Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (13 Feb 2019)
Sequence version 4 (28 Jun 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Triadin

Gene

TRDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.28.1.3 the ankyrin (ankyrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triadin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRDN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186439.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12261 TRDN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603283 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13061

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 47CytoplasmicAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 729LumenalAdd BLAST661

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, or sudden death after physical activity or emotional stress. Some patients have muscle weakness. CPVT5 inheritance is autosomal recessive.
See also OMIM:615441
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06735059T → R in CPVT5; results in intracellular retention and degradation of the mutant protein. 1 PublicationCorresponds to variant dbSNP:rs397515459EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10345

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TRDN

MalaCards human disease database

More...
MalaCardsi
TRDN
MIMi615441 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186439

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3286 Catecholaminergic polymorphic ventricular tachycardia
101016 Romano-Ward syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36941

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRDN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000656261 – 729TriadinAdd BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi270InterchainBy similarity
Glycosylationi647N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi691InterchainBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CaMK2.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13061

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13061

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13061

PeptideAtlas

More...
PeptideAtlasi
Q13061

PRoteomics IDEntifications database

More...
PRIDEi
Q13061

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59126

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13061

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13061

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186439 Expressed in 117 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13061 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038226
HPA058226

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer of variable subunit number; disulfide-linked (By similarity). Interacts with CASQ1 and RYR1 in skeletal muscle. Interacts with CASQ2.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115627, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q13061, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q13061

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK92 Eukaryota
ENOG410YQIE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049207

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015240

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG014932

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13061

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDEKKDY

Database of Orthologous Groups

More...
OrthoDBi
1200049at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350396

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007943 Asp-B-hydro/Triadin_dom
IPR010798 Triadin

The PANTHER Classification System

More...
PANTHERi
PTHR14106 PTHR14106, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05279 Asp-B-Hydro_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13061-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEITAEGNA STTTTVIDSK NGSVPKSPGK VLKRTVTEDI VTTFSSPAAW
60 70 80 90 100
LLVIALIITW SAVAIVMFDL VDYKNFSASS IAKIGSDPLK LVRDAMEETT
110 120 130 140 150
DWIYGFFSLL SDIISSEDEE DDDGDEDTDK GEIDEPPLRK KEIHKDKTEK
160 170 180 190 200
QEKPERKIQT KVTHKEKEKG KEKVREKEKP EKKATHKEKI EKKEKPETKT
210 220 230 240 250
LAKEQKKAKT AEKSEEKTKK EVKGGKQEKV KQTAAKVKEV QKTPSKPKEK
260 270 280 290 300
EDKEKAAVSK HEQKDQYAFC RYMIDIFVHG DLKPGQSPAI PPPLPTEQAS
310 320 330 340 350
RPTPASPALE EKEGEKKKAE KKVTSETKKK EKEDIKKKSE KETAIDVEKK
360 370 380 390 400
EPGKASETKQ GTVKIAAQAA AKKDEKKEDS KKTKKPAEVE QPKGKKQEKK
410 420 430 440 450
EKHVEPAKSP KKEHSVPSDK QVKAKTERAK EEIGAVSIKK AVPGKKEEKT
460 470 480 490 500
TKTVEQEIRK EKSGKTSSIL KDKEPIKGKE EKVPASLKEK EPETKKDEKM
510 520 530 540 550
SKAGKEVKPK PPQLQGKKEE KPEPQIKKEA KPAISEKVQI HKQDIVKPEK
560 570 580 590 600
TVSHGKPEEK VLKQVKAVTI EKTAKPKPTK KAEHREREPP SIKTDKPKPT
610 620 630 640 650
PKGTSEVTES GKKKTEISEK ESKEKADMKH LREEKVSTRK ESLQLHNVTK
660 670 680 690 700
AEKPARVSKD VEDVPASKKA KEGTEDVSPT KQKSPISFFQ CVYLDGYNGY
710 720
GFQFPFTPAD RPGESSGQAN SPGQKQQGQ
Length:729
Mass (Da):81,595
Last modified:June 28, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D9653203D52FA05
GO
Isoform 2 (identifier: Q13061-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-284: Missing.
     311-317: EKEGEKK → GKYFFFS
     318-729: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):33,236
Checksum:i22038B4C91C9D74C
GO
Isoform 3 (identifier: Q13061-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-167: VTHKEK → EVGHSS
     168-729: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,468
Checksum:iBB82F39A8FE2F9EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9ME53H9ME53_HUMAN
Cardiac triadin Trisk 32 isoform
TRDN
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY47H7BY47_HUMAN
Triadin
TRDN
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6P0H0Y6P0_HUMAN
Triadin
TRDN
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06735059T → R in CPVT5; results in intracellular retention and degradation of the mutant protein. 1 PublicationCorresponds to variant dbSNP:rs397515459EnsemblClinVar.1
Natural variantiVAR_057008128T → S1 PublicationCorresponds to variant dbSNP:rs9490809EnsemblClinVar.1
Natural variantiVAR_065263201L → V2 PublicationsCorresponds to variant dbSNP:rs6902416EnsemblClinVar.1
Natural variantiVAR_057009339S → N. Corresponds to variant dbSNP:rs35766971EnsemblClinVar.1
Natural variantiVAR_065264396K → N. Corresponds to variant dbSNP:rs6901953Ensembl.1
Natural variantiVAR_057010404V → G. Corresponds to variant dbSNP:rs28494009EnsemblClinVar.1
Natural variantiVAR_057011419D → E. Corresponds to variant dbSNP:rs17737379EnsemblClinVar.1
Natural variantiVAR_065265438I → S1 PublicationCorresponds to variant dbSNP:rs2873479EnsemblClinVar.1
Natural variantiVAR_057012470L → M. Corresponds to variant dbSNP:rs6569336EnsemblClinVar.1
Natural variantiVAR_057013540I → M. Corresponds to variant dbSNP:rs7771303EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045561162 – 167VTHKEK → EVGHSS in isoform 3. 1 Publication6
Alternative sequenceiVSP_045562168 – 729Missing in isoform 3. 1 PublicationAdd BLAST562
Alternative sequenceiVSP_045563265 – 284Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_045564311 – 317EKEGEKK → GKYFFFS in isoform 2. 1 Publication7
Alternative sequenceiVSP_045565318 – 729Missing in isoform 2. 1 PublicationAdd BLAST412

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18985 mRNA Translation: AAA75315.1
AL133257 Genomic DNA No translation available.
AL357352 Genomic DNA No translation available.
AL445259 Genomic DNA No translation available.
AL603902 Genomic DNA No translation available.
AL603911 Genomic DNA No translation available.
BC070290 mRNA Translation: AAH70290.1
BC139910 mRNA Translation: AAI39911.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55053.1 [Q13061-1]
CCDS59034.1 [Q13061-2]
CCDS59035.1 [Q13061-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68191

NCBI Reference Sequences

More...
RefSeqi
NP_001242949.1, NM_001256020.1 [Q13061-2]
NP_001242951.1, NM_001256022.1 [Q13061-3]
NP_006064.2, NM_006073.3 [Q13061-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.144744

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334268; ENSP00000333984; ENSG00000186439 [Q13061-1]
ENST00000542443; ENSP00000437684; ENSG00000186439 [Q13061-3]
ENST00000628709; ENSP00000486095; ENSG00000186439 [Q13061-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10345

UCSC genome browser

More...
UCSCi
uc010keo.3 human [Q13061-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18985 mRNA Translation: AAA75315.1
AL133257 Genomic DNA No translation available.
AL357352 Genomic DNA No translation available.
AL445259 Genomic DNA No translation available.
AL603902 Genomic DNA No translation available.
AL603911 Genomic DNA No translation available.
BC070290 mRNA Translation: AAH70290.1
BC139910 mRNA Translation: AAI39911.1
CCDSiCCDS55053.1 [Q13061-1]
CCDS59034.1 [Q13061-2]
CCDS59035.1 [Q13061-3]
PIRiS68191
RefSeqiNP_001242949.1, NM_001256020.1 [Q13061-2]
NP_001242951.1, NM_001256022.1 [Q13061-3]
NP_006064.2, NM_006073.3 [Q13061-1]
UniGeneiHs.144744

3D structure databases

ProteinModelPortaliQ13061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115627, 39 interactors
IntActiQ13061, 7 interactors
STRINGi9606.ENSP00000381240

Protein family/group databases

TCDBi8.A.28.1.3 the ankyrin (ankyrin) family

PTM databases

iPTMnetiQ13061
PhosphoSitePlusiQ13061

Polymorphism and mutation databases

BioMutaiTRDN

Proteomic databases

EPDiQ13061
jPOSTiQ13061
PaxDbiQ13061
PeptideAtlasiQ13061
PRIDEiQ13061
ProteomicsDBi59126

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334268; ENSP00000333984; ENSG00000186439 [Q13061-1]
ENST00000542443; ENSP00000437684; ENSG00000186439 [Q13061-3]
ENST00000628709; ENSP00000486095; ENSG00000186439 [Q13061-2]
GeneIDi10345
KEGGihsa:10345
UCSCiuc010keo.3 human [Q13061-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10345
DisGeNETi10345
EuPathDBiHostDB:ENSG00000186439.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRDN
GeneReviewsiTRDN

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0032833
HGNCiHGNC:12261 TRDN
HPAiHPA038226
HPA058226
MalaCardsiTRDN
MIMi603283 gene
615441 phenotype
neXtProtiNX_Q13061
OpenTargetsiENSG00000186439
Orphaneti3286 Catecholaminergic polymorphic ventricular tachycardia
101016 Romano-Ward syndrome
PharmGKBiPA36941

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK92 Eukaryota
ENOG410YQIE LUCA
GeneTreeiENSGT00510000049207
HOGENOMiHOG000015240
HOVERGENiHBG014932
InParanoidiQ13061
OMAiKDEKKDY
OrthoDBi1200049at2759
TreeFamiTF350396

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRDN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Triadin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10345

Protein Ontology

More...
PROi
PR:Q13061

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186439 Expressed in 117 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ13061 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007943 Asp-B-hydro/Triadin_dom
IPR010798 Triadin
PANTHERiPTHR14106 PTHR14106, 1 hit
PfamiView protein in Pfam
PF05279 Asp-B-Hydro_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRDN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13061
Secondary accession number(s): A5D6W5, F5H2W7, Q6NSB8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 28, 2011
Last modified: February 13, 2019
This is version 143 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again