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Protein

Secreted phosphoprotein 24

Gene

SPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could coordinate an aspect of bone turnover.By similarity

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted phosphoprotein 24
Short name:
Spp-24
Alternative name(s):
Secreted phosphoprotein 2
Gene namesi
Name:SPP2
Synonyms:SPP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000072080.10
HGNCiHGNC:11256 SPP2
MIMi602637 gene
neXtProtiNX_Q13103

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6694
OpenTargetsiENSG00000072080
PharmGKBiPA36086

Polymorphism and mutation databases

BioMutaiSPP2
DMDMi2498939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002240330 – 211Secreted phosphoprotein 24Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi92 ↔ 103By similarity
Modified residuei96PhosphoserineCombined sources1
Disulfide bondi116 ↔ 134By similarity
Modified residuei145PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ13103
PaxDbiQ13103
PeptideAtlasiQ13103
PRIDEiQ13103
ProteomicsDBi59154

PTM databases

iPTMnetiQ13103
PhosphoSitePlusiQ13103

Expressioni

Tissue specificityi

Detected in liver and plasma.1 Publication

Developmental stagei

Found in fetal liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000072080 Expressed in 36 organ(s), highest expression level in liver
CleanExiHS_SPP2
ExpressionAtlasiQ13103 baseline and differential
GenevisibleiQ13103 HS

Interactioni

Protein-protein interaction databases

IntActiQ13103, 1 interactor
STRINGi9606.ENSP00000168148

Structurei

3D structure databases

ProteinModelPortaliQ13103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWPI Eukaryota
ENOG410Z1VS LUCA
GeneTreeiENSGT00390000009001
HOGENOMiHOG000264228
HOVERGENiHBG065800
InParanoidiQ13103
OMAiHRARINT
OrthoDBiEOG091G0MTC
PhylomeDBiQ13103
TreeFamiTF335972

Family and domain databases

InterProiView protein in InterPro
IPR010892 Spp-24
PfamiView protein in Pfam
PF07448 Spp-24, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q13103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISRMEKMTM MMKILIMFAL GMNYWSCSGF PVYDYDPSSL RDALSASVVK
60 70 80 90 100
VNSQSLSPYL FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP
110 120 130 140 150
ATCAFQRDYY VSTAVCRSTV KVSAQQVQGV HARCSWSSST SESYSSEEMI
160 170 180 190 200
FGDMLGSHKW RNNYLFGLIS DESISEQFYD RSLGIMRRVL PPGNRRYPNH
210
RHRARINTDF E
Length:211
Mass (Da):24,338
Last modified:November 1, 1997 - v1
Checksum:iAED049E63464E38D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6K0C9J6K0_HUMAN
Secreted phosphoprotein 24
SPP2
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → V in AAI06706 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02569838S → F1 PublicationCorresponds to variant dbSNP:rs34347825Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20530 mRNA Translation: AAA87905.1
AJ272265 Genomic DNA Translation: CAB75571.1
AJ308099 mRNA Translation: CAC87050.1
AC006037 Genomic DNA Translation: AAX93090.1
CH471063 Genomic DNA Translation: EAW71070.1
BC069401 mRNA Translation: AAH69401.1
BC106705 mRNA Translation: AAI06706.1
BC112438 mRNA Translation: AAI12439.1
CCDSiCCDS2511.1
PIRiG01654
RefSeqiNP_008875.1, NM_006944.2
XP_005246159.1, XM_005246102.3
XP_011510000.1, XM_011511698.2
XP_011510001.1, XM_011511699.2
XP_011510002.1, XM_011511700.2
UniGeneiHs.444488

Genome annotation databases

EnsembliENST00000168148; ENSP00000168148; ENSG00000072080
ENST00000373368; ENSP00000362466; ENSG00000072080
GeneIDi6694
KEGGihsa:6694
UCSCiuc002vvk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20530 mRNA Translation: AAA87905.1
AJ272265 Genomic DNA Translation: CAB75571.1
AJ308099 mRNA Translation: CAC87050.1
AC006037 Genomic DNA Translation: AAX93090.1
CH471063 Genomic DNA Translation: EAW71070.1
BC069401 mRNA Translation: AAH69401.1
BC106705 mRNA Translation: AAI06706.1
BC112438 mRNA Translation: AAI12439.1
CCDSiCCDS2511.1
PIRiG01654
RefSeqiNP_008875.1, NM_006944.2
XP_005246159.1, XM_005246102.3
XP_011510000.1, XM_011511698.2
XP_011510001.1, XM_011511699.2
XP_011510002.1, XM_011511700.2
UniGeneiHs.444488

3D structure databases

ProteinModelPortaliQ13103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ13103, 1 interactor
STRINGi9606.ENSP00000168148

PTM databases

iPTMnetiQ13103
PhosphoSitePlusiQ13103

Polymorphism and mutation databases

BioMutaiSPP2
DMDMi2498939

Proteomic databases

EPDiQ13103
PaxDbiQ13103
PeptideAtlasiQ13103
PRIDEiQ13103
ProteomicsDBi59154

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000168148; ENSP00000168148; ENSG00000072080
ENST00000373368; ENSP00000362466; ENSG00000072080
GeneIDi6694
KEGGihsa:6694
UCSCiuc002vvk.2 human

Organism-specific databases

CTDi6694
DisGeNETi6694
EuPathDBiHostDB:ENSG00000072080.10
GeneCardsiSPP2
HGNCiHGNC:11256 SPP2
MIMi602637 gene
neXtProtiNX_Q13103
OpenTargetsiENSG00000072080
PharmGKBiPA36086
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWPI Eukaryota
ENOG410Z1VS LUCA
GeneTreeiENSGT00390000009001
HOGENOMiHOG000264228
HOVERGENiHBG065800
InParanoidiQ13103
OMAiHRARINT
OrthoDBiEOG091G0MTC
PhylomeDBiQ13103
TreeFamiTF335972

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiSPP2 human
GenomeRNAii6694
PROiPR:Q13103
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072080 Expressed in 36 organ(s), highest expression level in liver
CleanExiHS_SPP2
ExpressionAtlasiQ13103 baseline and differential
GenevisibleiQ13103 HS

Family and domain databases

InterProiView protein in InterPro
IPR010892 Spp-24
PfamiView protein in Pfam
PF07448 Spp-24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPP24_HUMAN
AccessioniPrimary (citable) accession number: Q13103
Secondary accession number(s): A4QMV3, Q3B892, Q546M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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