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UniProtKB - Q13093 (PAFA_HUMAN)

Entry version 192 (23 Feb 2022)
Sequence version 1 (01 Nov 1997)
Previous versions | rss
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Protein

Platelet-activating factor acetylhydrolase

Gene

PLA2G7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756).

At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265).

Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620).

Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782).

Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782).

Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (PubMed:2040620, PubMed:7700381).

As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529).

Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369).

11 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=12.5 µM for 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine1 Publication
  2. KM=3.1 µM for 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine1 Publication
  3. KM=7.9 µM for 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine1 Publication
  4. KM=6.2 µM for 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine1 Publication
  5. KM=11.3 µM for 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
  6. KM=15.5 µM for 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine1 Publication
  7. KM=43.1 µM for 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
  1. Vmax=167 µmol/h/mg enzyme toward 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine1 Publication
  2. Vmax=36.1 µmol/h/mg enzyme toward 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine1 Publication
  3. Vmax=43.4 µmol/h/mg enzyme toward 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine1 Publication
  4. Vmax=42.2 µmol/h/mg enzyme toward 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine1 Publication
  5. Vmax=100 µmol/h/mg enzyme toward 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
  6. Vmax=98.4 µmol/h/mg enzyme toward 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine1 Publication
  7. Vmax=5.0 µmol/min/mg enzyme toward 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei273Nucleophile1 Publication1
Active sitei296Charge relay systemPROSITE-ProRule annotation1 Publication1
Active sitei351Charge relay systemPROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.4, 2681
3.1.1.47, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13093

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q13093

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13093

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-PLA2G7, PAF-Acetylhydrolase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000204

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase (EC:3.1.1.477 Publications)
Short name:
PAF acetylhydrolase
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
Group-VIIA phospholipase A2
Short name:
gVIIA-PLA2
LDL-associated phospholipase A2
Short name:
LDL-PLA(2)
PAF 2-acylhydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G7
Synonyms:PAFAH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9040, PLA2G7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601690, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13093

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000146070

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

HDL, LDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Platelet-activating factor acetylhydrolase deficiency (PAFAD)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004268279V → F in PAFAD; loss of function; risk factor for coronary arthery disease and stroke. 5 PublicationsCorresponds to variant dbSNP:rs76863441EnsemblClinVar.1
Natural variantiVAR_011585281Q → R in PAFAD; loss of function. 1 PublicationCorresponds to variant dbSNP:rs201256712Ensembl.1
Asthma (ASTHMA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIM
Atopic hypersensitivity (ATOPY)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi108S → A: Activity is higher than wild-type. 1 Publication1
Mutagenesisi114H → A, Q or E: Impairs the association with LDL particles. 1 Publication1
Mutagenesisi115W → A: Impairs the association with LDL particles. 1 Publication1
Mutagenesisi116L → A: Reduces the association with LDL particles. 1 Publication1
Mutagenesisi117M → A: Reduces the association with LDL particles. 1 Publication1
Mutagenesisi205Y → A: Impairs the association with LDL particles. 1 Publication1
Mutagenesisi273S → A: Loss of activity. 1 Publication1
Mutagenesisi286D → A: Almost no activity. 1 Publication1
Mutagenesisi286D → N: Diminishes activity. 1 Publication1
Mutagenesisi296D → A: Loss of activity. 1 Publication1
Mutagenesisi296D → N: Loss of activity. 1 Publication1
Mutagenesisi304D → A: No change in activity. 1 Publication1
Mutagenesisi338D → A: Activity is higher than wild-type. 1 Publication1
Mutagenesisi351H → A: Loss of activity. 1 Publication1
Mutagenesisi367H → N: Reduces the association with HDL particles. 1 Publication1
Mutagenesisi368M → K: Impairs the association with HDL particles. 1 Publication1
Mutagenesisi369L → A: Impairs the association with HDL particles. 1 Publication1
Mutagenesisi370K → T: Reduces the association with HDL particles. 1 Publication1

Keywords - Diseasei

Asthma, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7941

MalaCards human disease database

More...MalaCardsi		PLA2G7
MIMi147050, phenotype
600807, phenotype
614278, phenotype

Open Targets

More...OpenTargetsi		ENSG00000146070

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33368

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13093, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3514

Drug and drug target database

More...DrugBanki		DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
DB05119, Rilapladib

DrugCentral

More...DrugCentrali		Q13093

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1432

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLA2G7

Domain mapping of disease mutations (DMDM)

More...DMDMi		2497687

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001783322 – 441Platelet-activating factor acetylhydrolaseAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q13093

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13093

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13093

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13093

PeptideAtlas

More...PeptideAtlasi		Q13093

PRoteomics IDEntifications database

More...PRIDEi		Q13093

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59145

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13093, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13093

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13093

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated upon monocyte differentiation toward macrophage lineage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146070, Expressed in visceral pleura and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13093, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146070, Tissue enhanced (lymphoid tissue, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113667, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q13093, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274793

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q13093

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13093, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13093

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q13093

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3847, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022501_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13093

Identification of Orthologs from Complete Genome Data

More...OMAi		TYYFQDQ

Database of Orthologous Groups

More...OrthoDBi		683132at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13093

TreeFam database of animal gene trees

More...TreeFami		TF313831

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR005065, PAF_acetylhydro-like
IPR016715, PAF_acetylhydro_eucaryote

The PANTHER Classification System

More...PANTHERi		PTHR10272, PTHR10272, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03403, PAF-AH_p_II, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF018169, PAF_acetylhydrolase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00120, LIPASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q13093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPPKLHVLF CLCGCLAVVY PFDWQYINPV AHMKSSAWVN KIQVLMAAAS 
        60         70         80         90        100
FGQTKIPRGN GPYSVGCTDL MFDHTNKGTF LRLYYPSQDN DRLDTLWIPN 
       110        120        130        140        150
KEYFWGLSKF LGTHWLMGNI LRLLFGSMTT PANWNSPLRP GEKYPLVVFS 
       160        170        180        190        200
HGLGAFRTLY SAIGIDLASH GFIVAAVEHR DRSASATYYF KDQSAAEIGD 
       210        220        230        240        250
KSWLYLRTLK QEEETHIRNE QVRQRAKECS QALSLILDID HGKPVKNALD 
       260        270        280        290        300
LKFDMEQLKD SIDREKIAVI GHSFGGATVI QTLSEDQRFR CGIALDAWMF 
       310        320        330        340        350
PLGDEVYSRI PQPLFFINSE YFQYPANIIK MKKCYSPDKE RKMITIRGSV 
       360        370        380        390        400
HQNFADFTFA TGKIIGHMLK LKGDIDSNVA IDLSNKASLA FLQKHLGLHK 
       410        420        430        440 
DFDQWDCLIE GDDENLIPGT NINTTNQHIM LQNSSGIEKY N
Length:441
Mass (Da):50,077
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BA9EEA9E8094A57
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04797045L → P1 PublicationCorresponds to variant dbSNP:rs45521937Ensembl.1
Natural variantiVAR_01158392R → H Retains the ability to associate with HDL particles. 3 PublicationsCorresponds to variant dbSNP:rs1805017EnsemblClinVar.1
Natural variantiVAR_047971191K → N1 PublicationCorresponds to variant dbSNP:rs45454695EnsemblClinVar.1
Natural variantiVAR_011584198I → T Associated with asthma and atopy; retains the ability to associate with HDL particles. 3 PublicationsCorresponds to variant dbSNP:rs1805018EnsemblClinVar.1
Natural variantiVAR_004268279V → F in PAFAD; loss of function; risk factor for coronary arthery disease and stroke. 5 PublicationsCorresponds to variant dbSNP:rs76863441EnsemblClinVar.1
Natural variantiVAR_011585281Q → R in PAFAD; loss of function. 1 PublicationCorresponds to variant dbSNP:rs201256712Ensembl.1
Natural variantiVAR_011586379V → A Retains the ability to associate with HDL particles. 5 PublicationsCorresponds to variant dbSNP:rs1051931EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U20157 mRNA Translation: AAC50126.1
U24577 mRNA Translation: AAB04170.1
EF568110 Genomic DNA Translation: ABQ01234.1
AL591242 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04301.1
BC038452 mRNA Translation: AAH38452.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4917.1

Protein sequence database of the Protein Information Resource

More...PIRi		S60247

NCBI Reference Sequences

More...RefSeqi		NP_001161829.1, NM_001168357.1
NP_005075.3, NM_005084.3
XP_005249465.1, XM_005249408.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274793; ENSP00000274793; ENSG00000146070
ENST00000537365; ENSP00000445666; ENSG00000146070

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7941

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7941

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000274793.12; ENSP00000274793.7; NM_005084.4; NP_005075.3

UCSC genome browser

More...UCSCi		uc010jzf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20157 mRNA Translation: AAC50126.1
U24577 mRNA Translation: AAB04170.1
EF568110 Genomic DNA Translation: ABQ01234.1
AL591242 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04301.1
BC038452 mRNA Translation: AAH38452.1
CCDSiCCDS4917.1
PIRiS60247
RefSeqiNP_001161829.1, NM_001168357.1
NP_005075.3, NM_005084.3
XP_005249465.1, XM_005249408.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D59X-ray1.50A/B47-429[»]
3D5EX-ray2.10A/B47-429[»]
3F96X-ray2.10A/B47-429[»]
3F97X-ray1.70A/B47-429[»]
3F98X-ray1.70A/B/C47-429[»]
3F9CX-ray2.30A/B47-429[»]
5I8PX-ray2.37A/B47-429[»]
5I9IX-ray2.70A/B47-429[»]
5JADX-ray2.05A46-428[»]
5JAHX-ray2.06A46-428[»]
5JALX-ray2.06A46-428[»]
5JANX-ray2.12A46-428[»]
5JAOX-ray2.06A46-428[»]
5JAPX-ray2.46A46-428[»]
5JARX-ray2.11A46-428[»]
5JASX-ray2.06A46-428[»]
5JATX-ray2.04A46-428[»]
5JAUX-ray1.95A46-428[»]
5LP1X-ray1.91A46-428[»]
5LYYX-ray2.17A46-428[»]
5LZ2X-ray2.10A46-428[»]
5LZ4X-ray2.07A46-428[»]
5LZ5X-ray2.05A46-428[»]
5LZ7X-ray2.10A46-428[»]
5LZ8X-ray2.11A46-428[»]
5LZ9X-ray2.06A46-428[»]
5YE7X-ray2.31A/B47-429[»]
5YE8X-ray1.85A/B47-429[»]
5YE9X-ray1.88A/B47-429[»]
5YEAX-ray1.80A/B47-429[»]
6M06X-ray2.10A/B54-424[»]
6M07X-ray2.64A/B54-422[»]
6M08X-ray2.19A/B54-424[»]
SMRiQ13093
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113667, 3 interactors
IntActiQ13093, 4 interactors
STRINGi9606.ENSP00000274793

Chemistry databases

BindingDBiQ13093
ChEMBLiCHEMBL3514
DrugBankiDB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
DB05119, Rilapladib
DrugCentraliQ13093
GuidetoPHARMACOLOGYi1432
SwissLipidsiSLP:000000204

Protein family/group databases

ESTHERihuman-PLA2G7, PAF-Acetylhydrolase

PTM databases

GlyGeniQ13093, 2 sites
iPTMnetiQ13093
PhosphoSitePlusiQ13093

Genetic variation databases

BioMutaiPLA2G7
DMDMi2497687

Proteomic databases

jPOSTiQ13093
MassIVEiQ13093
MaxQBiQ13093
PaxDbiQ13093
PeptideAtlasiQ13093
PRIDEiQ13093
ProteomicsDBi59145

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30742, 380 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		7941

Genome annotation databases

EnsembliENST00000274793; ENSP00000274793; ENSG00000146070
ENST00000537365; ENSP00000445666; ENSG00000146070
GeneIDi7941
KEGGihsa:7941
MANE-SelectiENST00000274793.12; ENSP00000274793.7; NM_005084.4; NP_005075.3
UCSCiuc010jzf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7941
DisGeNETi7941

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLA2G7
HGNCiHGNC:9040, PLA2G7
HPAiENSG00000146070, Tissue enhanced (lymphoid tissue, placenta)
MalaCardsiPLA2G7
MIMi147050, phenotype
600807, phenotype
601690, gene
614278, phenotype
neXtProtiNX_Q13093
OpenTargetsiENSG00000146070
PharmGKBiPA33368
VEuPathDBiHostDB:ENSG00000146070

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3847, Eukaryota
GeneTreeiENSGT00390000005233
HOGENOMiCLU_022501_0_1_1
InParanoidiQ13093
OMAiTYYFQDQ
OrthoDBi683132at2759
PhylomeDBiQ13093
TreeFamiTF313831

Enzyme and pathway databases

BRENDAi3.1.1.4, 2681
3.1.1.47, 2681
PathwayCommonsiQ13093
ReactomeiR-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiQ13093
SignaLinkiQ13093

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7941, 15 hits in 1036 CRISPR screens
EvolutionaryTraceiQ13093

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Lipoprotein-associated_phospholipase_A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7941
PharosiQ13093, Tchem

Protein Ontology

More...PROi		PR:Q13093
RNActiQ13093, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146070, Expressed in visceral pleura and 175 other tissues
GenevisibleiQ13093, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR005065, PAF_acetylhydro-like
IPR016715, PAF_acetylhydro_eucaryote
PANTHERiPTHR10272, PTHR10272, 1 hit
PfamiView protein in Pfam
PF03403, PAF-AH_p_II, 1 hit
PIRSFiPIRSF018169, PAF_acetylhydrolase, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120, LIPASE_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAFA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13093
Secondary accession number(s): A5HTT5
, Q15692, Q5VTT1, Q8IVA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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