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Entry version 203 (07 Oct 2020)
Sequence version 2 (01 Jan 1998)
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Protein

Protein flightless-1 homolog

Gene

FLII

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Activator, Developmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q13045

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13045

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein flightless-1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLII
Synonyms:FLIL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177731.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3750, FLII

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600362, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13045

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi586E → K: No change in ESR1 binding but reduced binding to ACTL6A and reduced coactivator function. 1 Publication1
Mutagenesisi603G → S: No change in binding to ACTL6A or in coactivator function. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2314

MalaCards human disease database

More...
MalaCardsi
FLII

Open Targets

More...
OpenTargetsi
ENSG00000177731

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
819, Smith-Magenis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28171

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q13045, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FLII

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202493

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187501 – 1269Protein flightless-1 homologAdd BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei436Phosphoserine; by SGK3Combined sources1 Publication1
Modified residuei818Phosphothreonine; by SGK31 Publication1
Modified residuei856PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13045

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13045

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q13045

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13045

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13045

PeptideAtlas

More...
PeptideAtlasi
Q13045

PRoteomics IDEntifications database

More...
PRIDEi
Q13045

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
26432
59121 [Q13045-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13045

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q13045

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13045

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q13045

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongest expression in skeletal muscle with high expression also in the heart and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177731, Expressed in adult mammalian kidney and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13045, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13045, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177731, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88.

Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS.

Interacts with the nuclear receptors ESR1 and THRB.

Interacts with SGK3.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108603, 112 interactors

Protein interaction database and analysis system

More...
IntActi
Q13045, 60 interactors

Molecular INTeraction database

More...
MINTi
Q13045

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324573

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q13045, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 32LRR 1Add BLAST26
Repeati33 – 55LRR 2Add BLAST23
Repeati56 – 78LRR 3Add BLAST23
Repeati80 – 103LRR 4Add BLAST24
Repeati104 – 126LRR 5Add BLAST23
Repeati127 – 149LRR 6Add BLAST23
Repeati150 – 173LRR 7Add BLAST24
Repeati175 – 196LRR 8Add BLAST22
Repeati197 – 222LRR 9Add BLAST26
Repeati223 – 245LRR 10Add BLAST23
Repeati247 – 268LRR 11Add BLAST22
Repeati269 – 291LRR 12Add BLAST23
Repeati293 – 316LRR 13Add BLAST24
Repeati318 – 339LRR 14Add BLAST22
Repeati340 – 363LRR 15Add BLAST24
Repeati501 – 559Gelsolin-like 1Add BLAST59
Repeati640 – 670Gelsolin-like 2Add BLAST31
Repeati755 – 798Gelsolin-like 3Add BLAST44
Repeati1068 – 1115Gelsolin-like 4Add BLAST48
Repeati1176 – 1218Gelsolin-like 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 427Interaction with LRRFIP1 and LRRFIP2Add BLAST427
Regioni495 – 827Interaction with ACTL6A1 PublicationAdd BLAST333

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 415Poly-Ala5
Compositional biasi892 – 978Glu-richAdd BLAST87

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0444, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002568_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13045

Identification of Orthologs from Complete Genome Data

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OMAi
FVWFGKK

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13045

TreeFam database of animal gene trees

More...
TreeFami
TF313468

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 5 hits
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR029919, FliI
IPR007123, Gelsolin-like_dom
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR007122, Villin/Gelsolin

The PANTHER Classification System

More...
PANTHERi
PTHR11977, PTHR11977, 1 hit
PTHR11977:SF92, PTHR11977:SF92, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00626, Gelsolin, 4 hits
PF13855, LRR_8, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00597, GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00262, GEL, 6 hits
SM00369, LRR_TYP, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE
60 70 80 90 100
ELAALQKLEH LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI
110 120 130 140 150
FKLDDLSVLD LSHNQLTECP RELENAKNML VLNLSHNSID TIPNQLFINL
160 170 180 190 200
TDLLYLDLSE NRLESLPPQM RRLVHLQTLV LNGNPLLHAQ LRQLPAMTAL
210 220 230 240 250
QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE CLYTLPSLRR
260 270 280 290 300
LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
310 320 330 340 350
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN
360 370 380 390 400
HLVTLPEAIH FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL
410 420 430 440 450
RLAGASPATV AAAAAAGSGP KDPMARKMRL RRRKDSAQDD QAKQVLKGMS
460 470 480 490 500
DVAQEKNKKQ EESADARAPS GKVRRWDQGL EKPRLDYSEF FTEDVGQLPG
510 520 530 540 550
LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS LNWEIYYWIG
560 570 580 590 600
GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
610 620 630 640 650
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL
660 670 680 690 700
DRGLDIYVWR GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP
710 720 730 740 750
EFWEALGGEP SEIKKHVPED FWPPQPKLYK VGLGLGYLEL PQINYKLSVE
760 770 780 790 800
HKQRPKVELM PRMRLLQSLL DTRCVYILDC WSDVFIWLGR KSPRLVRAAA
810 820 830 840 850
LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD VLTVDYTRNA
860 870 880 890 900
EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
910 920 930 940 950
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE
960 970 980 990 1000
KKEDKEEKAE GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF
1010 1020 1030 1040 1050
TFSLQKKFES LFPGKLEVVR MTQQQENPKF LSHFKRKFII HRGKRKAVQG
1060 1070 1080 1090 1100
AQQPSLYQIR TNGSALCTRC IQINTDSSLL NSEFCFILKV PFESEDNQGI
1110 1120 1130 1140 1150
VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP ENFFWVGIGA
1160 1170 1180 1190 1200
QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
1210 1220 1230 1240 1250
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE
1260
QHAFTRCFHA WSAFCKALA
Length:1,269
Mass (Da):144,751
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29AC7C07738B7B47
GO
Isoform 2 (identifier: Q13045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-191: Missing.
     416-416: Missing.

Show »
Length:1,214
Mass (Da):138,493
Checksum:iC0ACCF1BB28C366C
GO
Isoform 3 (identifier: Q13045-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEATGVLPFVRGVDLSGNDFK → MDLRGLRPVP

Show »
Length:1,258
Mass (Da):143,652
Checksum:i8D087C091CFAD08B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KS54J3KS54_HUMAN
Protein flightless-1 homolog
FLII
700Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLR6J3QLR6_HUMAN
Protein flightless-1 homolog
FLII
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQQ2J3QQQ2_HUMAN
Protein flightless-1 homolog
FLII
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP27K7EP27_HUMAN
Protein flightless-1 homolog
FLII
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQZ7K7EQZ7_HUMAN
Protein flightless-1 homolog
FLII
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQU5J3QQU5_HUMAN
Protein flightless-1 homolog
FLII
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP37K7EP37_HUMAN
Protein flightless-1 homolog
FLII
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS39J3KS39_HUMAN
Protein flightless-1 homolog
FLII
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT47J3KT47_HUMAN
Protein flightless-1 homolog
FLII
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJJ7K7EJJ7_HUMAN
Protein flightless-1 homolog
FLII
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG58522 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in BAG58522 (PubMed:14702039).Curated1
Sequence conflicti298Y → N in BAG58522 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0292581243R → H. Corresponds to variant dbSNP:rs8821Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468871 – 21MEATG…GNDFK → MDLRGLRPVP in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_044686138 – 191Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_044687416Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U80184 Genomic DNA Translation: AAC02796.1
AK295655 mRNA Translation: BAG58522.1 Different initiation.
AC127537 Genomic DNA No translation available.
BC025300 mRNA Translation: AAH25300.1
U01184 mRNA Translation: AAC03568.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11192.1 [Q13045-1]
CCDS58521.1 [Q13045-3]
CCDS58522.1 [Q13045-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49674

NCBI Reference Sequences

More...
RefSeqi
NP_001243193.1, NM_001256264.1 [Q13045-3]
NP_001243194.1, NM_001256265.1 [Q13045-2]
NP_002009.1, NM_002018.3 [Q13045-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327031; ENSP00000324573; ENSG00000177731 [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731 [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731 [Q13045-3]
ENST00000638207; ENSP00000491480; ENSG00000284571 [Q13045-1]
ENST00000638404; ENSP00000492392; ENSG00000284571 [Q13045-2]
ENST00000638812; ENSP00000491660; ENSG00000284571 [Q13045-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2314

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2314

UCSC genome browser

More...
UCSCi
uc002gsr.3, human [Q13045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80184 Genomic DNA Translation: AAC02796.1
AK295655 mRNA Translation: BAG58522.1 Different initiation.
AC127537 Genomic DNA No translation available.
BC025300 mRNA Translation: AAH25300.1
U01184 mRNA Translation: AAC03568.1
CCDSiCCDS11192.1 [Q13045-1]
CCDS58521.1 [Q13045-3]
CCDS58522.1 [Q13045-2]
PIRiA49674
RefSeqiNP_001243193.1, NM_001256264.1 [Q13045-3]
NP_001243194.1, NM_001256265.1 [Q13045-2]
NP_002009.1, NM_002018.3 [Q13045-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi108603, 112 interactors
IntActiQ13045, 60 interactors
MINTiQ13045
STRINGi9606.ENSP00000324573

PTM databases

iPTMnetiQ13045
MetOSiteiQ13045
PhosphoSitePlusiQ13045
SwissPalmiQ13045

Polymorphism and mutation databases

BioMutaiFLII
DMDMi18202493

Proteomic databases

EPDiQ13045
jPOSTiQ13045
MassIVEiQ13045
MaxQBiQ13045
PaxDbiQ13045
PeptideAtlasiQ13045
PRIDEiQ13045
ProteomicsDBi26432
59121 [Q13045-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1881, 154 antibodies

The DNASU plasmid repository

More...
DNASUi
2314

Genome annotation databases

EnsembliENST00000327031; ENSP00000324573; ENSG00000177731 [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731 [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731 [Q13045-3]
ENST00000638207; ENSP00000491480; ENSG00000284571 [Q13045-1]
ENST00000638404; ENSP00000492392; ENSG00000284571 [Q13045-2]
ENST00000638812; ENSP00000491660; ENSG00000284571 [Q13045-3]
GeneIDi2314
KEGGihsa:2314
UCSCiuc002gsr.3, human [Q13045-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2314
DisGeNETi2314
EuPathDBiHostDB:ENSG00000177731.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FLII
HGNCiHGNC:3750, FLII
HPAiENSG00000177731, Low tissue specificity
MalaCardsiFLII
MIMi600362, gene
neXtProtiNX_Q13045
OpenTargetsiENSG00000177731
Orphaneti819, Smith-Magenis syndrome
PharmGKBiPA28171

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0444, Eukaryota
GeneTreeiENSGT00940000156643
HOGENOMiCLU_002568_1_0_1
InParanoidiQ13045
OMAiFVWFGKK
OrthoDBi1376537at2759
PhylomeDBiQ13045
TreeFamiTF313468

Enzyme and pathway databases

PathwayCommonsiQ13045
SIGNORiQ13045

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2314, 199 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FLII, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FLII

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2314
PharosiQ13045, Tbio

Protein Ontology

More...
PROi
PR:Q13045
RNActiQ13045, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177731, Expressed in adult mammalian kidney and 245 other tissues
ExpressionAtlasiQ13045, baseline and differential
GenevisibleiQ13045, HS

Family and domain databases

Gene3Di3.40.20.10, 5 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR029919, FliI
IPR007123, Gelsolin-like_dom
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR007122, Villin/Gelsolin
PANTHERiPTHR11977, PTHR11977, 1 hit
PTHR11977:SF92, PTHR11977:SF92, 1 hit
PfamiView protein in Pfam
PF00626, Gelsolin, 4 hits
PF13855, LRR_8, 3 hits
PRINTSiPR00597, GELSOLIN
SMARTiView protein in SMART
SM00262, GEL, 6 hits
SM00369, LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLII_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13045
Secondary accession number(s): B4DIL0, F5H407, J3QLG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: October 7, 2020
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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