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Entry version 161 (05 Jun 2019)
Sequence version 3 (17 Oct 2006)
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Protein

A-kinase anchor protein 6

Gene

AKAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 6
Short name:
AKAP-6
Alternative name(s):
A-kinase anchor protein 100 kDa
Short name:
AKAP 100
Protein kinase A-anchoring protein 6
Short name:
PRKA6
mAKAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP6
Synonyms:AKAP100, KIAA0311
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:376 AKAP6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604691 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9472

Open Targets

More...
OpenTargetsi
ENSG00000151320

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24670

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKAP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645301 – 2319A-kinase anchor protein 6Add BLAST2319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1073PhosphoserineBy similarity1
Modified residuei1570PhosphoserineBy similarity1
Modified residuei1595PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13023

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13023

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13023

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13023

PeptideAtlas

More...
PeptideAtlasi
Q13023

PRoteomics IDEntifications database

More...
PRIDEi
Q13023

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59109

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in cardiac and skeletal muscle, followed by brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151320 Expressed in 151 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q13023 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13023 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001983
HPA048741

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. Interacts with SYNPO2.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
OPTNQ96CV92EBI-1056102,EBI-748974

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114857, 10 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q13023

Protein interaction database and analysis system

More...
IntActi
Q13023, 12 interactors

Molecular INTeraction database

More...
MINTi
Q13023

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q13023

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati762 – 848Spectrin 1Add BLAST87
Repeati1036 – 1150Spectrin 2Add BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2063 – 2076PKA-RII subunit binding domainAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1560 – 1701Ser-richAdd BLAST142

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJDE Eukaryota
ENOG410XT58 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00810000125473

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001568

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13023

KEGG Orthology (KO)

More...
KOi
K16523

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEECNLM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13023

TreeFam database of animal gene trees

More...
TreeFami
TF105405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018159 Spectrin/alpha-actinin

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00150 SPEC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTMSVTLSP LRSQDLDPMA TDASPMAINM TPTVEQGEGE EAMKDMDSDQ
60 70 80 90 100
QYEKPPPLHT GADWKIVLHL PEIETWLRMT SERVRDLTYS VQQDSDSKHV
110 120 130 140 150
DVHLVQLKDI CEDISDHVEQ IHALLETEFS LKLLSYSVNV IVDIHAVQLL
160 170 180 190 200
WHQLRVSVLV LRERILQGLQ DANGNYTRQT DILQAFSEET KEGRLDSLTE
210 220 230 240 250
VDDSGQLTIK CSQNYLSLDC GITAFELSDY SPSEDLLSGL GDMTSSQVKT
260 270 280 290 300
KPFDSWSYSE MEKEFPELIR SVGLLTVAAD SISTNGSEAV TEEVSQVSLS
310 320 330 340 350
VDDKGGCEED NASAVEEQPG LTLGVSSSSG EALTNAAQPS SETVQQESSS
360 370 380 390 400
SSHHDAKNQQ PVPCENATPK RTIRDCFNYN EDSPTQPTLP KRGLFLKEET
410 420 430 440 450
FKNDLKGNGG KRQMVDLKPE MSRSTPSLVD PPDRSKLCLV LQSSYPNSPS
460 470 480 490 500
AASQSYECLH KVGNGNLENT VKFHIKEISS SLGRLNDCYK EKSRLKKPHK
510 520 530 540 550
TSEEVPPCRT PKRGTGSGKQ AKNTKSSAVP NGELSYTSKA IEGPQTNSAS
560 570 580 590 600
TSSLEPCNQR SWNAKLQLQS ETSSSPAFTQ SSESSVGSDN IMSPVPLLSK
610 620 630 640 650
HKSKKGQASS PSHVTRNGEV VEAWYGSDEY LALPSHLKQT EVLALKLENL
660 670 680 690 700
TKLLPQKPRG ETIQNIDDWE LSEMNSDSEI YPTYHVKKKH TRLGRVSPSS
710 720 730 740 750
SSDIASSLGE SIESGPLSDI LSDEESSMPL AGMKKYADEK SERASSSEKN
760 770 780 790 800
ESHSATKSAL IQKLMQDIQH QDNYEAIWEK IEGFVNKLDE FIQWLNEAME
810 820 830 840 850
TTENWTPPKA EMDDLKLYLE THLSFKLNVD SHCALKEAVE EEGHQLLELI
860 870 880 890 900
ASHKAGLKDM LRMIASQWKE LQRQIKRQHS WILRALDTIK AEILATDVSV
910 920 930 940 950
EDEEGTGSPK AEVQLCYLEA QRDAVEQMSL KLYSEQYTSS SKRKEEFADM
960 970 980 990 1000
SKVHSVGSNG LLDFDSEYQE LWDWLIDMES LVMDSHDLMM SEEQQQHLYK
1010 1020 1030 1040 1050
RYSVEMSIRH LKKTELLSKV EALKKGGVLL PNDLLEKVDS INEKWELLGK
1060 1070 1080 1090 1100
TLGEKIQDTM AGHSGSSPRD LLSPESGSLV RQLEVRIKEL KGWLRDTELF
1110 1120 1130 1140 1150
IFNSCLRQEK EGTMNTEKQL QYFKSLCREI KQRRRGVASI LRLCQHLLDD
1160 1170 1180 1190 1200
RETCNLNADH QPMQLIIVNL ERRWEAIVMQ AVQWQTRLQK KMGKESETLN
1210 1220 1230 1240 1250
VIDPGLMDLN GMSEDALEWD EMDISNKLIS LNEESNDLDQ ELQPVIPSLK
1260 1270 1280 1290 1300
LGETSNEDPG YDEEADNHGG SQYASNITAP SSPHIYQVYS LHNVELYEDN
1310 1320 1330 1340 1350
HMPFLKNNPK VTGMTQPNVL TKSLSKDSSF SSTKSLPDLL GGSNLVKPCA
1360 1370 1380 1390 1400
CHGGDMSQNS GSESGIVSEG DTETTTNSEM CLLNAVDGSP SNLETEHLDP
1410 1420 1430 1440 1450
QMGDAVNVLK QKFTDEGESI KLPNSSQSSI SPVGCVNGKV GDLNSITKHT
1460 1470 1480 1490 1500
PDCLGEELQG KHDVFTFYDY SYLQGSKLKL PMIMKQSQSE KAHVEDPLLR
1510 1520 1530 1540 1550
GFYFDKKSCK SKHQTTELQP DVPPHERILA SASHEMDRIS YKSGNIEKTF
1560 1570 1580 1590 1600
TGMQNAKQLS LLSHSSSIES LSPGGDLFGL GIFKNGSDSL QRSTSLESWL
1610 1620 1630 1640 1650
TSYKSNEDLF SCHSSGDISV SSGSVGELSK RTLDLLNRLE NIQSPSEQKI
1660 1670 1680 1690 1700
KRSVSDITLQ SSSQKMSFTG QMSLDIASSI NEDSAASLTE LSSSDELSLC
1710 1720 1730 1740 1750
SEDIVLHKNK IPESNASFRK RLTRSVADES DVNVSMIVNV SCTSACTDDE
1760 1770 1780 1790 1800
DDSDLLSSST LTLTEEELCI KDEDDDSSIA TDDEIYEDCT LMSGLDYIKN
1810 1820 1830 1840 1850
ELQTWIRPKL SLTRDKKRCN VSDEMKGSKD ISSSEMTNPS DTLNIETLLN
1860 1870 1880 1890 1900
GSVKRVSENN GNGKNSSHTH ELGTKRENKK TIFKVNKDPY VADMENGNIE
1910 1920 1930 1940 1950
GIPERQKGKP NVTSKVSENL GSHGKEISES EHCKCKALMD SLDDSNTAGK
1960 1970 1980 1990 2000
EFVSQDVRHL PKKCPNHHHF ENQSTASTPT EKSFSELALE TRFNNRQDSD
2010 2020 2030 2040 2050
ALKSSDDAPS MAGKSAGCCL ALEQNGTEEN ASISNISCCN CEPDVFHQKD
2060 2070 2080 2090 2100
AEDCSVHNFV KEIIDMASTA LKSKSQPENE VAAPTSLTQI KEKVLEHSHR
2110 2120 2130 2140 2150
PIQLRKGDFY SYLSLSSHDS DCGEVTNYIE EKSSTPLPLD TTDSGLDDKE
2160 2170 2180 2190 2200
DIECFFEACV EGDSDGEEPC FSSAPPNESA VPSEAAMPLQ ATACSSEFSD
2210 2220 2230 2240 2250
SSLSADDADT VALSSPSSQE RAEVGKEVNG LPQTSSGCAE NLEFTPSKLD
2260 2270 2280 2290 2300
SEKESSGKPG ESGMPEEHNA ASAKSKVQDL SLKANQPTDK AALHPSPKTL
2310
TCEENLLNLH EKRHRNMHR
Length:2,319
Mass (Da):256,720
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7607B71AD2140727
GO
Isoform 2 (identifier: Q13023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1075: KTLGEKIQDTMAGHSGSSPRDLLSPE → VFAFLLLFVGYVYIFCVVKYSVRFLI
     1076-2319: Missing.

Note: No experimental confirmation available.
Show »
Length:1,075
Mass (Da):120,243
Checksum:i813200266D867C38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3H7G3V3H7_HUMAN
A-kinase anchor protein 6
AKAP6
1,245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3H2G3V3H2_HUMAN
A-kinase anchor protein 6
AKAP6
356Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3B5G3V3B5_HUMAN
A-kinase anchor protein 6
AKAP6
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3H6G3V3H6_HUMAN
A-kinase anchor protein 6
AKAP6
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V569G3V569_HUMAN
A-kinase anchor protein 6
AKAP6
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJT7H0YJT7_HUMAN
A-kinase anchor protein 6
AKAP6
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20770 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti974W → C in AAA92354 (PubMed:10413680).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028171337A → V. Corresponds to variant dbSNP:rs3742926Ensembl.1
Natural variantiVAR_028172408N → S. Corresponds to variant dbSNP:rs17099240Ensembl.1
Natural variantiVAR_050653558N → D. Corresponds to variant dbSNP:rs35210906Ensembl.1
Natural variantiVAR_050654892E → K. Corresponds to variant dbSNP:rs34572259Ensembl.1
Natural variantiVAR_035781910K → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0357821192M → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0281731492A → V1 PublicationCorresponds to variant dbSNP:rs11845640Ensembl.1
Natural variantiVAR_0506551516T → A. Corresponds to variant dbSNP:rs17099587Ensembl.1
Natural variantiVAR_0506561522V → I. Corresponds to variant dbSNP:rs34711402Ensembl.1
Natural variantiVAR_0357831702E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0357841839P → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs745389246Ensembl.1
Natural variantiVAR_0281742035N → D. Corresponds to variant dbSNP:rs1051695Ensembl.1
Natural variantiVAR_0281752171F → Y. Corresponds to variant dbSNP:rs4647899Ensembl.1
Natural variantiVAR_0281762209D → H. Corresponds to variant dbSNP:rs4402458Ensembl.1
Natural variantiVAR_0506572267E → D. Corresponds to variant dbSNP:rs35977369Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544971050 – 1075KTLGE…LLSPE → VFAFLLLFVGYVYIFCVVKY SVRFLI in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0544981076 – 2319Missing in isoform 2. 1 PublicationAdd BLAST1244

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17195 mRNA Translation: AAA92354.2
AB002309 mRNA Translation: BAA20770.2 Different initiation.
AL049781 Genomic DNA No translation available.
AL117672 Genomic DNA No translation available.
AL132988 Genomic DNA No translation available.
AL136298 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65931.1
BC150185 mRNA Translation: AAI50186.1
BC150288 mRNA Translation: AAI50289.1
BC154413 mRNA Translation: AAI54414.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9644.1 [Q13023-1]

NCBI Reference Sequences

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RefSeqi
NP_004265.3, NM_004274.4 [Q13023-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280979; ENSP00000280979; ENSG00000151320 [Q13023-1]
ENST00000557354; ENSP00000450531; ENSG00000151320 [Q13023-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9472

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9472

UCSC genome browser

More...
UCSCi
uc001wrq.4 human [Q13023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17195 mRNA Translation: AAA92354.2
AB002309 mRNA Translation: BAA20770.2 Different initiation.
AL049781 Genomic DNA No translation available.
AL117672 Genomic DNA No translation available.
AL132988 Genomic DNA No translation available.
AL136298 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65931.1
BC150185 mRNA Translation: AAI50186.1
BC150288 mRNA Translation: AAI50289.1
BC154413 mRNA Translation: AAI54414.1
CCDSiCCDS9644.1 [Q13023-1]
RefSeqiNP_004265.3, NM_004274.4 [Q13023-1]

3D structure databases

SMRiQ13023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114857, 10 interactors
ELMiQ13023
IntActiQ13023, 12 interactors
MINTiQ13023
STRINGi9606.ENSP00000280979

PTM databases

iPTMnetiQ13023
PhosphoSitePlusiQ13023

Polymorphism and mutation databases

BioMutaiAKAP6
DMDMi116241243

Proteomic databases

EPDiQ13023
jPOSTiQ13023
MaxQBiQ13023
PaxDbiQ13023
PeptideAtlasiQ13023
PRIDEiQ13023
ProteomicsDBi59109

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280979; ENSP00000280979; ENSG00000151320 [Q13023-1]
ENST00000557354; ENSP00000450531; ENSG00000151320 [Q13023-2]
GeneIDi9472
KEGGihsa:9472
UCSCiuc001wrq.4 human [Q13023-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9472
DisGeNETi9472

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKAP6
HGNCiHGNC:376 AKAP6
HPAiCAB001983
HPA048741
MIMi604691 gene
neXtProtiNX_Q13023
OpenTargetsiENSG00000151320
PharmGKBiPA24670

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJDE Eukaryota
ENOG410XT58 LUCA
GeneTreeiENSGT00810000125473
HOGENOMiHOG000001568
InParanoidiQ13023
KOiK16523
OMAiYEECNLM
PhylomeDBiQ13023
TreeFamiTF105405

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKAP6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AKAP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9472

Protein Ontology

More...
PROi
PR:Q13023

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151320 Expressed in 151 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ13023 baseline and differential
GenevisibleiQ13023 HS

Family and domain databases

InterProiView protein in InterPro
IPR018159 Spectrin/alpha-actinin
SMARTiView protein in SMART
SM00150 SPEC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13023
Secondary accession number(s): A7E242, A7E2D4, O15028
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: June 5, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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