Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G antigen 1

Gene

GAGE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

GO - Biological processi

  • cellular defense response Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 1
Short name:
GAGE-1
Alternative name(s):
Antigen MZ2-F
Cancer/testis antigen 4.1
Short name:
CT4.1
Gene namesi
Name:GAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000205777.17
HGNCiHGNC:4098 GAGE1
MIMi300594 gene
neXtProtiNX_Q13065

Pathology & Biotechi

Organism-specific databases

DisGeNETi2543
2576
2577
OpenTargetsiENSG00000205777

Polymorphism and mutation databases

DMDMi332278184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483391 – 139G antigen 1Add BLAST139

Proteomic databases

MaxQBiQ13065
PaxDbiQ13065
PeptideAtlasiQ13065
PRIDEiQ13065
ProteomicsDBi59128

PTM databases

iPTMnetiQ13065
PhosphoSitePlusiQ13065

Expressioni

Tissue specificityi

Expressed in a variety of tumor tissues but not in normal tissues, except testis.

Gene expression databases

BgeeiENSG00000205777
CleanExiHS_GAGE1
ExpressionAtlasiQ13065 baseline and differential
GenevisibleiQ13065 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ13065, 3 interactors
STRINGi9606.ENSP00000371128

Structurei

3D structure databases

ProteinModelPortaliQ13065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiQ13065
OMAiCECEKQS
PhylomeDBiQ13065
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q13065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110 120 130
NPEEVKTPEE EMRSHYVAQT GILWLLMNNC FLNLSPRKP
Length:139
Mass (Da):15,610
Last modified:May 3, 2011 - v2
Checksum:iAEF5EA1BC7F59811
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11Missing in AAA82744 (PubMed:7544395).Curated1
Sequence conflicti19Q → E in AAA82744 (PubMed:7544395).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19142 mRNA Translation: AAA82744.1
AC142496 Genomic DNA No translation available.
AC142497 Genomic DNA No translation available.
UniGeneiHs.278606

Genome annotation databases

EnsembliENST00000381709; ENSP00000371128; ENSG00000205777
UCSCiuc004dok.3 human

Similar proteinsi

Entry informationi

Entry nameiGAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q13065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health