UniProtKB - Q13042 (CDC16_HUMAN)
Cell division cycle protein 16 homolog
CDC16
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: GO_Central
- cell division Source: GO_Central
- metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
- positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
- protein K11-linked ubiquitination Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of mitotic cell cycle phase transition Source: Reactome
- ubiquitin-dependent protein catabolic process Source: Reactome
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q13042 |
Reactomei | R-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176412, Phosphorylation of the APC/C R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813, Separation of Sister Chromatids R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q13042 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle protein 16 homologAlternative name(s): Anaphase-promoting complex subunit 6 Short name: APC6 CDC16 homolog Short name: CDC16Hs Cyclosome subunit 6 |
Gene namesi | Name:CDC16 Synonyms:ANAPC6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130177.14 |
HGNCi | HGNC:1720, CDC16 |
MIMi | 603461, gene |
neXtProti | NX_Q13042 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
- spindle 1 Publication
Note: Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Cytoskeleton
- centrosome Source: MGI
- spindle Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Nucleus
- anaphase-promoting complex Source: UniProtKB
- nucleoplasm Source: Reactome
Other locations
- cytoplasm Source: LIFEdb
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 8881 |
OpenTargetsi | ENSG00000130177 |
PharmGKBi | PA26256 |
Miscellaneous databases
Pharosi | Q13042, Tbio |
Polymorphism and mutation databases
BioMutai | CDC16 |
DMDMi | 37537763 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106267 | 1 – 620 | Cell division cycle protein 16 homologAdd BLAST | 620 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 112 | Phosphoserine1 Publication | 1 | |
Modified residuei | 490 | Phosphoserine1 Publication | 1 | |
Modified residuei | 560 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 581 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 595 | Phosphoserine1 Publication | 1 | |
Modified residuei | 599 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q13042 |
jPOSTi | Q13042 |
MassIVEi | Q13042 |
MaxQBi | Q13042 |
PaxDbi | Q13042 |
PeptideAtlasi | Q13042 |
PRIDEi | Q13042 |
ProteomicsDBi | 59116 [Q13042-1] 59117 [Q13042-2] 59118 [Q13042-3] 69376 |
PTM databases
iPTMneti | Q13042 |
PhosphoSitePlusi | Q13042 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130177, Expressed in right uterine tube and 241 other tissues |
ExpressionAtlasi | Q13042, baseline and differential |
Genevisiblei | Q13042, HS |
Organism-specific databases
HPAi | ENSG00000130177, Low tissue specificity |
Interactioni
Subunit structurei
V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029).
Interacts with PPP5C and CDC20 (PubMed:9628895, PubMed:9405394).
Interacts with CDC26 (PubMed:19668213).
5 PublicationsBinary interactionsi
Hide detailsQ13042
With | #Exp. | IntAct |
---|---|---|
CDC26 [Q8NHZ8] | 15 | EBI-994830,EBI-2555941 |
MAPK9 [P45984] | 3 | EBI-994830,EBI-713568 |
Isoform 1 [Q13042-1]
With | #Exp. | IntAct |
---|---|---|
CDC26 [Q8NHZ8] | 5 | EBI-15798699,EBI-2555941 |
Protein-protein interaction databases
BioGRIDi | 114400, 199 interactors |
CORUMi | Q13042 |
DIPi | DIP-36423N |
IntActi | Q13042, 147 interactors |
MINTi | Q13042 |
STRINGi | 9606.ENSP00000353549 |
Miscellaneous databases
RNActi | Q13042, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q13042 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13042 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 33 | TPR 1Add BLAST | 30 | |
Repeati | 37 – 62 | TPR 2Add BLAST | 26 | |
Repeati | 70 – 93 | TPR 3Add BLAST | 24 | |
Repeati | 128 – 159 | TPR 4Add BLAST | 32 | |
Repeati | 164 – 187 | TPR 5Add BLAST | 24 | |
Repeati | 198 – 222 | TPR 6Add BLAST | 25 | |
Repeati | 232 – 260 | TPR 7Add BLAST | 29 | |
Repeati | 267 – 294 | TPR 8Add BLAST | 28 | |
Repeati | 299 – 329 | TPR 9Add BLAST | 31 | |
Repeati | 334 – 362 | TPR 10Add BLAST | 29 | |
Repeati | 369 – 397 | TPR 11Add BLAST | 29 | |
Repeati | 402 – 434 | TPR 12Add BLAST | 33 | |
Repeati | 442 – 474 | TPR 13Add BLAST | 33 | |
Repeati | 479 – 508 | TPR 14Add BLAST | 30 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1173, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_011751_3_2_1 |
InParanoidi | Q13042 |
OMAi | QFIDMRR |
PhylomeDBi | Q13042 |
TreeFami | TF101054 |
Family and domain databases
DisProti | DP01452 |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREEPQDI YWLAQCLYLT
60 70 80 90 100
AQYHRAAHAL RSRKLDKLYE ACRYLAARCH YAAKEHQQAL DVLDMEEPIN
110 120 130 140 150
KRLFEKYLKD ESGFKDPSSD WEMSQSSIKS SICLLRGKIY DALDNRTLAT
160 170 180 190 200
YSYKEALKLD VYCFEAFDLL TSHHMLTAQE EKELLESLPL SKLCNEEQEL
210 220 230 240 250
LRFLFENKLK KYNKPSETVI PESVDGLQEN LDVVVSLAER HYYNCDFKMC
260 270 280 290 300
YKLTSVVMEK DPFHASCLPV HIGTLVELNK ANELFYLSHK LVDLYPSNPV
310 320 330 340 350
SWFAVGCYYL MVGHKNEHAR RYLSKATTLE KTYGPAWIAY GHSFAVESEH
360 370 380 390 400
DQAMAAYFTA AQLMKGCHLP MLYIGLEYGL TNNSKLAERF FSQALSIAPE
410 420 430 440 450
DPFVMHEVGV VAFQNGEWKT AEKWFLDALE KIKAIGNEVT VDKWEPLLNN
460 470 480 490 500
LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS TYSAIGYIHS LMGNFENAVD
510 520 530 540 550
YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIGADIKD KLKCYDFDVH
560 570 580 590 600
TMKTLKNIIS PPWDFREFEV EKQTAEETGL TPLETSRKTP DSRPSLEETF
610 620
EIEMNESDMM LETSMSDHST
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T8C6 | Q5T8C6_HUMAN | Cell division cycle protein 16 homo... | CDC16 | 475 | Annotation score: | ||
A0A3B3ISD2 | A0A3B3ISD2_HUMAN | Cell division cycle protein 16 homo... | CDC16 | 539 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 | K → Q in AAC50200 (PubMed:7736578).Curated | 1 | |
Sequence conflicti | 299 | P → L in AAD45156 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057270 | 1 – 94 | Missing in isoform 4. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_008427 | 36 | Missing in isoform 2 and isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_008428 | 367 – 417 | Missing in isoform 3. CuratedAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18291 mRNA Translation: AAC50200.1 AF164598 mRNA Translation: AAD45156.1 AY599074 Genomic DNA Translation: AAS94323.1 AL160396 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09237.1 CH471085 Genomic DNA Translation: EAX09244.1 CH471085 Genomic DNA Translation: EAX09245.1 BC010875 mRNA Translation: AAH10875.1 BC017244 mRNA Translation: AAH17244.1 |
CCDSi | CCDS81786.1 [Q13042-2] CCDS81787.1 [Q13042-4] CCDS9542.2 [Q13042-1] |
PIRi | A56519 |
RefSeqi | NP_001072113.1, NM_001078645.2 [Q13042-1] NP_001305446.1, NM_001318517.2 [Q13042-2] NP_001305447.1, NM_001318518.2 [Q13042-3] NP_001317030.1, NM_001330101.1 [Q13042-2] NP_001317033.1, NM_001330104.1 [Q13042-4] NP_001317034.1, NM_001330105.1 [Q13042-4] NP_003894.3, NM_003903.4 [Q13042-1] XP_016876322.1, XM_017020833.1 [Q13042-4] |
Genome annotation databases
Ensembli | ENST00000252457; ENSP00000252457; ENSG00000130177 [Q13042-2] ENST00000356221; ENSP00000348554; ENSG00000130177 [Q13042-1] ENST00000360383; ENSP00000353549; ENSG00000130177 [Q13042-1] ENST00000375308; ENSP00000364457; ENSG00000130177 [Q13042-4] ENST00000375310; ENSP00000364459; ENSG00000130177 [Q13042-4] |
GeneIDi | 8881 |
KEGGi | hsa:8881 |
UCSCi | uc001vuk.1, human [Q13042-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18291 mRNA Translation: AAC50200.1 AF164598 mRNA Translation: AAD45156.1 AY599074 Genomic DNA Translation: AAS94323.1 AL160396 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09237.1 CH471085 Genomic DNA Translation: EAX09244.1 CH471085 Genomic DNA Translation: EAX09245.1 BC010875 mRNA Translation: AAH10875.1 BC017244 mRNA Translation: AAH17244.1 |
CCDSi | CCDS81786.1 [Q13042-2] CCDS81787.1 [Q13042-4] CCDS9542.2 [Q13042-1] |
PIRi | A56519 |
RefSeqi | NP_001072113.1, NM_001078645.2 [Q13042-1] NP_001305446.1, NM_001318517.2 [Q13042-2] NP_001305447.1, NM_001318518.2 [Q13042-3] NP_001317030.1, NM_001330101.1 [Q13042-2] NP_001317033.1, NM_001330104.1 [Q13042-4] NP_001317034.1, NM_001330105.1 [Q13042-4] NP_003894.3, NM_003903.4 [Q13042-1] XP_016876322.1, XM_017020833.1 [Q13042-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3HYM | X-ray | 2.80 | B/D/F/H/J/L | 212-539 | [»] | |
4UI9 | electron microscopy | 3.60 | J/K | 1-620 | [»] | |
5A31 | electron microscopy | 4.30 | J/K | 1-620 | [»] | |
5G04 | electron microscopy | 4.00 | J/K | 1-620 | [»] | |
5G05 | electron microscopy | 3.40 | J/K | 1-620 | [»] | |
5KHR | electron microscopy | 6.10 | J/K | 1-620 | [»] | |
5KHU | electron microscopy | 4.80 | J/K | 1-620 | [»] | |
5L9T | electron microscopy | 6.40 | J/K | 1-620 | [»] | |
5L9U | electron microscopy | 6.40 | J/K | 1-620 | [»] | |
5LCW | electron microscopy | 4.00 | J/K | 1-620 | [»] | |
6Q6G | electron microscopy | 3.20 | K/Q | 1-620 | [»] | |
6Q6H | electron microscopy | 3.20 | K/Q | 1-620 | [»] | |
6TLJ | electron microscopy | 3.80 | J/K | 1-620 | [»] | |
6TM5 | electron microscopy | 3.90 | J/K | 1-620 | [»] | |
SMRi | Q13042 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114400, 199 interactors |
CORUMi | Q13042 |
DIPi | DIP-36423N |
IntActi | Q13042, 147 interactors |
MINTi | Q13042 |
STRINGi | 9606.ENSP00000353549 |
PTM databases
iPTMneti | Q13042 |
PhosphoSitePlusi | Q13042 |
Polymorphism and mutation databases
BioMutai | CDC16 |
DMDMi | 37537763 |
Proteomic databases
EPDi | Q13042 |
jPOSTi | Q13042 |
MassIVEi | Q13042 |
MaxQBi | Q13042 |
PaxDbi | Q13042 |
PeptideAtlasi | Q13042 |
PRIDEi | Q13042 |
ProteomicsDBi | 59116 [Q13042-1] 59117 [Q13042-2] 59118 [Q13042-3] 69376 |
Protocols and materials databases
Antibodypediai | 11890, 401 antibodies |
DNASUi | 8881 |
Genome annotation databases
Ensembli | ENST00000252457; ENSP00000252457; ENSG00000130177 [Q13042-2] ENST00000356221; ENSP00000348554; ENSG00000130177 [Q13042-1] ENST00000360383; ENSP00000353549; ENSG00000130177 [Q13042-1] ENST00000375308; ENSP00000364457; ENSG00000130177 [Q13042-4] ENST00000375310; ENSP00000364459; ENSG00000130177 [Q13042-4] |
GeneIDi | 8881 |
KEGGi | hsa:8881 |
UCSCi | uc001vuk.1, human [Q13042-1] |
Organism-specific databases
CTDi | 8881 |
DisGeNETi | 8881 |
EuPathDBi | HostDB:ENSG00000130177.14 |
GeneCardsi | CDC16 |
HGNCi | HGNC:1720, CDC16 |
HPAi | ENSG00000130177, Low tissue specificity |
MIMi | 603461, gene |
neXtProti | NX_Q13042 |
OpenTargetsi | ENSG00000130177 |
PharmGKBi | PA26256 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1173, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_011751_3_2_1 |
InParanoidi | Q13042 |
OMAi | QFIDMRR |
PhylomeDBi | Q13042 |
TreeFami | TF101054 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q13042 |
Reactomei | R-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176412, Phosphorylation of the APC/C R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813, Separation of Sister Chromatids R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q13042 |
Miscellaneous databases
BioGRID-ORCSi | 8881, 776 hits in 851 CRISPR screens |
ChiTaRSi | CDC16, human |
EvolutionaryTracei | Q13042 |
GeneWikii | CDC16 |
GenomeRNAii | 8881 |
Pharosi | Q13042, Tbio |
PROi | PR:Q13042 |
RNActi | Q13042, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130177, Expressed in right uterine tube and 241 other tissues |
ExpressionAtlasi | Q13042, baseline and differential |
Genevisiblei | Q13042, HS |
Family and domain databases
DisProti | DP01452 |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC16_HUMAN | |
Accessioni | Q13042Primary (citable) accession number: Q13042 Secondary accession number(s): A2A365 Q9Y564 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | October 3, 2003 | |
Last modified: | December 2, 2020 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM