UniProtKB - Q13087 (PDIA2_HUMAN)

BLAST

>sp|Q13087|PDIA2_HUMAN Protein disulfide-isomerase A2 OS=Homo sapiens OX=9606 GN=PDIA2 PE=1 SV=2
MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHP
ALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTL
KFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQ
DLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEEL
GLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEA
APRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASI
TAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTH
CKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKS
TRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL

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History
Entry version 177 (10 Oct 2018)
Sequence version 2 (27 May 2002)
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Protein

Protein disulfide-isomerase A2

Gene

PDIA2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.2 Publications

Catalytic activityⁱ

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	71	NucleophileBy similarity	1
Siteⁱ	72	Contributes to redox potential valueBy similarity	1
Siteⁱ	73	Contributes to redox potential valueBy similarity	1
Active siteⁱ	74	NucleophileBy similarity	1
Siteⁱ	138	Lowers pKa of C-terminal Cys of first active siteBy similarity	1
Active siteⁱ	418	NucleophileBy similarity	1
Siteⁱ	419	Contributes to redox potential valueBy similarity	1
Siteⁱ	420	Contributes to redox potential valueBy similarity	1
Active siteⁱ	421	NucleophileBy similarity	1
Siteⁱ	482	Lowers pKa of C-terminal Cys of second active siteBy similarity	1

GO - Molecular functionⁱ

disulfide oxidoreductase activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22013210
peptide disulfide oxidoreductase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16677074
protein disulfide isomerase activity Source: GO_Central
steroid binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
peptidyl-proline hydroxylation Source: GOC
protein folding
Source: ProtInc
Traceable author statementⁱ
- 8561901
protein folding in endoplasmic reticulum
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22013210
protein retention in ER lumen
Source: ProtInc
Traceable author statementⁱ
- 8561901
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: GO_Central
response to endoplasmic reticulum stress Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone, Isomerase
Ligand	Lipid-binding, Steroid-binding

Enzyme and pathway databases

BRENDAⁱ	5.3.4.1 2681

BRENDAⁱ

5.3.4.1 2681

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein disulfide-isomerase A2 (EC:5.3.4.1) Alternative name(s): Pancreas-specific protein disulfide isomerase Short name: PDIp
Gene namesⁱ	Name:PDIA2 Synonyms:PDIP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185615.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14180 PDIA2
MIMⁱ	608012 gene
neXtProtⁱ	NX_Q13087

Keywords - Cellular componentⁱ

Endoplasmic reticulum

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	18	C → A: Impairs interchain disulfide bridge formation. 1 Publication	1
Mutagenesisⁱ	284	N → Q: Increases formation of a highly stable disulfide-bonded PDIA2 dimer. 1 Publication	1
Mutagenesisⁱ	364	C → A: No effect on interchain disulfide bridge formation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64714
Open Targets More...OpenTargetsⁱ	ENSG00000185615
PharmGKBⁱ	PA33153

Polymorphism and mutation databases

BioMutaⁱ	PDIA2
DMDMⁱ	21264492

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000034222	22 – 525	Protein disulfide-isomerase A2Add BLAST		504

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	18	Interchain1 Publication
Disulfide bondⁱ	71 ↔ 74	Redox-activePROSITE-ProRule annotation
Glycosylationⁱ	127	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	284	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	418 ↔ 421	Redox-activePROSITE-ProRule annotation
Glycosylationⁱ	516	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

The disulfide-linked homodimer exhibits an enhanced chaperone activity.

Glycosylated.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13087
PaxDbⁱ	Q13087
PeptideAtlas More...PeptideAtlasⁱ	Q13087
PRIDEⁱ	Q13087
ProteomicsDBⁱ	59143 59144 [Q13087-2]

PTM databases

GlyConnectⁱ	1655
iPTMnetⁱ	Q13087
PhosphoSitePlusⁱ	Q13087

Expressionⁱ

Tissue specificityⁱ

Highly expressed in pancreas (at protein level).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000185615 Expressed in 113 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PDIA2
ExpressionAtlasⁱ	Q13087 baseline and differential
Genevisibleⁱ	Q13087 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051692 HPA053492

HPAⁱ

HPA051692
HPA053492

Interactionⁱ

Subunit structureⁱ

Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	3	EBI-1752525,EBI-389883

With

Entry

#Exp.

IntAct

Notes

NCK1

P16333

EBI-1752525,EBI-389883

Protein-protein interaction databases

BioGridⁱ	122240, 20 interactors
IntActⁱ	Q13087, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q13087
STRINGⁱ	9606.ENSP00000219406

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q13087
SMRⁱ	Q13087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 152	Thioredoxin 1PROSITE-ProRule annotationAdd BLAST		126
Domainⁱ	367 – 496	Thioredoxin 2PROSITE-ProRule annotationAdd BLAST		130

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	522 – 525	Prevents secretion from ERPROSITE-ProRule annotation		4

Sequence similaritiesⁱ

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domainⁱ

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG0190 Eukaryota COG0526 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133691
HOVERGENⁱ	HBG005920
InParanoidⁱ	Q13087
KEGG Orthology (KO) More...KOⁱ	K09581
OMAⁱ	TTKKYAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08WM
PhylomeDBⁱ	Q13087
TreeFamⁱ	TF106381

Family and domain databases

InterProⁱ	View protein in InterPro IPR005792 Prot_disulphide_isomerase IPR036249 Thioredoxin-like_sf IPR017937 Thioredoxin_CS IPR013766 Thioredoxin_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085 Thioredoxin, 2 hits
SUPFAMⁱ	SSF52833 SSF52833, 4 hits
TIGRFAMsⁱ	TIGR01130 ER_PDI_fam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit PS00194 THIOREDOXIN_1, 2 hits PS51352 THIOREDOXIN_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q13087-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQLLPVLL LLLLRASCPW GQEQGARSPS EEPPEEEIPK EDGILVLSRH 
        60         70         80         90        100
TLGLALREHP ALLVEFYAPW CGHCQALAPE YSKAAAVLAA ESMVVTLAKV 
       110        120        130        140        150
DGPAQRELAE EFGVTEYPTL KFFRNGNRTH PEEYTGPRDA EGIAEWLRRR 
       160        170        180        190        200
VGPSAMRLED EAAAQALIGG RDLVVIGFFQ DLQDEDVATF LALAQDALDM 
       210        220        230        240        250
TFGLTDRPRL FQQFGLTKDT VVLFKKFDEG RADFPVDEEL GLDLGDLSRF 
       260        270        280        290        300
LVTHSMRLVT EFNSQTSAKI FAARILNHLL LFVNQTLAAH RELLAGFGEA 
       310        320        330        340        350
APRFRGQVLF VVVDVAADNE HVLQYFGLKA EAAPTLRLVN LETTKKYAPV 
       360        370        380        390        400
DGGPVTAASI TAFCHAVLNG QVKPYLLSQE IPPDWDQRPV KTLVGKNFEQ 
       410        420        430        440        450
VAFDETKNVF VKFYAPWCTH CKEMAPAWEA LAEKYQDHED IIIAELDATA 
       460        470        480        490        500
NELDAFAVHG FPTLKYFPAG PGRKVIEYKS TRDLETFSKF LDNGGVLPTE 
       510        520 
EPPEEPAAPF PEPPANSTMG SKEEL

Length:525

Mass (Da):58,206

Last modified:May 27, 2002 - v2

Checksum:ⁱB741851AA2C40540

Isoform 2 (identifier: Q13087-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
181-183: Missing.

« Hide

        10         20         30         40         50
MSRQLLPVLL LLLLRASCPW GQEQGARSPS EEPPEEEIPK EDGILVLSRH 
        60         70         80         90        100
TLGLALREHP ALLVEFYAPW CGHCQALAPE YSKAAAVLAA ESMVVTLAKV 
       110        120        130        140        150
DGPAQRELAE EFGVTEYPTL KFFRNGNRTH PEEYTGPRDA EGIAEWLRRR 
       160        170        180        190        200
VGPSAMRLED EAAAQALIGG RDLVVIGFFQ DEDVATFLAL AQDALDMTFG 
       210        220        230        240        250
LTDRPRLFQQ FGLTKDTVVL FKKFDEGRAD FPVDEELGLD LGDLSRFLVT 
       260        270        280        290        300
HSMRLVTEFN SQTSAKIFAA RILNHLLLFV NQTLAAHREL LAGFGEAAPR 
       310        320        330        340        350
FRGQVLFVVV DVAADNEHVL QYFGLKAEAA PTLRLVNLET TKKYAPVDGG 
       360        370        380        390        400
PVTAASITAF CHAVLNGQVK PYLLSQEIPP DWDQRPVKTL VGKNFEQVAF 
       410        420        430        440        450
DETKNVFVKF YAPWCTHCKE MAPAWEALAE KYQDHEDIII AELDATANEL 
       460        470        480        490        500
DAFAVHGFPT LKYFPAGPGR KVIEYKSTRD LETFSKFLDN GGVLPTEEPP 
       510        520 
EEPAAPFPEP PANSTMGSKE EL

Show »

Length:522

Mass (Da):57,850

Checksum:ⁱ815CD5F3060B5747

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y4J5	H0Y4J5_HUMAN	Protein disulfide-isomerase A2 Protein disulfide-isomerase A2	PDIA2	227	Annotation score:
Q4TT65	Q4TT65_HUMAN	Protein disulfide isomerase family ... Protein disulfide isomerase family A, member 2 (Protein disulfide-isomerase A2)	PDIA2 LA16c-314G4.2-007	154	Annotation score:

Sequence cautionⁱ

The sequence AAC50401 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence AAH75029 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence BAG58339 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	96	T → M in BAG58339 (PubMed:14702039).Curated		1
Sequence conflictⁱ	484	L → Q in BAG58339 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048087	39	P → S. Corresponds to variant dbSNP:rs45455191Ensembl.	1
Natural variantⁱVAR_048088	119	T → R. Corresponds to variant dbSNP:rs45614840Ensembl.	1
Natural variantⁱVAR_048089	185	E → K. Corresponds to variant dbSNP:rs419949Ensembl.	1
Natural variantⁱVAR_048090	286	T → M. Corresponds to variant dbSNP:rs2685127Ensembl.	1
Natural variantⁱVAR_048091	382	P → A. Corresponds to variant dbSNP:rs45529833Ensembl.	1
Natural variantⁱVAR_048092	388	R → Q. Corresponds to variant dbSNP:rs400037Ensembl.	1
Natural variantⁱVAR_048093	502	P → S3 PublicationsCorresponds to variant dbSNP:rs1048786Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039292	181 – 183	Missing in isoform 2. Curated		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB127078 mRNA Translation: BAE48734.1 AE006463 Genomic DNA Translation: AAK61223.1 Z69667 Genomic DNA Translation: CAI95586.1 Z69667 Genomic DNA Translation: CAO78188.1 CH471112 Genomic DNA Translation: EAW85838.1 BC000537 mRNA Translation: AAH00537.2 BC075029 mRNA Translation: AAH75029.1 Sequence problems. U19948 mRNA Translation: AAC50401.1 Sequence problems. AK295383 mRNA Translation: BAG58339.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42089.1 [Q13087-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006840.2, NM_006849.2 [Q13087-1]
UniGeneⁱ	Hs.66581

Genome annotation databases

Ensemblⁱ	ENST00000219406; ENSP00000219406; ENSG00000185615 [Q13087-1] ENST00000404312; ENSP00000384410; ENSG00000185615 [Q13087-2]
GeneIDⁱ	64714
KEGGⁱ	hsa:64714
UCSC genome browser More...UCSCⁱ	uc002cgo.2 human [Q13087-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q13087	cDNA FLJ42941 fis, clone BRSTN2000872, highly similar to Protein disulfide-isomerase A2		HUMAN		370	UniRef100_Q13087

Protein	Similar proteins		Species	Score	Length	Source
Q13087	Protein disulfide-isomerase A2		PONAB		525	UniRef90_Q13087
cDNA FLJ42941 fis, clone BRSTN2000872, highly similar to Protein disulfide-isomerase A2		HUMAN		370
Uncharacterized protein		MACFA		591
Uncharacterized protein		RHIRO		528
Uncharacterized protein		COLAP		525
+16

Protein	Similar proteins		Species	Score	Length	Source
Q13087	Protein disulfide-isomerase A2		PONAB		525	UniRef50_Q13087
cDNA FLJ42941 fis, clone BRSTN2000872, highly similar to Protein disulfide-isomerase A2		HUMAN		370
Uncharacterized protein		MACFA		591
Uncharacterized protein		RHIRO		528
Uncharacterized protein		COLAP		525
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB127078 mRNA Translation: BAE48734.1 AE006463 Genomic DNA Translation: AAK61223.1 Z69667 Genomic DNA Translation: CAI95586.1 Z69667 Genomic DNA Translation: CAO78188.1 CH471112 Genomic DNA Translation: EAW85838.1 BC000537 mRNA Translation: AAH00537.2 BC075029 mRNA Translation: AAH75029.1 Sequence problems. U19948 mRNA Translation: AAC50401.1 Sequence problems. AK295383 mRNA Translation: BAG58339.1 Different initiation.
CCDSⁱ	CCDS42089.1 [Q13087-1]
RefSeqⁱ	NP_006840.2, NM_006849.2 [Q13087-1]
UniGeneⁱ	Hs.66581

3D structure databases

ProteinModelPortalⁱ	Q13087
SMRⁱ	Q13087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122240, 20 interactors
IntActⁱ	Q13087, 12 interactors
MINTⁱ	Q13087
STRINGⁱ	9606.ENSP00000219406

PTM databases

GlyConnectⁱ	1655
iPTMnetⁱ	Q13087
PhosphoSitePlusⁱ	Q13087

Polymorphism and mutation databases

BioMutaⁱ	PDIA2
DMDMⁱ	21264492

Proteomic databases

MaxQBⁱ	Q13087
PaxDbⁱ	Q13087
PeptideAtlasⁱ	Q13087
PRIDEⁱ	Q13087
ProteomicsDBⁱ	59143 59144 [Q13087-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64714
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000219406; ENSP00000219406; ENSG00000185615 [Q13087-1] ENST00000404312; ENSP00000384410; ENSG00000185615 [Q13087-2]
GeneIDⁱ	64714
KEGGⁱ	hsa:64714
UCSCⁱ	uc002cgo.2 human [Q13087-1]

Organism-specific databases

CTDⁱ	64714
DisGeNETⁱ	64714
EuPathDBⁱ	HostDB:ENSG00000185615.15
GeneCardsⁱ	PDIA2
H-InvDBⁱ	HIX0202311
HGNCⁱ	HGNC:14180 PDIA2
HPAⁱ	HPA051692 HPA053492
MIMⁱ	608012 gene
neXtProtⁱ	NX_Q13087
OpenTargetsⁱ	ENSG00000185615
PharmGKBⁱ	PA33153
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0190 Eukaryota COG0526 LUCA
GeneTreeⁱ	ENSGT00860000133691
HOVERGENⁱ	HBG005920
InParanoidⁱ	Q13087
KOⁱ	K09581
OMAⁱ	TTKKYAP
OrthoDBⁱ	EOG091G08WM
PhylomeDBⁱ	Q13087
TreeFamⁱ	TF106381

Enzyme and pathway databases

BRENDAⁱ	5.3.4.1 2681

BRENDAⁱ

5.3.4.1 2681

Miscellaneous databases

GenomeRNAiⁱ	64714
Protein Ontology More...PROⁱ	PR:Q13087
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185615 Expressed in 113 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PDIA2
ExpressionAtlasⁱ	Q13087 baseline and differential
Genevisibleⁱ	Q13087 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005792 Prot_disulphide_isomerase IPR036249 Thioredoxin-like_sf IPR017937 Thioredoxin_CS IPR013766 Thioredoxin_domain
Pfamⁱ	View protein in Pfam PF00085 Thioredoxin, 2 hits
SUPFAMⁱ	SSF52833 SSF52833, 4 hits
TIGRFAMsⁱ	TIGR01130 ER_PDI_fam, 1 hit
PROSITEⁱ	View protein in PROSITE PS00014 ER_TARGET, 1 hit PS00194 THIOREDOXIN_1, 2 hits PS51352 THIOREDOXIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDIA2_HUMAN
Accessionⁱ	Q13087Primary (citable) accession number: Q13087 Secondary accession number(s): A6ZJ64 Q9BW95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	May 27, 2002
	Last modified:	October 10, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13087 (PDIA2_HUMAN)

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Protein disulfide-isomerase A2

PDIA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ