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Entry version 195 (22 Apr 2020)
Sequence version 1 (01 Nov 1996)
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Protein

TNF receptor-associated factor 1

Gene

TRAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.6 Publications

Caution

Lacks a RING domain and has therefore no E3 ubiquitin-protein ligase activity by itself.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q13077

SIGNOR Signaling Network Open Resource

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SIGNORi
Q13077

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TNF receptor-associated factor 1
Alternative name(s):
Epstein-Barr virus-induced protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAF1
Synonyms:EBI6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12031 TRAF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601711 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13077

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163D → A: Abolishes CASP8-mediated cleavage. 2 Publications1
Mutagenesisi185K → R: Nearly abolished ubiquitination; when associated with R-193. 1 Publication1
Mutagenesisi193K → R: Nearly abolished ubiquitination; when associated with R-185. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7185

Open Targets

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OpenTargetsi
ENSG00000056558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36708

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13077 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TRAF1

Domain mapping of disease mutations (DMDM)

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DMDMi
6707734

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563971 – 416TNF receptor-associated factor 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei163 – 164Cleavage; by CASP82

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13077

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13077

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13077

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13077

PeptideAtlas

More...
PeptideAtlasi
Q13077

PRoteomics IDEntifications database

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PRIDEi
Q13077

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59136 [Q13077-1]
59137 [Q13077-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13077

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13077

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000056558 Expressed in right coronary artery and 116 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13077 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000056558 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:15383523, PubMed:20385093). Heterotrimer with TRAF2 (PubMed:8069916, PubMed:19287455, PubMed:20385093).

Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2 (PubMed:10037686, PubMed:10809768, PubMed:10903733, PubMed:11035039, PubMed:11313261, PubMed:16323247, PubMed:19287455, PubMed:19698991, PubMed:8069916, PubMed:8627180, PubMed:8710854, PubMed:9418902, PubMed:9607925, PubMed:9642260, PubMed:9705938, PubMed:9718306, PubMed:9774460).

Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2 (PubMed:11907583, PubMed:20447407, PubMed:20385093).

Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity).

Interacts with MAP3K14.

Interacts with GPS2 (By similarity).

By similarity21 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q13077
With#Exp.IntAct
B2R8Y43EBI-359224,EBI-10175581
itself4EBI-359224,EBI-359224
Q5W1503EBI-359224,EBI-10248148
Q96EJ45EBI-359224,EBI-750454
Q9NWL93EBI-359224,EBI-10315054
A1CF [Q9NQ94]6EBI-359224,EBI-2809489
ACTN3 [Q08043]3EBI-359224,EBI-2880652
AKAP17A - isoform 3 [Q02040-3]3EBI-359224,EBI-10222656
AQP1 [P29972]3EBI-359224,EBI-745213
ARID5A [Q03989]3EBI-359224,EBI-948603
ARSJ [Q8N5N6]3EBI-359224,EBI-10266832
BARD1 [A0AVN2]3EBI-359224,EBI-9977322
BARD1 [Q99728]3EBI-359224,EBI-473181
BCL6 [P41182]5EBI-359224,EBI-765407
BEX2 [Q9BXY8]3EBI-359224,EBI-745073
BIRC2 [Q13490]5EBI-359224,EBI-514538
BIRC3 [Q13489]2EBI-359224,EBI-517709
C1orf109 [Q9NX04]6EBI-359224,EBI-8643161
C1orf216 [Q8TAB5]6EBI-359224,EBI-747505
C2CD6 [Q53TS8]3EBI-359224,EBI-739879
C4orf45 [Q96LM5]3EBI-359224,EBI-12020542
C5orf30 [Q96GV9]3EBI-359224,EBI-2350695
CARHSP1 [Q9Y2V2]3EBI-359224,EBI-718719
CCDC116 [Q8IYX3]6EBI-359224,EBI-744311
CCDC120 [Q96HB5]3EBI-359224,EBI-744556
CCDC120 - isoform 4 [Q96HB5-4]4EBI-359224,EBI-10185348
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-359224,EBI-10247802
CCDC185 [Q8N715]3EBI-359224,EBI-740814
CCDC198 [Q9NVL8]3EBI-359224,EBI-10238351
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-359224,EBI-10175300
CDCA3 [Q99618]6EBI-359224,EBI-739534
CDK18 [Q07002]3EBI-359224,EBI-746238
CDKN1A [P38936]3EBI-359224,EBI-375077
CDKN2B [P42772]7EBI-359224,EBI-711280
CFLAR [O15519]6EBI-359224,EBI-514941
CHCHD3 [Q9NX63]3EBI-359224,EBI-743375
COX5B [P10606]3EBI-359224,EBI-1053725
CRACR2A [Q9BSW2]3EBI-359224,EBI-739773
CRY2 [Q49AN0]3EBI-359224,EBI-2212355
CRYGA [Q24JT5]3EBI-359224,EBI-10239205
CYB5R2 [Q6BCY4]3EBI-359224,EBI-744761
DEPTOR [Q8TB45]3EBI-359224,EBI-2359040
DMRT3 [Q9NQL9]3EBI-359224,EBI-9679045
DOK3 [Q7L591]4EBI-359224,EBI-2834978
DOK3 - isoform 3 [Q7L591-3]3EBI-359224,EBI-10694655
DUSP13 [Q9UII6]3EBI-359224,EBI-749800
DUSP21 [Q9H596]3EBI-359224,EBI-7357329
DUSP4 [Q13115]3EBI-359224,EBI-6591081
EBF2 [Q9HAK2]3EBI-359224,EBI-12267154
ECH1 [Q13011]4EBI-359224,EBI-711968
EHHADH [Q08426]3EBI-359224,EBI-2339219
ENKD1 [Q9H0I2]3EBI-359224,EBI-744099
EWSR1 [Q01844]3EBI-359224,EBI-739737
FAM161A [Q3B820]5EBI-359224,EBI-719941
FAM161B [Q96MY7]3EBI-359224,EBI-7225287
FAM86C1 [Q9NVL1]3EBI-359224,EBI-751617
FBF1 - isoform 6 [Q8TES7-6]3EBI-359224,EBI-10244131
FBXL18 [Q96D16]3EBI-359224,EBI-744419
FOSL2 [P15408]5EBI-359224,EBI-3893419
GADD45GIP1 [Q8TAE8]3EBI-359224,EBI-372506
GATA1 - isoform 2 [P15976-2]3EBI-359224,EBI-9090198
GATA2 [P23769]3EBI-359224,EBI-2806671
GATAD2B [Q8WXI9]4EBI-359224,EBI-923440
GCA [P28676]3EBI-359224,EBI-947242
GCM2 [O75603]3EBI-359224,EBI-10188645
GEM [P55040]6EBI-359224,EBI-744104
GIT2 [Q14161]2EBI-359224,EBI-1046878
GLIS3 - isoform 2 [Q8NEA6-2]3EBI-359224,EBI-12232117
GLRX3 [O76003]5EBI-359224,EBI-374781
GMCL2 [Q8NEA9]3EBI-359224,EBI-745707
GNG5 [P63218]3EBI-359224,EBI-10220734
GORASP2 [Q9H8Y8]7EBI-359224,EBI-739467
HAUS1 [Q96CS2]3EBI-359224,EBI-2514791
HELT [A0A087WSW0]3EBI-359224,EBI-12057631
HEY2 [Q9UBP5]6EBI-359224,EBI-750630
HGS [O14964]3EBI-359224,EBI-740220
HNRNPM [P52272]3EBI-359224,EBI-486809
HOXA1 [P49639]3EBI-359224,EBI-740785
Hoxa1 [P09022] from Mus musculus.4EBI-359224,EBI-3957603
HOXB5 [P09067]3EBI-359224,EBI-3893317
HOXC8 [P31273]3EBI-359224,EBI-1752118
HOXD12 [P35452]3EBI-359224,EBI-10206752
JOSD1 [Q15040]3EBI-359224,EBI-2510602
KANK2 [Q63ZY3]3EBI-359224,EBI-2556193
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-359224,EBI-10188326
KLHL38 [Q2WGJ6]3EBI-359224,EBI-6426443
KRT3 [P12035]3EBI-359224,EBI-2430095
KRT75 [O95678]3EBI-359224,EBI-2949715
LATS1 [Q6PJG3]3EBI-359224,EBI-10253976
LCOR [Q96JN0]3EBI-359224,EBI-746045
LCOR - isoform 2 [Q96JN0-2]3EBI-359224,EBI-10961483
LIN37 [Q96GY3]3EBI-359224,EBI-748884
LMNTD2 [Q8IXW0]3EBI-359224,EBI-12028858
LNX1 [Q8TBB1]7EBI-359224,EBI-739832
LRRN1 [Q6UXK5]3EBI-359224,EBI-12136157
MAPRE2 [Q15555]9EBI-359224,EBI-739717
MATR3 [P43243]3EBI-359224,EBI-352602
METTL17 [Q9H7H0]7EBI-359224,EBI-749353
MGC50722 [Q8IVT4]3EBI-359224,EBI-14086479
MORN3 [Q6PF18]8EBI-359224,EBI-9675802
MOS [P00540]6EBI-359224,EBI-1757866
MSGN1 [A6NI15]3EBI-359224,EBI-11991020
MYEF2 - isoform 2 [Q9P2K5-2]3EBI-359224,EBI-10318831
MYOZ1 [Q9NP98]3EBI-359224,EBI-744402
NEBL [O76041]4EBI-359224,EBI-2880203
NUFIP2 [Q7Z417]3EBI-359224,EBI-1210753
NUP58 [Q9BVL2]9EBI-359224,EBI-2811583
OLIG3 [Q7RTU3]6EBI-359224,EBI-10225049
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-359224,EBI-11022007
PBX3 [Q5JS98]3EBI-359224,EBI-10244393
PBX3 [Q96AL5]3EBI-359224,EBI-741171
PDE4D [Q08499]3EBI-359224,EBI-1642831
PHF21A [Q96BD5]4EBI-359224,EBI-745085
PIN1 [Q13526]3EBI-359224,EBI-714158
PITX1 [P78337]3EBI-359224,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-359224,EBI-12138495
PKN1 [Q16512]3EBI-359224,EBI-602382
PLEKHN1 [Q494U1]4EBI-359224,EBI-10241513
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-359224,EBI-12014286
POM121L1P [Q3SYA9]3EBI-359224,EBI-10241319
POP5 [Q969H6]6EBI-359224,EBI-366525
PPP1R13B [Q96KQ4]3EBI-359224,EBI-1105153
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-359224,EBI-12000762
PRDM7 [Q9NQW5]3EBI-359224,EBI-10312471
PSMA1 [P25786]3EBI-359224,EBI-359352
PSMB1 [P20618]7EBI-359224,EBI-372273
QRICH1 [Q2TAL8]6EBI-359224,EBI-2798044
RASAL2 [Q9UJF2]3EBI-359224,EBI-359444
RASSF5 [Q8WWW0]3EBI-359224,EBI-367390
RBM41 [Q96IZ5]3EBI-359224,EBI-740773
RBM45 [Q8IUH3]3EBI-359224,EBI-2512147
RBM45 - isoform 3 [Q8IUH3-3]3EBI-359224,EBI-10964453
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-359224,EBI-1504830
RIPK1 [Q13546]6EBI-359224,EBI-358507
RIPOR3 [Q96MK2]3EBI-359224,EBI-12010512
RIPPLY1 [Q0D2K3]3EBI-359224,EBI-10226430
RTP5 [Q14D33]3EBI-359224,EBI-10217913
SAMD11 [Q96NU1]3EBI-359224,EBI-14067109
SCNM1 [Q9BWG6]8EBI-359224,EBI-748391
SHC3 [Q92529]3EBI-359224,EBI-79084
SHFL [Q9NUL5]3EBI-359224,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-359224,EBI-11955083
SIK3 - isoform 3 [Q9Y2K2-7]3EBI-359224,EBI-17172855
SLC25A48 [Q6ZT89]3EBI-359224,EBI-10255185
SLC25A6 [P12236]3EBI-359224,EBI-356254
SNRNP25 [Q9BV90]3EBI-359224,EBI-9675976
SNW1 [Q13573]3EBI-359224,EBI-632715
SOHLH1 [Q5JUK2]3EBI-359224,EBI-12288855
SPATA46 [Q5T0L3]3EBI-359224,EBI-750105
SPG21 [Q9NZD8]6EBI-359224,EBI-742688
SSC5D [A1L4H1]3EBI-359224,EBI-10172867
STK3 [Q13188]6EBI-359224,EBI-992580
SYCE1 [Q8N0S2]3EBI-359224,EBI-6872807
TBC1D8 [O95759]3EBI-359224,EBI-10979580
TBX18 [O95935]3EBI-359224,EBI-12085364
TCEA2 [Q15560]3EBI-359224,EBI-710310
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-359224,EBI-11746252
TCL1A [P56279]8EBI-359224,EBI-749995
TEAD4 [D3DUQ6]3EBI-359224,EBI-10176734
TEAD4 [Q15561]6EBI-359224,EBI-747736
TFAP2D [Q7Z6R9]3EBI-359224,EBI-11952651
TFAP4 [Q01664]6EBI-359224,EBI-2514218
TFPT [A0A024R4Q5]4EBI-359224,EBI-11527449
THAP7 [Q9BT49]6EBI-359224,EBI-741350
TLE5 [Q08117]3EBI-359224,EBI-717810
TLE5 - isoform 2 [Q08117-2]6EBI-359224,EBI-11741437
TRAF2 [Q12933]11EBI-359224,EBI-355744
TRAF6 [Q9Y4K3]17EBI-359224,EBI-359276
TRIM23 [P36406]3EBI-359224,EBI-740098
TRIM42 [Q8IWZ5]3EBI-359224,EBI-5235829
TRPV6 [Q9Y260]3EBI-359224,EBI-750052
TSHZ2 [Q9NRE2]3EBI-359224,EBI-10687282
TSSC4 [Q9Y5U2]3EBI-359224,EBI-717229
USP2 [O75604]3EBI-359224,EBI-743272
UTP14C [Q5TAP6]3EBI-359224,EBI-11737646
VEZF1 [Q14119]3EBI-359224,EBI-11980193
WAC [Q9BTA9]3EBI-359224,EBI-749118
yscK [P69974] from Yersinia pestis.2EBI-359224,EBI-2842860
ZBTB16 [Q05516]5EBI-359224,EBI-711925
ZC2HC1C [Q53FD0]3EBI-359224,EBI-740767
ZFYVE21 [Q9BQ24]3EBI-359224,EBI-2849569
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-359224,EBI-8656416
ZIC1 [Q15915]3EBI-359224,EBI-11963196
ZNF124 [Q15973]6EBI-359224,EBI-2555767
ZNF20 [P17024]6EBI-359224,EBI-717634
ZNF23 [P17027]3EBI-359224,EBI-5657766
ZNF417 [Q8TAU3]3EBI-359224,EBI-740727
ZNF440 [Q8IYI8]7EBI-359224,EBI-726439
ZNF490 [Q9ULM2]3EBI-359224,EBI-1105370
ZNF502 [Q8TBZ5]7EBI-359224,EBI-10273699
ZNF512B [Q96KM6]7EBI-359224,EBI-1049952
ZNF564 [Q8TBZ8]6EBI-359224,EBI-10273713
ZNF572 [Q7Z3I7]6EBI-359224,EBI-10172590
ZNF581 [Q9P0T4]3EBI-359224,EBI-745520
ZNF587 [Q96SQ5]6EBI-359224,EBI-6427977
ZNF627 [Q7L945]3EBI-359224,EBI-2797561
ZNF648 [Q5T619]3EBI-359224,EBI-11985915
ZNF662 - isoform 3 [Q6ZS27-3]3EBI-359224,EBI-10255155
ZNF669 [Q96BR6]3EBI-359224,EBI-12006574
ZNF688 [A0A0S2Z5X4]3EBI-359224,EBI-16429014
ZNF844 [Q08AG5]3EBI-359224,EBI-10225757

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113037, 236 interactors

Database of interacting proteins

More...
DIPi
DIP-27514N

Protein interaction database and analysis system

More...
IntActi
Q13077, 253 interactors

Molecular INTeraction database

More...
MINTi
Q13077

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362994

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13077 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13077

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13077

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 412MATHPROSITE-ProRule annotationAdd BLAST147

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili182 – 264Add BLAST83

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.1 Publication
The MATH/TRAF domain binds to receptor cytoplasmic domains.1 Publication
Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISDN Eukaryota
ENOG410YE68 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021061_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13077

KEGG Orthology (KO)

More...
KOi
K03172

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKQWKAQ

Database of Orthologous Groups

More...
OrthoDBi
918518at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13077

TreeFam database of animal gene trees

More...
TreeFami
TF321154

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03779 MATH_TRAF1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.210.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027136 TRAF1
IPR037306 TRAF1_MATH
IPR032070 TRAF_BIRC3-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10131:SF96 PTHR10131:SF96, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16673 TRAF_BIRC3_bd, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015614 TRAF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00061 MATH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599 SSF49599, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50144 MATH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13077-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE
60 70 80 90 100
DQICPKCRGE DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS
110 120 130 140 150
PQSVQEHEVT SQTSHLNLLL GFMKQWKARL GCGLESGPMA LEQNLSDLQL
160 170 180 190 200
QAAVEVAGDL EVDCYRAPCS ESQEELALQH FMKEKLLAEL EGKLRVFENI
210 220 230 240 250
VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ QTLAQKDQAL
260 270 280 290 300
GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK
310 320 330 340 350
YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL
360 370 380 390 400
DQNNREHAID AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY
410
VKDDTMFLKC IVETST
Length:416
Mass (Da):46,164
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA956A123A40D284A
GO
Isoform 2 (identifier: Q13077-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Show »
Length:294
Mass (Da):33,296
Checksum:i99A72217E03E143C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03449 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054161139M → T1 PublicationCorresponds to variant dbSNP:rs113495277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430921 – 122Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19261 mRNA Translation: AAA62309.1
AK090468 mRNA Translation: BAC03449.1 Frameshift.
AK295959 mRNA Translation: BAG58739.1
AK315476 mRNA Translation: BAG37860.1
AL832989 mRNA Translation: CAH56343.1
BT019408 mRNA Translation: AAV38215.1
AC006430 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87479.1
BC024145 mRNA Translation: AAH24145.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55335.1 [Q13077-2]
CCDS6825.1 [Q13077-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
B55649

NCBI Reference Sequences

More...
RefSeqi
NP_001177874.1, NM_001190945.1 [Q13077-1]
NP_001177876.1, NM_001190947.1 [Q13077-2]
NP_005649.1, NM_005658.4 [Q13077-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373887; ENSP00000362994; ENSG00000056558 [Q13077-1]
ENST00000540010; ENSP00000443183; ENSG00000056558 [Q13077-1]
ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7185

UCSC genome browser

More...
UCSCi
uc004bku.3 human [Q13077-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19261 mRNA Translation: AAA62309.1
AK090468 mRNA Translation: BAC03449.1 Frameshift.
AK295959 mRNA Translation: BAG58739.1
AK315476 mRNA Translation: BAG37860.1
AL832989 mRNA Translation: CAH56343.1
BT019408 mRNA Translation: AAV38215.1
AC006430 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87479.1
BC024145 mRNA Translation: AAH24145.1
CCDSiCCDS55335.1 [Q13077-2]
CCDS6825.1 [Q13077-1]
PIRiB55649
RefSeqiNP_001177874.1, NM_001190945.1 [Q13077-1]
NP_001177876.1, NM_001190947.1 [Q13077-2]
NP_005649.1, NM_005658.4 [Q13077-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M0DX-ray2.80C181-244[»]
5E1TX-ray2.80A/B/C220-416[»]
5H10X-ray3.21A/B/C220-416[»]
SMRiQ13077
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113037, 236 interactors
DIPiDIP-27514N
IntActiQ13077, 253 interactors
MINTiQ13077
STRINGi9606.ENSP00000362994

PTM databases

iPTMnetiQ13077
PhosphoSitePlusiQ13077

Polymorphism and mutation databases

BioMutaiTRAF1
DMDMi6707734

Proteomic databases

jPOSTiQ13077
MassIVEiQ13077
MaxQBiQ13077
PaxDbiQ13077
PeptideAtlasiQ13077
PRIDEiQ13077
ProteomicsDBi59136 [Q13077-1]
59137 [Q13077-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
807 356 antibodies

The DNASU plasmid repository

More...
DNASUi
7185

Genome annotation databases

EnsembliENST00000373887; ENSP00000362994; ENSG00000056558 [Q13077-1]
ENST00000540010; ENSP00000443183; ENSG00000056558 [Q13077-1]
ENST00000546084; ENSP00000438583; ENSG00000056558 [Q13077-2]
GeneIDi7185
KEGGihsa:7185
UCSCiuc004bku.3 human [Q13077-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7185
DisGeNETi7185

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRAF1
HGNCiHGNC:12031 TRAF1
HPAiENSG00000056558 Low tissue specificity
MIMi601711 gene
neXtProtiNX_Q13077
OpenTargetsiENSG00000056558
PharmGKBiPA36708

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISDN Eukaryota
ENOG410YE68 LUCA
GeneTreeiENSGT00940000161076
HOGENOMiCLU_021061_0_0_1
InParanoidiQ13077
KOiK03172
OMAiMKQWKAQ
OrthoDBi918518at2759
PhylomeDBiQ13077
TreeFamiTF321154

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling
R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway
SignaLinkiQ13077
SIGNORiQ13077

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRAF1 human
EvolutionaryTraceiQ13077

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7185
PharosiQ13077 Tbio

Protein Ontology

More...
PROi
PR:Q13077
RNActiQ13077 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000056558 Expressed in right coronary artery and 116 other tissues
GenevisibleiQ13077 HS

Family and domain databases

CDDicd03779 MATH_TRAF1, 1 hit
Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027136 TRAF1
IPR037306 TRAF1_MATH
IPR032070 TRAF_BIRC3-bd
PANTHERiPTHR10131:SF96 PTHR10131:SF96, 1 hit
PfamiView protein in Pfam
PF16673 TRAF_BIRC3_bd, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRAF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13077
Secondary accession number(s): B4DJ77, Q658U1, Q8NF13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 22, 2020
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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