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Protein

Serine/threonine-protein kinase 4

Gene

STK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.By similarity16 Publications

Caution

Was originally thought to be phosphorylated at Thr-120 (PubMed:19940129). However, this work has been retracted (PubMed:27825096).1 Publication1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Activity regulationi

Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59ATP1
Active sitei149Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activator activity Source: BHF-UCL
  • protein serine/threonine kinase activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-2028269 Signaling by Hippo
SignaLinkiQ13043
SIGNORiQ13043

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 4 (EC:2.7.11.1)
Alternative name(s):
Mammalian STE20-like protein kinase 1
Short name:
MST-1
STE20-like kinase MST1
Serine/threonine-protein kinase Krs-2
Cleaved into the following 2 chains:
Gene namesi
Name:STK4
Synonyms:KRS2, MST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101109.11
HGNCiHGNC:11408 STK4
MIMi604965 gene
neXtProtiNX_Q13043

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations (TIIAC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T-cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, autoimmune manifestations, and cardiac malformations, including atrial septal defect.
See also OMIM:614868

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59K → R: Loss of activity. 2 Publications1
Mutagenesisi175T → A: No effect on activity. 1 Publication1
Mutagenesisi177T → A: No effect on activity. 1 Publication1
Mutagenesisi183T → A: Loss of activity. 1 Publication1
Mutagenesisi326D → N: Resistant to proteolytic cleavage by caspase during apoptosis; when associated with N-349. 1 Publication1
Mutagenesisi349D → N: Resistant to proteolytic cleavage by caspase during apoptosis; when associated with N-326. 1 Publication1
Mutagenesisi444L → P: Loss of homodimerization, activation, and autophosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi6789
MalaCardsiSTK4
MIMi614868 phenotype
OpenTargetsiENSG00000101109
Orphaneti314689 Combined immunodeficiency due to STK4 deficiency
PharmGKBiPA36215

Chemistry databases

ChEMBLiCHEMBL4598
GuidetoPHARMACOLOGYi2225

Polymorphism and mutation databases

BioMutaiSTK4
DMDMi13124559

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866911 – 487Serine/threonine-protein kinase 4Add BLAST487
ChainiPRO_00004137351 – 326Serine/threonine-protein kinase 4 37kDa subunitAdd BLAST326
ChainiPRO_0000413736327 – 487Serine/threonine-protein kinase 4 18kDa subunitAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei183Phosphothreonine; by autocatalysis1 Publication1
Modified residuei265PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei340PhosphothreonineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Modified residuei387Phosphothreonine; by PKB/AKT1Combined sources1 Publication1
Modified residuei410PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei433PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3.4 Publications
Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei326 – 327Cleavage; by caspase-32
Sitei349 – 350Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13043
MaxQBiQ13043
PaxDbiQ13043
PeptideAtlasiQ13043
PRIDEiQ13043
ProteomicsDBi59119
59120 [Q13043-2]

PTM databases

iPTMnetiQ13043
PhosphoSitePlusiQ13043

Miscellaneous databases

PMAP-CutDBiQ13043

Expressioni

Tissue specificityi

Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed.1 Publication

Inductioni

Activity increases during mitosis.

Gene expression databases

BgeeiENSG00000101109 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_MST1
HS_STK4
ExpressionAtlasiQ13043 baseline and differential
GenevisibleiQ13043 HS

Organism-specific databases

HPAiCAB004038
HPA015270

Interactioni

Subunit structurei

Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714). Interacts with SCRIB in the presence of DLG5 (PubMed:28169360).By similarity13 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112665, 70 interactors
CORUMiQ13043
DIPiDIP-32491N
ELMiQ13043
IntActiQ13043, 174 interactors
MINTiQ13043
STRINGi9606.ENSP00000361892

Chemistry databases

BindingDBiQ13043

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13043
SMRiQ13043
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13043

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini433 – 480SARAHPROSITE-ProRule annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili290 – 310Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi373 – 378Poly-Glu6

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0201 Eukaryota
ENOG410XP9G LUCA
GeneTreeiENSGT00930000150827
HOVERGENiHBG108518
InParanoidiQ13043
KOiK04411
OMAiGEGSYGC
OrthoDBiEOG091G065P
PhylomeDBiQ13043
TreeFamiTF354217

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024205 Mst1_SARAH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR011524 SARAH_dom
PfamiView protein in Pfam
PF11629 Mst1_SARAH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50951 SARAH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13043-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK
60 70 80 90 100
ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI
110 120 130 140 150
VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI
160 170 180 190 200
KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG
210 220 230 240 250
YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW
260 270 280 290 300
SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VRSAKGVSIL RDLINEAMDV
310 320 330 340 350
KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG
360 370 380 390 400
ANTMIEHDDT LPSQLGTMVI NAEDEEEEGT MKRRDETMQP AKPSFLEYFE
410 420 430 440 450
QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA
460 470 480
LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
Length:487
Mass (Da):55,630
Last modified:February 21, 2001 - v2
Checksum:i150758EBC5F77D5C
GO
Isoform 2 (identifier: Q13043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-462: LKSWTVEDLQKRLLALDPMMEQEIEEI → KTSQEQQSGKDICIQNCQGNLLCRYAF
     463-487: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):52,335
Checksum:i9CFFF2D1FBC316E8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H5B4F5H5B4_HUMAN
Serine/threonine-protein kinase 4
STK4
432Annotation score:
A0A087WVN8A0A087WVN8_HUMAN
Serine/threonine-protein kinase 4
STK4
155Annotation score:
A0A087WYT4A0A087WYT4_HUMAN
Serine/threonine-protein kinase 4
STK4
64Annotation score:

Sequence cautioni

The sequence AAH29511 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58916 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222P → R in AAA83254 (PubMed:7665586).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041123162H → N1 PublicationCorresponds to variant dbSNP:rs55850759Ensembl.1
Natural variantiVAR_041124310R → Q1 PublicationCorresponds to variant dbSNP:rs35447878EnsemblClinVar.1
Natural variantiVAR_027040312V → M2 PublicationsCorresponds to variant dbSNP:rs17420378Ensembl.1
Natural variantiVAR_041125355I → T1 PublicationCorresponds to variant dbSNP:rs35944046EnsemblClinVar.1
Natural variantiVAR_041126416P → L1 PublicationCorresponds to variant dbSNP:rs33963346EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019851436 – 462LKSWT…EIEEI → KTSQEQQSGKDICIQNCQGN LLCRYAF in isoform 2. CuratedAdd BLAST27
Alternative sequenceiVSP_019852463 – 487Missing in isoform 2. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18297 mRNA Translation: AAA83254.1
U60207 mRNA Translation: AAB17262.1
AK315238 mRNA Translation: BAG37665.1
Z93016 Genomic DNA No translation available.
AL109839 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75882.1
BC029511 mRNA Translation: AAH29511.1 Sequence problems.
BC058916 mRNA Translation: AAH58916.1 Sequence problems.
BC093768 mRNA Translation: AAH93768.1
CCDSiCCDS13341.1 [Q13043-1]
CCDS86957.1 [Q13043-2]
RefSeqiNP_006273.1, NM_006282.3 [Q13043-1]
XP_005260590.1, XM_005260533.2
UniGeneiHs.472838

Genome annotation databases

EnsembliENST00000372801; ENSP00000361887; ENSG00000101109 [Q13043-2]
ENST00000372806; ENSP00000361892; ENSG00000101109 [Q13043-1]
GeneIDi6789
KEGGihsa:6789
UCSCiuc002xnb.4 human [Q13043-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18297 mRNA Translation: AAA83254.1
U60207 mRNA Translation: AAB17262.1
AK315238 mRNA Translation: BAG37665.1
Z93016 Genomic DNA No translation available.
AL109839 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75882.1
BC029511 mRNA Translation: AAH29511.1 Sequence problems.
BC058916 mRNA Translation: AAH58916.1 Sequence problems.
BC093768 mRNA Translation: AAH93768.1
CCDSiCCDS13341.1 [Q13043-1]
CCDS86957.1 [Q13043-2]
RefSeqiNP_006273.1, NM_006282.3 [Q13043-1]
XP_005260590.1, XM_005260533.2
UniGeneiHs.472838

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JO8NMR-A/B432-480[»]
3COMX-ray2.20A/B2-311[»]
4NR2X-ray2.00A/B/C/D/E/F/G/H432-480[»]
4OH8X-ray2.28A432-480[»]
5TWGX-ray2.30E343-356[»]
5TWHX-ray2.50E358-374[»]
ProteinModelPortaliQ13043
SMRiQ13043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112665, 70 interactors
CORUMiQ13043
DIPiDIP-32491N
ELMiQ13043
IntActiQ13043, 174 interactors
MINTiQ13043
STRINGi9606.ENSP00000361892

Chemistry databases

BindingDBiQ13043
ChEMBLiCHEMBL4598
GuidetoPHARMACOLOGYi2225

PTM databases

iPTMnetiQ13043
PhosphoSitePlusiQ13043

Polymorphism and mutation databases

BioMutaiSTK4
DMDMi13124559

Proteomic databases

EPDiQ13043
MaxQBiQ13043
PaxDbiQ13043
PeptideAtlasiQ13043
PRIDEiQ13043
ProteomicsDBi59119
59120 [Q13043-2]

Protocols and materials databases

DNASUi6789
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372801; ENSP00000361887; ENSG00000101109 [Q13043-2]
ENST00000372806; ENSP00000361892; ENSG00000101109 [Q13043-1]
GeneIDi6789
KEGGihsa:6789
UCSCiuc002xnb.4 human [Q13043-1]

Organism-specific databases

CTDi6789
DisGeNETi6789
EuPathDBiHostDB:ENSG00000101109.11
GeneCardsiSTK4
H-InvDBiHIX0015851
HGNCiHGNC:11408 STK4
HPAiCAB004038
HPA015270
MalaCardsiSTK4
MIMi604965 gene
614868 phenotype
neXtProtiNX_Q13043
OpenTargetsiENSG00000101109
Orphaneti314689 Combined immunodeficiency due to STK4 deficiency
PharmGKBiPA36215
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0201 Eukaryota
ENOG410XP9G LUCA
GeneTreeiENSGT00930000150827
HOVERGENiHBG108518
InParanoidiQ13043
KOiK04411
OMAiGEGSYGC
OrthoDBiEOG091G065P
PhylomeDBiQ13043
TreeFamiTF354217

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-2028269 Signaling by Hippo
SignaLinkiQ13043
SIGNORiQ13043

Miscellaneous databases

ChiTaRSiSTK4 human
EvolutionaryTraceiQ13043
GeneWikiiSTK4
GenomeRNAii6789
PMAP-CutDBiQ13043
PROiPR:Q13043
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101109 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_MST1
HS_STK4
ExpressionAtlasiQ13043 baseline and differential
GenevisibleiQ13043 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024205 Mst1_SARAH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR011524 SARAH_dom
PfamiView protein in Pfam
PF11629 Mst1_SARAH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50951 SARAH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK4_HUMAN
AccessioniPrimary (citable) accession number: Q13043
Secondary accession number(s): B2RCR8
, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 198 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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