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Protein

Striatin-3

Gene

STRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Caution

Was originally thought to be nuclear.1 Publication

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • calmodulin binding Source: GO_Central
  • DNA-binding transcription factor activity Source: UniProtKB
  • protein-containing complex binding Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

SignaLinkiQ13033

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-3
Alternative name(s):
Cell cycle autoantigen SG2NA
S/G2 antigen
Gene namesi
Name:STRN3
Synonyms:GS2NA, SG2NA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000196792.11
HGNCiHGNC:15720 STRN3
MIMi614766 gene
neXtProtiNX_Q13033

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29966
OpenTargetsiENSG00000196792
PharmGKBiPA38394

Polymorphism and mutation databases

BioMutaiSTRN3
DMDMi223634717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512361 – 797Striatin-3Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei150PhosphothreonineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei335PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13033
MaxQBiQ13033
PaxDbiQ13033
PeptideAtlasiQ13033
PRIDEiQ13033
ProteomicsDBi59114
59115 [Q13033-2]

PTM databases

iPTMnetiQ13033
PhosphoSitePlusiQ13033

Expressioni

Gene expression databases

BgeeiENSG00000196792 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_STRN3
ExpressionAtlasiQ13033 baseline and differential
GenevisibleiQ13033 HS

Organism-specific databases

HPAiCAB069925
HPA003392
HPA004636

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).Curated1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118999, 89 interactors
CORUMiQ13033
IntActiQ13033, 65 interactors
STRINGi9606.ENSP00000350071

Structurei

Secondary structure

1797
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ13033
SMRiQ13033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati478 – 517WD 1Add BLAST40
Repeati531 – 570WD 2Add BLAST40
Repeati584 – 623WD 3Add BLAST40
Repeati679 – 718WD 4Add BLAST40
Repeati721 – 760WD 5Add BLAST40
Repeati767 – 796WD 6Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 79Caveolin-bindingSequence analysis9
Regioni166 – 183Calmodulin-bindingSequence analysisAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 136Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 13Poly-Gly8

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiQ13033
KOiK17608
OMAiSEPEICT
OrthoDBiEOG091G0509
PhylomeDBiQ13033
TreeFamiTF313387

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta (identifier: Q13033-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG
60 70 80 90 100
PAAGPELSRP QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL
110 120 130 140 150
QGERKGQENL KKDLVRRIKM LEYALKQERA KYHKLKYGTE LNQGDLKMPT
160 170 180 190 200
FESEETKDTE APTAPQNSQL TWKQGRQLLR QYLQEVGYTD TILDVRSQRV
210 220 230 240 250
RSLLGLSNSE PNGSVETKNL EQILNGGESP KQKGQEIKRS SGDVLETFNF
260 270 280 290 300
LENADDSDED EENDMIEGIP EGKDKHRMNK HKIGNEGLAA DLTDDPDTEE
310 320 330 340 350
ALKEFDFLVT AEDGEGAGEA RSSGDGTEWD KDDLSPTAEV WDVDQGLISK
360 370 380 390 400
LKEQYKKERK GKKGVKRANR TKLYDMIADL GDDELPHIPS GIINQSRSAS
410 420 430 440 450
TRMTDHEGAR AEEAEPITFP SGGGKSFIMG SDDVLLSVLG LGDLADLTVT
460 470 480 490 500
NDADYSYDLP ANKDAFRKTW NPKYTLRSHF DGVRALAFHP VEPVLVTASE
510 520 530 540 550
DHTLKLWNLQ KTVPAKKSAS LDVEPIYTFR AHIGPVLSLA ISSNGEQCFS
560 570 580 590 600
GGIDATIQWW NMPSPSVDPY DTYEPNVLAG TLVGHTDAVW GLAYSGIKNQ
610 620 630 640 650
LLSCSADGTV RLWNPQEKLP CICTYNGDKK HGIPTSVDFI GCDPAHMVTS
660 670 680 690 700
FNTGSAVIYD LETSQSLVIL SSQVDSGLQS NNHINRVVSH PTLPVTITAH
710 720 730 740 750
EDRHIKFFDN KTGKMIHSMV AHLDAVTSLA VDPNGIYLMS GSHDCSIRLW
760 770 780 790
NLDSKTCVQE ITAHRKKLDE SIYDVAFHSS KAYIASAGAD ALAKVFV
Length:797
Mass (Da):87,209
Last modified:February 10, 2009 - v3
Checksum:i2179BD257186DFB0
GO
Isoform Alpha (identifier: Q13033-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-413: Missing.

Show »
Length:713
Mass (Da):77,745
Checksum:i8252FEA677586912
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V340G3V340_HUMAN
Striatin-3
STRN3
332Annotation score:
G3V3G7G3V3G7_HUMAN
Striatin-3
STRN3
112Annotation score:
H0YJT2H0YJT2_HUMAN
Striatin-3
STRN3
172Annotation score:
H0YJZ4H0YJZ4_HUMAN
Striatin-3
STRN3
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63Y → N in AAB81551 (PubMed:7864889).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054337471N → S2 PublicationsCorresponds to variant dbSNP:rs2273171Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006786330 – 413Missing in isoform Alpha. 3 PublicationsAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17989 mRNA Translation: AAB81551.1
AK314041 mRNA Translation: BAG36750.1
AL049830 Genomic DNA No translation available.
BC132673 mRNA Translation: AAI32674.1
AF243424 mRNA Translation: AAF81201.1
CCDSiCCDS41938.1 [Q13033-1]
CCDS9641.1 [Q13033-2]
PIRiJC2522
RefSeqiNP_001077362.1, NM_001083893.1 [Q13033-1]
NP_055389.3, NM_014574.3 [Q13033-2]
UniGeneiHs.401843

Genome annotation databases

EnsembliENST00000355683; ENSP00000347909; ENSG00000196792 [Q13033-2]
ENST00000357479; ENSP00000350071; ENSG00000196792 [Q13033-1]
GeneIDi29966
KEGGihsa:29966
UCSCiuc001wqu.3 human [Q13033-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17989 mRNA Translation: AAB81551.1
AK314041 mRNA Translation: BAG36750.1
AL049830 Genomic DNA No translation available.
BC132673 mRNA Translation: AAI32674.1
AF243424 mRNA Translation: AAF81201.1
CCDSiCCDS41938.1 [Q13033-1]
CCDS9641.1 [Q13033-2]
PIRiJC2522
RefSeqiNP_001077362.1, NM_001083893.1 [Q13033-1]
NP_055389.3, NM_014574.3 [Q13033-2]
UniGeneiHs.401843

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N6JX-ray2.00A/B86-131[»]
ProteinModelPortaliQ13033
SMRiQ13033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118999, 89 interactors
CORUMiQ13033
IntActiQ13033, 65 interactors
STRINGi9606.ENSP00000350071

PTM databases

iPTMnetiQ13033
PhosphoSitePlusiQ13033

Polymorphism and mutation databases

BioMutaiSTRN3
DMDMi223634717

Proteomic databases

EPDiQ13033
MaxQBiQ13033
PaxDbiQ13033
PeptideAtlasiQ13033
PRIDEiQ13033
ProteomicsDBi59114
59115 [Q13033-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355683; ENSP00000347909; ENSG00000196792 [Q13033-2]
ENST00000357479; ENSP00000350071; ENSG00000196792 [Q13033-1]
GeneIDi29966
KEGGihsa:29966
UCSCiuc001wqu.3 human [Q13033-1]

Organism-specific databases

CTDi29966
DisGeNETi29966
EuPathDBiHostDB:ENSG00000196792.11
GeneCardsiSTRN3
H-InvDBiHIX0037669
HGNCiHGNC:15720 STRN3
HPAiCAB069925
HPA003392
HPA004636
MIMi614766 gene
neXtProtiNX_Q13033
OpenTargetsiENSG00000196792
PharmGKBiPA38394
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiQ13033
KOiK17608
OMAiSEPEICT
OrthoDBiEOG091G0509
PhylomeDBiQ13033
TreeFamiTF313387

Enzyme and pathway databases

SignaLinkiQ13033

Miscellaneous databases

ChiTaRSiSTRN3 human
GeneWikiiSTRN3
GenomeRNAii29966
PROiPR:Q13033
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196792 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_STRN3
ExpressionAtlasiQ13033 baseline and differential
GenevisibleiQ13033 HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRN3_HUMAN
AccessioniPrimary (citable) accession number: Q13033
Secondary accession number(s): A2RTX7, A6NHZ7, Q9NRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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