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Protein

Protein flightless-1 homolog

Gene

FLII

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: HGNC
  • actin filament binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Activator, Developmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ13045

Names & Taxonomyi

Protein namesi
Recommended name:
Protein flightless-1 homolog
Gene namesi
Name:FLII
Synonyms:FLIL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000177731.15
HGNCiHGNC:3750 FLII
MIMi600362 gene
neXtProtiNX_Q13045

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi586E → K: No change in ESR1 binding but reduced binding to ACTL6A and reduced coactivator function. 1 Publication1
Mutagenesisi603G → S: No change in binding to ACTL6A or in coactivator function. 1 Publication1

Organism-specific databases

DisGeNETi2314
MalaCardsiFLII
OpenTargetsiENSG00000177731
Orphaneti819 Smith-Magenis syndrome
PharmGKBiPA28171

Polymorphism and mutation databases

BioMutaiFLII
DMDMi18202493

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187501 – 1269Protein flightless-1 homologAdd BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei436Phosphoserine; by SGK3Combined sources1 Publication1
Modified residuei818Phosphothreonine; by SGK31 Publication1
Modified residuei856PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13045
MaxQBiQ13045
PaxDbiQ13045
PeptideAtlasiQ13045
PRIDEiQ13045
ProteomicsDBi59121

PTM databases

iPTMnetiQ13045
PhosphoSitePlusiQ13045

Expressioni

Tissue specificityi

Strongest expression in skeletal muscle with high expression also in the heart and lung.1 Publication

Gene expression databases

BgeeiENSG00000177731 Expressed in 233 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_FLII
ExpressionAtlasiQ13045 baseline and differential
GenevisibleiQ13045 HS

Organism-specific databases

HPAiCAB016132
HPA007084
HPA008903

Interactioni

Subunit structurei

Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88. Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS. Interacts with the nuclear receptors ESR1 and THRB. Interacts with SGK3.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRFIP1Q32MZ42EBI-351549,EBI-1369100

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108603, 82 interactors
IntActiQ13045, 47 interactors
MINTiQ13045
STRINGi9606.ENSP00000324573

Structurei

3D structure databases

ProteinModelPortaliQ13045
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 32LRR 1Add BLAST26
Repeati33 – 55LRR 2Add BLAST23
Repeati56 – 78LRR 3Add BLAST23
Repeati80 – 103LRR 4Add BLAST24
Repeati104 – 126LRR 5Add BLAST23
Repeati127 – 149LRR 6Add BLAST23
Repeati150 – 173LRR 7Add BLAST24
Repeati175 – 196LRR 8Add BLAST22
Repeati197 – 222LRR 9Add BLAST26
Repeati223 – 245LRR 10Add BLAST23
Repeati247 – 268LRR 11Add BLAST22
Repeati269 – 291LRR 12Add BLAST23
Repeati293 – 316LRR 13Add BLAST24
Repeati318 – 339LRR 14Add BLAST22
Repeati340 – 363LRR 15Add BLAST24
Repeati501 – 559Gelsolin-like 1Add BLAST59
Repeati640 – 670Gelsolin-like 2Add BLAST31
Repeati755 – 798Gelsolin-like 3Add BLAST44
Repeati1068 – 1115Gelsolin-like 4Add BLAST48
Repeati1176 – 1218Gelsolin-like 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 427Interaction with LRRFIP1 and LRRFIP2Add BLAST427
Regioni495 – 827Interaction with ACTL6A1 PublicationAdd BLAST333

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 415Poly-Ala5
Compositional biasi892 – 978Glu-richAdd BLAST87

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0444 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000016110
HOVERGENiHBG051627
InParanoidiQ13045
OMAiYKSAQVY
OrthoDBiEOG091G00R0
PhylomeDBiQ13045
TreeFamiTF313468

Family and domain databases

Gene3Di3.40.20.10, 5 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029919 FliI
IPR007123 Gelsolin-like_dom
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF55 PTHR11977:SF55, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 4 hits
PF12799 LRR_4, 1 hit
PF13855 LRR_8, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEATGVLPFV RGVDLSGNDF KGGYFPENVK AMTSLRWLKL NRTGLCYLPE
60 70 80 90 100
ELAALQKLEH LSVSHNNLTT LHGELSSLPS LRAIVARANS LKNSGVPDDI
110 120 130 140 150
FKLDDLSVLD LSHNQLTECP RELENAKNML VLNLSHNSID TIPNQLFINL
160 170 180 190 200
TDLLYLDLSE NRLESLPPQM RRLVHLQTLV LNGNPLLHAQ LRQLPAMTAL
210 220 230 240 250
QTLHLRSTQR TQSNLPTSLE GLSNLADVDL SCNDLTRVPE CLYTLPSLRR
260 270 280 290 300
LNLSSNQITE LSLCIDQWVH VETLNLSRNQ LTSLPSAICK LSKLKKLYLN
310 320 330 340 350
SNKLDFDGLP SGIGKLTNLE EFMAANNNLE LVPESLCRCP KLRKLVLNKN
360 370 380 390 400
HLVTLPEAIH FLTEIEVLDV RENPNLVMPP KPADRAAEWY NIDFSLQNQL
410 420 430 440 450
RLAGASPATV AAAAAAGSGP KDPMARKMRL RRRKDSAQDD QAKQVLKGMS
460 470 480 490 500
DVAQEKNKKQ EESADARAPS GKVRRWDQGL EKPRLDYSEF FTEDVGQLPG
510 520 530 540 550
LTIWQIENFV PVLVEEAFHG KFYEADCYIV LKTFLDDSGS LNWEIYYWIG
560 570 580 590 600
GEATLDKKAC SAIHAVNLRN YLGAECRTVR EEMGDESEEF LQVFDNDISY
610 620 630 640 650
IEGGTASGFY TVEDTHYVTR MYRVYGKKNI KLEPVPLKGT SLDPRFVFLL
660 670 680 690 700
DRGLDIYVWR GAQATLSSTT KARLFAEKIN KNERKGKAEI TLLVQGQELP
710 720 730 740 750
EFWEALGGEP SEIKKHVPED FWPPQPKLYK VGLGLGYLEL PQINYKLSVE
760 770 780 790 800
HKQRPKVELM PRMRLLQSLL DTRCVYILDC WSDVFIWLGR KSPRLVRAAA
810 820 830 840 850
LKLGQELCGM LHRPRHATVS RSLEGTEAQV FKAKFKNWDD VLTVDYTRNA
860 870 880 890 900
EAVLQSPGLS GKVKRDAEKK DQMKADLTAL FLPRQPPMSL AEAEQLMEEW
910 920 930 940 950
NEDLDGMEGF VLEGKKFARL PEEEFGHFYT QDCYVFLCRY WVPVEYEEEE
960 970 980 990 1000
KKEDKEEKAE GKEGEEATAE AEEKQPEEDF QCIVYFWQGR EASNMGWLTF
1010 1020 1030 1040 1050
TFSLQKKFES LFPGKLEVVR MTQQQENPKF LSHFKRKFII HRGKRKAVQG
1060 1070 1080 1090 1100
AQQPSLYQIR TNGSALCTRC IQINTDSSLL NSEFCFILKV PFESEDNQGI
1110 1120 1130 1140 1150
VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP ENFFWVGIGA
1160 1170 1180 1190 1200
QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN
1210 1220 1230 1240 1250
GQEVYMWVGT QTSQVEIKLS LKACQVYIQH MRSKEHERPR RLRLVRKGNE
1260
QHAFTRCFHA WSAFCKALA
Length:1,269
Mass (Da):144,751
Last modified:January 1, 1998 - v2
Checksum:i29AC7C07738B7B47
GO
Isoform 2 (identifier: Q13045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-191: Missing.
     416-416: Missing.

Note: No experimental confirmation available.
Show »
Length:1,214
Mass (Da):138,493
Checksum:iC0ACCF1BB28C366C
GO
Isoform 3 (identifier: Q13045-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEATGVLPFVRGVDLSGNDFK → MDLRGLRPVP

Show »
Length:1,258
Mass (Da):143,652
Checksum:i8D087C091CFAD08B
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KS54J3KS54_HUMAN
Protein flightless-1 homolog
FLII
700Annotation score:
J3QLR6J3QLR6_HUMAN
Protein flightless-1 homolog
FLII
185Annotation score:
K7EP37K7EP37_HUMAN
Protein flightless-1 homolog
FLII
99Annotation score:
K7EP27K7EP27_HUMAN
Protein flightless-1 homolog
FLII
133Annotation score:
J3QQQ2J3QQQ2_HUMAN
Protein flightless-1 homolog
FLII
279Annotation score:
J3QQU5J3QQU5_HUMAN
Protein flightless-1 homolog
FLII
117Annotation score:
K7EQZ7K7EQZ7_HUMAN
Protein flightless-1 homolog
FLII
207Annotation score:
J3KS39J3KS39_HUMAN
Protein flightless-1 homolog
FLII
51Annotation score:
J3KT47J3KT47_HUMAN
Protein flightless-1 homolog
FLII
29Annotation score:
K7EJJ7K7EJJ7_HUMAN
Protein flightless-1 homolog
FLII
23Annotation score:

Sequence cautioni

The sequence BAG58522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in BAG58522 (PubMed:14702039).Curated1
Sequence conflicti298Y → N in BAG58522 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0292581243R → H. Corresponds to variant dbSNP:rs8821Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0468871 – 21MEATG…GNDFK → MDLRGLRPVP in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_044686138 – 191Missing in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_044687416Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80184 Genomic DNA Translation: AAC02796.1
AK295655 mRNA Translation: BAG58522.1 Different initiation.
AC127537 Genomic DNA No translation available.
BC025300 mRNA Translation: AAH25300.1
U01184 mRNA Translation: AAC03568.1
CCDSiCCDS11192.1 [Q13045-1]
CCDS58521.1 [Q13045-3]
CCDS58522.1 [Q13045-2]
PIRiA49674
RefSeqiNP_001243193.1, NM_001256264.1 [Q13045-3]
NP_001243194.1, NM_001256265.1 [Q13045-2]
NP_002009.1, NM_002018.3 [Q13045-1]
UniGeneiHs.513984

Genome annotation databases

EnsembliENST00000327031; ENSP00000324573; ENSG00000177731 [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731 [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731 [Q13045-3]
ENST00000638207; ENSP00000491480; ENSG00000284571 [Q13045-1]
ENST00000638404; ENSP00000492392; ENSG00000284571 [Q13045-2]
ENST00000638812; ENSP00000491660; ENSG00000284571 [Q13045-3]
GeneIDi2314
KEGGihsa:2314
UCSCiuc002gsr.3 human [Q13045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80184 Genomic DNA Translation: AAC02796.1
AK295655 mRNA Translation: BAG58522.1 Different initiation.
AC127537 Genomic DNA No translation available.
BC025300 mRNA Translation: AAH25300.1
U01184 mRNA Translation: AAC03568.1
CCDSiCCDS11192.1 [Q13045-1]
CCDS58521.1 [Q13045-3]
CCDS58522.1 [Q13045-2]
PIRiA49674
RefSeqiNP_001243193.1, NM_001256264.1 [Q13045-3]
NP_001243194.1, NM_001256265.1 [Q13045-2]
NP_002009.1, NM_002018.3 [Q13045-1]
UniGeneiHs.513984

3D structure databases

ProteinModelPortaliQ13045
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108603, 82 interactors
IntActiQ13045, 47 interactors
MINTiQ13045
STRINGi9606.ENSP00000324573

PTM databases

iPTMnetiQ13045
PhosphoSitePlusiQ13045

Polymorphism and mutation databases

BioMutaiFLII
DMDMi18202493

Proteomic databases

EPDiQ13045
MaxQBiQ13045
PaxDbiQ13045
PeptideAtlasiQ13045
PRIDEiQ13045
ProteomicsDBi59121

Protocols and materials databases

DNASUi2314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327031; ENSP00000324573; ENSG00000177731 [Q13045-1]
ENST00000545457; ENSP00000438536; ENSG00000177731 [Q13045-2]
ENST00000579294; ENSP00000463534; ENSG00000177731 [Q13045-3]
ENST00000638207; ENSP00000491480; ENSG00000284571 [Q13045-1]
ENST00000638404; ENSP00000492392; ENSG00000284571 [Q13045-2]
ENST00000638812; ENSP00000491660; ENSG00000284571 [Q13045-3]
GeneIDi2314
KEGGihsa:2314
UCSCiuc002gsr.3 human [Q13045-1]

Organism-specific databases

CTDi2314
DisGeNETi2314
EuPathDBiHostDB:ENSG00000177731.15
GeneCardsiFLII
HGNCiHGNC:3750 FLII
HPAiCAB016132
HPA007084
HPA008903
MalaCardsiFLII
MIMi600362 gene
neXtProtiNX_Q13045
OpenTargetsiENSG00000177731
Orphaneti819 Smith-Magenis syndrome
PharmGKBiPA28171
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0444 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119111
HOGENOMiHOG000016110
HOVERGENiHBG051627
InParanoidiQ13045
OMAiYKSAQVY
OrthoDBiEOG091G00R0
PhylomeDBiQ13045
TreeFamiTF313468

Enzyme and pathway databases

SIGNORiQ13045

Miscellaneous databases

ChiTaRSiFLII human
GeneWikiiFLII
GenomeRNAii2314
PROiPR:Q13045
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177731 Expressed in 233 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_FLII
ExpressionAtlasiQ13045 baseline and differential
GenevisibleiQ13045 HS

Family and domain databases

Gene3Di3.40.20.10, 5 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029919 FliI
IPR007123 Gelsolin-like_dom
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF55 PTHR11977:SF55, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 4 hits
PF12799 LRR_4, 1 hit
PF13855 LRR_8, 3 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFLII_HUMAN
AccessioniPrimary (citable) accession number: Q13045
Secondary accession number(s): B4DIL0, F5H407, J3QLG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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