Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PDZK1-interacting protein 1

Gene

PDZK1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in tumor biology.

Names & Taxonomyi

Protein namesi
Recommended name:
PDZK1-interacting protein 1
Alternative name(s):
17 kDa membrane-associated protein
Protein DD96
Gene namesi
Name:PDZK1IP1
Synonyms:MAP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162366.7
HGNCiHGNC:16887 PDZK1IP1
MIMi607178 gene
neXtProtiNX_Q13113

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10158
OpenTargetsiENSG00000162366
PharmGKBiPA142671188

Polymorphism and mutation databases

BioMutaiPDZK1IP1
DMDMi6225642

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582821 – 114PDZK1-interacting protein 1Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13113
PaxDbiQ13113
PeptideAtlasiQ13113
PRIDEiQ13113
ProteomicsDBi59164

PTM databases

iPTMnetiQ13113
PhosphoSitePlusiQ13113
SwissPalmiQ13113

Expressioni

Tissue specificityi

Expressed at significant levels only in a single epithelial cell population, the proximal tubular epithelial cells of the kidney. Diffusely expressed in various carcinomas originating from kidney, colon, lung and breast.

Gene expression databases

BgeeiENSG00000162366 Expressed in 145 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_PDZK1IP1
GenevisibleiQ13113 HS

Organism-specific databases

HPAiHPA014907

Interactioni

Subunit structurei

Interacts with PDZK1.1 Publication

Protein-protein interaction databases

BioGridi115460, 4 interactors
IntActiQ13113, 65 interactors
STRINGi9606.ENSP00000294338

Structurei

3D structure databases

ProteinModelPortaliQ13113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J305 Eukaryota
ENOG41116TZ LUCA
GeneTreeiENSGT00390000014478
HOGENOMiHOG000231172
HOVERGENiHBG080155
InParanoidiQ13113
OMAiEPAHMIL
OrthoDBiEOG091G13G3
PhylomeDBiQ13113
TreeFamiTF328829

Family and domain databases

InterProiView protein in InterPro
IPR026628 PDZK-int_prot1
IPR031627 PDZK1IP1/SMIM24
PANTHERiPTHR15296 PTHR15296, 1 hit
PTHR15296:SF0 PTHR15296:SF0, 1 hit
PfamiView protein in Pfam
PF15807 MAP17, 1 hit

Sequencei

Sequence statusi: Complete.

Q13113-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALSLLILG LLTAVPPASC QQGLGNLQPW MQGLIAVAVF LVLVAIAFAV
60 70 80 90 100
NHFWCQEEPE PAHMILTVGN KADGVLVGTD GRYSSMAASF RSSEHENAYE
110
NVPEEEGKVR STPM
Length:114
Mass (Da):12,227
Last modified:November 1, 1996 - v1
Checksum:i7DEB64C3AF78CB18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → M in AAH12303 (PubMed:15489334).Curated1
Sequence conflicti51N → K in AAH12303 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21049 mRNA Translation: AAA92690.1
CR450304 mRNA Translation: CAG29300.1
AL135960 Genomic DNA Translation: CAB72104.1
CH471059 Genomic DNA Translation: EAX06878.1
BC012303 mRNA Translation: AAH12303.1
CCDSiCCDS546.1
RefSeqiNP_005755.1, NM_005764.3
UniGeneiHs.431099

Genome annotation databases

EnsembliENST00000294338; ENSP00000294338; ENSG00000162366
ENST00000371885; ENSP00000360952; ENSG00000162366
GeneIDi10158
KEGGihsa:10158
UCSCiuc001cqw.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21049 mRNA Translation: AAA92690.1
CR450304 mRNA Translation: CAG29300.1
AL135960 Genomic DNA Translation: CAB72104.1
CH471059 Genomic DNA Translation: EAX06878.1
BC012303 mRNA Translation: AAH12303.1
CCDSiCCDS546.1
RefSeqiNP_005755.1, NM_005764.3
UniGeneiHs.431099

3D structure databases

ProteinModelPortaliQ13113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115460, 4 interactors
IntActiQ13113, 65 interactors
STRINGi9606.ENSP00000294338

PTM databases

iPTMnetiQ13113
PhosphoSitePlusiQ13113
SwissPalmiQ13113

Polymorphism and mutation databases

BioMutaiPDZK1IP1
DMDMi6225642

Proteomic databases

EPDiQ13113
PaxDbiQ13113
PeptideAtlasiQ13113
PRIDEiQ13113
ProteomicsDBi59164

Protocols and materials databases

DNASUi10158
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294338; ENSP00000294338; ENSG00000162366
ENST00000371885; ENSP00000360952; ENSG00000162366
GeneIDi10158
KEGGihsa:10158
UCSCiuc001cqw.4 human

Organism-specific databases

CTDi10158
DisGeNETi10158
EuPathDBiHostDB:ENSG00000162366.7
GeneCardsiPDZK1IP1
HGNCiHGNC:16887 PDZK1IP1
HPAiHPA014907
MIMi607178 gene
neXtProtiNX_Q13113
OpenTargetsiENSG00000162366
PharmGKBiPA142671188
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J305 Eukaryota
ENOG41116TZ LUCA
GeneTreeiENSGT00390000014478
HOGENOMiHOG000231172
HOVERGENiHBG080155
InParanoidiQ13113
OMAiEPAHMIL
OrthoDBiEOG091G13G3
PhylomeDBiQ13113
TreeFamiTF328829

Miscellaneous databases

ChiTaRSiPDZK1IP1 human
GeneWikiiPDZK1IP1
GenomeRNAii10158
PROiPR:Q13113
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162366 Expressed in 145 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_PDZK1IP1
GenevisibleiQ13113 HS

Family and domain databases

InterProiView protein in InterPro
IPR026628 PDZK-int_prot1
IPR031627 PDZK1IP1/SMIM24
PANTHERiPTHR15296 PTHR15296, 1 hit
PTHR15296:SF0 PTHR15296:SF0, 1 hit
PfamiView protein in Pfam
PF15807 MAP17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDZ1I_HUMAN
AccessioniPrimary (citable) accession number: Q13113
Secondary accession number(s): Q6ICT9, Q96EI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again