UniProtKB - Q13098 (CSN1_HUMAN)
COP9 signalosome complex subunit 1
GPS1
Functioni
GO - Molecular functioni
- GTPase inhibitor activity Source: ProtInc
GO - Biological processi
- inactivation of MAPK activity Source: ProtInc
- JNK cascade Source: ProtInc
- nucleotide-excision repair, DNA damage recognition Source: Reactome
- post-translational protein modification Source: Reactome
- protein deneddylation Source: UniProtKB
- transcription-coupled nucleotide-excision repair Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q13098 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 1Short name: SGN1 Short name: Signalosome subunit 1 Alternative name(s): G protein pathway suppressor 1 Short name: GPS-1 JAB1-containing signalosome subunit 1 Protein MFH |
Gene namesi | Name:GPS1 Synonyms:COPS1, CSN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4549, GPS1 |
MIMi | 601934, gene |
neXtProti | NX_Q13098 |
VEuPathDBi | HostDB:ENSG00000169727.12 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- COP9 signalosome Source: UniProtKB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 2873 |
OpenTargetsi | ENSG00000169727 |
PharmGKBi | PA28944 |
Miscellaneous databases
Pharosi | Q13098, Tbio |
Genetic variation databases
BioMutai | GPS1 |
DMDMi | 223590263 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000120959 | 2 – 491 | COP9 signalosome complex subunit 1Add BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 468 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 474 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 479 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 483 | PhosphoserineCombined sources1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13098 |
jPOSTi | Q13098 |
MassIVEi | Q13098 |
MaxQBi | Q13098 |
PaxDbi | Q13098 |
PeptideAtlasi | Q13098 |
PRIDEi | Q13098 |
ProteomicsDBi | 59147 [Q13098-4] 59148 [Q13098-5] 59149 [Q13098-6] 59150 [Q13098-7] |
TopDownProteomicsi | Q13098-5 [Q13098-5] |
PTM databases
iPTMneti | Q13098 |
MetOSitei | Q13098 |
PhosphoSitePlusi | Q13098 |
SwissPalmi | Q13098 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000169727, Expressed in cerebellar vermis and 221 other tissues |
ExpressionAtlasi | Q13098, baseline and differential |
Genevisiblei | Q13098, HS |
Organism-specific databases
HPAi | ENSG00000169727, Low tissue specificity |
Interactioni
Subunit structurei
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (PubMed:11114242).
Interacts directly with inositol kinase ITPK1 (PubMed:12324474).
Interacts with CAPN8 (By similarity).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ13098
With | #Exp. | IntAct |
---|---|---|
COPS5 [Q92905] | 16 | EBI-725197,EBI-594661 |
Isoform 2 [Q13098-7]
With | #Exp. | IntAct |
---|---|---|
CNOT2 [Q9NZN8] | 3 | EBI-10983983,EBI-743033 |
COPS2 [P61201] | 5 | EBI-10983983,EBI-1050386 |
COPS8 [Q99627] | 4 | EBI-10983983,EBI-2510102 |
Protein-protein interaction databases
BioGRIDi | 109131, 103 interactors |
ComplexPortali | CPX-1870, COP9 signalosome variant 1 CPX-1871, COP9 signalosome variant 2 |
CORUMi | Q13098 |
DIPi | DIP-42077N |
IntActi | Q13098, 56 interactors |
MINTi | Q13098 |
STRINGi | 9606.ENSP00000376167 |
Miscellaneous databases
RNActi | Q13098, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 269 – 431 | PCIPROSITE-ProRule annotationAdd BLAST | 163 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0686, Eukaryota |
GeneTreei | ENSGT00510000046608 |
InParanoidi | Q13098 |
OMAi | IYLQNWA |
OrthoDBi | 859626at2759 |
PhylomeDBi | Q13098 |
TreeFami | TF101167 |
Family and domain databases
InterProi | View protein in InterPro IPR033008, CSN1 IPR000717, PCI_dom IPR019585, Rpn7/CSN1 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF2, PTHR14145:SF2, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP SLDLEQYAAS
60 70 80 90 100
YSGLMRIERL QFIADHCPTL RVEALKMALS FVQRTFNVDM YEEIHRKLSE
110 120 130 140 150
ATRSSLRELQ NAPDAIPESG VEPPALDTAW VEATRKKALL KLEKLDTDLK
160 170 180 190 200
NYKGNSIKES IRRGHDDLGD HYLDCGDLSN ALKCYSRARD YCTSAKHVIN
210 220 230 240 250
MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS QTQAILTKLK
260 270 280 290 300
CAAGLAELAA RKYKQAAKCL LLASFDHCDF PELLSPSNVA IYGGLCALAT
310 320 330 340 350
FDRQELQRNV ISSSSFKLFL ELEPQVRDII FKFYESKYAS CLKMLDEMKD
360 370 380 390 400
NLLLDMYLAP HVRTLYTQIR NRALIQYFSP YVSADMHRMA AAFNTTVAAL
410 420 430 440 450
EDELTQLILE GLISARVDSH SKILYARDVD QRSTTFEKSL LMGKEFQRRA
460 470 480 490
KAMMLRAAVL RNQIHVKSPP REGSQGELTP ANSQSRMSTN M
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JFE4 | C9JFE4_HUMAN | COP9 signalosome complex subunit 1 | GPS1 hCG_1987516 | 471 | Annotation score: | ||
A0A096LP07 | A0A096LP07_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 486 | Annotation score: | ||
A0A096LPJ3 | A0A096LPJ3_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 490 | Annotation score: | ||
A8K070 | A8K070_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 526 | Annotation score: | ||
J3KRJ4 | J3KRJ4_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 253 | Annotation score: | ||
J3QQX0 | J3QQX0_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 79 | Annotation score: | ||
J3KSA5 | J3KSA5_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 210 | Annotation score: | ||
J3QLT0 | J3QLT0_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 168 | Annotation score: | ||
J3KTB0 | J3KTB0_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 139 | Annotation score: | ||
J3KRE8 | J3KRE8_HUMAN | COP9 signalosome complex subunit 1 | GPS1 | 186 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 259 | A → T in BAC04120 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036240 | 1 – 11 | MPLPVQVFNLQ → MRDSSAPSSASSSVTDLYCT PHSSRSDLVLPGTAGDFSLS ASLSACTLLYE in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_036241 | 12 – 109 | GAVEP…SLREL → PASSVSGSGGAESQDRMRDS SAPSSASSSVTDLYCTPHSS RSDLVLPGMAGDFSLSASLS ACTLLYEGAVEPMQIDVDPQ EDP in isoform 3. 1 PublicationAdd BLAST | 98 | |
Alternative sequenceiVSP_036242 | 103 – 106 | Missing in isoform 2 and isoform 4. 2 Publications | 4 | |
Alternative sequenceiVSP_011882 | 471 – 491 | REGSQ…MSTNM → TSTDLGPPGGSVLPAAQLRG LATGCHPACVPSLGLRRQAA ASCGPSWKERPAGLDPVGFC PQGADCAAPRPSGTISQTPP VPASVRCRQVGGVH in isoform 3. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20285 mRNA Translation: AAC50906.2 Different initiation. AK093283 mRNA Translation: BAC04120.1 AC135056 Genomic DNA No translation available. BC000155 mRNA Translation: AAH00155.3 BC064503 mRNA Translation: AAH64503.1 BT009834 mRNA Translation: AAP88836.1 |
CCDSi | CCDS11800.1 [Q13098-7] CCDS32774.1 [Q13098-4] CCDS82226.1 [Q13098-5] |
PIRi | G01646 |
RefSeqi | NP_001308021.1, NM_001321092.1 [Q13098-5] NP_004118.3, NM_004127.5 [Q13098-4] NP_997657.1, NM_212492.2 [Q13098-7] XP_016880023.1, XM_017024534.1 |
Genome annotation databases
Ensembli | ENST00000306823; ENSP00000302873; ENSG00000169727 [Q13098-4] ENST00000392358; ENSP00000376167; ENSG00000169727 [Q13098-7] ENST00000578552; ENSP00000462265; ENSG00000169727 [Q13098-5] |
GeneIDi | 2873 |
KEGGi | hsa:2873 |
UCSCi | uc002kdk.2, human [Q13098-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20285 mRNA Translation: AAC50906.2 Different initiation. AK093283 mRNA Translation: BAC04120.1 AC135056 Genomic DNA No translation available. BC000155 mRNA Translation: AAH00155.3 BC064503 mRNA Translation: AAH64503.1 BT009834 mRNA Translation: AAP88836.1 |
CCDSi | CCDS11800.1 [Q13098-7] CCDS32774.1 [Q13098-4] CCDS82226.1 [Q13098-5] |
PIRi | G01646 |
RefSeqi | NP_001308021.1, NM_001321092.1 [Q13098-5] NP_004118.3, NM_004127.5 [Q13098-4] NP_997657.1, NM_212492.2 [Q13098-7] XP_016880023.1, XM_017024534.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4D10 | X-ray | 3.80 | A/I | 12-491 | [»] | |
4D18 | X-ray | 4.08 | A/I | 12-491 | [»] | |
4WSN | X-ray | 5.50 | A/I/Q/Y/g/o | 12-491 | [»] | |
6R6H | electron microscopy | 8.40 | A | 1-491 | [»] | |
6R7F | electron microscopy | 8.20 | A | 37-469 | [»] | |
6R7H | electron microscopy | 8.80 | A | 37-469 | [»] | |
6R7I | electron microscopy | 5.90 | A | 37-491 | [»] | |
6R7N | electron microscopy | 6.50 | A | 1-491 | [»] | |
SMRi | Q13098 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109131, 103 interactors |
ComplexPortali | CPX-1870, COP9 signalosome variant 1 CPX-1871, COP9 signalosome variant 2 |
CORUMi | Q13098 |
DIPi | DIP-42077N |
IntActi | Q13098, 56 interactors |
MINTi | Q13098 |
STRINGi | 9606.ENSP00000376167 |
PTM databases
iPTMneti | Q13098 |
MetOSitei | Q13098 |
PhosphoSitePlusi | Q13098 |
SwissPalmi | Q13098 |
Genetic variation databases
BioMutai | GPS1 |
DMDMi | 223590263 |
Proteomic databases
EPDi | Q13098 |
jPOSTi | Q13098 |
MassIVEi | Q13098 |
MaxQBi | Q13098 |
PaxDbi | Q13098 |
PeptideAtlasi | Q13098 |
PRIDEi | Q13098 |
ProteomicsDBi | 59147 [Q13098-4] 59148 [Q13098-5] 59149 [Q13098-6] 59150 [Q13098-7] |
TopDownProteomicsi | Q13098-5 [Q13098-5] |
Protocols and materials databases
Antibodypediai | 19873, 350 antibodies |
DNASUi | 2873 |
Genome annotation databases
Ensembli | ENST00000306823; ENSP00000302873; ENSG00000169727 [Q13098-4] ENST00000392358; ENSP00000376167; ENSG00000169727 [Q13098-7] ENST00000578552; ENSP00000462265; ENSG00000169727 [Q13098-5] |
GeneIDi | 2873 |
KEGGi | hsa:2873 |
UCSCi | uc002kdk.2, human [Q13098-4] |
Organism-specific databases
CTDi | 2873 |
DisGeNETi | 2873 |
GeneCardsi | GPS1 |
HGNCi | HGNC:4549, GPS1 |
HPAi | ENSG00000169727, Low tissue specificity |
MIMi | 601934, gene |
neXtProti | NX_Q13098 |
OpenTargetsi | ENSG00000169727 |
PharmGKBi | PA28944 |
VEuPathDBi | HostDB:ENSG00000169727.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0686, Eukaryota |
GeneTreei | ENSGT00510000046608 |
InParanoidi | Q13098 |
OMAi | IYLQNWA |
OrthoDBi | 859626at2759 |
PhylomeDBi | Q13098 |
TreeFami | TF101167 |
Enzyme and pathway databases
PathwayCommonsi | Q13098 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 2873, 702 hits in 1003 CRISPR screens |
ChiTaRSi | GPS1, human |
GeneWikii | GPS1 |
GenomeRNAii | 2873 |
Pharosi | Q13098, Tbio |
PROi | PR:Q13098 |
RNActi | Q13098, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169727, Expressed in cerebellar vermis and 221 other tissues |
ExpressionAtlasi | Q13098, baseline and differential |
Genevisiblei | Q13098, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033008, CSN1 IPR000717, PCI_dom IPR019585, Rpn7/CSN1 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR14145:SF2, PTHR14145:SF2, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF10602, RPN7, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN1_HUMAN | |
Accessioni | Q13098Primary (citable) accession number: Q13098 Secondary accession number(s): Q8NA10, Q9BWL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 10, 2009 | |
Last modified: | April 7, 2021 | |
This is version 197 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families