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Protein

39S ribosomal protein L28, mitochondrial

Gene

MRPL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L28, mitochondrial
Short name:
L28mt
Short name:
MRP-L28
Alternative name(s):
Melanoma antigen p15
Melanoma-associated antigen recognized by T-lymphocytes
Mitochondrial large ribosomal subunit protein bL28m1 Publication
Gene namesi
Name:MRPL28
Synonyms:MAAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000086504.15
HGNCiHGNC:14484 MRPL28
MIMi604853 gene
neXtProtiNX_Q13084

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi10573
PharmGKBiPA30515

Polymorphism and mutation databases

BioMutaiMRPL28
DMDMi85695426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionBy similarityAdd BLAST55
ChainiPRO_000003050656 – 25639S ribosomal protein L28, mitochondrialAdd BLAST201

Proteomic databases

EPDiQ13084
MaxQBiQ13084
PaxDbiQ13084
PeptideAtlasiQ13084
PRIDEiQ13084
ProteomicsDBi59138

PTM databases

iPTMnetiQ13084
PhosphoSitePlusiQ13084
SwissPalmiQ13084

Expressioni

Tissue specificityi

Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

Gene expression databases

BgeeiENSG00000086504 Expressed in 220 organ(s), highest expression level in apex of heart
CleanExiHS_MRPL28
ExpressionAtlasiQ13084 baseline and differential
GenevisibleiQ13084 HS

Organism-specific databases

HPAiCAB033542
HPA030594
HPA055589

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25278503, PubMed:11551941). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503). Interacts with OXA1L.By similarity1 Publication3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115824, 74 interactors
CORUMiQ13084
DIPiDIP-61135N
IntActiQ13084, 42 interactors
MINTiQ13084
STRINGi9606.ENSP00000199706

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13084
SMRiQ13084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3279 Eukaryota
ENOG410XQHX LUCA
GeneTreeiENSGT00390000017359
HOVERGENiHBG083707
InParanoidiQ13084
KOiK02902
OMAiWVGLTLE
OrthoDBiEOG091G0IF3
PhylomeDBiQ13084
TreeFamiTF313040

Family and domain databases

Gene3Di2.30.170.40, 1 hit
InterProiView protein in InterPro
IPR034704 L28p-like
IPR026569 Ribo_L28/L24
IPR037147 Ribo_L28/L24_sf
PANTHERiPTHR13528 PTHR13528, 1 hit
PfamiView protein in Pfam
PF00830 Ribosomal_L28, 1 hit
SUPFAMiSSF143800 SSF143800, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q13084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF
60 70 80 90 100
KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQI YANNDKLSKR
110 120 130 140 150
LKKVWKPQLF EREFYSEILD KKFTVTVTMR TLDLIDEAYG LDFYILKTPK
160 170 180 190 200
EDLCSKFGMD LKRGMLLRLA RQDPQLHPED PERRAAIYDK YKEFAIPEEE
210 220 230 240 250
AEWVGLTLEE AIEKQRLLEE KDPVPLFKIY VAELIQQLQQ QALSEPAVVQ

KRASGQ
Length:256
Mass (Da):30,157
Last modified:January 24, 2006 - v4
Checksum:i6578FD1E98FC5A6E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2IDC6A2IDC6_HUMAN
39S ribosomal protein L28, mitochon...
MRPL28
240Annotation score:
A2IDC7A2IDC7_HUMAN
39S ribosomal protein L28, mitochon...
MRPL28
194Annotation score:
Q4TT37Q4TT37_HUMAN
39S ribosomal protein L28, mitochon...
MRPL28
218Annotation score:
A2IDC5A2IDC5_HUMAN
39S ribosomal protein L28, mitochon...
MRPL28
48Annotation score:

Sequence cautioni

The sequence AAC50181 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK61226 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147K → KASG in AAK61226 (PubMed:11157797).Curated1
Sequence conflicti148 – 150TPK → ASG (PubMed:15616553).Curated3
Sequence conflicti252R → T in AAC50181 (PubMed:7751637).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05421927H → Y2 PublicationsCorresponds to variant dbSNP:rs3194151Ensembl.1
Natural variantiVAR_052024160D → E1 PublicationCorresponds to variant dbSNP:rs11557302Ensembl.1
Natural variantiVAR_061806230Y → C. Corresponds to variant dbSNP:rs13226Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315180 mRNA Translation: BAG37621.1
AE006463 Genomic DNA Translation: AAK61226.1 Sequence problems.
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85827.1
CH471112 Genomic DNA Translation: EAW85829.1
CH471112 Genomic DNA Translation: EAW85832.1
CH471112 Genomic DNA Translation: EAW85834.1
BC000507 mRNA Translation: AAH00507.2
BC000990 mRNA Translation: AAH00990.2
U19796 mRNA Translation: AAC50181.1 Different initiation.
BT009857 mRNA Translation: AAP88859.1
CCDSiCCDS32349.1
RefSeqiNP_006419.2, NM_006428.4
XP_005255098.1, XM_005255041.1
XP_011520653.1, XM_011522351.2
UniGeneiHs.513230

Genome annotation databases

EnsembliENST00000199706; ENSP00000199706; ENSG00000086504
ENST00000389675; ENSP00000374326; ENSG00000086504
GeneIDi10573
KEGGihsa:10573
UCSCiuc002cgs.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315180 mRNA Translation: BAG37621.1
AE006463 Genomic DNA Translation: AAK61226.1 Sequence problems.
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85827.1
CH471112 Genomic DNA Translation: EAW85829.1
CH471112 Genomic DNA Translation: EAW85832.1
CH471112 Genomic DNA Translation: EAW85834.1
BC000507 mRNA Translation: AAH00507.2
BC000990 mRNA Translation: AAH00990.2
U19796 mRNA Translation: AAC50181.1 Different initiation.
BT009857 mRNA Translation: AAP88859.1
CCDSiCCDS32349.1
RefSeqiNP_006419.2, NM_006428.4
XP_005255098.1, XM_005255041.1
XP_011520653.1, XM_011522351.2
UniGeneiHs.513230

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40X1-256[»]
5OOLelectron microscopy3.06X1-256[»]
5OOMelectron microscopy3.03X1-256[»]
ProteinModelPortaliQ13084
SMRiQ13084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115824, 74 interactors
CORUMiQ13084
DIPiDIP-61135N
IntActiQ13084, 42 interactors
MINTiQ13084
STRINGi9606.ENSP00000199706

PTM databases

iPTMnetiQ13084
PhosphoSitePlusiQ13084
SwissPalmiQ13084

Polymorphism and mutation databases

BioMutaiMRPL28
DMDMi85695426

Proteomic databases

EPDiQ13084
MaxQBiQ13084
PaxDbiQ13084
PeptideAtlasiQ13084
PRIDEiQ13084
ProteomicsDBi59138

Protocols and materials databases

DNASUi10573
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199706; ENSP00000199706; ENSG00000086504
ENST00000389675; ENSP00000374326; ENSG00000086504
GeneIDi10573
KEGGihsa:10573
UCSCiuc002cgs.3 human

Organism-specific databases

CTDi10573
DisGeNETi10573
EuPathDBiHostDB:ENSG00000086504.15
GeneCardsiMRPL28
HGNCiHGNC:14484 MRPL28
HPAiCAB033542
HPA030594
HPA055589
MIMi604853 gene
neXtProtiNX_Q13084
PharmGKBiPA30515
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3279 Eukaryota
ENOG410XQHX LUCA
GeneTreeiENSGT00390000017359
HOVERGENiHBG083707
InParanoidiQ13084
KOiK02902
OMAiWVGLTLE
OrthoDBiEOG091G0IF3
PhylomeDBiQ13084
TreeFamiTF313040

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL28 human
GeneWikiiMRPL28
GenomeRNAii10573
PROiPR:Q13084
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086504 Expressed in 220 organ(s), highest expression level in apex of heart
CleanExiHS_MRPL28
ExpressionAtlasiQ13084 baseline and differential
GenevisibleiQ13084 HS

Family and domain databases

Gene3Di2.30.170.40, 1 hit
InterProiView protein in InterPro
IPR034704 L28p-like
IPR026569 Ribo_L28/L24
IPR037147 Ribo_L28/L24_sf
PANTHERiPTHR13528 PTHR13528, 1 hit
PfamiView protein in Pfam
PF00830 Ribosomal_L28, 1 hit
SUPFAMiSSF143800 SSF143800, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM28_HUMAN
AccessioniPrimary (citable) accession number: Q13084
Secondary accession number(s): B2RCM4
, D3DU46, Q4TT39, Q96S26, Q9BQD8, Q9BR04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 155 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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