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UniProtKB - Q13087 (PDIA2_HUMAN)

Entry version 198 (23 Feb 2022)
Sequence version 2 (27 May 2002)
Previous versions | rss
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Protein

Protein disulfide-isomerase A2

Gene

PDIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Catalyzes the rearrangement of -S-S- bonds in proteins. EC:5.3.4.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei71NucleophileBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei72Contributes to redox potential valueBy similarity1
Sitei73Contributes to redox potential valueBy similarity1
Active sitei74NucleophileBy similarity1
Sitei138Lowers pKa of C-terminal Cys of first active siteBy similarity1
Active sitei418NucleophileBy similarity1
Sitei419Contributes to redox potential valueBy similarity1
Sitei420Contributes to redox potential valueBy similarity1
Active sitei421NucleophileBy similarity1
Sitei482Lowers pKa of C-terminal Cys of second active siteBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Isomerase
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.3.4.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q13087

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q13087

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein disulfide-isomerase A2 (EC:5.3.4.1)
Alternative name(s):
Pancreas-specific protein disulfide isomerase
Short name:
PDIp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDIA2
Synonyms:PDIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14180, PDIA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608012, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q13087

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185615

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18C → A: Impairs interchain disulfide bridge formation. 1 Publication1
Mutagenesisi284N → Q: Increases formation of a highly stable disulfide-bonded PDIA2 dimer. 1 Publication1
Mutagenesisi364C → A: No effect on interchain disulfide bridge formation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		64714

Open Targets

More...OpenTargetsi		ENSG00000185615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33153

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q13087, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PDIA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		21264492

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003422222 – 525Protein disulfide-isomerase A2Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi18Interchain1 Publication
Disulfide bondi71 ↔ 74Redox-activePROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi284N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi418 ↔ 421Redox-activePROSITE-ProRule annotation
Glycosylationi516N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The disulfide-linked homodimer exhibits an enhanced chaperone activity.
Glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q13087

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q13087

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q13087

PeptideAtlas

More...PeptideAtlasi		Q13087

PRoteomics IDEntifications database

More...PRIDEi		Q13087

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59143 [Q13087-1]
59144 [Q13087-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1655, 6 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q13087, 3 sites, 8 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q13087

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q13087

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185615, Expressed in pancreas and 132 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q13087, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q13087, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185615, Tissue enriched (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked.

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122240, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q13087, 12 interactors

Molecular INTeraction database

More...MINTi		Q13087

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219406

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q13087, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q13087

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 152Thioredoxin 1PROSITE-ProRule annotationAdd BLAST126
Domaini367 – 496Thioredoxin 2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni492 – 525DisorderedSequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi522 – 525Prevents secretion from ERPROSITE-ProRule annotation4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0190, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025879_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q13087

Identification of Orthologs from Complete Genome Data

More...OMAi		DYVWSEE

Database of Orthologous Groups

More...OrthoDBi		462118at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q13087

TreeFam database of animal gene trees

More...TreeFami		TF106381

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005792, Prot_disulphide_isomerase
IPR036249, Thioredoxin-like_sf
IPR017937, Thioredoxin_CS
IPR013766, Thioredoxin_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00085, Thioredoxin, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52833, SSF52833, 4 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01130, ER_PDI_fam, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00014, ER_TARGET, 1 hit
PS00194, THIOREDOXIN_1, 2 hits
PS51352, THIOREDOXIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13087-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQLLPVLL LLLLRASCPW GQEQGARSPS EEPPEEEIPK EDGILVLSRH 
        60         70         80         90        100
TLGLALREHP ALLVEFYAPW CGHCQALAPE YSKAAAVLAA ESMVVTLAKV 
       110        120        130        140        150
DGPAQRELAE EFGVTEYPTL KFFRNGNRTH PEEYTGPRDA EGIAEWLRRR 
       160        170        180        190        200
VGPSAMRLED EAAAQALIGG RDLVVIGFFQ DLQDEDVATF LALAQDALDM 
       210        220        230        240        250
TFGLTDRPRL FQQFGLTKDT VVLFKKFDEG RADFPVDEEL GLDLGDLSRF 
       260        270        280        290        300
LVTHSMRLVT EFNSQTSAKI FAARILNHLL LFVNQTLAAH RELLAGFGEA 
       310        320        330        340        350
APRFRGQVLF VVVDVAADNE HVLQYFGLKA EAAPTLRLVN LETTKKYAPV 
       360        370        380        390        400
DGGPVTAASI TAFCHAVLNG QVKPYLLSQE IPPDWDQRPV KTLVGKNFEQ 
       410        420        430        440        450
VAFDETKNVF VKFYAPWCTH CKEMAPAWEA LAEKYQDHED IIIAELDATA 
       460        470        480        490        500
NELDAFAVHG FPTLKYFPAG PGRKVIEYKS TRDLETFSKF LDNGGVLPTE 
       510        520 
EPPEEPAAPF PEPPANSTMG SKEEL
Length:525
Mass (Da):58,206
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB741851AA2C40540
GO
Isoform 2 (identifier: Q13087-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.

Show »
Length:522
Mass (Da):57,850
Checksum:i815CD5F3060B5747
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4J5H0Y4J5_HUMAN
Protein disulfide-isomerase A2
PDIA2
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4TT65Q4TT65_HUMAN
Protein disulfide isomerase family ...
PDIA2 LA16c-314G4.2-007
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50401 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH75029 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAG58339 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96T → M in BAG58339 (PubMed:14702039).Curated1
Sequence conflicti484L → Q in BAG58339 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04808739P → S. Corresponds to variant dbSNP:rs45455191Ensembl.1
Natural variantiVAR_048088119T → R. Corresponds to variant dbSNP:rs45614840Ensembl.1
Natural variantiVAR_048089185E → K. Corresponds to variant dbSNP:rs419949Ensembl.1
Natural variantiVAR_048090286T → M. Corresponds to variant dbSNP:rs2685127Ensembl.1
Natural variantiVAR_048091382P → A. Corresponds to variant dbSNP:rs45529833Ensembl.1
Natural variantiVAR_048092388R → Q. Corresponds to variant dbSNP:rs400037Ensembl.1
Natural variantiVAR_048093502P → S3 PublicationsCorresponds to variant dbSNP:rs1048786Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039292181 – 183Missing in isoform 2. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB127078 mRNA Translation: BAE48734.1
AE006463 Genomic DNA Translation: AAK61223.1
Z69667 Genomic DNA Translation: CAI95586.1
Z69667 Genomic DNA Translation: CAO78188.1
CH471112 Genomic DNA Translation: EAW85838.1
BC000537 mRNA Translation: AAH00537.2
BC075029 mRNA Translation: AAH75029.1 Sequence problems.
U19948 mRNA Translation: AAC50401.1 Sequence problems.
AK295383 mRNA Translation: BAG58339.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42089.1 [Q13087-1]

NCBI Reference Sequences

More...RefSeqi		NP_006840.2, NM_006849.2 [Q13087-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219406; ENSP00000219406; ENSG00000185615
ENST00000404312; ENSP00000384410; ENSG00000185615 [Q13087-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64714

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64714

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000219406.11; ENSP00000219406.7; NM_006849.4; NP_006840.2

UCSC genome browser

More...UCSCi		uc002cgo.2, human [Q13087-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127078 mRNA Translation: BAE48734.1
AE006463 Genomic DNA Translation: AAK61223.1
Z69667 Genomic DNA Translation: CAI95586.1
Z69667 Genomic DNA Translation: CAO78188.1
CH471112 Genomic DNA Translation: EAW85838.1
BC000537 mRNA Translation: AAH00537.2
BC075029 mRNA Translation: AAH75029.1 Sequence problems.
U19948 mRNA Translation: AAC50401.1 Sequence problems.
AK295383 mRNA Translation: BAG58339.1 Different initiation.
CCDSiCCDS42089.1 [Q13087-1]
RefSeqiNP_006840.2, NM_006849.2 [Q13087-1]

3D structure databases

SMRiQ13087
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122240, 24 interactors
IntActiQ13087, 12 interactors
MINTiQ13087
STRINGi9606.ENSP00000219406

PTM databases

GlyConnecti1655, 6 N-Linked glycans (1 site)
GlyGeniQ13087, 3 sites, 8 N-linked glycans (1 site)
iPTMnetiQ13087
PhosphoSitePlusiQ13087

Genetic variation databases

BioMutaiPDIA2
DMDMi21264492

Proteomic databases

MassIVEiQ13087
MaxQBiQ13087
PaxDbiQ13087
PeptideAtlasiQ13087
PRIDEiQ13087
ProteomicsDBi59143 [Q13087-1]
59144 [Q13087-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22619, 373 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		64714

Genome annotation databases

EnsembliENST00000219406; ENSP00000219406; ENSG00000185615
ENST00000404312; ENSP00000384410; ENSG00000185615 [Q13087-2]
GeneIDi64714
KEGGihsa:64714
MANE-SelectiENST00000219406.11; ENSP00000219406.7; NM_006849.4; NP_006840.2
UCSCiuc002cgo.2, human [Q13087-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64714
DisGeNETi64714

GeneCards: human genes, protein and diseases

More...GeneCardsi		PDIA2
HGNCiHGNC:14180, PDIA2
HPAiENSG00000185615, Tissue enriched (pancreas)
MIMi608012, gene
neXtProtiNX_Q13087
OpenTargetsiENSG00000185615
PharmGKBiPA33153
VEuPathDBiHostDB:ENSG00000185615

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0190, Eukaryota
GeneTreeiENSGT00940000161859
HOGENOMiCLU_025879_1_0_1
InParanoidiQ13087
OMAiDYVWSEE
OrthoDBi462118at2759
PhylomeDBiQ13087
TreeFamiTF106381

Enzyme and pathway databases

BRENDAi5.3.4.1, 2681
PathwayCommonsiQ13087
SignaLinkiQ13087

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64714, 6 hits in 1030 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64714
PharosiQ13087, Tbio

Protein Ontology

More...PROi		PR:Q13087
RNActiQ13087, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185615, Expressed in pancreas and 132 other tissues
ExpressionAtlasiQ13087, baseline and differential
GenevisibleiQ13087, HS

Family and domain databases

InterProiView protein in InterPro
IPR005792, Prot_disulphide_isomerase
IPR036249, Thioredoxin-like_sf
IPR017937, Thioredoxin_CS
IPR013766, Thioredoxin_domain
PfamiView protein in Pfam
PF00085, Thioredoxin, 2 hits
SUPFAMiSSF52833, SSF52833, 4 hits
TIGRFAMsiTIGR01130, ER_PDI_fam, 1 hit
PROSITEiView protein in PROSITE
PS00014, ER_TARGET, 1 hit
PS00194, THIOREDOXIN_1, 2 hits
PS51352, THIOREDOXIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDIA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13087
Secondary accession number(s): A6ZJ64
, B4DI27, Q2WGM4, Q4TT67, Q6B010, Q96KJ6, Q9BW95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: February 23, 2022
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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