPEEEGKVR STPM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | T → M in AAH12303 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 51 | N → K in AAH12303 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21049 mRNA Translation: AAA92690.1 CR450304 mRNA Translation: CAG29300.1 AL135960 Genomic DNA Translation: CAB72104.1 CH471059 Genomic DNA Translation: EAX06878.1 BC012303 mRNA Translation: AAH12303.1 |
CCDSi | CCDS546.1 |
RefSeqi | NP_005755.1, NM_005764.3 |
Genome annotation databases
Ensembli | ENST00000294338; ENSP00000294338; ENSG00000162366 ENST00000371885; ENSP00000360952; ENSG00000162366 |
GeneIDi | 10158 |
KEGGi | hsa:10158 |
MANE-Selecti | ENST00000294338.7; ENSP00000294338.2; NM_005764.4; NP_005755.1 |
UCSCi | uc001cqw.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U21049 mRNA Translation: AAA92690.1 CR450304 mRNA Translation: CAG29300.1 AL135960 Genomic DNA Translation: CAB72104.1 CH471059 Genomic DNA Translation: EAX06878.1 BC012303 mRNA Translation: AAH12303.1 |
CCDSi | CCDS546.1 |
RefSeqi | NP_005755.1, NM_005764.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7FEN | electron microscopy | 2.95 | B | 1-56 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115460, 77 interactors |
IntActi | Q13113, 86 interactors |
STRINGi | 9606.ENSP00000294338 |
PTM databases
iPTMneti | Q13113 |
PhosphoSitePlusi | Q13113 |
SwissPalmi | Q13113 |
Genetic variation databases
BioMutai | PDZK1IP1 |
DMDMi | 6225642 |
Proteomic databases
EPDi | Q13113 |
jPOSTi | Q13113 |
MassIVEi | Q13113 |
PaxDbi | Q13113 |
PeptideAtlasi | Q13113 |
PRIDEi | Q13113 |
ProteomicsDBi | 59164 |
Protocols and materials databases
Antibodypediai | 2658, 29 antibodies from 12 providers |
DNASUi | 10158 |
Genome annotation databases
Ensembli | ENST00000294338; ENSP00000294338; ENSG00000162366 ENST00000371885; ENSP00000360952; ENSG00000162366 |
GeneIDi | 10158 |
KEGGi | hsa:10158 |
MANE-Selecti | ENST00000294338.7; ENSP00000294338.2; NM_005764.4; NP_005755.1 |
UCSCi | uc001cqw.4, human |
Organism-specific databases
CTDi | 10158 |
DisGeNETi | 10158 |
GeneCardsi | PDZK1IP1 |
HGNCi | HGNC:16887, PDZK1IP1 |
HPAi | ENSG00000162366, Tissue enriched (kidney) |
MIMi | 607178, gene |
neXtProti | NX_Q13113 |
OpenTargetsi | ENSG00000162366 |
PharmGKBi | PA142671188 |
VEuPathDBi | HostDB:ENSG00000162366 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SAPW, Eukaryota |
GeneTreei | ENSGT00940000154660 |
HOGENOMi | CLU_168651_0_0_1 |
InParanoidi | Q13113 |
OMAi | NFRSSEH |
OrthoDBi | 1588365at2759 |
PhylomeDBi | Q13113 |
TreeFami | TF328829 |
Enzyme and pathway databases
PathwayCommonsi | Q13113 |
SignaLinki | Q13113 |
Miscellaneous databases
BioGRID-ORCSi | 10158, 37 hits in 1029 CRISPR screens |
ChiTaRSi | PDZK1IP1, human |
GeneWikii | PDZK1IP1 |
GenomeRNAii | 10158 |
Pharosi | Q13113, Tbio |
PROi | PR:Q13113 |
RNActi | Q13113, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162366, Expressed in adult mammalian kidney and 164 other tissues |
Genevisiblei | Q13113, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026628, PDZK-int_prot1 IPR031627, PDZK1IP1/SMIM24 |
PANTHERi | PTHR15296, PTHR15296, 1 hit PTHR15296:SF0, PTHR15296:SF0, 1 hit |
Pfami | View protein in Pfam PF15807, MAP17, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDZ1I_HUMAN | |
Accessioni | Q13113Primary (citable) accession number: Q13113 Secondary accession number(s): Q6ICT9, Q96EI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references