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UniProtKB - Q13099 (IFT88_HUMAN)

Entry version 186 (07 Oct 2020)
Sequence version 3 (12 Aug 2020)
Previous versions | rss
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Protein

Intraflagellar transport protein 88 homolog

Gene

IFT88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • kinesin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13099

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5610787, Hedgehog 'off' state
R-HSA-5620924, Intraflagellar transport
R-HSA-9613829, Chaperone Mediated Autophagy
R-HSA-9615710, Late endosomal microautophagy
R-HSA-9646399, Aggrephagy

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q13099

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 88 homolog
Alternative name(s):
Recessive polycystic kidney disease protein Tg737 homolog
Tetratricopeptide repeat protein 10
Short name:
TPR repeat protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFT88
Synonyms:TG737, TTC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000032742.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:20606, IFT88

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600595, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8100

MalaCards human disease database

More...MalaCardsi		IFT88

Open Targets

More...OpenTargetsi		ENSG00000032742

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		791, Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134991804

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13099, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IFT88

Domain mapping of disease mutations (DMDM)

More...DMDMi		206729873

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063911 – 824Intraflagellar transport protein 88 homologAdd BLAST824

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q13099

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13099

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13099

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13099

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13099

PeptideAtlas

More...PeptideAtlasi		Q13099

PRoteomics IDEntifications database

More...PRIDEi		Q13099

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59151 [Q13099-1]
59152 [Q13099-2]
59153 [Q13099-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13099

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13099

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000032742, Expressed in testis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13099, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13099, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000032742, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity).

Interacts with IFT20, IFT22, HSPB11, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81 (By similarity).

Interacts with IFT172 (By similarity).

Interacts with IFT57 (By similarity).

Interacts with IFT46 (By similarity).

Interacts with TTC30B (By similarity).

Interacts with C2CD3 (By similarity).

Interacts with ENTR1 (via N-terminus) (PubMed:27767179).

Interacts with LRRC56 (PubMed:30388400).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113771, 48 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5022, IFT-B complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q13099

Protein interaction database and analysis system

More...IntActi		Q13099, 53 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000323580

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13099, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13099

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati197 – 230TPR 1Add BLAST34
Repeati233 – 266TPR 2Add BLAST34
Repeati272 – 305TPR 3Add BLAST34
Repeati307 – 338TPR 4Add BLAST32
Repeati415 – 448TPR 5Add BLAST34
Repeati450 – 483TPR 6Add BLAST34
Repeati484 – 517TPR 7Add BLAST34
Repeati518 – 551TPR 8Add BLAST34
Repeati552 – 585TPR 9Add BLAST34
Repeati586 – 619TPR 10Add BLAST34
Repeati620 – 653TPR 11Add BLAST34
Repeati654 – 687TPR 12Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2003, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010738_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13099

KEGG Orthology (KO)

More...KOi		K16474

Identification of Orthologs from Complete Genome Data

More...OMAi		TKNKMFP

Database of Orthologous Groups

More...OrthoDBi		259837at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13099

TreeFam database of animal gene trees

More...TreeFami		TF313218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006597, Sel1-like
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00671, SEL1, 4 hits
SM00028, TPR, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q13099-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP 
        60         70         80         90        100
PITAKISSTA VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA 
       110        120        130        140        150
AGFTKAALRG SAFDPLSQSR GPASPLEAKK KDSPEEKIKQ LEKEVNELVE 
       160        170        180        190        200
ESCIANSCGD LKLALEKAKD AGRKERVLVR QREQVTTPEN INLDLTYSVL 
       210        220        230        240        250
FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG NIYLKQRNYS 
       260        270        280        290        300
KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS 
       310        320        330        340        350
MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP 
       360        370        380        390        400
HTNLVTEAIK NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW 
       410        420        430        440        450
CVEVVKASQY VELANDLEIN KAVTYLRQKD YNQAVEILKV LEKKDSRVKS 
       460        470        480        490        500
AAATNLSALY YMGKDFAQAS SYADIAVNSD RYNPAALTNK GNTVFANGDY 
       510        520        530        540        550
EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC FLKLHAILRN 
       560        570        580        590        600
SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG 
       610        620        630        640        650
DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ 
       660        670        680        690        700
PTQVKWQLMV ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD 
       710        720        730        740        750
LGLKDAQEYA RKLKRLEKMK EIREQRIKSG RDGSGGSRGK REGSASGDSG 
       760        770        780        790        800
QNYSASSKGE RLSARLRALP GTNEPYESSS NKEIDASYVD PLGPQIERPK 
       810        820 
TAAKKRIDED DFADEELGDD LLPE
Length:824
Mass (Da):93,192
Last modified:August 12, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12E30169CFC5476B
GO
Isoform 1 (identifier: Q13099-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKFTNTKVQM

Show »
Length:833
Mass (Da):94,270
Checksum:i383887C9D79AF0DA
GO
Isoform 3 (identifier: Q13099-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKFTNTKVQM
     52-70: Missing.

Show »
Length:814
Mass (Da):92,381
Checksum:iB5364A6022DC66F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6C2F5H6C2_HUMAN
Probable UDP-N-acetylglucosamine--p...
IFT88
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SRW8F6SRW8_HUMAN
Intraflagellar transport protein 88...
IFT88
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201F → S in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti326K → E in AAH30776 (PubMed:15489334).Curated1
Sequence conflicti379I → V in AAH30776 (PubMed:15489334).Curated1
Sequence conflicti380M → T in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti398Y → C in AAA86720 (PubMed:7633404).Curated1
Sequence conflicti599E → G in AAH30776 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046464374M → I1 PublicationCorresponds to variant dbSNP:rs2442455EnsemblClinVar.1
Natural variantiVAR_046465446S → N1 PublicationCorresponds to variant dbSNP:rs9509307EnsemblClinVar.1
Natural variantiVAR_046466662S → G. Corresponds to variant dbSNP:rs9552254Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0606411M → MKFTNTKVQM in isoform 1 and isoform 3. 1
Alternative sequenceiVSP_06064252 – 70Missing in isoform 3. Add BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U20362 mRNA Translation: AAA86720.1
AK300769 mRNA Translation: BAG62434.1
AL161772 Genomic DNA No translation available.
AL590096 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08272.1
BC030776 mRNA Translation: AAH30776.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31944.1 [Q13099-1]
CCDS31945.1 [Q13099-2]

NCBI Reference Sequences

More...RefSeqi		NP_001305420.1, NM_001318491.1
NP_006522.2, NM_006531.4 [Q13099-2]
NP_783195.2, NM_175605.4 [Q13099-1]
XP_005266610.1, XM_005266553.2
XP_006719933.1, XM_006719870.3 [Q13099-2]
XP_011533543.1, XM_011535241.2
XP_011533544.1, XM_011535242.1
XP_011533545.1, XM_011535243.1 [Q13099-2]
XP_016876246.1, XM_017020757.1 [Q13099-2]
XP_016876247.1, XM_017020758.1 [Q13099-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1]
ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8100

UCSC genome browser

More...UCSCi		uc001unh.4, human [Q13099-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20362 mRNA Translation: AAA86720.1
AK300769 mRNA Translation: BAG62434.1
AL161772 Genomic DNA No translation available.
AL590096 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08272.1
BC030776 mRNA Translation: AAH30776.2
CCDSiCCDS31944.1 [Q13099-1]
CCDS31945.1 [Q13099-2]
RefSeqiNP_001305420.1, NM_001318491.1
NP_006522.2, NM_006531.4 [Q13099-2]
NP_783195.2, NM_175605.4 [Q13099-1]
XP_005266610.1, XM_005266553.2
XP_006719933.1, XM_006719870.3 [Q13099-2]
XP_011533543.1, XM_011535241.2
XP_011533544.1, XM_011535242.1
XP_011533545.1, XM_011535243.1 [Q13099-2]
XP_016876246.1, XM_017020757.1 [Q13099-2]
XP_016876247.1, XM_017020758.1 [Q13099-3]

3D structure databases

SMRiQ13099
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113771, 48 interactors
ComplexPortaliCPX-5022, IFT-B complex
CORUMiQ13099
IntActiQ13099, 53 interactors
STRINGi9606.ENSP00000323580

PTM databases

iPTMnetiQ13099
PhosphoSitePlusiQ13099

Polymorphism and mutation databases

BioMutaiIFT88
DMDMi206729873

Proteomic databases

EPDiQ13099
jPOSTiQ13099
MassIVEiQ13099
MaxQBiQ13099
PaxDbiQ13099
PeptideAtlasiQ13099
PRIDEiQ13099
ProteomicsDBi59151 [Q13099-1]
59152 [Q13099-2]
59153 [Q13099-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22319, 243 antibodies

The DNASU plasmid repository

More...DNASUi		8100

Genome annotation databases

EnsembliENST00000319980; ENSP00000323580; ENSG00000032742 [Q13099-1]
ENST00000351808; ENSP00000261632; ENSG00000032742 [Q13099-2]
GeneIDi8100
KEGGihsa:8100
UCSCiuc001unh.4, human [Q13099-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8100
DisGeNETi8100
EuPathDBiHostDB:ENSG00000032742.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		IFT88
HGNCiHGNC:20606, IFT88
HPAiENSG00000032742, Tissue enhanced (testis)
MalaCardsiIFT88
MIMi600595, gene
neXtProtiNX_Q13099
OpenTargetsiENSG00000032742
Orphaneti791, Retinitis pigmentosa
PharmGKBiPA134991804

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2003, Eukaryota
GeneTreeiENSGT00390000015473
HOGENOMiCLU_010738_1_0_1
InParanoidiQ13099
KOiK16474
OMAiTKNKMFP
OrthoDBi259837at2759
PhylomeDBiQ13099
TreeFamiTF313218

Enzyme and pathway databases

PathwayCommonsiQ13099
ReactomeiR-HSA-5610787, Hedgehog 'off' state
R-HSA-5620924, Intraflagellar transport
R-HSA-9613829, Chaperone Mediated Autophagy
R-HSA-9615710, Late endosomal microautophagy
R-HSA-9646399, Aggrephagy
SIGNORiQ13099

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8100, 11 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IFT88, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IFT88

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8100
PharosiQ13099, Tbio

Protein Ontology

More...PROi		PR:Q13099
RNActiQ13099, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000032742, Expressed in testis and 229 other tissues
ExpressionAtlasiQ13099, baseline and differential
GenevisibleiQ13099, HS

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR006597, Sel1-like
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF13174, TPR_6, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00671, SEL1, 4 hits
SM00028, TPR, 11 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFT88_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13099
Secondary accession number(s): A2A491
, B4DUS2, Q5SZJ6, Q8N719
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 12, 2020
Last modified: October 7, 2020
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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