UniProtKB - Q13077 (TRAF1_HUMAN)
TNF receptor-associated factor 1
TRAF1
Functioni
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
6 PublicationsCaution
GO - Molecular functioni
- identical protein binding Source: IntAct
- thioesterase binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- positive regulation of JNK cascade Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- protein-containing complex assembly Source: ProtInc
- protein K63-linked ubiquitination Source: GO_Central
- regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- tumor necrosis factor-mediated signaling pathway Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q13077 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway |
SignaLinki | Q13077 |
SIGNORi | Q13077 |
Names & Taxonomyi
Protein namesi | Recommended name: TNF receptor-associated factor 1Alternative name(s): Epstein-Barr virus-induced protein 6 |
Gene namesi | Name:TRAF1 Synonyms:EBI6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12031, TRAF1 |
MIMi | 601711, gene |
neXtProti | NX_Q13077 |
VEuPathDBi | HostDB:ENSG00000056558 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: ProtInc
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 163 | D → A: Abolishes CASP8-mediated cleavage. 2 Publications | 1 | |
Mutagenesisi | 185 | K → R: Nearly abolished ubiquitination; when associated with R-193. 1 Publication | 1 | |
Mutagenesisi | 193 | K → R: Nearly abolished ubiquitination; when associated with R-185. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7185 |
OpenTargetsi | ENSG00000056558 |
PharmGKBi | PA36708 |
Miscellaneous databases
Pharosi | Q13077, Tbio |
Genetic variation databases
BioMutai | TRAF1 |
DMDMi | 6707734 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056397 | 1 – 416 | TNF receptor-associated factor 1Add BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 146 | PhosphoserineBy similarity | 1 | |
Cross-linki | 185 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 193 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 163 – 164 | Cleavage; by CASP8 | 2 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q13077 |
MassIVEi | Q13077 |
MaxQBi | Q13077 |
PaxDbi | Q13077 |
PeptideAtlasi | Q13077 |
PRIDEi | Q13077 |
ProteomicsDBi | 59136 [Q13077-1] 59137 [Q13077-2] |
PTM databases
iPTMneti | Q13077 |
PhosphoSitePlusi | Q13077 |
Expressioni
Gene expression databases
Bgeei | ENSG00000056558, Expressed in lymph node and 134 other tissues |
Genevisiblei | Q13077, HS |
Organism-specific databases
HPAi | ENSG00000056558, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Homotrimer (PubMed:15383523, PubMed:20385093). Heterotrimer with TRAF2 (PubMed:8069916, PubMed:19287455, PubMed:20385093).
Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:10037686, PubMed:10809768, PubMed:10903733, PubMed:11035039, PubMed:11313261, PubMed:16323247, PubMed:19287455, PubMed:19698991, PubMed:8069916, PubMed:8627180, PubMed:8710854, PubMed:9418902, PubMed:9607925, PubMed:9642260, PubMed:9705938, PubMed:9718306, PubMed:9774460).
Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2 (PubMed:11907583, PubMed:20447407, PubMed:20385093).
Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity).
Interacts with MAP3K14.
Interacts with GPS2 (By similarity).
By similarity21 PublicationsBinary interactionsi
Q13077
GO - Molecular functioni
- identical protein binding Source: IntAct
- thioesterase binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113037, 301 interactors |
DIPi | DIP-27514N |
IntActi | Q13077, 255 interactors |
MINTi | Q13077 |
STRINGi | 9606.ENSP00000362994 |
Miscellaneous databases
RNActi | Q13077, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13077 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13077 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 266 – 412 | MATHPROSITE-ProRule annotationAdd BLAST | 147 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 182 – 264 | Add BLAST | 83 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00940000161076 |
HOGENOMi | CLU_021061_0_0_1 |
InParanoidi | Q13077 |
OMAi | PKCRGDD |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q13077 |
TreeFami | TF321154 |
Family and domain databases
CDDi | cd03779, MATH_TRAF1, 1 hit |
Gene3Di | 2.60.210.10, 1 hit |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027136, TRAF1 IPR037306, TRAF1_MATH IPR032070, TRAF_BIRC3-bd |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF96, PTHR10131:SF96, 1 hit |
Pfami | View protein in Pfam PF16673, TRAF_BIRC3_bd, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE
60 70 80 90 100
DQICPKCRGE DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS
110 120 130 140 150
PQSVQEHEVT SQTSHLNLLL GFMKQWKARL GCGLESGPMA LEQNLSDLQL
160 170 180 190 200
QAAVEVAGDL EVDCYRAPCS ESQEELALQH FMKEKLLAEL EGKLRVFENI
210 220 230 240 250
VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ QTLAQKDQAL
260 270 280 290 300
GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK
310 320 330 340 350
YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL
360 370 380 390 400
DQNNREHAID AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY
410
VKDDTMFLKC IVETST
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054161 | 139 | M → T1 PublicationCorresponds to variant dbSNP:rs113495277Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043092 | 1 – 122 | Missing in isoform 2. 1 PublicationAdd BLAST | 122 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19261 mRNA Translation: AAA62309.1 AK090468 mRNA Translation: BAC03449.1 Frameshift. AK295959 mRNA Translation: BAG58739.1 AK315476 mRNA Translation: BAG37860.1 AL832989 mRNA Translation: CAH56343.1 BT019408 mRNA Translation: AAV38215.1 AC006430 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87479.1 BC024145 mRNA Translation: AAH24145.1 |
CCDSi | CCDS55335.1 [Q13077-2] CCDS6825.1 [Q13077-1] |
PIRi | B55649 |
RefSeqi | NP_001177874.1, NM_001190945.1 [Q13077-1] NP_001177876.1, NM_001190947.1 [Q13077-2] NP_005649.1, NM_005658.4 [Q13077-1] |
Genome annotation databases
Ensembli | ENST00000373887; ENSP00000362994; ENSG00000056558 ENST00000540010; ENSP00000443183; ENSG00000056558 ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2] |
GeneIDi | 7185 |
KEGGi | hsa:7185 |
MANE-Selecti | ENST00000373887.8; ENSP00000362994.3; NM_005658.5; NP_005649.1 |
UCSCi | uc004bku.3, human [Q13077-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U19261 mRNA Translation: AAA62309.1 AK090468 mRNA Translation: BAC03449.1 Frameshift. AK295959 mRNA Translation: BAG58739.1 AK315476 mRNA Translation: BAG37860.1 AL832989 mRNA Translation: CAH56343.1 BT019408 mRNA Translation: AAV38215.1 AC006430 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87479.1 BC024145 mRNA Translation: AAH24145.1 |
CCDSi | CCDS55335.1 [Q13077-2] CCDS6825.1 [Q13077-1] |
PIRi | B55649 |
RefSeqi | NP_001177874.1, NM_001190945.1 [Q13077-1] NP_001177876.1, NM_001190947.1 [Q13077-2] NP_005649.1, NM_005658.4 [Q13077-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3M0D | X-ray | 2.80 | C | 181-244 | [»] | |
5E1T | X-ray | 2.80 | A/B/C | 220-416 | [»] | |
5H10 | X-ray | 3.21 | A/B/C | 220-416 | [»] | |
SMRi | Q13077 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113037, 301 interactors |
DIPi | DIP-27514N |
IntActi | Q13077, 255 interactors |
MINTi | Q13077 |
STRINGi | 9606.ENSP00000362994 |
PTM databases
iPTMneti | Q13077 |
PhosphoSitePlusi | Q13077 |
Genetic variation databases
BioMutai | TRAF1 |
DMDMi | 6707734 |
Proteomic databases
jPOSTi | Q13077 |
MassIVEi | Q13077 |
MaxQBi | Q13077 |
PaxDbi | Q13077 |
PeptideAtlasi | Q13077 |
PRIDEi | Q13077 |
ProteomicsDBi | 59136 [Q13077-1] 59137 [Q13077-2] |
Protocols and materials databases
Antibodypediai | 807, 378 antibodies from 41 providers |
DNASUi | 7185 |
Genome annotation databases
Ensembli | ENST00000373887; ENSP00000362994; ENSG00000056558 ENST00000540010; ENSP00000443183; ENSG00000056558 ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2] |
GeneIDi | 7185 |
KEGGi | hsa:7185 |
MANE-Selecti | ENST00000373887.8; ENSP00000362994.3; NM_005658.5; NP_005649.1 |
UCSCi | uc004bku.3, human [Q13077-1] |
Organism-specific databases
CTDi | 7185 |
DisGeNETi | 7185 |
GeneCardsi | TRAF1 |
HGNCi | HGNC:12031, TRAF1 |
HPAi | ENSG00000056558, Tissue enhanced (lymphoid) |
MIMi | 601711, gene |
neXtProti | NX_Q13077 |
OpenTargetsi | ENSG00000056558 |
PharmGKBi | PA36708 |
VEuPathDBi | HostDB:ENSG00000056558 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00940000161076 |
HOGENOMi | CLU_021061_0_0_1 |
InParanoidi | Q13077 |
OMAi | PKCRGDD |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q13077 |
TreeFami | TF321154 |
Enzyme and pathway databases
PathwayCommonsi | Q13077 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway |
SignaLinki | Q13077 |
SIGNORi | Q13077 |
Miscellaneous databases
BioGRID-ORCSi | 7185, 8 hits in 1043 CRISPR screens |
ChiTaRSi | TRAF1, human |
EvolutionaryTracei | Q13077 |
GeneWikii | TRAF1 |
GenomeRNAii | 7185 |
Pharosi | Q13077, Tbio |
PROi | PR:Q13077 |
RNActi | Q13077, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000056558, Expressed in lymph node and 134 other tissues |
Genevisiblei | Q13077, HS |
Family and domain databases
CDDi | cd03779, MATH_TRAF1, 1 hit |
Gene3Di | 2.60.210.10, 1 hit |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027136, TRAF1 IPR037306, TRAF1_MATH IPR032070, TRAF_BIRC3-bd |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF96, PTHR10131:SF96, 1 hit |
Pfami | View protein in Pfam PF16673, TRAF_BIRC3_bd, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAF1_HUMAN | |
Accessioni | Q13077Primary (citable) accession number: Q13077 Secondary accession number(s): B4DJ77, Q658U1, Q8NF13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references