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Entry version 186 (07 Oct 2020)
Sequence version 3 (12 Aug 2020)
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Protein

Intraflagellar transport protein 88 homolog

Gene

IFT88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • kinesin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13099

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5610787, Hedgehog 'off' state
R-HSA-5620924, Intraflagellar transport
R-HSA-9613829, Chaperone Mediated Autophagy
R-HSA-9615710, Late endosomal microautophagy
R-HSA-9646399, Aggrephagy

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13099

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 88 homolog
Alternative name(s):
Recessive polycystic kidney disease protein Tg737 homolog
Tetratricopeptide repeat protein 10
Short name:
TPR repeat protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFT88
Synonyms:TG737, TTC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000032742.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20606, IFT88

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600595, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8100

MalaCards human disease database

More...
MalaCardsi
IFT88

Open Targets

More...
OpenTargetsi
ENSG00000032742

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
791, Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134991804

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13099, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFT88

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729873

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063911 – 824Intraflagellar transport protein 88 homologAdd BLAST824

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13099

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13099

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13099

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13099

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13099

PeptideAtlas

More...
PeptideAtlasi
Q13099

PRoteomics IDEntifications database

More...
PRIDEi
Q13099

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59151 [Q13099-1]
59152 [Q13099-2]
59153 [Q13099-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13099

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13099

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000032742, Expressed in testis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13099, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13099, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000032742, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity).

Interacts with IFT20, IFT22, HSPB11, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81 (By similarity).

Interacts with IFT172 (By similarity).

Interacts with IFT57 (By similarity).

Interacts with IFT46 (By similarity).

Interacts with TTC30B (By similarity).

Interacts with C2CD3 (By similarity).

Interacts with ENTR1 (via N-terminus) (PubMed:27767179).

Interacts with LRRC56 (PubMed:30388400).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113771, 48 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5022, IFT-B complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q13099

Protein interaction database and analysis system

More...
IntActi
Q13099, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323580

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13099, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13099

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati197 – 230TPR 1Add BLAST34
Repeati233 – 266TPR 2Add BLAST34
Repeati272 – 305TPR 3Add BLAST34
Repeati307 – 338TPR 4Add BLAST32
Repeati415 – 448TPR 5Add BLAST34
Repeati450 – 483TPR 6Add BLAST34
Repeati484 – 517TPR 7Add BLAST34
Repeati518 – 551TPR 8Add BLAST34
Repeati552 – 585TPR 9Add BLAST34
Repeati586 – 619TPR 10Add BLAST34
Repeati620 – 653TPR 11Add BLAST34
Repeati654 – 687TPR 12Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2003, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010738_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13099

KEGG Orthology (KO)

More...
KOi
K16474

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKNKMFP

Database of Orthologous Groups

More...
OrthoDBi
259837at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13099

TreeFam database of animal gene trees

More...
TreeFami
TF313218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006597, Sel1-like
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00671, SEL1, 4 hits
SM00028, TPR, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q13099-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP
60 70 80 90 100
PITAKISSTA VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA
110 120 130 140 150
AGFTKAALRG SAFDPLSQSR GPASPLEAKK KDSPEEKIKQ LEKEVNELVE
160 170 180 190 200
ESCIANSCGD LKLALEKAKD AGRKERVLVR QREQVTTPEN INLDLTYSVL
210 220 230 240 250
FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG NIYLKQRNYS
260 270 280 290 300
KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS
310 320 330 340 350
MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP
360 370 380 390 400
HTNLVTEAIK NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW
410 420 430 440 450
CVEVVKASQY VELANDLEIN KAVTYLRQKD YNQAVEILKV LEKKDSRVKS
460 470 480 490 500
AAATNLSALY YMGKDFAQAS SYADIAVNSD RYNPAALTNK GNTVFANGDY
510 520 530 540 550
EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC FLKLHAILRN
560 570 580 590 600
SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG
610 620 630 640 650
DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ
660 670 680 690 700
PTQVKWQLMV ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD
710 720 730 740 750
LGLKDAQEYA RKLKRLEKMK EIREQRIKSG RDGSGGSRGK REGSASGDSG
760 770 780 790 800
QNYSASSKGE RLSARLRALP GTNEPYESSS NKEIDASYVD PLGPQIERPK
810 820
TAAKKRIDED DFADEELGDD LLPE
Length:824
Mass (Da):93,192
Last modified:August 12, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12E30169CFC5476B
GO
Isoform 1 (identifier: Q13099-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKFTNTKVQM

Show »
Length:833
Mass (Da):94,270
Checksum:i383887C9D79AF0DA
GO
Isoform 3 (identifier: Q13099-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKFTNTKVQM
     52-70: Missing.

Show »
Length:814
Mass (Da):92,381
Checksum:iB5364A6022DC66F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6C2F5H6C2_HUMAN
Probable UDP-N-acetylglucosamine--p...
IFT88
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SRW8F6SRW8_HUMAN
Intraflagellar transport protein 88...
IFT88
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201F → S in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti326K → E in AAH30776 (PubMed:15489334).Curated1
Sequence conflicti379I → V in AAH30776 (PubMed:15489334).Curated1
Sequence conflicti380M → T in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti398Y → C in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti599E → G in AAH30776 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046464374M → I1 PublicationCorresponds to variant dbSNP:rs2442455EnsemblClinVar.1
Natural variantiVAR_046465446S → N1 PublicationCorresponds to variant dbSNP:rs9509307EnsemblClinVar.1
Natural variantiVAR_046466662S → G. Corresponds to variant dbSNP:rs9552254Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0606411M → MKFTNTKVQM in isoform 1 and isoform 3. 1
Alternative sequenceiVSP_06064252 – 70Missing in isoform 3. Add BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U20362 mRNA Translation: AAA86720.1
AK300769 mRNA Translation: BAG62434.1
AL161772 Genomic DNA No translation available.
AL590096 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08272.1
BC030776 mRNA Translation: AAH30776.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31944.1 [Q13099-1]
CCDS31945.1 [Q13099-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001305420.1, NM_001318491.1
NP_006522.2, NM_006531.4 [Q13099-2]
NP_783195.2, NM_175605.4 [Q13099-1]
XP_005266610.1, XM_005266553.2
XP_006719933.1, XM_006719870.3 [Q13099-2]
XP_011533543.1, XM_011535241.2
XP_011533544.1, XM_011535242.1
XP_011533545.1, XM_011535243.1 [Q13099-2]
XP_016876246.1, XM_017020757.1 [Q13099-2]
XP_016876247.1, XM_017020758.1 [Q13099-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1]
ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8100

UCSC genome browser

More...
UCSCi
uc001unh.4, human [Q13099-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20362 mRNA Translation: AAA86720.1
AK300769 mRNA Translation: BAG62434.1
AL161772 Genomic DNA No translation available.
AL590096 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08272.1
BC030776 mRNA Translation: AAH30776.2
CCDSiCCDS31944.1 [Q13099-1]
CCDS31945.1 [Q13099-2]
RefSeqiNP_001305420.1, NM_001318491.1
NP_006522.2, NM_006531.4 [Q13099-2]
NP_783195.2, NM_175605.4 [Q13099-1]
XP_005266610.1, XM_005266553.2
XP_006719933.1, XM_006719870.3 [Q13099-2]
XP_011533543.1, XM_011535241.2
XP_011533544.1, XM_011535242.1
XP_011533545.1, XM_011535243.1 [Q13099-2]
XP_016876246.1, XM_017020757.1 [Q13099-2]
XP_016876247.1, XM_017020758.1 [Q13099-3]

3D structure databases

SMRiQ13099
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113771, 48 interactors
ComplexPortaliCPX-5022, IFT-B complex
CORUMiQ13099
IntActiQ13099, 53 interactors
STRINGi9606.ENSP00000323580

PTM databases

iPTMnetiQ13099
PhosphoSitePlusiQ13099

Polymorphism and mutation databases

BioMutaiIFT88
DMDMi206729873

Proteomic databases

EPDiQ13099
jPOSTiQ13099
MassIVEiQ13099
MaxQBiQ13099
PaxDbiQ13099
PeptideAtlasiQ13099
PRIDEiQ13099
ProteomicsDBi59151 [Q13099-1]
59152 [Q13099-2]
59153 [Q13099-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22319, 243 antibodies

The DNASU plasmid repository

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DNASUi
8100

Genome annotation databases

EnsembliENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1]
ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2]
GeneIDi8100
KEGGihsa:8100
UCSCiuc001unh.4, human [Q13099-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8100
DisGeNETi8100
EuPathDBiHostDB:ENSG00000032742.17

GeneCards: human genes, protein and diseases

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GeneCardsi
IFT88
HGNCiHGNC:20606, IFT88
HPAiENSG00000032742, Tissue enhanced (testis)
MalaCardsiIFT88
MIMi600595, gene
neXtProtiNX_Q13099
OpenTargetsiENSG00000032742
Orphaneti791, Retinitis pigmentosa
PharmGKBiPA134991804

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2003, Eukaryota
GeneTreeiENSGT00390000015473
HOGENOMiCLU_010738_1_0_1
InParanoidiQ13099
KOiK16474
OMAiTKNKMFP
OrthoDBi259837at2759
PhylomeDBiQ13099
TreeFamiTF313218

Enzyme and pathway databases

PathwayCommonsiQ13099
ReactomeiR-HSA-5610787, Hedgehog 'off' state
R-HSA-5620924, Intraflagellar transport
R-HSA-9613829, Chaperone Mediated Autophagy
R-HSA-9615710, Late endosomal microautophagy
R-HSA-9646399, Aggrephagy
SIGNORiQ13099

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8100, 11 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IFT88, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IFT88

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8100
PharosiQ13099, Tbio

Protein Ontology

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PROi
PR:Q13099
RNActiQ13099, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000032742, Expressed in testis and 229 other tissues
ExpressionAtlasiQ13099, baseline and differential
GenevisibleiQ13099, HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR006597, Sel1-like
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00671, SEL1, 4 hits
SM00028, TPR, 11 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFT88_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13099
Secondary accession number(s): A2A491
, B4DUS2, Q5SZJ6, Q8N719
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 12, 2020
Last modified: October 7, 2020
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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