UniProtKB - Q13093 (PAFA_HUMAN)
Protein
Platelet-activating factor acetylhydrolase
Gene
PLA2G7
Organism
Homo sapiens (Human)
Status
Functioni
Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369).11 Publications
Catalytic activityi
- a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+7 PublicationsEC:3.1.1.477 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + propanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + pentanoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H+2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H+2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H+2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=12.5 µM for 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine1 Publication
- KM=3.1 µM for 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine1 Publication
- KM=7.9 µM for 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine1 Publication
- KM=6.2 µM for 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine1 Publication
- KM=11.3 µM for 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
- KM=15.5 µM for 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine1 Publication
- KM=43.1 µM for 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
- Vmax=167 µmol/h/mg enzyme toward 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine1 Publication
- Vmax=36.1 µmol/h/mg enzyme toward 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine1 Publication
- Vmax=43.4 µmol/h/mg enzyme toward 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine1 Publication
- Vmax=42.2 µmol/h/mg enzyme toward 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine1 Publication
- Vmax=100 µmol/h/mg enzyme toward 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
- Vmax=98.4 µmol/h/mg enzyme toward 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine1 Publication
- Vmax=5.0 µmol/min/mg enzyme toward 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 273 | Nucleophile1 Publication | 1 | |
Active sitei | 296 | Charge relay systemPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 351 | Charge relay systemPROSITE-ProRule annotation1 Publication | 1 |
GO - Molecular functioni
- 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB
- calcium-independent phospholipase A2 activity Source: UniProtKB
- phospholipid binding Source: BHF-UCL
GO - Biological processi
- lipid oxidation Source: BHF-UCL
- low-density lipoprotein particle remodeling Source: BHF-UCL
- phosphatidylcholine catabolic process Source: UniProtKB
- plasma lipoprotein particle oxidation Source: BHF-UCL
- platelet activating factor catabolic process Source: UniProtKB
- platelet activating factor metabolic process Source: UniProtKB
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of monocyte chemotaxis Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism |
Enzyme and pathway databases
BRENDAi | 3.1.1.4, 2681 3.1.1.47, 2681 |
PathwayCommonsi | Q13093 |
Reactomei | R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SABIO-RKi | Q13093 |
Protein family/group databases
ESTHERi | human-PLA2G7, PAF-Acetylhydrolase |
Chemistry databases
SwissLipidsi | SLP:000000204 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-activating factor acetylhydrolase (EC:3.1.1.477 Publications)Short name: PAF acetylhydrolase Alternative name(s): 1-alkyl-2-acetylglycerophosphocholine esterase 2-acetyl-1-alkylglycerophosphocholine esterase Group-VIIA phospholipase A2 Short name: gVIIA-PLA2 LDL-associated phospholipase A2 Short name: LDL-PLA(2) PAF 2-acylhydrolase |
Gene namesi | Name:PLA2G7 Synonyms:PAFAH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9040, PLA2G7 |
MIMi | 601690, gene |
neXtProti | NX_Q13093 |
VEuPathDBi | HostDB:ENSG00000146070.16 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: Reactome
- high-density lipoprotein particle Source: UniProtKB
- low-density lipoprotein particle Source: UniProtKB
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
HDL, LDL, SecretedPathology & Biotechi
Involvement in diseasei
Platelet-activating factor acetylhydrolase deficiency (PAFAD)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004268 | 279 | V → F in PAFAD; loss of function; risk factor for coronary arthery disease and stroke. 5 PublicationsCorresponds to variant dbSNP:rs76863441EnsemblClinVar. | 1 | |
Natural variantiVAR_011585 | 281 | Q → R in PAFAD; loss of function. 1 PublicationCorresponds to variant dbSNP:rs201256712Ensembl. | 1 |
Asthma (ASTHMA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIMAtopic hypersensitivity (ATOPY)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | S → A: Activity is higher than wild-type. 1 Publication | 1 | |
Mutagenesisi | 114 | H → A, Q or E: Impairs the association with LDL particles. 1 Publication | 1 | |
Mutagenesisi | 115 | W → A: Impairs the association with LDL particles. 1 Publication | 1 | |
Mutagenesisi | 116 | L → A: Reduces the association with LDL particles. 1 Publication | 1 | |
Mutagenesisi | 117 | M → A: Reduces the association with LDL particles. 1 Publication | 1 | |
Mutagenesisi | 205 | Y → A: Impairs the association with LDL particles. 1 Publication | 1 | |
Mutagenesisi | 273 | S → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 286 | D → A: Almost no activity. 1 Publication | 1 | |
Mutagenesisi | 286 | D → N: Diminishes activity. 1 Publication | 1 | |
Mutagenesisi | 296 | D → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 296 | D → N: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 304 | D → A: No change in activity. 1 Publication | 1 | |
Mutagenesisi | 338 | D → A: Activity is higher than wild-type. 1 Publication | 1 | |
Mutagenesisi | 351 | H → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 367 | H → N: Reduces the association with HDL particles. 1 Publication | 1 | |
Mutagenesisi | 368 | M → K: Impairs the association with HDL particles. 1 Publication | 1 | |
Mutagenesisi | 369 | L → A: Impairs the association with HDL particles. 1 Publication | 1 | |
Mutagenesisi | 370 | K → T: Reduces the association with HDL particles. 1 Publication | 1 |
Keywords - Diseasei
Asthma, Disease variantOrganism-specific databases
DisGeNETi | 7941 |
MalaCardsi | PLA2G7 |
MIMi | 147050, phenotype 600807, phenotype 614278, phenotype |
OpenTargetsi | ENSG00000146070 |
PharmGKBi | PA33368 |
Miscellaneous databases
Pharosi | Q13093, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3514 |
DrugBanki | DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate DB05119, Rilapladib |
DrugCentrali | Q13093 |
GuidetoPHARMACOLOGYi | 1432 |
Genetic variation databases
BioMutai | PLA2G7 |
DMDMi | 2497687 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000017833 | 22 – 441 | Platelet-activating factor acetylhydrolaseAdd BLAST | 420 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 423 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 433 | N-linked (GlcNAc...) asparagine | 1 |
Post-translational modificationi
N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q13093 |
MassIVEi | Q13093 |
MaxQBi | Q13093 |
PaxDbi | Q13093 |
PeptideAtlasi | Q13093 |
PRIDEi | Q13093 |
ProteomicsDBi | 59145 |
PTM databases
GlyGeni | Q13093, 2 sites |
iPTMneti | Q13093 |
PhosphoSitePlusi | Q13093 |
Expressioni
Tissue specificityi
Plasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221).2 Publications
Inductioni
Up-regulated upon monocyte differentiation toward macrophage lineage.1 Publication
Gene expression databases
Bgeei | ENSG00000146070, Expressed in visceral pleura and 175 other tissues |
Genevisiblei | Q13093, HS |
Organism-specific databases
HPAi | ENSG00000146070, Tissue enhanced (adipose tissue, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113667, 2 interactors |
IntActi | Q13093, 4 interactors |
STRINGi | 9606.ENSP00000274793 |
Chemistry databases
BindingDBi | Q13093 |
Miscellaneous databases
RNActi | Q13093, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q13093 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13093 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3847, Eukaryota |
GeneTreei | ENSGT00390000005233 |
HOGENOMi | CLU_022501_0_1_1 |
InParanoidi | Q13093 |
OMAi | FLTGNWI |
OrthoDBi | 683132at2759 |
PhylomeDBi | Q13093 |
TreeFami | TF313831 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR005065, PAF_acetylhydro-like IPR016715, PAF_acetylhydro_eucaryote |
PANTHERi | PTHR10272, PTHR10272, 1 hit |
Pfami | View protein in Pfam PF03403, PAF-AH_p_II, 1 hit |
PIRSFi | PIRSF018169, PAF_acetylhydrolase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q13093-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVPPKLHVLF CLCGCLAVVY PFDWQYINPV AHMKSSAWVN KIQVLMAAAS
60 70 80 90 100
FGQTKIPRGN GPYSVGCTDL MFDHTNKGTF LRLYYPSQDN DRLDTLWIPN
110 120 130 140 150
KEYFWGLSKF LGTHWLMGNI LRLLFGSMTT PANWNSPLRP GEKYPLVVFS
160 170 180 190 200
HGLGAFRTLY SAIGIDLASH GFIVAAVEHR DRSASATYYF KDQSAAEIGD
210 220 230 240 250
KSWLYLRTLK QEEETHIRNE QVRQRAKECS QALSLILDID HGKPVKNALD
260 270 280 290 300
LKFDMEQLKD SIDREKIAVI GHSFGGATVI QTLSEDQRFR CGIALDAWMF
310 320 330 340 350
PLGDEVYSRI PQPLFFINSE YFQYPANIIK MKKCYSPDKE RKMITIRGSV
360 370 380 390 400
HQNFADFTFA TGKIIGHMLK LKGDIDSNVA IDLSNKASLA FLQKHLGLHK
410 420 430 440
DFDQWDCLIE GDDENLIPGT NINTTNQHIM LQNSSGIEKY N
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047970 | 45 | L → P1 PublicationCorresponds to variant dbSNP:rs45521937Ensembl. | 1 | |
Natural variantiVAR_011583 | 92 | R → H Retains the ability to associate with HDL particles. 3 PublicationsCorresponds to variant dbSNP:rs1805017EnsemblClinVar. | 1 | |
Natural variantiVAR_047971 | 191 | K → N1 PublicationCorresponds to variant dbSNP:rs45454695EnsemblClinVar. | 1 | |
Natural variantiVAR_011584 | 198 | I → T Associated with asthma and atopy; retains the ability to associate with HDL particles. 3 PublicationsCorresponds to variant dbSNP:rs1805018EnsemblClinVar. | 1 | |
Natural variantiVAR_004268 | 279 | V → F in PAFAD; loss of function; risk factor for coronary arthery disease and stroke. 5 PublicationsCorresponds to variant dbSNP:rs76863441EnsemblClinVar. | 1 | |
Natural variantiVAR_011585 | 281 | Q → R in PAFAD; loss of function. 1 PublicationCorresponds to variant dbSNP:rs201256712Ensembl. | 1 | |
Natural variantiVAR_011586 | 379 | V → A Retains the ability to associate with HDL particles. 5 PublicationsCorresponds to variant dbSNP:rs1051931EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20157 mRNA Translation: AAC50126.1 U24577 mRNA Translation: AAB04170.1 EF568110 Genomic DNA Translation: ABQ01234.1 AL591242 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04301.1 BC038452 mRNA Translation: AAH38452.1 |
CCDSi | CCDS4917.1 |
PIRi | S60247 |
RefSeqi | NP_001161829.1, NM_001168357.1 NP_005075.3, NM_005084.3 XP_005249465.1, XM_005249408.4 |
Genome annotation databases
Ensembli | ENST00000274793; ENSP00000274793; ENSG00000146070 ENST00000537365; ENSP00000445666; ENSG00000146070 |
GeneIDi | 7941 |
KEGGi | hsa:7941 |
UCSCi | uc010jzf.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20157 mRNA Translation: AAC50126.1 U24577 mRNA Translation: AAB04170.1 EF568110 Genomic DNA Translation: ABQ01234.1 AL591242 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04301.1 BC038452 mRNA Translation: AAH38452.1 |
CCDSi | CCDS4917.1 |
PIRi | S60247 |
RefSeqi | NP_001161829.1, NM_001168357.1 NP_005075.3, NM_005084.3 XP_005249465.1, XM_005249408.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3D59 | X-ray | 1.50 | A/B | 47-429 | [»] | |
3D5E | X-ray | 2.10 | A/B | 47-429 | [»] | |
3F96 | X-ray | 2.10 | A/B | 47-429 | [»] | |
3F97 | X-ray | 1.70 | A/B | 47-429 | [»] | |
3F98 | X-ray | 1.70 | A/B/C | 47-429 | [»] | |
3F9C | X-ray | 2.30 | A/B | 47-429 | [»] | |
5I8P | X-ray | 2.37 | A/B | 47-429 | [»] | |
5I9I | X-ray | 2.70 | A/B | 47-429 | [»] | |
5JAD | X-ray | 2.05 | A | 46-428 | [»] | |
5JAH | X-ray | 2.06 | A | 46-428 | [»] | |
5JAL | X-ray | 2.06 | A | 46-428 | [»] | |
5JAN | X-ray | 2.12 | A | 46-428 | [»] | |
5JAO | X-ray | 2.06 | A | 46-428 | [»] | |
5JAP | X-ray | 2.46 | A | 46-428 | [»] | |
5JAR | X-ray | 2.11 | A | 46-428 | [»] | |
5JAS | X-ray | 2.06 | A | 46-428 | [»] | |
5JAT | X-ray | 2.04 | A | 46-428 | [»] | |
5JAU | X-ray | 1.95 | A | 46-428 | [»] | |
5LP1 | X-ray | 1.91 | A | 46-428 | [»] | |
5LYY | X-ray | 2.17 | A | 46-428 | [»] | |
5LZ2 | X-ray | 2.10 | A | 46-428 | [»] | |
5LZ4 | X-ray | 2.07 | A | 46-428 | [»] | |
5LZ5 | X-ray | 2.05 | A | 46-428 | [»] | |
5LZ7 | X-ray | 2.10 | A | 46-428 | [»] | |
5LZ8 | X-ray | 2.11 | A | 46-428 | [»] | |
5LZ9 | X-ray | 2.06 | A | 46-428 | [»] | |
5YE7 | X-ray | 2.31 | A/B | 47-429 | [»] | |
5YE8 | X-ray | 1.85 | A/B | 47-429 | [»] | |
5YE9 | X-ray | 1.88 | A/B | 47-429 | [»] | |
5YEA | X-ray | 1.80 | A/B | 47-429 | [»] | |
6M06 | X-ray | 2.10 | A/B | 54-424 | [»] | |
6M07 | X-ray | 2.64 | A/B | 54-422 | [»] | |
6M08 | X-ray | 2.19 | A/B | 54-424 | [»] | |
SMRi | Q13093 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113667, 2 interactors |
IntActi | Q13093, 4 interactors |
STRINGi | 9606.ENSP00000274793 |
Chemistry databases
BindingDBi | Q13093 |
ChEMBLi | CHEMBL3514 |
DrugBanki | DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate DB05119, Rilapladib |
DrugCentrali | Q13093 |
GuidetoPHARMACOLOGYi | 1432 |
SwissLipidsi | SLP:000000204 |
Protein family/group databases
ESTHERi | human-PLA2G7, PAF-Acetylhydrolase |
PTM databases
GlyGeni | Q13093, 2 sites |
iPTMneti | Q13093 |
PhosphoSitePlusi | Q13093 |
Genetic variation databases
BioMutai | PLA2G7 |
DMDMi | 2497687 |
Proteomic databases
jPOSTi | Q13093 |
MassIVEi | Q13093 |
MaxQBi | Q13093 |
PaxDbi | Q13093 |
PeptideAtlasi | Q13093 |
PRIDEi | Q13093 |
ProteomicsDBi | 59145 |
Protocols and materials databases
Antibodypediai | 30742, 367 antibodies |
DNASUi | 7941 |
Genome annotation databases
Ensembli | ENST00000274793; ENSP00000274793; ENSG00000146070 ENST00000537365; ENSP00000445666; ENSG00000146070 |
GeneIDi | 7941 |
KEGGi | hsa:7941 |
UCSCi | uc010jzf.4, human |
Organism-specific databases
CTDi | 7941 |
DisGeNETi | 7941 |
GeneCardsi | PLA2G7 |
HGNCi | HGNC:9040, PLA2G7 |
HPAi | ENSG00000146070, Tissue enhanced (adipose tissue, lymphoid tissue) |
MalaCardsi | PLA2G7 |
MIMi | 147050, phenotype 600807, phenotype 601690, gene 614278, phenotype |
neXtProti | NX_Q13093 |
OpenTargetsi | ENSG00000146070 |
PharmGKBi | PA33368 |
VEuPathDBi | HostDB:ENSG00000146070.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3847, Eukaryota |
GeneTreei | ENSGT00390000005233 |
HOGENOMi | CLU_022501_0_1_1 |
InParanoidi | Q13093 |
OMAi | FLTGNWI |
OrthoDBi | 683132at2759 |
PhylomeDBi | Q13093 |
TreeFami | TF313831 |
Enzyme and pathway databases
BRENDAi | 3.1.1.4, 2681 3.1.1.47, 2681 |
PathwayCommonsi | Q13093 |
Reactomei | R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin |
SABIO-RKi | Q13093 |
Miscellaneous databases
BioGRID-ORCSi | 7941, 15 hits in 985 CRISPR screens |
EvolutionaryTracei | Q13093 |
GeneWikii | Lipoprotein-associated_phospholipase_A2 |
GenomeRNAii | 7941 |
Pharosi | Q13093, Tchem |
PROi | PR:Q13093 |
RNActi | Q13093, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146070, Expressed in visceral pleura and 175 other tissues |
Genevisiblei | Q13093, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR005065, PAF_acetylhydro-like IPR016715, PAF_acetylhydro_eucaryote |
PANTHERi | PTHR10272, PTHR10272, 1 hit |
Pfami | View protein in Pfam PF03403, PAF-AH_p_II, 1 hit |
PIRSFi | PIRSF018169, PAF_acetylhydrolase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAFA_HUMAN | |
Accessioni | Q13093Primary (citable) accession number: Q13093 Secondary accession number(s): A5HTT5 Q8IVA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families