UniProtKB - Q13111 (CAF1A_HUMAN)

BLAST

>sp|Q13111|CAF1A_HUMAN Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3
MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTS
VQSKSPDLEASLDTLENNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLT
EDSNEQPDSLVDHNKLNSEASPSREAINGQREDTGDQQGLLKAIQNDKLAFPGETLSDIP
CKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAGGILFKGKVPMV
VLQDILAVRPPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPP
APPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKL
KEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLE
EKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLA
PRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIV
ERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDS
DEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVR
QKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEE
QTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTY
LHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWS
YVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGF
QADTEEEEEEEGDCMIVDVPDAAEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS

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History
Entry version 175 (12 Sep 2018)
Sequence version 3 (28 Mar 2018)
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Protein

Chromatin assembly factor 1 subunit A

Gene

CHAF1A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

chromatin binding
Source: ProtInc
Traceable author statementⁱ
- 7600578
chromo shadow domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15882967
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16826239
unfolded protein binding
Source: ProtInc
Traceable author statementⁱ
- 7600578

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
chromatin assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 8858152
DNA repair Source: UniProtKB-KW
DNA replication Source: UniProtKB-KW
DNA replication-dependent nucleosome assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 14718166

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Cell cycle, DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

SIGNORⁱ	Q13111

SIGNORⁱ

Q13111

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chromatin assembly factor 1 subunit A Short name: CAF-1 subunit A Alternative name(s): Chromatin assembly factor I p150 subunit Short name: CAF-I 150 kDa subunit Short name: CAF-I p150 Short name: hp150
Gene namesⁱ	Name:CHAF1A Synonyms:CAF, CAF1P150
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167670.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1910 CHAF1A
MIMⁱ	601246 gene
neXtProtⁱ	NX_Q13111

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	240	V → E: Abolishes interaction with CBX5; when associated with E-242. 1 Publication		1
Mutagenesisⁱ	242	L → E: Abolishes interaction with CBX5; when associated with E-240. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10036
Open Targets More...OpenTargetsⁱ	ENSG00000167670
PharmGKBⁱ	PA26446

Polymorphism and mutation databases

BioMutaⁱ	CHAF1A
DMDMⁱ	229462842

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089276	1 – 956	Chromatin assembly factor 1 subunit AAdd BLAST		956

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	65	PhosphoserineCombined sources	1
Modified residueⁱ	123	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1
Modified residueⁱ	141	PhosphoserineCombined sources	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	206	PhosphoserineCombined sources	1
Modified residueⁱ	224	PhosphoserineCombined sources	1
Modified residueⁱ	310	PhosphoserineCombined sources	1
Modified residueⁱ	722	PhosphothreonineCombined sources	1
Modified residueⁱ	772	PhosphoserineCombined sources	1
Modified residueⁱ	775	PhosphoserineCombined sources	1
Modified residueⁱ	803	PhosphoserineCombined sources	1
Modified residueⁱ	865	PhosphothreonineCombined sources	1
Modified residueⁱ	868	PhosphoserineCombined sources	1
Modified residueⁱ	873	PhosphoserineCombined sources	1
Modified residueⁱ	951	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q13111
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13111
PaxDbⁱ	Q13111
PeptideAtlas More...PeptideAtlasⁱ	Q13111
PRIDEⁱ	Q13111
ProteomicsDBⁱ	59160 59161 [Q13111-2] 59162 [Q13111-3]

PTM databases

iPTMnetⁱ	Q13111
PhosphoSitePlusⁱ	Q13111

Miscellaneous databases

PMAP-CutDBⁱ	Q13111

PMAP-CutDBⁱ

Q13111

Expressionⁱ

Developmental stageⁱ

Active complex is found in G1, S and G2 phases.

Gene expression databases

Bgeeⁱ	ENSG00000167670 Expressed in 219 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CHAF1A
ExpressionAtlasⁱ	Q13111 baseline and differential
Genevisibleⁱ	Q13111 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015186

HPAⁱ

CAB015186

Interactionⁱ

Subunit structureⁱ

Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1. Binds MBD1. Interacts directly with CBX5 via the PxVxL motif. During DNA replication, it forms a S phase-specific complex that facilitates DNA methylation and histone H3 'Lys-9' methylation during replication-coupled chromatin assembly and is at least composed of the CHAF1A, MBD1 and SETDB1. Interacts with CBX5.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-1020839,EBI-1020839
CBX5	P45973	7	EBI-1020839,EBI-78219
GFI1	Q99684	4	EBI-1020839,EBI-949368
H3F3B	P84243	2	EBI-1020839,EBI-120658
HIST2H3A	Q71DI3	2	EBI-1020839,EBI-750650
MBD1	Q9UIS9	3	EBI-1020839,EBI-867196
NCK1	P16333	2	EBI-1020839,EBI-389883
PCNA	P12004	4	EBI-1020839,EBI-358311
PIK3R1	P27986	2	EBI-1020839,EBI-79464
REL	Q04864	3	EBI-1020839,EBI-307352
TCF4	P15884	3	EBI-1020839,EBI-533224

GO - Molecular functionⁱ

chromo shadow domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15882967
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16826239
unfolded protein binding
Source: ProtInc
Traceable author statementⁱ
- 7600578

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115349, 81 interactors
ComplexPortalⁱ	CPX-569 Chromatin assembly factor 1 complex
CORUMⁱ	Q13111
Database of interacting proteins More...DIPⁱ	DIP-31135N
ELMⁱ	Q13111
IntActⁱ	Q13111, 53 interactors
Molecular INTeraction database More...MINTⁱ	Q13111
STRINGⁱ	9606.ENSP00000301280

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13111
SMRⁱ	Q13111
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 314	Binds to CBX1 chromo shadow domainAdd BLAST	314
Regionⁱ	1 – 49	Binds to PCNAAdd BLAST	49
Regionⁱ	642 – 678	Necessary for homodimerization and competence for chromatin assemblyAdd BLAST	37
Regionⁱ	660 – 956	Binds to p60Add BLAST	297

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	233 – 246	PxVxL motifAdd BLAST		14

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	323 – 453	Arg/Glu/Lys-richAdd BLAST	131
Compositional biasⁱ	602 – 608	Poly-Glu	7
Compositional biasⁱ	619 – 623	Poly-Asp	5
Compositional biasⁱ	905 – 911	Poly-Glu	7

Domainⁱ

Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.

Sequence similaritiesⁱ

Belongs to the CHAF1A family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4364 Eukaryota ENOG4111K9K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000034888
HOGENOMⁱ	HOG000111290
HOVERGENⁱ	HBG050779
InParanoidⁱ	Q13111
KEGG Orthology (KO) More...KOⁱ	K10750
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VQK
PhylomeDBⁱ	Q13111
TreeFamⁱ	TF350377

Family and domain databases

InterProⁱ	View protein in InterPro IPR029105 CAF1-p150_C2 IPR029091 CAF1_asu_N IPR022043 CAF1A
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15539 CAF1-p150_C2, 1 hit PF15557 CAF1-p150_N, 1 hit PF12253 CAF1A, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13111-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEELECGAP GARGAATAMD CKDRPAFPVK KLIQARLPFK RLNLVPKGKA 
        60         70         80         90        100
DDMSDDQGTS VQSKSPDLEA SLDTLENNCH VGSDIDFRPK LVNGKGPLDN 
       110        120        130        140        150
FLRNRIETSI GQSTVIIDLT EDSNEQPDSL VDHNKLNSEA SPSREAINGQ 
       160        170        180        190        200
REDTGDQQGL LKAIQNDKLA FPGETLSDIP CKTEEEGVGC GGAGRRGDSQ 
       210        220        230        240        250
ECSPRSCPEL TSGPRMCPRK EQDSWSEAGG ILFKGKVPMV VLQDILAVRP 
       260        270        280        290        300
PQIKSLPATP QGKNMTPESE VLESFPEEDS VLSHSSLSSP SSTSSPEGPP 
       310        320        330        340        350
APPKQHSSTS PFPTSTPLRR ITKKFVKGST EKNKLRLQRD QERLGKQLKL 
       360        370        380        390        400
RAEREEKEKL KEEAKRAKEE AKKKKEEEKE LKEKERREKR EKDEKEKAEK 
       410        420        430        440        450
QRLKEERRKE RQEALEAKLE EKRKKEEEKR LREEEKRIKA EKAEITRFFQ 
       460        470        480        490        500
KPKTPQAPKT LAGSCGKFAP FEIKEHMVLA PRRRTAFHPD LCSQLDQLLQ 
       510        520        530        540        550
QQSGEFSFLK DLKGRQPLRS GPTHVSTRNA DIFNSDVVIV ERGKGDGVPE 
       560        570        580        590        600
RRKFGRMKLL QFCENHRPAY WGTWNKKTAL IRARDPWAQD TKLLDYEVDS 
       610        620        630        640        650
DEEWEEEEPG ESLSHSEGDD DDDMGEDEDE DDGFFVPHGY LSEDEGVTEE 
       660        670        680        690        700
CADPENHKVR QKLKAKEWDE FLAKGKRFRV LQPVKIGCVW AADRDCAGDD 
       710        720        730        740        750
LKVLQQFAAC FLETLPAQEE QTPKASKRER RDEQILAQLL PLLHGNVNGS 
       760        770        780        790        800
KVIIREFQEH CRRGLLSNHT GSPRSPSTTY LHTPTPSEDA AIPSKSRLKR 
       810        820        830        840        850
LISENSVYEK RPDFRMCWYV HPQVLQSFQQ EHLPVPCQWS YVTSVPSAPK 
       860        870        880        890        900
EDSGSVPSTG PSQGTPISLK RKSAGSMCIT QFMKKRRHDG QIGAEDMDGF 
       910        920        930        940        950
QADTEEEEEE EGDCMIVDVP DAAEVQAPCG AASGAGGGVG VDTGKATLTA 

SPLGAS

Length:956

Mass (Da):106,910

Last modified:March 28, 2018 - v3

Checksum:ⁱ90617F8FE8DB7FD0

Isoform 2 (identifier: Q13111-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
710-749: CFLETLPAQE...LPLLHGNVNG → HWVHPESRGD...CVKSTLSCFT
750-956: Missing.

« Hide

        10         20         30         40         50
MLEELECGAP GARGAATAMD CKDRPAFPVK KLIQARLPFK RLNLVPKGKA 
        60         70         80         90        100
DDMSDDQGTS VQSKSPDLEA SLDTLENNCH VGSDIDFRPK LVNGKGPLDN 
       110        120        130        140        150
FLRNRIETSI GQSTVIIDLT EDSNEQPDSL VDHNKLNSEA SPSREAINGQ 
       160        170        180        190        200
REDTGDQQGL LKAIQNDKLA FPGETLSDIP CKTEEEGVGC GGAGRRGDSQ 
       210        220        230        240        250
ECSPRSCPEL TSGPRMCPRK EQDSWSEAGG ILFKGKVPMV VLQDILAVRP 
       260        270        280        290        300
PQIKSLPATP QGKNMTPESE VLESFPEEDS VLSHSSLSSP SSTSSPEGPP 
       310        320        330        340        350
APPKQHSSTS PFPTSTPLRR ITKKFVKGST EKNKLRLQRD QERLGKQLKL 
       360        370        380        390        400
RAEREEKEKL KEEAKRAKEE AKKKKEEEKE LKEKERREKR EKDEKEKAEK 
       410        420        430        440        450
QRLKEERRKE RQEALEAKLE EKRKKEEEKR LREEEKRIKA EKAEITRFFQ 
       460        470        480        490        500
KPKTPQAPKT LAGSCGKFAP FEIKEHMVLA PRRRTAFHPD LCSQLDQLLQ 
       510        520        530        540        550
QQSGEFSFLK DLKGRQPLRS GPTHVSTRNA DIFNSDVVIV ERGKGDGVPE 
       560        570        580        590        600
RRKFGRMKLL QFCENHRPAY WGTWNKKTAL IRARDPWAQD TKLLDYEVDS 
       610        620        630        640        650
DEEWEEEEPG ESLSHSEGDD DDDMGEDEDE DDGFFVPHGY LSEDEGVTEE 
       660        670        680        690        700
CADPENHKVR QKLKAKEWDE FLAKGKRFRV LQPVKIGCVW AADRDCAGDD 
       710        720        730        740 
LKVLQQFAAH WVHPESRGDV CRTLRVSSPQ SRYLNRLNSC VKSTLSCFT

Show »

Length:749

Mass (Da):84,685

Checksum:ⁱA7176E2D8D18CA0F

Isoform 3 (identifier: Q13111-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
772-944: Missing.

« Hide

        10         20         30         40         50
MLEELECGAP GARGAATAMD CKDRPAFPVK KLIQARLPFK RLNLVPKGKA 
        60         70         80         90        100
DDMSDDQGTS VQSKSPDLEA SLDTLENNCH VGSDIDFRPK LVNGKGPLDN 
       110        120        130        140        150
FLRNRIETSI GQSTVIIDLT EDSNEQPDSL VDHNKLNSEA SPSREAINGQ 
       160        170        180        190        200
REDTGDQQGL LKAIQNDKLA FPGETLSDIP CKTEEEGVGC GGAGRRGDSQ 
       210        220        230        240        250
ECSPRSCPEL TSGPRMCPRK EQDSWSEAGG ILFKGKVPMV VLQDILAVRP 
       260        270        280        290        300
PQIKSLPATP QGKNMTPESE VLESFPEEDS VLSHSSLSSP SSTSSPEGPP 
       310        320        330        340        350
APPKQHSSTS PFPTSTPLRR ITKKFVKGST EKNKLRLQRD QERLGKQLKL 
       360        370        380        390        400
RAEREEKEKL KEEAKRAKEE AKKKKEEEKE LKEKERREKR EKDEKEKAEK 
       410        420        430        440        450
QRLKEERRKE RQEALEAKLE EKRKKEEEKR LREEEKRIKA EKAEITRFFQ 
       460        470        480        490        500
KPKTPQAPKT LAGSCGKFAP FEIKEHMVLA PRRRTAFHPD LCSQLDQLLQ 
       510        520        530        540        550
QQSGEFSFLK DLKGRQPLRS GPTHVSTRNA DIFNSDVVIV ERGKGDGVPE 
       560        570        580        590        600
RRKFGRMKLL QFCENHRPAY WGTWNKKTAL IRARDPWAQD TKLLDYEVDS 
       610        620        630        640        650
DEEWEEEEPG ESLSHSEGDD DDDMGEDEDE DDGFFVPHGY LSEDEGVTEE 
       660        670        680        690        700
CADPENHKVR QKLKAKEWDE FLAKGKRFRV LQPVKIGCVW AADRDCAGDD 
       710        720        730        740        750
LKVLQQFAAC FLETLPAQEE QTPKASKRER RDEQILAQLL PLLHGNVNGS 
       760        770        780 
KVIIREFQEH CRRGLLSNHT GKATLTASPL GAS

Show »

Length:783

Mass (Da):88,269

Checksum:ⁱ44E39E1CCE193030

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EPA1	K7EPA1_HUMAN	Chromatin assembly factor 1 subunit... Chromatin assembly factor 1 subunit A	CHAF1A	291	Annotation score:
K7EJF1	K7EJF1_HUMAN	Chromatin assembly factor 1 subunit... Chromatin assembly factor 1 subunit A	CHAF1A	151	Annotation score:
K7ENC7	K7ENC7_HUMAN	Chromatin assembly factor 1 subunit... Chromatin assembly factor 1 subunit A	CHAF1A	17	Annotation score:
K7EME9	K7EME9_HUMAN	Chromatin assembly factor 1 subunit... Chromatin assembly factor 1 subunit A	CHAF1A	47	Annotation score:

Sequence cautionⁱ

The sequence AAA76736 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAF04291 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH52620 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated

The sequence AAH52620 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	775	S → T in AAA76736 (PubMed:7600578).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055329	167	D → V. Corresponds to variant dbSNP:rs35651457Ensembl.	1
Natural variantⁱVAR_055330	239	M → V. Corresponds to variant dbSNP:rs2230635Ensembl.	1
Natural variantⁱVAR_055331	850	K → R. Corresponds to variant dbSNP:rs8100525Ensembl.	1
Natural variantⁱVAR_055332	923	A → V2 PublicationsCorresponds to variant dbSNP:rs9352Ensembl.	1
Natural variantⁱVAR_055333	950	A → S. Corresponds to variant dbSNP:rs243383Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004149	710 – 749	CFLET…GNVNG → HWVHPESRGDVCRTLRVSSP QSRYLNRLNSCVKSTLSCFT in isoform 2. CuratedAdd BLAST	40
Alternative sequenceⁱVSP_004150	750 – 956	Missing in isoform 2. CuratedAdd BLAST	207
Alternative sequenceⁱVSP_004151	772 – 944	Missing in isoform 3. CuratedAdd BLAST	173

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190465 Genomic DNA Translation: AAF04291.1 Different initiation. AC011498 Genomic DNA No translation available. KF459577 Genomic DNA No translation available. BC052620 mRNA Translation: AAH52620.1 Sequence problems. BC067093 mRNA Translation: AAH67093.1 U20979 mRNA Translation: AAA76736.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32875.1 [Q13111-1]
PIRⁱ	A56731
NCBI Reference Sequences More...RefSeqⁱ	NP_005474.2, NM_005483.2 [Q13111-1]
UniGeneⁱ	Hs.79018

Genome annotation databases

Ensemblⁱ	ENST00000301280; ENSP00000301280; ENSG00000167670 [Q13111-1]
GeneIDⁱ	10036
KEGGⁱ	hsa:10036
UCSC genome browser More...UCSCⁱ	uc002mal.4 human [Q13111-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13111	Uncharacterized protein		PAPAN		957	UniRef90_Q13111
Uncharacterized protein		RHIBE		957
Chromatin assembly factor 1 subunit A		MACMU		957
Uncharacterized protein		CERAT		956
Chromatin assembly factor 1, subunit A (P150), isoform CRA_a		HUMAN		956
+29

Protein	Similar proteins		Species	Score	Length	Source
Q13111	Chromatin assembly factor 1 subunit A		CHICK		937	UniRef50_Q13111
Chromatin assembly factor 1 subunit A		BOVIN		964
Chromatin assembly factor 1 subunit A	)	MOUSE		911
Chromatin assembly factor 1 subunit A		MACMU		957
Uncharacterized protein		PAPAN		957
+235
Q13111-2	Uncharacterized protein		MANLE		644	UniRef50_Q13111-2
UPI0005F440EF		MANLE		652

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190465 Genomic DNA Translation: AAF04291.1 Different initiation. AC011498 Genomic DNA No translation available. KF459577 Genomic DNA No translation available. BC052620 mRNA Translation: AAH52620.1 Sequence problems. BC067093 mRNA Translation: AAH67093.1 U20979 mRNA Translation: AAA76736.1 Different initiation.
CCDSⁱ	CCDS32875.1 [Q13111-1]
PIRⁱ	A56731
RefSeqⁱ	NP_005474.2, NM_005483.2 [Q13111-1]
UniGeneⁱ	Hs.79018

3D structure databases

ProteinModelPortalⁱ	Q13111
SMRⁱ	Q13111
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115349, 81 interactors
ComplexPortalⁱ	CPX-569 Chromatin assembly factor 1 complex
CORUMⁱ	Q13111
DIPⁱ	DIP-31135N
ELMⁱ	Q13111
IntActⁱ	Q13111, 53 interactors
MINTⁱ	Q13111
STRINGⁱ	9606.ENSP00000301280

PTM databases

iPTMnetⁱ	Q13111
PhosphoSitePlusⁱ	Q13111

Polymorphism and mutation databases

BioMutaⁱ	CHAF1A
DMDMⁱ	229462842

Proteomic databases

EPDⁱ	Q13111
MaxQBⁱ	Q13111
PaxDbⁱ	Q13111
PeptideAtlasⁱ	Q13111
PRIDEⁱ	Q13111
ProteomicsDBⁱ	59160 59161 [Q13111-2] 59162 [Q13111-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301280; ENSP00000301280; ENSG00000167670 [Q13111-1]
GeneIDⁱ	10036
KEGGⁱ	hsa:10036
UCSCⁱ	uc002mal.4 human [Q13111-1]

Organism-specific databases

CTDⁱ	10036
DisGeNETⁱ	10036
EuPathDBⁱ	HostDB:ENSG00000167670.15
GeneCardsⁱ	CHAF1A
HGNCⁱ	HGNC:1910 CHAF1A
HPAⁱ	CAB015186
MIMⁱ	601246 gene
neXtProtⁱ	NX_Q13111
OpenTargetsⁱ	ENSG00000167670
PharmGKBⁱ	PA26446
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4364 Eukaryota ENOG4111K9K LUCA
GeneTreeⁱ	ENSGT00440000034888
HOGENOMⁱ	HOG000111290
HOVERGENⁱ	HBG050779
InParanoidⁱ	Q13111
KOⁱ	K10750
OrthoDBⁱ	EOG091G0VQK
PhylomeDBⁱ	Q13111
TreeFamⁱ	TF350377

Enzyme and pathway databases

SIGNORⁱ	Q13111

SIGNORⁱ

Q13111

Miscellaneous databases

ChiTaRSⁱ	CHAF1A human
GeneWikiⁱ	CHAF1A
GenomeRNAiⁱ	10036
PMAP-CutDBⁱ	Q13111
Protein Ontology More...PROⁱ	PR:Q13111
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167670 Expressed in 219 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CHAF1A
ExpressionAtlasⁱ	Q13111 baseline and differential
Genevisibleⁱ	Q13111 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029105 CAF1-p150_C2 IPR029091 CAF1_asu_N IPR022043 CAF1A
Pfamⁱ	View protein in Pfam PF15539 CAF1-p150_C2, 1 hit PF15557 CAF1-p150_N, 1 hit PF12253 CAF1A, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAF1A_HUMAN
Accessionⁱ	Q13111Primary (citable) accession number: Q13111 Secondary accession number(s): Q6NXG5, Q7Z7K3, Q9UJY8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	March 28, 2018
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q13111 (CAF1A_HUMAN)

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Chromatin assembly factor 1 subunit A

CHAF1A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ