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Protein

G antigen 6

Gene

GAGE6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 6
Short name:
GAGE-6
Alternative name(s):
Cancer/testis antigen 4.6
Short name:
CT4.6
Gene namesi
Name:GAGE6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4103 GAGE6
MIMi300599 gene
neXtProtiNX_Q13070

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483441 – 117G antigen 6Add BLAST117

Proteomic databases

MaxQBiQ13070
PeptideAtlasiQ13070
PRIDEiQ13070
ProteomicsDBi59133

PTM databases

iPTMnetiQ13070
PhosphoSitePlusiQ13070

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

CleanExiHS_GAGE6

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ13070, 2 interactors

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
HOVERGENiHBG056227
InParanoidiQ13070

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q13070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEVDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,892
Last modified:November 1, 1996 - v1
Checksum:i234A865E3FCCCD06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19147 mRNA Translation: AAA82749.1
RefSeqiNP_001467.1, NM_001476.1
UniGeneiHs.632808

Genome annotation databases

GeneIDi2578
KEGGihsa:2578

Similar proteinsi

Entry informationi

Entry nameiGAGE6_HUMAN
AccessioniPrimary (citable) accession number: Q13070
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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