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UniProtKB - Q13111 (CAF1A_HUMAN)

Entry version 196 (23 Feb 2022)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Chromatin assembly factor 1 subunit A

Gene

CHAF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.

By similarity

Caution

Was reported to form, during DNA replication, a S phase-specific complex that would facilitate methylation of H3 'Lys-9' during replication-coupled chromatin assembly and vould be at least composed of the CAF-1 subunit CHAF1A, MBD1 and SETDB1 (PubMed:15327775). However, this paper has been retracted because some data, results and conclusions are not reliable (PubMed:30849389).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processCell cycle, DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13111

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13111

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13111

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin assembly factor 1 subunit ACurated
Short name:
CAF-1 subunit A
Alternative name(s):
Chromatin assembly factor I p150 subunit
Short name:
CAF-I 150 kDa subunit
Short name:
CAF-I p150
Short name:
hp150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHAF1AImported
Synonyms:CAF, CAF1P150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1910, CHAF1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601246, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13111

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167670

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi240V → E: Abolishes interaction with CBX5; when associated with E-242. 1 Publication1
Mutagenesisi242L → E: Abolishes interaction with CBX5; when associated with E-240. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10036

Open Targets

More...OpenTargetsi		ENSG00000167670

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26446

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13111, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHAF1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		229462842

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892761 – 956Chromatin assembly factor 1 subunit AAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei65PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei206PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei722PhosphothreonineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei803PhosphoserineCombined sources1
Modified residuei865PhosphothreonineCombined sources1
Modified residuei868PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13111

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13111

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13111

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13111

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13111

PeptideAtlas

More...PeptideAtlasi		Q13111

PRoteomics IDEntifications database

More...PRIDEi		Q13111

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59160 [Q13111-1]
59161 [Q13111-2]
59162 [Q13111-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13111, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13111

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13111

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Active complex is found in G1, S and G2 phases.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167670, Expressed in secondary oocyte and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13111, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13111, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167670, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1.

Interacts with MBD1 (PubMed:12697822).

Interacts directly with CBX5 via the PxVxL motif.

Interacts with CBX5.

Interacts with histones H3.1, H3.2 and H3.1t (PubMed:33857403).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115349, 170 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-569, Chromatin assembly factor 1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13111

Database of interacting proteins

More...DIPi		DIP-31135N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q13111

Protein interaction database and analysis system

More...IntActi		Q13111, 63 interactors

Molecular INTeraction database

More...MINTi		Q13111

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301280

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13111, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 314Binds to CBX1 chromo shadow domainAdd BLAST314
Regioni1 – 49Binds to PCNAAdd BLAST49
Regioni45 – 65DisorderedSequence analysisAdd BLAST21
Regioni122 – 155DisorderedSequence analysisAdd BLAST34
Regioni188 – 222DisorderedSequence analysisAdd BLAST35
Regioni250 – 432DisorderedSequence analysisAdd BLAST183
Regioni599 – 639DisorderedSequence analysisAdd BLAST41
Regioni642 – 678Necessary for homodimerization and competence for chromatin assemblyAdd BLAST37
Regioni660 – 956Binds to p60Add BLAST297
Regioni765 – 790DisorderedSequence analysisAdd BLAST26
Regioni844 – 873DisorderedSequence analysisAdd BLAST30
Regioni933 – 956DisorderedSequence analysisAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi233 – 246PxVxL motifAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi279 – 294Polar residuesSequence analysisAdd BLAST16
Compositional biasi324 – 432Basic and acidic residuesSequence analysisAdd BLAST109
Compositional biasi599 – 633Acidic residuesSequence analysisAdd BLAST35
Compositional biasi768 – 785Polar residuesSequence analysisAdd BLAST18
Compositional biasi844 – 870Polar residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CHAF1A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4364, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000034888

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014846_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13111

Identification of Orthologs from Complete Genome Data

More...OMAi		RRRGMDC

Database of Orthologous Groups

More...OrthoDBi		1362011at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13111

TreeFam database of animal gene trees

More...TreeFami		TF350377

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029105, CAF1-p150_C2
IPR029091, CAF1_p150_N
IPR022043, CAF1A

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15539, CAF1-p150_C2, 1 hit
PF15557, CAF1-p150_N, 1 hit
PF12253, CAF1A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13111-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEELECGAP GARGAATAMD CKDRPAFPVK KLIQARLPFK RLNLVPKGKA 
        60         70         80         90        100
DDMSDDQGTS VQSKSPDLEA SLDTLENNCH VGSDIDFRPK LVNGKGPLDN 
       110        120        130        140        150
FLRNRIETSI GQSTVIIDLT EDSNEQPDSL VDHNKLNSEA SPSREAINGQ 
       160        170        180        190        200
REDTGDQQGL LKAIQNDKLA FPGETLSDIP CKTEEEGVGC GGAGRRGDSQ 
       210        220        230        240        250
ECSPRSCPEL TSGPRMCPRK EQDSWSEAGG ILFKGKVPMV VLQDILAVRP 
       260        270        280        290        300
PQIKSLPATP QGKNMTPESE VLESFPEEDS VLSHSSLSSP SSTSSPEGPP 
       310        320        330        340        350
APPKQHSSTS PFPTSTPLRR ITKKFVKGST EKNKLRLQRD QERLGKQLKL 
       360        370        380        390        400
RAEREEKEKL KEEAKRAKEE AKKKKEEEKE LKEKERREKR EKDEKEKAEK 
       410        420        430        440        450
QRLKEERRKE RQEALEAKLE EKRKKEEEKR LREEEKRIKA EKAEITRFFQ 
       460        470        480        490        500
KPKTPQAPKT LAGSCGKFAP FEIKEHMVLA PRRRTAFHPD LCSQLDQLLQ 
       510        520        530        540        550
QQSGEFSFLK DLKGRQPLRS GPTHVSTRNA DIFNSDVVIV ERGKGDGVPE 
       560        570        580        590        600
RRKFGRMKLL QFCENHRPAY WGTWNKKTAL IRARDPWAQD TKLLDYEVDS 
       610        620        630        640        650
DEEWEEEEPG ESLSHSEGDD DDDMGEDEDE DDGFFVPHGY LSEDEGVTEE 
       660        670        680        690        700
CADPENHKVR QKLKAKEWDE FLAKGKRFRV LQPVKIGCVW AADRDCAGDD 
       710        720        730        740        750
LKVLQQFAAC FLETLPAQEE QTPKASKRER RDEQILAQLL PLLHGNVNGS 
       760        770        780        790        800
KVIIREFQEH CRRGLLSNHT GSPRSPSTTY LHTPTPSEDA AIPSKSRLKR 
       810        820        830        840        850
LISENSVYEK RPDFRMCWYV HPQVLQSFQQ EHLPVPCQWS YVTSVPSAPK 
       860        870        880        890        900
EDSGSVPSTG PSQGTPISLK RKSAGSMCIT QFMKKRRHDG QIGAEDMDGF 
       910        920        930        940        950
QADTEEEEEE EGDCMIVDVP DAAEVQAPCG AASGAGGGVG VDTGKATLTA 

SPLGAS
Length:956
Mass (Da):106,910
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90617F8FE8DB7FD0
GO
Isoform 2 (identifier: Q13111-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-749: CFLETLPAQE...LPLLHGNVNG → HWVHPESRGD...CVKSTLSCFT
     750-956: Missing.

Show »
Length:749
Mass (Da):84,685
Checksum:iA7176E2D8D18CA0F
GO
Isoform 3 (identifier: Q13111-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     772-944: Missing.

Show »
Length:783
Mass (Da):88,269
Checksum:i44E39E1CCE193030
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPA1K7EPA1_HUMAN
Chromatin assembly factor 1 subunit...
CHAF1A
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJF1K7EJF1_HUMAN
Chromatin assembly factor 1 subunit...
CHAF1A
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EME9K7EME9_HUMAN
Chromatin assembly factor 1 subunit...
CHAF1A
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENC7K7ENC7_HUMAN
Chromatin assembly factor 1 subunit...
CHAF1A
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA76736 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAF04291 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH52620 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated
The sequence AAH52620 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti775S → T in AAA76736 (PubMed:7600578).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055329167D → V. Corresponds to variant dbSNP:rs35651457Ensembl.1
Natural variantiVAR_055330239M → V. Corresponds to variant dbSNP:rs2230635Ensembl.1
Natural variantiVAR_055331850K → R. Corresponds to variant dbSNP:rs8100525Ensembl.1
Natural variantiVAR_055332923A → V2 PublicationsCorresponds to variant dbSNP:rs9352Ensembl.1
Natural variantiVAR_055333950A → S. Corresponds to variant dbSNP:rs243383Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004149710 – 749CFLET…GNVNG → HWVHPESRGDVCRTLRVSSP QSRYLNRLNSCVKSTLSCFT in isoform 2. CuratedAdd BLAST40
Alternative sequenceiVSP_004150750 – 956Missing in isoform 2. CuratedAdd BLAST207
Alternative sequenceiVSP_004151772 – 944Missing in isoform 3. CuratedAdd BLAST173

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF190465 Genomic DNA Translation: AAF04291.1 Different initiation.
AC011498 Genomic DNA No translation available.
KF459577 Genomic DNA No translation available.
BC052620 mRNA Translation: AAH52620.1 Sequence problems.
BC067093 mRNA Translation: AAH67093.1
U20979 mRNA Translation: AAA76736.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32875.1 [Q13111-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A56731

NCBI Reference Sequences

More...RefSeqi		NP_005474.2, NM_005483.2 [Q13111-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301280; ENSP00000301280; ENSG00000167670

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10036

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000301280.10; ENSP00000301280.4; NM_005483.3; NP_005474.2

UCSC genome browser

More...UCSCi		uc002mal.4, human [Q13111-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190465 Genomic DNA Translation: AAF04291.1 Different initiation.
AC011498 Genomic DNA No translation available.
KF459577 Genomic DNA No translation available.
BC052620 mRNA Translation: AAH52620.1 Sequence problems.
BC067093 mRNA Translation: AAH67093.1
U20979 mRNA Translation: AAA76736.1 Different initiation.
CCDSiCCDS32875.1 [Q13111-1]
PIRiA56731
RefSeqiNP_005474.2, NM_005483.2 [Q13111-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115349, 170 interactors
ComplexPortaliCPX-569, Chromatin assembly factor 1 complex
CORUMiQ13111
DIPiDIP-31135N
ELMiQ13111
IntActiQ13111, 63 interactors
MINTiQ13111
STRINGi9606.ENSP00000301280

PTM databases

GlyGeniQ13111, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ13111
PhosphoSitePlusiQ13111

Genetic variation databases

BioMutaiCHAF1A
DMDMi229462842

Proteomic databases

EPDiQ13111
jPOSTiQ13111
MassIVEiQ13111
MaxQBiQ13111
PaxDbiQ13111
PeptideAtlasiQ13111
PRIDEiQ13111
ProteomicsDBi59160 [Q13111-1]
59161 [Q13111-2]
59162 [Q13111-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4198, 234 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		10036

Genome annotation databases

EnsembliENST00000301280; ENSP00000301280; ENSG00000167670
GeneIDi10036
KEGGihsa:10036
MANE-SelectiENST00000301280.10; ENSP00000301280.4; NM_005483.3; NP_005474.2
UCSCiuc002mal.4, human [Q13111-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10036
DisGeNETi10036

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHAF1A
HGNCiHGNC:1910, CHAF1A
HPAiENSG00000167670, Tissue enhanced (bone)
MIMi601246, gene
neXtProtiNX_Q13111
OpenTargetsiENSG00000167670
PharmGKBiPA26446
VEuPathDBiHostDB:ENSG00000167670

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4364, Eukaryota
GeneTreeiENSGT00440000034888
HOGENOMiCLU_014846_0_0_1
InParanoidiQ13111
OMAiRRRGMDC
OrthoDBi1362011at2759
PhylomeDBiQ13111
TreeFamiTF350377

Enzyme and pathway databases

PathwayCommonsiQ13111
SignaLinkiQ13111
SIGNORiQ13111

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10036, 733 hits in 1060 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHAF1A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CHAF1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10036
PharosiQ13111, Tbio

Protein Ontology

More...PROi		PR:Q13111
RNActiQ13111, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167670, Expressed in secondary oocyte and 232 other tissues
ExpressionAtlasiQ13111, baseline and differential
GenevisibleiQ13111, HS

Family and domain databases

InterProiView protein in InterPro
IPR029105, CAF1-p150_C2
IPR029091, CAF1_p150_N
IPR022043, CAF1A
PfamiView protein in Pfam
PF15539, CAF1-p150_C2, 1 hit
PF15557, CAF1-p150_N, 1 hit
PF12253, CAF1A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAF1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13111
Secondary accession number(s): Q6NXG5, Q7Z7K3, Q9UJY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 28, 2018
Last modified: February 23, 2022
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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