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Entry version 200 (31 Jul 2019)
Sequence version 3 (21 Dec 2004)
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Protein

PR domain zinc finger protein 2

Gene

PRDM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri360 – 382C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1134 – 1156C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1162 – 1185C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1191 – 1214C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1333 – 1355C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1455 – 1478C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 2 (EC:2.1.1.43)
Alternative name(s):
GATA-3-binding protein G3B
Lysine N-methyltransferase 8
MTB-ZF
MTE-binding protein
PR domain-containing protein 2
Retinoblastoma protein-interacting zinc finger protein
Zinc finger protein RIZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM2
Synonyms:KMT8, RIZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9347 PRDM2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601196 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13029

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106C → Y: Reduced histone methyltransferase activity. 1 Publication1
Mutagenesisi159A → V: Reduced histone methyltransferase activity. 1 Publication1
Mutagenesisi188I → V: Loss of histone methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7799

Open Targets

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OpenTargetsi
ENSG00000116731

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33715

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56757653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000416341 – 1718PR domain zinc finger protein 2Add BLAST1718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei421PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki690Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei743PhosphoserineCombined sources1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei781PhosphoserineBy similarity1
Modified residuei785PhosphoserineBy similarity1
Modified residuei796PhosphoserineCombined sources1
Cross-linki866Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q13029

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13029

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13029

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13029

PeptideAtlas

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PeptideAtlasi
Q13029

PRoteomics IDEntifications database

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PRIDEi
Q13029

ProteomicsDB human proteome resource

More...
ProteomicsDBi
3002
59110 [Q13029-1]
59111 [Q13029-2]
59112 [Q13029-3]
65150

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13029

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13029

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000116731 Expressed in 229 organ(s), highest expression level in middle temporal gyrus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13029 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13029 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA005809

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the retinoblastoma protein (RB).

Interacts with GATA3.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113575, 14 interactors

Database of interacting proteins

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DIPi
DIP-428N

Protein interaction database and analysis system

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IntActi
Q13029, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000235372

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11718
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13029

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13029

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 141SETPROSITE-ProRule annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni294 – 316Retinoblastoma protein bindingAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi970 – 979SH3-bindingSequence analysis10
Motifi985 – 998SH3-bindingSequence analysisAdd BLAST14
Motifi1028 – 1052SH3-bindingSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi268 – 296Asp/Glu-rich (acidic)Add BLAST29
Compositional biasi933 – 1049Pro-richAdd BLAST117
Compositional biasi1052 – 1074Poly-SerAdd BLAST23
Compositional biasi1361 – 1447Arg/Lys-rich (basic)Add BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri360 – 382C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1134 – 1156C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1162 – 1185C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1191 – 1214C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1333 – 1355C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1455 – 1478C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2461 Eukaryota
ENOG410ZFVU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231078

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13029

KEGG Orthology (KO)

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KOi
K11432

Identification of Orthologs from Complete Genome Data

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OMAi
HAFKCRY

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13029

TreeFam database of animal gene trees

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TreeFami
TF332173

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009170 RIZ_retinblastoma-bd_prot
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

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Pfami
View protein in Pfam
PF00856 SET, 1 hit
PF00096 zf-C2H2, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002395 RIZ_SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13029-1) [UniParc]FASTAAdd to basket
Also known as: RIZ1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQNTTEPVA ATETLAEVPE HVLRGLPEEV RLFPSAVDKT RIGVWATKPI
60 70 80 90 100
LKGKKFGPFV GDKKKRSQVK NNVYMWEVYY PNLGWMCIDA TDPEKGNWLR
110 120 130 140 150
YVNWACSGEE QNLFPLEINR AIYYKTLKPI APGEELLVWY NGEDNPEIAA
160 170 180 190 200
AIEEERASAR SKRSSPKSRK GKKKSQENKN KGNKIQDIQL KTSEPDFTSA
210 220 230 240 250
NMRDSAEGPK EDEEKPSASA LEQPATLQEV ASQEVPPELA TPAPAWEPQP
260 270 280 290 300
EPDERLEAAA CEVNDLGEEE EEEEEEDEEE EEDDDDDELE DEGEEEASMP
310 320 330 340 350
NENSVKEPEI RCDEKPEDLL EEPKTTSEET LEDCSEVTPA MQIPRTKEEA
360 370 380 390 400
NGDVFETFMF PCQHCERKFT TKQGLERHMH IHISTVNHAF KCKYCGKAFG
410 420 430 440 450
TQINRRRHER RHEAGLKRKP SQTLQPSEDL ADGKASGENV ASKDDSSPPS
460 470 480 490 500
LGPDCLIMNS EKASQDTINS SVVEENGEVK ELHPCKYCKK VFGTHTNMRR
510 520 530 540 550
HQRRVHERHL IPKGVRRKGG LEEPQPPAEQ AQATQNVYVP STEPEEEGEA
560 570 580 590 600
DDVYIMDISS NISENLNYYI DGKIQTNNNT SNCDVIEMES ASADLYGINC
610 620 630 640 650
LLTPVTVEIT QNIKTTQVPV TEDLPKEPLG STNSEAKKRR TASPPALPKI
660 670 680 690 700
KAETDSDPMV PSCSLSLPLS ISTTEAVSFH KEKSVYLSSK LKQLLQTQDK
710 720 730 740 750
LTPAGISATE IAKLGPVCVS APASMLPVTS SRFKRRTSSP PSSPQHSPAL
760 770 780 790 800
RDFGKPSDGK AAWTDAGLTS KKSKLESHSD SPAWSLSGRD ERETVSPPCF
810 820 830 840 850
DEYKMSKEWT ASSAFSSVCN QQPLDLSSGV KQKAEGTGKT PVQWESVLDL
860 870 880 890 900
SVHKKHCSDS EGKEFKESHS VQPTCSAVKK RKPTTCMLQK VLLNEYNGID
910 920 930 940 950
LPVENPADGT RSPSPCKSLE AQPDPDLGPG SGFPAPTVES TPDVCPSSPA
960 970 980 990 1000
LQTPSLSSGQ LPPLLIPTDP SSPPPCPPVL TVATPPPPLL PTVPLPAPSS
1010 1020 1030 1040 1050
SASPHPCPSP LSNATAQSPL PILSPTVSPS PSPIPPVEPL MSAASPGPPT
1060 1070 1080 1090 1100
LSSSSSSSSS SSSFSSSSSS SSPSPPPLSA ISSVVSSGDN LEASLPMISF
1110 1120 1130 1140 1150
KQEELENEGL KPREEPQSAA EQDVVVQETF NKNFVCNVCE SPFLSIKDLT
1160 1170 1180 1190 1200
KHLSIHAEEW PFKCEFCVQL FKDKTDLSEH RFLLHGVGNI FVCSVCKKEF
1210 1220 1230 1240 1250
AFLCNLQQHQ RDLHPDKVCT HHEFESGTLR PQNFTDPSKA HVEHMQSLPE
1260 1270 1280 1290 1300
DPLETSKEEE ELNDSSEELY TTIKIMASGI KTKDPDVRLG LNQHYPSFKP
1310 1320 1330 1340 1350
PPFQYHHRNP MGIGVTATNF TTHNIPQTFT TAIRCTKCGK GVDNMPELHK
1360 1370 1380 1390 1400
HILACASASD KKRYTPKKNP VPLKQTVQPK NGVVVLDNSG KNAFRRMGQP
1410 1420 1430 1440 1450
KRLNFSVELS KMSSNKLKLN ALKKKNQLVQ KAILQKNKSA KQKADLKNAC
1460 1470 1480 1490 1500
ESSSHICPYC NREFTYIGSL NKHAAFSCPK KPLSPPKKKV SHSSKKGGHS
1510 1520 1530 1540 1550
SPASSDKNSN SNHRRRTADA EIKMQSMQTP LGKTRARSSG PTQVPLPSSS
1560 1570 1580 1590 1600
FRSKQNVKFA ASVKSKKPSS SSLRNSSPIR MAKITHVEGK KPKAVAKNHS
1610 1620 1630 1640 1650
AQLSSKTSRS LHVRVQKSKA VLQSKSTLAS KKRTDRFNIK SRERSGGPVT
1660 1670 1680 1690 1700
RSLQLAAAAD LSENKREDGS AKQELKDFSY SLRLASRCSP PAAPYITRQY
1710
RKVKAPAAAQ FQGPFFKE
Length:1,718
Mass (Da):188,915
Last modified:December 21, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i536BD68667AFE433
GO
Isoform 2 (identifier: Q13029-2) [UniParc]FASTAAdd to basket
Also known as: MTB-Zf

The sequence of this isoform differs from the canonical sequence as follows:
     1679-1682: SYSL → RNFL
     1683-1718: Missing.

Note: No experimental confirmation available.
Show »
Length:1,682
Mass (Da):184,961
Checksum:iF353A6402F93712D
GO
Isoform 3 (identifier: Q13029-3) [UniParc]FASTAAdd to basket
Also known as: RIZ2

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Note: Produced by alternative initiation at Met-202 of isoform 1.
Show »
Length:1,517
Mass (Da):166,061
Checksum:i2AB9A94179532CE7
GO
Isoform 4 (identifier: Q13029-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-226: GKKKSQENKN...SASALEQPAT → ATASAWRPDA...LTAPEVTWNQ
     227-1718: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:226
Mass (Da):25,519
Checksum:iD7CE11A6D48E16D7
GO
Isoform 5 (identifier: Q13029-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.
     1679-1682: SYSL → RNFL
     1683-1718: Missing.

Note: No experimental confirmation available.
Show »
Length:1,481
Mass (Da):162,107
Checksum:i87F7398540D3A5F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJM6D6RJM6_HUMAN
PR domain zinc finger protein 2
PRDM2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RED5D6RED5_HUMAN
PR domain zinc finger protein 2
PRDM2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3F7S4R3F7_HUMAN
PR domain zinc finger protein 2
PRDM2
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAA0D6RAA0_HUMAN
PR domain zinc finger protein 2
PRDM2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9J3H0Y9J3_HUMAN
PR domain zinc finger protein 2
PRDM2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA08110 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164S → T in AAA87023 (PubMed:7590293).Curated1
Sequence conflicti196D → S in AAA87023 (PubMed:7590293).Curated1
Sequence conflicti200A → G in AAA87023 (PubMed:7590293).Curated1
Sequence conflicti276 – 293EDEEE…LEDEG → VGGGGGVVVVVSWKARGE in AAA87023 (PubMed:7590293).CuratedAdd BLAST18
Sequence conflicti307 – 318EPEIR…EKPED → SQKYGVMRSQKI in AAA87023 (PubMed:7590293).CuratedAdd BLAST12
Sequence conflicti336 – 337EV → DL in AAA87023 (PubMed:7590293).Curated2
Sequence conflicti371T → I in AAA87023 (PubMed:7590293).Curated1
Sequence conflicti466 – 467DT → VS in AAA87023 (PubMed:7590293).Curated2
Sequence conflicti530Q → L in BX647310 (PubMed:17974005).Curated1
Sequence conflicti534 – 550TQNVY…EEGEA → PRTCMYQAQSRRGRGSR in AAA87023 (PubMed:7590293).CuratedAdd BLAST17
Sequence conflicti703P → PP (PubMed:7538672).Curated1
Sequence conflicti703P → PP (PubMed:8654390).Curated1
Sequence conflicti856H → R in BX647310 (PubMed:17974005).Curated1
Sequence conflicti1456I → T in BX647310 (PubMed:17974005).Curated1
Isoform 4 (identifier: Q13029-4)
Sequence conflicti198Q → R in BC014468 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052929283D → E. Corresponds to variant dbSNP:rs2076324Ensembl.1
Natural variantiVAR_052930450S → N. Corresponds to variant dbSNP:rs17350795Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189741 – 201Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_046421171 – 226GKKKS…EQPAT → ATASAWRPDALHQRPRTSPG SIGRSKLQLQPSSRDHSSKS RHSGCSLTAPEVTWNQ in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_046422227 – 1718Missing in isoform 4. 1 PublicationAdd BLAST1492
Alternative sequenceiVSP_0069271679 – 1682SYSL → RNFL in isoform 2 and isoform 5. 2 Publications4
Alternative sequenceiVSP_0069281683 – 1718Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17838 mRNA Translation: AAC50820.2
BX647310 mRNA No translation available.
AL031277 Genomic DNA No translation available.
AL583942 Genomic DNA No translation available.
AL359771 Genomic DNA No translation available.
BC014468 mRNA No translation available.
U23736 mRNA Translation: AAA87023.1
D45132 mRNA Translation: BAA08110.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS150.1 [Q13029-1]
CCDS151.1 [Q13029-2]
CCDS30603.1 [Q13029-5]
CCDS44061.1 [Q13029-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38902

NCBI Reference Sequences

More...
RefSeqi
NP_001007258.1, NM_001007257.2 [Q13029-5]
NP_001129082.1, NM_001135610.1 [Q13029-4]
NP_036363.2, NM_012231.4 [Q13029-1]
NP_056950.2, NM_015866.4 [Q13029-2]
XP_016857744.1, XM_017002255.1 [Q13029-1]
XP_016857745.1, XM_017002256.1 [Q13029-1]
XP_016857746.1, XM_017002257.1 [Q13029-2]
XP_016857748.1, XM_017002259.1 [Q13029-3]
XP_016857749.1, XM_017002260.1 [Q13029-3]
XP_016857750.1, XM_017002261.1 [Q13029-3]
XP_016857751.1, XM_017002262.1 [Q13029-5]
XP_016857752.1, XM_017002263.1 [Q13029-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000235372; ENSP00000235372; ENSG00000116731 [Q13029-1]
ENST00000311066; ENSP00000312352; ENSG00000116731 [Q13029-2]
ENST00000343137; ENSP00000341621; ENSG00000116731 [Q13029-5]
ENST00000376048; ENSP00000365216; ENSG00000116731 [Q13029-4]
ENST00000413440; ENSP00000411103; ENSG00000116731 [Q13029-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7799

UCSC genome browser

More...
UCSCi
uc001avg.4 human [Q13029-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17838 mRNA Translation: AAC50820.2
BX647310 mRNA No translation available.
AL031277 Genomic DNA No translation available.
AL583942 Genomic DNA No translation available.
AL359771 Genomic DNA No translation available.
BC014468 mRNA No translation available.
U23736 mRNA Translation: AAA87023.1
D45132 mRNA Translation: BAA08110.1 Different initiation.
CCDSiCCDS150.1 [Q13029-1]
CCDS151.1 [Q13029-2]
CCDS30603.1 [Q13029-5]
CCDS44061.1 [Q13029-4]
PIRiI38902
RefSeqiNP_001007258.1, NM_001007257.2 [Q13029-5]
NP_001129082.1, NM_001135610.1 [Q13029-4]
NP_036363.2, NM_012231.4 [Q13029-1]
NP_056950.2, NM_015866.4 [Q13029-2]
XP_016857744.1, XM_017002255.1 [Q13029-1]
XP_016857745.1, XM_017002256.1 [Q13029-1]
XP_016857746.1, XM_017002257.1 [Q13029-2]
XP_016857748.1, XM_017002259.1 [Q13029-3]
XP_016857749.1, XM_017002260.1 [Q13029-3]
XP_016857750.1, XM_017002261.1 [Q13029-3]
XP_016857751.1, XM_017002262.1 [Q13029-5]
XP_016857752.1, XM_017002263.1 [Q13029-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JV0NMR-A1-161[»]
2QPWX-ray1.79A2-148[»]
SMRiQ13029
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113575, 14 interactors
DIPiDIP-428N
IntActiQ13029, 5 interactors
STRINGi9606.ENSP00000235372

PTM databases

iPTMnetiQ13029
PhosphoSitePlusiQ13029

Polymorphism and mutation databases

BioMutaiPRDM2
DMDMi56757653

Proteomic databases

EPDiQ13029
jPOSTiQ13029
MaxQBiQ13029
PaxDbiQ13029
PeptideAtlasiQ13029
PRIDEiQ13029
ProteomicsDBi3002
59110 [Q13029-1]
59111 [Q13029-2]
59112 [Q13029-3]
65150

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7799
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235372; ENSP00000235372; ENSG00000116731 [Q13029-1]
ENST00000311066; ENSP00000312352; ENSG00000116731 [Q13029-2]
ENST00000343137; ENSP00000341621; ENSG00000116731 [Q13029-5]
ENST00000376048; ENSP00000365216; ENSG00000116731 [Q13029-4]
ENST00000413440; ENSP00000411103; ENSG00000116731 [Q13029-5]
GeneIDi7799
KEGGihsa:7799
UCSCiuc001avg.4 human [Q13029-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7799
DisGeNETi7799

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRDM2
HGNCiHGNC:9347 PRDM2
HPAiHPA005809
MIMi601196 gene
neXtProtiNX_Q13029
OpenTargetsiENSG00000116731
PharmGKBiPA33715

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2461 Eukaryota
ENOG410ZFVU LUCA
GeneTreeiENSGT00940000159410
HOGENOMiHOG000231078
InParanoidiQ13029
KOiK11432
OMAiHAFKCRY
OrthoDBi1318335at2759
PhylomeDBiQ13029
TreeFamiTF332173

Enzyme and pathway databases

SIGNORiQ13029

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRDM2 human
EvolutionaryTraceiQ13029

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PRDM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7799

Protein Ontology

More...
PROi
PR:Q13029

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116731 Expressed in 229 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiQ13029 baseline and differential
GenevisibleiQ13029 HS

Family and domain databases

InterProiView protein in InterPro
IPR009170 RIZ_retinblastoma-bd_prot
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF00096 zf-C2H2, 2 hits
PIRSFiPIRSF002395 RIZ_SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRDM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13029
Secondary accession number(s): B1AJZ4
, B5MC68, Q13149, Q14550, Q5THJ1, Q5VUL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 21, 2004
Last modified: July 31, 2019
This is version 200 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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