UniProtKB - Q13107 (UBP4_HUMAN)
Ubiquitin carboxyl-terminal hydrolase 4
USP4
Functioni
Caution
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).6 Publications EC:3.4.19.12
Activity regulationi
Kineticsi
- KM=0.15 µM for ubiquitin-rhodamine1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 311 | NucleophilePROSITE-ProRule annotation | 1 | |
Metal bindingi | 461 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 464 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 799 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 802 | ZincCombined sources1 Publication | 1 | |
Active sitei | 881 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- adenosine receptor binding Source: UniProtKB
- cysteine-type peptidase activity Source: UniProtKB-KW
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
GO - Biological processi
- negative regulation of protein ubiquitination Source: UniProtKB
- protein deubiquitination Source: UniProtKB
- protein localization to cell surface Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- spliceosomal tri-snRNP complex assembly Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q13107 |
Reactomei | R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5689880, Ub-specific processing proteases |
Protein family/group databases
MEROPSi | C19.010 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase 4 (EC:3.4.19.126 Publications)Alternative name(s): Deubiquitinating enzyme 4 Ubiquitin thioesterase 4 Ubiquitin-specific-processing protease 4 Ubiquitous nuclear protein homolog |
Gene namesi | Name:USP4 Synonyms:UNP, UNPH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114316.12 |
HGNCi | HGNC:12627, USP4 |
MIMi | 603486, gene |
neXtProti | NX_Q13107 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- Cytoplasm 2 Publications
Note: Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.2 Publications
Cytosol
- cytosol Source: HPA
Lysosome
- lysosome Source: ProtInc
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 24 | M → D: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 40 | R → E: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 51 | F → D: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 88 | I → P: Severe reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 88 | I → R: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 89 | D → G: Severe reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 90 | E → A: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 91 | L → E: Moderate reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 92 | D → R: Severe reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 134 | E → A: Severe reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 136 | Y → A: Severe reduction in catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 311 | C → A: Loss of activity. Its ubiquitination by TRIM21 is enhanced. 2 Publications | 1 | |
Mutagenesisi | 384 – 385 | PQ → AV: Severe reduction in catalytic activity. 1 Publication | 2 | |
Mutagenesisi | 386 | F → G: Lowers affinity for ubiquitin characterized by a 10-fold increase in ubiquitin release and a slight reduction in ubiquitin binding. 1 Publication | 1 | |
Mutagenesisi | 459 – 463 | LVCPE → AVRPH: Reduces the interaction with RB1. 1 Publication | 5 | |
Mutagenesisi | 463 | E → Q: Reduces the interaction with RB1. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 7375 |
OpenTargetsi | ENSG00000114316 |
PharmGKBi | PA37252 |
Miscellaneous databases
Pharosi | Q13107, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2406900 |
Polymorphism and mutation databases
BioMutai | USP4 |
DMDMi | 116242839 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080621 | 1 – 963 | Ubiquitin carboxyl-terminal hydrolase 4Add BLAST | 963 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 675 | PhosphoserineBy similarity | 1 | |
Modified residuei | 680 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13107 |
jPOSTi | Q13107 |
MassIVEi | Q13107 |
MaxQBi | Q13107 |
PaxDbi | Q13107 |
PeptideAtlasi | Q13107 |
PRIDEi | Q13107 |
ProteomicsDBi | 59158 [Q13107-1] 59159 [Q13107-2] 7631 |
PTM databases
iPTMneti | Q13107 |
PhosphoSitePlusi | Q13107 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000114316, Expressed in sural nerve and 236 other tissues |
ExpressionAtlasi | Q13107, baseline and differential |
Genevisiblei | Q13107, HS |
Organism-specific databases
HPAi | ENSG00000114316, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RB1 (both dephosphorylated and hypophosphorylated forms) (PubMed:11571652).
Interacts with RBL1 and RBL2 (By similarity).
Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct (PubMed:16339847).
Interacts with SART3; recruits USP4 to its substrate PRPF3 (PubMed:20595234).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ13107
With | #Exp. | IntAct |
---|---|---|
ADORA2A [P29274] | 4 | EBI-723290,EBI-2902702 |
HUWE1 [Q7Z6Z7] | 4 | EBI-723290,EBI-625934 |
RIPK1 [Q13546] | 4 | EBI-723290,EBI-358507 |
itself | 3 | EBI-723290,EBI-723290 |
Isoform 1 [Q13107-1]
With | #Exp. | IntAct |
---|---|---|
TRIM21 [P19474] | 3 | EBI-723305,EBI-81290 |
GO - Molecular functioni
- adenosine receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 113221, 127 interactors |
IntActi | Q13107, 56 interactors |
MINTi | Q13107 |
STRINGi | 9606.ENSP00000265560 |
Chemistry databases
BindingDBi | Q13107 |
Miscellaneous databases
RNActi | Q13107, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13107 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13107 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 122 | DUSPPROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 142 – 226 | Ubiquitin-like 1Sequence analysisAdd BLAST | 85 | |
Domaini | 302 – 923 | USPPROSITE-ProRule annotationAdd BLAST | 622 | |
Domaini | 483 – 571 | Ubiquitin-like 2Sequence analysisAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 216 | Necessary for interaction with SART31 PublicationAdd BLAST | 190 | |
Regioni | 229 – 295 | Required for USP4 activation by providing conformational flexibility between the DUSP and catalytic domains1 PublicationAdd BLAST | 67 | |
Regioni | 384 – 386 | Regulates ubiquitin dissociation1 Publication | 3 | |
Regioni | 405 – 407 | Necessary for interaction with RBL2By similarity | 3 | |
Regioni | 459 – 463 | Necessary for interaction with RB1 and RBL2By similarity1 Publication | 5 | |
Regioni | 485 – 775 | Interacts with DUSP and ubiquitin-like 1 domains and is required for USP4 activation1 PublicationAdd BLAST | 291 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 141 | Nuclear export signalBy similarity | 9 | |
Motifi | 767 – 772 | Nuclear localization signalBy similarity | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000156645 |
HOGENOMi | CLU_001060_7_1_1 |
InParanoidi | Q13107 |
OMAi | LQRGAQX |
PhylomeDBi | Q13107 |
TreeFami | TF106276 |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEGGGCRER PDAETQKSEL GPLMRTTLQR GAQWYLIDSR WFKQWKKYVG
60 70 80 90 100
FDSWDMYNVG EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA
110 120 130 140 150
WNKLLNWYGC VEGQQPIVRK VVEHGLFVKH CKVEVYLLEL KLCENSDPTN
160 170 180 190 200
VLSCHFSKAD TIATIEKEMR KLFNIPAERE TRLWNKYMSN TYEQLSKLDN
210 220 230 240 250
TVQDAGLYQG QVLVIEPQNE DGTWPRQTLQ SKSSTAPSRN FTTSPKSSAS
260 270 280 290 300
PYSSVSASLI ANGDSTSTCG MHSSGVSRGG SGFSASYNCQ EPPSSHIQPG
310 320 330 340 350
LCGLGNLGNT CFMNSALQCL SNTAPLTDYF LKDEYEAEIN RDNPLGMKGE
360 370 380 390 400
IAEAYAELIK QMWSGRDAHV APRMFKTQVG RFAPQFSGYQ QQDSQELLAF
410 420 430 440 450
LLDGLHEDLN RVKKKPYLEL KDANGRPDAV VAKEAWENHR LRNDSVIVDT
460 470 480 490 500
FHGLFKSTLV CPECAKVSVT FDPFCYLTLP LPLKKDRVME VFLVPADPHC
510 520 530 540 550
RPTQYRVTVP LMGAVSDLCE ALSRLSGIAA ENMVVADVYN HRFHKIFQMD
560 570 580 590 600
EGLNHIMPRD DIFVYEVCST SVDGSECVTL PVYFRERKSR PSSTSSASAL
610 620 630 640 650
YGQPLLLSVP KHKLTLESLY QAVCDRISRY VKQPLPDEFG SSPLEPGACN
660 670 680 690 700
GSRNSCEGED EEEMEHQEEG KEQLSETEGS GEDEPGNDPS ETTQKKIKGQ
710 720 730 740 750
PCPKRLFTFS LVNSYGTADI NSLAADGKLL KLNSRSTLAM DWDSETRRLY
760 770 780 790 800
YDEQESEAYE KHVSMLQPQK KKKTTVALRD CIELFTTMET LGEHDPWYCP
810 820 830 840 850
NCKKHQQATK KFDLWSLPKI LVVHLKRFSY NRYWRDKLDT VVEFPIRGLN
860 870 880 890 900
MSEFVCNLSA RPYVYDLIAV SNHYGAMGVG HYTAYAKNKL NGKWYYFDDS
910 920 930 940 950
NVSLASEDQI VTKAAYVLFY QRRDDEFYKT PSLSSSGSSD GGTRPSSSQQ
960
GFGDDEACSM DTN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C189 | H7C189_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP4 | 621 | Annotation score: | ||
C9JNU9 | C9JNU9_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP4 | 363 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 373 | R → S in AAB72237 (PubMed:7784062).Curated | 1 | |
Sequence conflicti | 744 | S → R in AAB72237 (PubMed:7784062).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028180 | 620 | Y → C. Corresponds to variant dbSNP:rs9311440EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005258 | 232 – 279 | KSSTA…GVSRG → N in isoform 2. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_044814 | 233 – 313 | SSTAP…NTCFM → VSFFLPRLECNGAILAHCNF CLPGSSNSPASASRVAPSHL ANFFFFEMESHSVTKLECGG AVSAYSRVQVMLLPQPPEWL G in isoform 3. 1 PublicationAdd BLAST | 81 | |
Alternative sequenceiVSP_044815 | 314 – 963 | Missing in isoform 3. 1 PublicationAdd BLAST | 650 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20657 mRNA Translation: AAB72237.1 AF017305 mRNA Translation: AAC27355.1 AF017306 mRNA Translation: AAC27356.1 AK291795 mRNA Translation: BAF84484.1 AC121247 Genomic DNA No translation available. BC068017 mRNA No translation available. BC125130 mRNA Translation: AAI25131.1 |
CCDSi | CCDS2793.1 [Q13107-1] CCDS2794.1 [Q13107-2] CCDS58832.1 [Q13107-3] |
PIRi | T09478 |
RefSeqi | NP_001238806.1, NM_001251877.1 [Q13107-3] NP_003354.2, NM_003363.3 [Q13107-1] NP_955475.1, NM_199443.2 [Q13107-2] |
Genome annotation databases
Ensembli | ENST00000265560; ENSP00000265560; ENSG00000114316 [Q13107-1] ENST00000351842; ENSP00000341028; ENSG00000114316 [Q13107-2] ENST00000416417; ENSP00000400623; ENSG00000114316 [Q13107-3] |
GeneIDi | 7375 |
KEGGi | hsa:7375 |
UCSCi | uc003cwq.3, human [Q13107-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20657 mRNA Translation: AAB72237.1 AF017305 mRNA Translation: AAC27355.1 AF017306 mRNA Translation: AAC27356.1 AK291795 mRNA Translation: BAF84484.1 AC121247 Genomic DNA No translation available. BC068017 mRNA No translation available. BC125130 mRNA Translation: AAI25131.1 |
CCDSi | CCDS2793.1 [Q13107-1] CCDS2794.1 [Q13107-2] CCDS58832.1 [Q13107-3] |
PIRi | T09478 |
RefSeqi | NP_001238806.1, NM_001251877.1 [Q13107-3] NP_003354.2, NM_003363.3 [Q13107-1] NP_955475.1, NM_199443.2 [Q13107-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Y6E | X-ray | 2.40 | A/B/C/D/E/F | 296-490 | [»] | |
A/B/C/D/E/F | 765-932 | [»] | ||||
5CTR | X-ray | 3.01 | C/D | 1-230 | [»] | |
SMRi | Q13107 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113221, 127 interactors |
IntActi | Q13107, 56 interactors |
MINTi | Q13107 |
STRINGi | 9606.ENSP00000265560 |
Chemistry databases
BindingDBi | Q13107 |
ChEMBLi | CHEMBL2406900 |
Protein family/group databases
MEROPSi | C19.010 |
PTM databases
iPTMneti | Q13107 |
PhosphoSitePlusi | Q13107 |
Polymorphism and mutation databases
BioMutai | USP4 |
DMDMi | 116242839 |
Proteomic databases
EPDi | Q13107 |
jPOSTi | Q13107 |
MassIVEi | Q13107 |
MaxQBi | Q13107 |
PaxDbi | Q13107 |
PeptideAtlasi | Q13107 |
PRIDEi | Q13107 |
ProteomicsDBi | 59158 [Q13107-1] 59159 [Q13107-2] 7631 |
Protocols and materials databases
Antibodypediai | 13556, 364 antibodies |
Genome annotation databases
Ensembli | ENST00000265560; ENSP00000265560; ENSG00000114316 [Q13107-1] ENST00000351842; ENSP00000341028; ENSG00000114316 [Q13107-2] ENST00000416417; ENSP00000400623; ENSG00000114316 [Q13107-3] |
GeneIDi | 7375 |
KEGGi | hsa:7375 |
UCSCi | uc003cwq.3, human [Q13107-1] |
Organism-specific databases
CTDi | 7375 |
DisGeNETi | 7375 |
EuPathDBi | HostDB:ENSG00000114316.12 |
GeneCardsi | USP4 |
HGNCi | HGNC:12627, USP4 |
HPAi | ENSG00000114316, Low tissue specificity |
MIMi | 603486, gene |
neXtProti | NX_Q13107 |
OpenTargetsi | ENSG00000114316 |
PharmGKBi | PA37252 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000156645 |
HOGENOMi | CLU_001060_7_1_1 |
InParanoidi | Q13107 |
OMAi | LQRGAQX |
PhylomeDBi | Q13107 |
TreeFami | TF106276 |
Enzyme and pathway databases
PathwayCommonsi | Q13107 |
Reactomei | R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5689880, Ub-specific processing proteases |
Miscellaneous databases
BioGRID-ORCSi | 7375, 6 hits in 852 CRISPR screens |
ChiTaRSi | USP4, human |
EvolutionaryTracei | Q13107 |
GeneWikii | USP4 |
GenomeRNAii | 7375 |
Pharosi | Q13107, Tbio |
PROi | PR:Q13107 |
RNActi | Q13107, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114316, Expressed in sural nerve and 236 other tissues |
ExpressionAtlasi | Q13107, baseline and differential |
Genevisiblei | Q13107, HS |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBP4_HUMAN | |
Accessioni | Q13107Primary (citable) accession number: Q13107 Secondary accession number(s): A8K6Y0 Q08AK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 190 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries