UniProtKB - Q13099 (IFT88_HUMAN)
Intraflagellar transport protein 88 homolog
IFT88
Functioni
GO - Molecular functioni
- kinesin binding Source: GO_Central
GO - Biological processi
- cilium assembly Source: UniProtKB
- inner ear receptor cell stereocilium organization Source: GO_Central
- intraciliary transport Source: GO_Central
- intraciliary transport involved in cilium assembly Source: Reactome
- kidney development Source: GO_Central
- non-motile cilium assembly Source: GO_Central
- regulation of autophagosome assembly Source: UniProtKB
- regulation of cilium assembly Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q13099 |
Reactomei | R-HSA-5610787, Hedgehog 'off' state R-HSA-5620924, Intraflagellar transport R-HSA-9613829, Chaperone Mediated Autophagy R-HSA-9615710, Late endosomal microautophagy R-HSA-9646399, Aggrephagy |
SIGNORi | Q13099 |
Names & Taxonomyi
Protein namesi | Recommended name: Intraflagellar transport protein 88 homologAlternative name(s): Recessive polycystic kidney disease protein Tg737 homolog Tetratricopeptide repeat protein 10 Short name: TPR repeat protein 10 |
Gene namesi | Name:IFT88 Synonyms:TG737, TTC10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20606, IFT88 |
MIMi | 600595, gene |
neXtProti | NX_Q13099 |
VEuPathDBi | HostDB:ENSG00000032742.17 |
Subcellular locationi
Cytoskeleton
- centriole By similarity
- cilium basal body 3 Publications
- centrosome 1 Publication
Other locations
Note: Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome.1 Publication
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: UniProtKB
- ciliary basal body Source: UniProtKB
Other locations
- ciliary base Source: GO_Central
- ciliary tip Source: Reactome
- cilium Source: UniProtKB
- cytoplasm Source: UniProtKB-SubCell
- intraciliary transport particle B Source: UniProtKB
- motile cilium Source: BHF-UCL
- non-motile cilium Source: GO_Central
- sperm flagellum Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, FlagellumPathology & Biotechi
Organism-specific databases
DisGeNETi | 8100 |
MalaCardsi | IFT88 |
OpenTargetsi | ENSG00000032742 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA134991804 |
Miscellaneous databases
Pharosi | Q13099, Tbio |
Genetic variation databases
BioMutai | IFT88 |
DMDMi | 206729873 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106391 | 1 – 824 | Intraflagellar transport protein 88 homologAdd BLAST | 824 |
Proteomic databases
EPDi | Q13099 |
jPOSTi | Q13099 |
MassIVEi | Q13099 |
MaxQBi | Q13099 |
PaxDbi | Q13099 |
PeptideAtlasi | Q13099 |
PRIDEi | Q13099 |
ProteomicsDBi | 59151 [Q13099-1] 59152 [Q13099-2] 59153 [Q13099-3] |
PTM databases
iPTMneti | Q13099 |
PhosphoSitePlusi | Q13099 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000032742, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q13099, baseline and differential |
Genevisiblei | Q13099, HS |
Organism-specific databases
HPAi | ENSG00000032742, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity).
Interacts with IFT20, IFT22, HSPB11, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81 (By similarity).
Interacts with IFT172 (By similarity).
Interacts with IFT57 (By similarity).
Interacts with IFT46 (By similarity).
Interacts with TTC30B (By similarity).
Interacts with C2CD3 (By similarity).
Interacts with ENTR1 (via N-terminus) (PubMed:27767179).
Interacts with LRRC56 (PubMed:30388400).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ13099
GO - Molecular functioni
- kinesin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113771, 48 interactors |
ComplexPortali | CPX-5022, IFT-B complex |
CORUMi | Q13099 |
IntActi | Q13099, 53 interactors |
STRINGi | 9606.ENSP00000323580 |
Miscellaneous databases
RNActi | Q13099, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 197 – 230 | TPR 1Add BLAST | 34 | |
Repeati | 233 – 266 | TPR 2Add BLAST | 34 | |
Repeati | 272 – 305 | TPR 3Add BLAST | 34 | |
Repeati | 307 – 338 | TPR 4Add BLAST | 32 | |
Repeati | 415 – 448 | TPR 5Add BLAST | 34 | |
Repeati | 450 – 483 | TPR 6Add BLAST | 34 | |
Repeati | 484 – 517 | TPR 7Add BLAST | 34 | |
Repeati | 518 – 551 | TPR 8Add BLAST | 34 | |
Repeati | 552 – 585 | TPR 9Add BLAST | 34 | |
Repeati | 586 – 619 | TPR 10Add BLAST | 34 | |
Repeati | 620 – 653 | TPR 11Add BLAST | 34 | |
Repeati | 654 – 687 | TPR 12Add BLAST | 34 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG2003, Eukaryota |
GeneTreei | ENSGT00390000015473 |
HOGENOMi | CLU_010738_1_0_1 |
InParanoidi | Q13099 |
OMAi | TKNKMFP |
OrthoDBi | 259837at2759 |
PhylomeDBi | Q13099 |
TreeFami | TF313218 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR006597, Sel1-like IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13174, TPR_6, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00671, SEL1, 4 hits SM00028, TPR, 11 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP
60 70 80 90 100
PITAKISSTA VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA
110 120 130 140 150
AGFTKAALRG SAFDPLSQSR GPASPLEAKK KDSPEEKIKQ LEKEVNELVE
160 170 180 190 200
ESCIANSCGD LKLALEKAKD AGRKERVLVR QREQVTTPEN INLDLTYSVL
210 220 230 240 250
FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG NIYLKQRNYS
260 270 280 290 300
KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS
310 320 330 340 350
MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP
360 370 380 390 400
HTNLVTEAIK NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW
410 420 430 440 450
CVEVVKASQY VELANDLEIN KAVTYLRQKD YNQAVEILKV LEKKDSRVKS
460 470 480 490 500
AAATNLSALY YMGKDFAQAS SYADIAVNSD RYNPAALTNK GNTVFANGDY
510 520 530 540 550
EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC FLKLHAILRN
560 570 580 590 600
SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG
610 620 630 640 650
DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ
660 670 680 690 700
PTQVKWQLMV ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD
710 720 730 740 750
LGLKDAQEYA RKLKRLEKMK EIREQRIKSG RDGSGGSRGK REGSASGDSG
760 770 780 790 800
QNYSASSKGE RLSARLRALP GTNEPYESSS NKEIDASYVD PLGPQIERPK
810 820
TAAKKRIDED DFADEELGDD LLPE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H6C2 | F5H6C2_HUMAN | Probable UDP-N-acetylglucosamine--p... | IFT88 | 368 | Annotation score: | ||
F6SRW8 | F6SRW8_HUMAN | Intraflagellar transport protein 88... | IFT88 | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 201 | F → S in AAA86720 (PubMed:7633404).Curated | 1 | |
Sequence conflicti | 326 | K → E in AAH30776 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 379 | I → V in AAH30776 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 380 | M → T in AAA86720 (PubMed:7633404).Curated | 1 | |
Sequence conflicti | 398 | Y → C in AAA86720 (PubMed:7633404).Curated | 1 | |
Sequence conflicti | 599 | E → G in AAH30776 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046464 | 374 | M → I1 PublicationCorresponds to variant dbSNP:rs2442455EnsemblClinVar. | 1 | |
Natural variantiVAR_046465 | 446 | S → N1 PublicationCorresponds to variant dbSNP:rs9509307EnsemblClinVar. | 1 | |
Natural variantiVAR_046466 | 662 | S → G. Corresponds to variant dbSNP:rs9552254Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060641 | 1 | M → MKFTNTKVQM in isoform 1 and isoform 3. | 1 | |
Alternative sequenceiVSP_060642 | 52 – 70 | Missing in isoform 3. Add BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20362 mRNA Translation: AAA86720.1 AK300769 mRNA Translation: BAG62434.1 AL161772 Genomic DNA No translation available. AL590096 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08272.1 BC030776 mRNA Translation: AAH30776.2 |
CCDSi | CCDS31944.1 [Q13099-1] CCDS31945.1 [Q13099-2] |
RefSeqi | NP_001305420.1, NM_001318491.1 NP_006522.2, NM_006531.4 [Q13099-2] NP_783195.2, NM_175605.4 [Q13099-1] XP_005266610.1, XM_005266553.2 XP_006719933.1, XM_006719870.3 [Q13099-2] XP_011533543.1, XM_011535241.2 XP_011533544.1, XM_011535242.1 XP_011533545.1, XM_011535243.1 [Q13099-2] XP_016876246.1, XM_017020757.1 [Q13099-2] XP_016876247.1, XM_017020758.1 [Q13099-3] |
Genome annotation databases
Ensembli | ENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1] ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2] |
GeneIDi | 8100 |
KEGGi | hsa:8100 |
UCSCi | uc001unh.4, human [Q13099-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20362 mRNA Translation: AAA86720.1 AK300769 mRNA Translation: BAG62434.1 AL161772 Genomic DNA No translation available. AL590096 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08272.1 BC030776 mRNA Translation: AAH30776.2 |
CCDSi | CCDS31944.1 [Q13099-1] CCDS31945.1 [Q13099-2] |
RefSeqi | NP_001305420.1, NM_001318491.1 NP_006522.2, NM_006531.4 [Q13099-2] NP_783195.2, NM_175605.4 [Q13099-1] XP_005266610.1, XM_005266553.2 XP_006719933.1, XM_006719870.3 [Q13099-2] XP_011533543.1, XM_011535241.2 XP_011533544.1, XM_011535242.1 XP_011533545.1, XM_011535243.1 [Q13099-2] XP_016876246.1, XM_017020757.1 [Q13099-2] XP_016876247.1, XM_017020758.1 [Q13099-3] |
3D structure databases
SMRi | Q13099 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113771, 48 interactors |
ComplexPortali | CPX-5022, IFT-B complex |
CORUMi | Q13099 |
IntActi | Q13099, 53 interactors |
STRINGi | 9606.ENSP00000323580 |
PTM databases
iPTMneti | Q13099 |
PhosphoSitePlusi | Q13099 |
Genetic variation databases
BioMutai | IFT88 |
DMDMi | 206729873 |
Proteomic databases
EPDi | Q13099 |
jPOSTi | Q13099 |
MassIVEi | Q13099 |
MaxQBi | Q13099 |
PaxDbi | Q13099 |
PeptideAtlasi | Q13099 |
PRIDEi | Q13099 |
ProteomicsDBi | 59151 [Q13099-1] 59152 [Q13099-2] 59153 [Q13099-3] |
Protocols and materials databases
Antibodypediai | 22319, 243 antibodies |
DNASUi | 8100 |
Genome annotation databases
Ensembli | ENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1] ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2] |
GeneIDi | 8100 |
KEGGi | hsa:8100 |
UCSCi | uc001unh.4, human [Q13099-2] |
Organism-specific databases
CTDi | 8100 |
DisGeNETi | 8100 |
GeneCardsi | IFT88 |
HGNCi | HGNC:20606, IFT88 |
HPAi | ENSG00000032742, Tissue enhanced (testis) |
MalaCardsi | IFT88 |
MIMi | 600595, gene |
neXtProti | NX_Q13099 |
OpenTargetsi | ENSG00000032742 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA134991804 |
VEuPathDBi | HostDB:ENSG00000032742.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2003, Eukaryota |
GeneTreei | ENSGT00390000015473 |
HOGENOMi | CLU_010738_1_0_1 |
InParanoidi | Q13099 |
OMAi | TKNKMFP |
OrthoDBi | 259837at2759 |
PhylomeDBi | Q13099 |
TreeFami | TF313218 |
Enzyme and pathway databases
PathwayCommonsi | Q13099 |
Reactomei | R-HSA-5610787, Hedgehog 'off' state R-HSA-5620924, Intraflagellar transport R-HSA-9613829, Chaperone Mediated Autophagy R-HSA-9615710, Late endosomal microautophagy R-HSA-9646399, Aggrephagy |
SIGNORi | Q13099 |
Miscellaneous databases
BioGRID-ORCSi | 8100, 11 hits in 877 CRISPR screens |
ChiTaRSi | IFT88, human |
GeneWikii | IFT88 |
GenomeRNAii | 8100 |
Pharosi | Q13099, Tbio |
PROi | PR:Q13099 |
RNActi | Q13099, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000032742, Expressed in testis and 229 other tissues |
ExpressionAtlasi | Q13099, baseline and differential |
Genevisiblei | Q13099, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR006597, Sel1-like IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13174, TPR_6, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00671, SEL1, 4 hits SM00028, TPR, 11 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFT88_HUMAN | |
Accessioni | Q13099Primary (citable) accession number: Q13099 Secondary accession number(s): A2A491 Q8N719 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | August 12, 2020 | |
Last modified: | February 10, 2021 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with genetic variants
List of human entries with genetic variants